Gene Symbol: Kdm4c
Description: lysine (K)-specific demethylase 4C
Alias: 2410141F18Rik, AA517467, Gasc1, Jmjd2c, lysine-specific demethylase 4C, gene amplified in squamous cell carcinoma 1, jmjC domain-containing histone demethylation protein 3C, jumonji domain containing 2C, jumonji domain-containing protein 2C
Species: mouse
Products:     Kdm4c

Top Publications

  1. Wissmann M, Yin N, Müller J, Greschik H, Fodor B, Jenuwein T, et al. Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol. 2007;9:347-53 pubmed
    ..Here, we identify the Jumonji C (JMJC) domain-containing protein JMJD2C as the first histone tridemethylase regulating androgen receptor function...
  2. Loh Y, Zhang W, Chen X, George J, Ng H. Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Genes Dev. 2007;21:2545-57 pubmed
    ..Here, we show that the H3K9Me2 and H3K9Me3 demethylase genes, Jmjd1a and Jmjd2c, are positively regulated by the ES cell transcription factor Oct4...
  3. Wang J, Zhang M, Zhang Y, Kou Z, Han Z, Chen D, et al. The histone demethylase JMJD2C is stage-specifically expressed in preimplantation mouse embryos and is required for embryonic development. Biol Reprod. 2010;82:105-11 pubmed publisher
    ..In the present study, we investigated the expression characteristics and function of JMJD2C, a histone demethylase that belongs to the JmjC-domain-containing histone demethylases, during preimplantation ..
  4. Fodor B, Kubicek S, Yonezawa M, O Sullivan R, Sengupta R, Perez Burgos L, et al. Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells. Genes Dev. 2006;20:1557-62 pubmed
    ..These data reveal that certain members of the jmjC class of hydroxylases can work in a pathway that actively antagonizes a histone lysine trimethyl state. ..
  5. Ishimura A, Terashima M, Kimura H, Akagi K, Suzuki Y, Sugano S, et al. Jmjd2c histone demethylase enhances the expression of Mdm2 oncogene. Biochem Biophys Res Commun. 2009;389:366-71 pubmed publisher
    b>Jmjd2c is a candidate oncogene that encodes histone lysine demethylase...
  6. Sudo G, Kagawa T, Kokubu Y, Inazawa J, Taga T. Increase in GFAP-positive astrocytes in histone demethylase GASC1/KDM4C/JMJD2C hypomorphic mutant mice. Genes Cells. 2016;21:218-25 pubmed publisher
    GASC1, also known as KDM4C/JMJD2C, is a histone demethylase for histone H3 lysine 9 (H3K9) and H3K36...
  7. Jung E, Sim Y, Jeong H, Kim S, Yun Y, Song J, et al. Jmjd2C increases MyoD transcriptional activity through inhibiting G9a-dependent MyoD degradation. Biochim Biophys Acta. 2015;1849:1081-94 pubmed publisher
    ..we provide evidence for a unique regulatory mechanism of MyoD transcriptional activity through demethylation by Jmjd2C demethylase whose level increases during muscle differentiation...
  8. Trojer P, Zhang J, Yonezawa M, Schmidt A, Zheng H, Jenuwein T, et al. Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins. J Biol Chem. 2009;284:8395-405 pubmed publisher
    ..We also identify members of the JMJD2/KDM4 subfamily of jumonji-C type histone demethylases as being responsible for the removal of H1.4K26 methylation. ..
  9. Burton A, Azevedo C, Andreassi C, Riccio A, Saiardi A. Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation. Proc Natl Acad Sci U S A. 2013;110:18970-5 pubmed publisher
    ..of the high-energy inositol pyrophosphates (IP7), is associated with chromatin and interacts with Jumonji domain containing 2C (JMJD2C), a recently identified histone lysine demethylase...

