Gene Symbol: Kdm4a
Description: lysine (K)-specific demethylase 4A
Alias: D4Ertd222e, JHDM3A, Jmjd2, Jmjd2a, mKIAA0677, lysine-specific demethylase 4A, jmjC domain-containing histone demethylation protein 3A, jumonji domain containing 2A, jumonji domain-containing protein 2A
Species: mouse
Products:     Kdm4a

Top Publications

  1. Fodor B, Kubicek S, Yonezawa M, O Sullivan R, Sengupta R, Perez Burgos L, et al. Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells. Genes Dev. 2006;20:1557-62 pubmed
    ..Using a candidate approach, we identified the subgroup of murine Jmjd2 proteins to antagonize H3K9me3 at pericentric heterochromatin...
  2. Sankar A, Kooistra S, Gonzalez J, Ohlsson C, Poutanen M, Helin K. Maternal expression of the histone demethylase Kdm4a is crucial for pre-implantation development. Development. 2017;144:3264-3277 pubmed publisher
    ..KDM4A (JMJD2A) is a lysine demethylase with specificity towards di- and tri-methylated lysine 9 and lysine 36 of histone H3 (..
  3. Kim T, Jin F, Shin S, Oh S, Lightfoot S, Grande J, et al. Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1. J Clin Invest. 2016;126:706-20 pubmed publisher
    ..We found that overexpression of lysine-specific demethylase 4A (KDM4A, also known as JMJD2A) was positively correlated with Gleason score and metastasis in human prostate tumors...
  4. Frankel W, Yang Y, Mahaffey C, Beyer B, O Brien T. Szt2, a novel gene for seizure threshold in mice. Genes Brain Behav. 2009;8:568-76 pubmed publisher
    ..While the biological function of Szt2 remains unknown, its high conservation, unique structure and effect on seizure threshold suggest that it serves an important role in the central nervous system. ..
  5. Pathak S, Maitra S, Chakravarty S, Kumar A. Histone Lysine Demethylases of JMJD2 or KDM4 Family are Important Epigenetic Regulators in Reward Circuitry in the Etiopathology of Depression. Neuropsychopharmacology. 2017;42:854-863 pubmed publisher
    ..demethylases, which can remove methylation from H3K9, in particular Jumonji domain containing demethylases 2 or Jmjd2 family, has not been studied...
  6. Kawazu M, Saso K, Tong K, McQuire T, Goto K, Son D, et al. Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development. PLoS ONE. 2011;6:e17830 pubmed publisher
    ..Taken together, these findings suggest an essential role for JMJD2B in the estrogen signaling, and identify JMJD2B as a potential therapeutic target in breast cancer. ..
  7. Zhang D, Yoon H, Wong J. JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2). Mol Cell Biol. 2005;25:6404-14 pubmed
    ..Here we report the characterization of a novel N-CoR-interacting protein, JMJD2A (previously known as KIAA0677)...
  8. Wu L, Wary K, REVSKOY S, Gao X, Tsang K, Komarova Y, et al. Histone Demethylases KDM4A and KDM4C Regulate Differentiation of Embryonic Stem Cells to Endothelial Cells. Stem Cell Reports. 2015;5:10-21 pubmed publisher
    ..Here we demonstrated that the histone demethylases KDM4A and KDM4C played an indispensable but independent role in mediating the expression of fetal liver kinase (Flk)1 ..
  9. Trojer P, Zhang J, Yonezawa M, Schmidt A, Zheng H, Jenuwein T, et al. Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins. J Biol Chem. 2009;284:8395-405 pubmed publisher
    ..We also identify members of the JMJD2/KDM4 subfamily of jumonji-C type histone demethylases as being responsible for the removal of H1.4K26 methylation.

