Genomes and Genes
Gene Symbol: Kdm5a
Description: lysine (K)-specific demethylase 5A
Alias: AA409370, C76986, Jarid1a, RBP2, Rbbp2, lysine-specific demethylase 5A, RBBP-2, histone demethylase JARID1A, jumonji, AT rich interactive domain 1A (Rbp2 like), jumonji/ARID domain-containing protein 1A, retinoblastoma binding protein 2
- Albert M, Schmitz S, Kooistra S, Malatesta M, Morales Torres C, Rekling J, et al. The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3. PLoS Genet. 2013;9:e1003461 pubmed publisher..Taken together, these results suggest that Jarid1b regulates mouse development by protecting developmental genes from inappropriate acquisition of active histone modifications. ..
- Lin W, Cao J, Liu J, Beshiri M, Fujiwara Y, Francis J, et al. Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proc Natl Acad Sci U S A. 2011;108:13379-86 pubmed publisherAberrations in epigenetic processes, such as histone methylation, can cause cancer. Retinoblastoma binding protein 2 (RBP2; also called JARID1A or KDM5A) can demethylate tri- and dimethylated lysine 4 in histone H3, which are epigenetic ..
- Dahl J, Jung I, Aanes H, Greggains G, Manaf A, Lerdrup M, et al. Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition. Nature. 2016;537:548-552 pubmed publisher..Active removal of broad H3K4me3 domains by the lysine demethylases KDM5A and KDM5B is required for normal zygotic genome activation and is essential for early embryo development...
- Liefke R, Oswald F, Alvarado C, Ferres Marco D, Mittler G, Rodriguez P, et al. Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex. Genes Dev. 2010;24:590-601 pubmed publisher..Here we show that the histone demethylase KDM5A is an integral, conserved component of Notch/RBP-J gene silencing...
- Shao G, Chen J, Zhang L, Huang P, Lu H, Jin J, et al. Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development. In Vitro Cell Dev Biol Anim. 2014;50:603-13 pubmed publisher..dynamic changes of H3K4me and its key regulators (Ash1l, Ash2l, Kmt2a, Kmt2b, Kmt2c, Setd1a, Setd7, Kdm1a, Kdm1b, Kdm5a, Kdm5b, Kdm5c, and Kdm5d) in mouse oocytes and preimplantation embryos...
- Peng J, Valouev A, Swigut T, Zhang J, Zhao Y, Sidow A, et al. Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell. 2009;139:1290-302 pubmed publisher..Our findings illuminate a mechanism of histone methylation regulation in pluripotent cells and during early cell-fate transitions. ..
- Footz T, Brinkman Mills P, Banting G, Maier S, Riazi M, Bridgland L, et al. Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere. Genome Res. 2001;11:1053-70 pubmed
- Gough S, Lee F, Yang F, Walker R, Zhu Y, Pineda M, et al. NUP98-PHF23 is a chromatin-modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD histone reader function. Cancer Discov. 2014;4:564-77 pubmed publisher..Furthermore, AML driven by a related fusion gene, NUP98-JARID1A (NJL), was also sensitive to disulfiram...
- Pasini D, Hansen K, Christensen J, Agger K, Cloos P, Helin K. Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2. Genes Dev. 2008;22:1345-55 pubmed publisher..Here, we show a functional interplay between the PRC2 complex and the H3K4me3 demethylase Rbp2 (Jarid1a) in mouse embryonic stem (ES) cells...
- van Oevelen C, Wang J, Asp P, Yan Q, Kaelin W, Kluger Y, et al. A role for mammalian Sin3 in permanent gene silencing. Mol Cell. 2008;32:359-70 pubmed publisher..Here, we have investigated genome-wide binding of mouse Sin3 and RBP2 as well as histone modifications and nucleosome positioning as a function of myogenic differentiation...