Gene Symbol: Kdm5a
Description: lysine (K)-specific demethylase 5A
Alias: AA409370, C76986, Jarid1a, RBP2, Rbbp2, lysine-specific demethylase 5A, RBBP-2, histone demethylase JARID1A, jumonji, AT rich interactive domain 1A (Rbp2 like), jumonji/ARID domain-containing protein 1A, retinoblastoma binding protein 2
Species: mouse
Products:     Kdm5a

Top Publications

  1. Klose R, Yan Q, Tothova Z, Yamane K, Erdjument Bromage H, Tempst P, et al. The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell. 2007;128:889-900 pubmed
    ..b>Retinoblastoma binding protein 2 (RBP2), a nuclear protein implicated in the regulation of transcription and differentiation by the ..
  2. Ohno T, Nakajima K, Kojima M, Toyoda M, Takeuchi T. Modifiers of the jumonji mutation downregulate cyclin D1 expression and cardiac cell proliferation. Biochem Biophys Res Commun. 2004;317:925-9 pubmed
    ..These results suggest the modifier(s) of the jmj mutation can downregulate cardiac cell proliferation by repressing cyclin D1 expression in the same way as jmj. ..
  3. Cao J, Liu Z, Cheung W, Zhao M, Chen S, Chan S, et al. Histone demethylase RBP2 is critical for breast cancer progression and metastasis. Cell Rep. 2014;6:868-77 pubmed publisher
    ..Using bioinformatic analysis of human breast cancer gene-expression data sets, we identified histone demethylase RBP2 as a putative mediator of metastatic progression...
  4. DiTacchio L, Le H, Vollmers C, Hatori M, Witcher M, Secombe J, et al. Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock. Science. 2011;333:1881-5 pubmed publisher
    ..We found that the JumonjiC (JmjC) and ARID domain-containing histone lysine demethylase 1a (JARID1a) formed a complex with CLOCK-BMAL1, which was recruited to the Per2 promoter...
  5. Chaturvedi C, Somasundaram B, Singh K, Carpenedo R, Stanford W, Dilworth F, et al. Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C and the H3K4 demethylase Jarid1a/KDM5A. Proc Natl Acad Sci U S A. 2012;109:18845-50 pubmed publisher
    ..within two distinct protein complexes, one containing the coactivator Mediator and one containing the corepressor Jarid1a/KDM5A...
  6. Beshiri M, Holmes K, Richter W, HESS S, Islam A, Yan Q, et al. Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation. Proc Natl Acad Sci U S A. 2012;109:18499-504 pubmed publisher
    ..the activating epigenetic mark of trimethylated lysine 4 on histone H3, lysine (K)-specific demethylase 5A (KDM5A), reinforces the effects of the retinoblastoma (RB) family of transcriptional repressors on differentiation...
  7. Wang C, Wang J, Li J, Hu G, Shan S, Li Q, et al. KDM5A controls bone morphogenic protein 2-induced osteogenic differentiation of bone mesenchymal stem cells during osteoporosis. Cell Death Dis. 2016;7:e2335 pubmed publisher
    ..patients, we revealed an upregulation of the epigenetic modifying protein lysine (K)-specific demethylase 5A (KDM5A) and decreased Runt-related transcription factor 2 (RUNX2) expression...
  8. Zhao D, Zhang Q, Liu Y, Li X, Zhao K, Ding Y, et al. H3K4me3 Demethylase Kdm5a Is Required for NK Cell Activation by Associating with p50 to Suppress SOCS1. Cell Rep. 2016;15:288-99 pubmed publisher
    The H3K4me3 demethylase Kdm5a regulates gene transcription and is implicated in carcinogenesis. However, the role of Kdm5a in innate immune response remains poorly understood...
  9. Váraljai R, Islam A, Beshiri M, Rehman J, Lopez Bigas N, Benevolenskaya E. Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells. Genes Dev. 2015;29:1817-34 pubmed publisher
    ..Previously, we identified the histone demethylase KDM5A (lysine [K]-specific demethylase 5A), which demethylates histone H3 on Lys4 (H3K4), as a pRB-interacting protein ..

More Information


  1. Albert M, Schmitz S, Kooistra S, Malatesta M, Morales Torres C, Rekling J, et al. The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3. PLoS Genet. 2013;9:e1003461 pubmed publisher
    ..Taken together, these results suggest that Jarid1b regulates mouse development by protecting developmental genes from inappropriate acquisition of active histone modifications. ..
  2. Lin W, Cao J, Liu J, Beshiri M, Fujiwara Y, Francis J, et al. Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proc Natl Acad Sci U S A. 2011;108:13379-86 pubmed publisher
    Aberrations in epigenetic processes, such as histone methylation, can cause cancer. Retinoblastoma binding protein 2 (RBP2; also called JARID1A or KDM5A) can demethylate tri- and dimethylated lysine 4 in histone H3, which are epigenetic ..
  3. Dahl J, Jung I, Aanes H, Greggains G, Manaf A, Lerdrup M, et al. Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition. Nature. 2016;537:548-552 pubmed publisher
    ..Active removal of broad H3K4me3 domains by the lysine demethylases KDM5A and KDM5B is required for normal zygotic genome activation and is essential for early embryo development...
  4. Liefke R, Oswald F, Alvarado C, Ferres Marco D, Mittler G, Rodriguez P, et al. Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex. Genes Dev. 2010;24:590-601 pubmed publisher
    ..Here we show that the histone demethylase KDM5A is an integral, conserved component of Notch/RBP-J gene silencing...
  5. Shao G, Chen J, Zhang L, Huang P, Lu H, Jin J, et al. Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development. In Vitro Cell Dev Biol Anim. 2014;50:603-13 pubmed publisher
    ..dynamic changes of H3K4me and its key regulators (Ash1l, Ash2l, Kmt2a, Kmt2b, Kmt2c, Setd1a, Setd7, Kdm1a, Kdm1b, Kdm5a, Kdm5b, Kdm5c, and Kdm5d) in mouse oocytes and preimplantation embryos...
  6. Peng J, Valouev A, Swigut T, Zhang J, Zhao Y, Sidow A, et al. Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell. 2009;139:1290-302 pubmed publisher
    ..Our findings illuminate a mechanism of histone methylation regulation in pluripotent cells and during early cell-fate transitions. ..
  7. Footz T, Brinkman Mills P, Banting G, Maier S, Riazi M, Bridgland L, et al. Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere. Genome Res. 2001;11:1053-70 pubmed
  8. Gough S, Lee F, Yang F, Walker R, Zhu Y, Pineda M, et al. NUP98-PHF23 is a chromatin-modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD histone reader function. Cancer Discov. 2014;4:564-77 pubmed publisher
    ..Furthermore, AML driven by a related fusion gene, NUP98-JARID1A (NJL), was also sensitive to disulfiram...
  9. Pasini D, Hansen K, Christensen J, Agger K, Cloos P, Helin K. Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2. Genes Dev. 2008;22:1345-55 pubmed publisher
    ..Here, we show a functional interplay between the PRC2 complex and the H3K4me3 demethylase Rbp2 (Jarid1a) in mouse embryonic stem (ES) cells...
  10. van Oevelen C, Wang J, Asp P, Yan Q, Kaelin W, Kluger Y, et al. A role for mammalian Sin3 in permanent gene silencing. Mol Cell. 2008;32:359-70 pubmed publisher
    ..Here, we have investigated genome-wide binding of mouse Sin3 and RBP2 as well as histone modifications and nucleosome positioning as a function of myogenic differentiation...