More Information


  1. Zhou J, Wang F, Xu C, Zhou Z, Zhang W. The histone demethylase JMJD2A regulates the expression of BDNF and mediates neuropathic pain in mice. Exp Cell Res. 2017;361:155-162 pubmed publisher
    b>JMJD2A is a JmjC histone demethylase that catalyzes the demethylation of di- and trimethylated Lys9 and Lys36 in histone H3 (H3K9me2/3 and H3K36me2/3)...
  2. Zhang Q, Chen H, Wang L, Liu D, Hill J, Liu Z. The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice. J Clin Invest. 2011;121:2447-56 pubmed publisher
    ..To understand the role of JMJD2A, a histone trimethyl demethylase, in cardiac hypertrophy, we generated mouse lines with heart-specific Jmjd2a ..
  3. Dahl J, Jung I, Aanes H, Greggains G, Manaf A, Lerdrup M, et al. Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition. Nature. 2016;537:548-552 pubmed publisher
    ..Our results provide insight into the onset of the developmental program in mouse embryos and demonstrate a role for broad H3K4me3 domains in MZT. ..
  4. Young L, Hendzel M. The oncogenic potential of Jumonji D2 (JMJD2/KDM4) histone demethylase overexpression. Biochem Cell Biol. 2013;91:369-77 pubmed publisher
    ..Knockout mouse models for Kdm4b and Kdm4d have not resulted in gross abnormalities, while mouse models for Kdm4a and Kdm4c have not been reported...
  5. Das A, Chai J, Jung K, Das N, Kang S, Lee Y, et al. JMJD2A attenuation affects cell cycle and tumourigenic inflammatory gene regulation in lipopolysaccharide stimulated neuroectodermal stem cells. Exp Cell Res. 2014;328:361-78 pubmed publisher
    b>JMJD2A is a lysine trimethyl-specific histone demethylase that is highly expressed in a variety of tumours. The role of JMJD2A in tumour progression remains unclear...
  6. Jeong Y, Park J, Ko Y, Kang Y. JHDM3A module as an effector molecule in guide-directed modification of target chromatin. J Biol Chem. 2011;286:4461-70 pubmed publisher
    ..We investigated whether JHDM3A/JMJD2A, a trimethylated histone H3-lysine 9 (H3K9me3)-specific demethylase, could function as an effector molecule ..
  7. Agger K, Miyagi S, Pedersen M, Kooistra S, Johansen J, Helin K. Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells. Genes Dev. 2016;30:1278-88 pubmed publisher
    ..Using Jmjd2a, Jmjd2b, and Jmjd2c conditional triple-knockout mice, we show that Jmjd2/Kdm4 activities are required for MLL-AF9 ..
  8. Wang J, Zhang M, Zhang Y, Kou Z, Han Z, Chen D, et al. The histone demethylase JMJD2C is stage-specifically expressed in preimplantation mouse embryos and is required for embryonic development. Biol Reprod. 2010;82:105-11 pubmed publisher
    ..Our data suggest that the deregulation of these critical genes synergistically causes the developmental defects observed in JMJD2C-depleted embryos. ..
  9. Ishiguro K, Watanabe O, Nakamura M, Yamamura T, Matsushita M, Goto H, et al. Inhibition of KDM4A activity as a strategy to suppress interleukin-6 production and attenuate colitis induction. Clin Immunol. 2017;180:120-127 pubmed publisher
    ..Atractylodin inhibited KDM4A but not KDM6A activity. Atractylodin administration attenuated colitis induction...
  10. Johmura Y, Sun J, Kitagawa K, Nakanishi K, Kuno T, Naiki Ito A, et al. SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence. Nat Commun. 2016;7:10574 pubmed publisher
    ..We demonstrate here that SCF(Fbxo22)-KDM4A is a senescence-associated E3 ligase targeting methylated p53 for degradation...
  11. Pedersen M, Kooistra S, Radzisheuskaya A, Laugesen A, Johansen J, Hayward D, et al. Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development. EMBO J. 2016;35:1550-64 pubmed publisher
    ..To elucidate the functions of the Jmjd2 family of H3K9/H3K36 histone demethylases, we generated conditional Jmjd2a/Kdm4a, Jmjd2b/Kdm4b and Jmjd2c/Kdm4c/Gasc1 single, double and triple knockout mouse embryonic stem cells (ESCs)...