More Information


  1. Ozaki Y, Fujiwara K, Ikeda M, Ozaki T, Terui T, Soma M, et al. The oncogenic role of GASC1 in chemically induced mouse skin cancer. Mamm Genome. 2015;26:591-7 pubmed publisher
    Gene amplified in squamous cell carcinoma (SCC) 1 (GASC1), also known as KDM4C/JMJD2C, encodes a histone demethylase that specifically demethylates lysine residues (H3K9, H3K36, and H1...
  2. Kawazu M, Saso K, Tong K, McQuire T, Goto K, Son D, et al. Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development. PLoS ONE. 2011;6:e17830 pubmed publisher
    ..Taken together, these findings suggest an essential role for JMJD2B in the estrogen signaling, and identify JMJD2B as a potential therapeutic target in breast cancer. ..
  3. Cheung N, Fung T, Zeisig B, Holmes K, Rane J, Mowen K, et al. Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia. Cancer Cell. 2016;29:32-48 pubmed publisher
    ..PRMT1 is necessary but not sufficient for leukemic transformation, which requires co-recruitment of KDM4C, an H3K9 demethylase, by chimeric transcription factors to mediate epigenetic reprogramming...
  4. Pedersen M, Agger K, Laugesen A, Johansen J, Cloos P, Christensen J, et al. The demethylase JMJD2C localizes to H3K4me3-positive transcription start sites and is dispensable for embryonic development. Mol Cell Biol. 2014;34:1031-45 pubmed publisher
    The histone demethylase JMJD2C, also known as KDM4C/GASC1, has activity against methylated H3K9 and H3K36 and is amplified and/or overexpressed in human cancers...
  5. Zeruth G, Williams J, Cole Y, Jetten A. HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity. PLoS ONE. 2015;10:e0131303 pubmed publisher
  6. Das P, Shao Z, Beyaz S, Apostolou E, Pinello L, De Los Angeles A, et al. Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity. Mol Cell. 2014;53:32-48 pubmed publisher
    ..In-depth analyses demonstrate that the closely related HDMs Jmjd2b and Jmjd2c are necessary for self-renewal of ESCs and induced pluripotent stem cell generation...
  7. Sridharan R, Gonzales Cope M, Chronis C, Bonora G, McKee R, Huang C, et al. Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1? in reprogramming to pluripotency. Nat Cell Biol. 2013;15:872-82 pubmed publisher
    ..Together, our findings demonstrate that Cbx3 and H3K9 methylation restrict late reprogramming events, and suggest that a marked change in global chromatin character constitutes an epigenetic roadblock for reprogramming. ..
  8. Agger K, Miyagi S, Pedersen M, Kooistra S, Johansen J, Helin K. Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells. Genes Dev. 2016;30:1278-88 pubmed publisher
    ..Using Jmjd2a, Jmjd2b, and Jmjd2c conditional triple-knockout mice, we show that Jmjd2/Kdm4 activities are required for MLL-AF9 translocated AML in ..
  9. Pedersen M, Kooistra S, Radzisheuskaya A, Laugesen A, Johansen J, Hayward D, et al. Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development. EMBO J. 2016;35:1550-64 pubmed publisher
    ..of the Jmjd2 family of H3K9/H3K36 histone demethylases, we generated conditional Jmjd2a/Kdm4a, Jmjd2b/Kdm4b and Jmjd2c/Kdm4c/Gasc1 single, double and triple knockout mouse embryonic stem cells (ESCs)...
  10. Fisher C, Marks H, Cho L, Andrews R, Wormald S, Carroll T, et al. An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers. Nucleic Acids Res. 2017;45:e174 pubmed publisher
    ..Our strategy to generate null mutant mouse ES cells is applicable to thousands of genes and repurposes existing IKMC Intermediate Vectors. ..
  11. Dahl J, Jung I, Aanes H, Greggains G, Manaf A, Lerdrup M, et al. Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition. Nature. 2016;537:548-552 pubmed publisher
    ..Our results provide insight into the onset of the developmental program in mouse embryos and demonstrate a role for broad H3K4me3 domains in MZT. ..
  12. Fujiwara K, Fujita Y, Kasai A, Onaka Y, Hashimoto H, Okada H, et al. Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse. Transl Psychiatry. 2016;6:e766 pubmed publisher
    ..Our findings provide evidence for the involvement of histone demethylation in the formation of functional neural networks during development. ..
  13. Wu L, Wary K, REVSKOY S, Gao X, Tsang K, Komarova Y, et al. Histone Demethylases KDM4A and KDM4C Regulate Differentiation of Embryonic Stem Cells to Endothelial Cells. Stem Cell Reports. 2015;5:10-21 pubmed publisher
    ..Here we demonstrated that the histone demethylases KDM4A and KDM4C played an indispensable but independent role in mediating the expression of fetal liver kinase (Flk)1 and VE-..
  14. Tomaz R, Harman J, Karimlou D, Weavers L, Fritsch L, Bou Kheir T, et al. Jmjd2c facilitates the assembly of essential enhancer-protein complexes at the onset of embryonic stem cell differentiation. Development. 2017;144:567-579 pubmed publisher
    ..However, little is known about their importance at the exit of ESC pluripotency. Here, we reveal that Jmjd2c facilitates this process by stabilising the assembly of mediator-cohesin complexes at lineage-specific enhancers...