Gene Symbol: Kdm4d
Description: lysine (K)-specific demethylase 4D
Alias: 4932416A15, Jmjd2d, lysine-specific demethylase 4D, jmjC domain-containing histone demethylation protein 3D, jumonji domain containing 2D, jumonji domain-containing protein 2D
Fodor B, Kubicek S, Yonezawa M, O Sullivan R, Sengupta R, Perez Burgos L, et al
. Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells. Genes Dev. 2006;20:1557-62 pubmed
..These data reveal that certain members of the jmjC class of hydroxylases can work in a pathway that actively antagonizes a histone lysine trimethyl state. ..
Nudel U, Katcoff D, Zakut R, Shani M, Carmon Y, Finer M, et al
. Isolation and characterization of rat skeletal muscle and cytoplasmic actin genes. Proc Natl Acad Sci U S A. 1982;79:2763-7 pubmed
..Several intron sites are conserved from at least the echinoderms to the vertebrates; others appear to be present in some actin genes and not in others. ..
Iwamori N, Zhao M, Meistrich M, Matzuk M. The testis-enriched histone demethylase, KDM4D, regulates methylation of histone H3 lysine 9 during spermatogenesis in the mouse but is dispensable for fertility. Biol Reprod. 2011;84:1225-34 pubmed publisher
..Here, we report the targeted disruption of KDM4D, a testis-enriched tridemethylase of H3K9...
Matoba S, Liu Y, Lu F, Iwabuchi K, Shen L, Inoue A, et al
. Embryonic development following somatic cell nuclear transfer impeded by persisting histone methylation. Cell. 2014;159:884-95 pubmed publisher
..RRRs are enriched for H3K9me3 in donor somatic cells and its removal by ectopically expressed H3K9me3 demethylase Kdm4d not only reactivates the majority of RRRs, but also greatly improves SCNT efficiency...
Dahl J, Jung I, Aanes H, Greggains G, Manaf A, Lerdrup M, et al
. Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition. Nature. 2016;537:548-552 pubmed publisher
..Our results provide insight into the onset of the developmental program in mouse embryos and demonstrate a role for broad H3K4me3 domains in MZT. ..
Trojer P, Zhang J, Yonezawa M, Schmidt A, Zheng H, Jenuwein T, et al
. Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins. J Biol Chem. 2009;284:8395-405 pubmed publisher
..We also identify members of the JMJD2/KDM4 subfamily of jumonji-C type histone demethylases as being responsible for the removal of H1.4K26 methylation. ..
Zhang Q, Chen H, Wang L, Liu D, Hill J, Liu Z. The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice. J Clin Invest. 2011;121:2447-56 pubmed publisher
..Our studies reveal that JMJD2A promotes cardiac hypertrophy under pathological conditions and suggest what we believe to be a novel mechanism for JMJD2A in reprogramming of gene expression involved in cardiac hypertrophy. ..
Khoury Haddad H, Guttmann Raviv N, Ipenberg I, Huggins D, Jeyasekharan A, Ayoub N. PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair. Proc Natl Acad Sci U S A. 2014;111:E728-37 pubmed publisher
..Here, we reveal a previously unrecognized role of KDM4D in the DNA damage response (DDR)...