Gene Symbol: Kdm2a
Description: lysine (K)-specific demethylase 2A
Alias: 100043628, 5530401A10Rik, AA589516, AW536790, Cxxc8, Fbl11, Fbl7, Fbxl11, Gm4560, Jhdm1, Jhdm1a, lalina, lysine-specific demethylase 2A, F-box and leucine-rich repeat protein 11, F-box protein containing leucine repeats, F-box/LRR-repeat protein 11, [Histone-H3]-lysine-36 demethylase 1A, jmjC domain-containing histone demethylation protein 1A
Blackledge N, Zhou J, Tolstorukov M, Farcas A, Park P, Klose R. CpG islands recruit a histone H3 lysine 36 demethylase. Mol Cell. 2010;38:179-90 pubmed publisher
..Here we show that CpG islands directly recruit the H3K36-specific lysine demethylase enzyme KDM2A. Nucleation of KDM2A at these elements results in removal of H3K36 methylation, creating CpG island chromatin that ..
Zhou J, Blackledge N, Farcas A, Klose R. Recognition of CpG island chromatin by KDM2A requires direct and specific interaction with linker DNA. Mol Cell Biol. 2012;32:479-89 pubmed publisher
..We previously demonstrated that the histone demethylase KDM2A is specifically recruited to CpG islands to define a unique chromatin architecture and highlight gene regulatory ..
Kawakami E, Tokunaga A, Ozawa M, Sakamoto R, Yoshida N. The histone demethylase Fbxl11/Kdm2a plays an essential role in embryonic development by repressing cell-cycle regulators. Mech Dev. 2015;135:31-42 pubmed publisher
..b>Fbxl11 (F-box and leucine-rich repeat 11)/Kdm2a is a histone demethylase that selectively removes mono- and di-..
Lu T, Jackson M, Wang B, Yang M, Chance M, Miyagi M, et al
. Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65. Proc Natl Acad Sci U S A. 2010;107:46-51 pubmed publisher
..SET domain-containing protein 1 (NSD1), and a lysine demethylase, F-box and leucine-rich repeat protein 11 (FBXL11)...
Fukuda T, Tokunaga A, Sakamoto R, Yoshida N. Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly. Mol Cell Neurosci. 2011;46:614-24 pubmed publisher
..5 brain. Our findings suggest that the Fbxl10 gene makes important contributions to embryonic neural development by regulating cell proliferation and cell death in mice. ..
Pan D, Mao C, Zou T, Yao A, Cooper M, Boyartchuk V, et al
. The histone demethylase Jhdm1a regulates hepatic gluconeogenesis. PLoS Genet. 2012;8:e1002761 pubmed publisher
..screen against the known histone demethylases and identify a histone H3 lysine 36 (H3K36) demethylase, Jhdm1a, as a key negative regulator of gluconeogenic gene expression...
Yi Q, Cao Y, Liu O, Lu Y, Wang J, Wang S, et al
. Spatial and temporal expression of histone demethylase, Kdm2a, during murine molar development. Biotech Histochem. 2016;91:137-44 pubmed publisher
The histone demethylase, lysine (K)-specific demethylase 2A (Kdm2a), is highly conserved and expressed ubiquitously...
Dahl J, Jung I, Aanes H, Greggains G, Manaf A, Lerdrup M, et al
. Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition. Nature. 2016;537:548-552 pubmed publisher
..Our results provide insight into the onset of the developmental program in mouse embryos and demonstrate a role for broad H3K4me3 domains in MZT. ..