Kdm1a

Summary

Gene Symbol: Kdm1a
Description: lysine (K)-specific demethylase 1A
Alias: 1810043O07Rik, AA408884, Aof2, D4Ertd478e, Kdm1, Lsd1, mKIAA0601, lysine-specific histone demethylase 1A, BRAF35-HDAC complex protein BHC110, amine oxidase (flavin containing) domain 2, flavin-containing amine oxidase domain-containing protein 2, lysine (K)-specific demethylase 1, lysine-specific histone demethylase 1
Species: mouse
Products:     Kdm1a

Top Publications

  1. Metzger E, Wissmann M, Yin N, Müller J, Schneider R, Peters A, et al. LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature. 2005;437:436-9 pubmed
    ..Here we show that lysine-specific demethylase 1 (LSD1; also known as BHC110) co-localizes with the androgen receptor in normal human prostate and prostate tumour...
  2. Wissmann M, Yin N, Müller J, Greschik H, Fodor B, Jenuwein T, et al. Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol. 2007;9:347-53 pubmed
    ..Recently, lysine-specific demethylase 1 (LSD1), the first histone demethylase, was identified...
  3. Zhu D, Hölz S, Metzger E, Pavlovic M, Jandausch A, Jilg C, et al. Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells. Nat Commun. 2014;5:3174 pubmed publisher
    ..Here we demonstrate that lysine-specific demethylase 1 (Lsd1) regulates differentiation onset of TSCs...
  4. Whyte W, Bilodeau S, Orlando D, Hoke H, Frampton G, Foster C, et al. Enhancer decommissioning by LSD1 during embryonic stem cell differentiation. Nature. 2012;482:221-5 pubmed publisher
    ..Here we show that the histone demethylase lysine-specific demethylase 1 (LSD1; ref...
  5. Tsai W, Nguyen T, Shi Y, Barton M. p53-targeted LSD1 functions in repression of chromatin structure and transcription in vivo. Mol Cell Biol. 2008;28:5139-46 pubmed publisher
    ..We found that p53 directly interacts with lysine-specific demethylase 1 (LSD1) to alter chromatin structure and confer developmental repression of the tumor marker alpha-fetoprotein (AFP)...
  6. Sun G, Alzayady K, Stewart R, Ye P, Yang S, Li W, et al. Histone demethylase LSD1 regulates neural stem cell proliferation. Mol Cell Biol. 2010;30:1997-2005 pubmed publisher
    Lysine-specific demethylase 1 (LSD1) functions as a transcriptional coregulator by modulating histone methylation. Its role in neural stem cells has not been studied...
  7. Zhang J, Bonasio R, Strino F, Kluger Y, Holloway J, Modzelewski A, et al. SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors. Genes Dev. 2013;27:749-66 pubmed publisher
    ..regulates transcription in somatic cells and during spermatogenesis through the formation of a stable complex with LSD1 and CoREST...
  8. Choi J, Jang H, Kim H, Kim S, Cho E, Youn H. Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors. Biochem Biophys Res Commun. 2010;401:327-32 pubmed publisher
    ..Here we identify that lysine specific demethylase 1, (LSD1) is responsible for removing the repressive histone codes during C2C12 mouse myoblast differentiation...
  9. Sun G, Ye P, Murai K, Lang M, Li S, Zhang H, et al. miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells. Nat Commun. 2011;2:529 pubmed publisher
    ..In addition, we show that the histone lysine-specific demethylase 1 (LSD1), a transcriptional co-repressor of nuclear receptor TLX, is a downstream target of miR-137...

More Information

Publications77

  1. Foster C, Dovey O, Lezina L, Luo J, Gant T, Barlev N, et al. Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stability. Mol Cell Biol. 2010;30:4851-63 pubmed publisher
    Lysine-specific demethylase 1 (LSD1), which demethylates mono- and dimethylated histone H3-Lys4 as part of a complex including CoREST and histone deacetylases (HDACs), is essential for embryonic development in the mouse beyond embryonic ..
  2. Su S, Ying H, Chiu Y, Lin F, Chen M, Lin K. Involvement of histone demethylase LSD1 in Blimp-1-mediated gene repression during plasma cell differentiation. Mol Cell Biol. 2009;29:1421-31 pubmed publisher
    ..Here we report that a proline-rich domain in Blimp-1 directly interacts with LSD1, a histone lysine demethylase...
  3. Xu J, Bauer D, Kerenyi M, Vo T, Hou S, Hsu Y, et al. Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A. Proc Natl Acad Sci U S A. 2013;110:6518-23 pubmed publisher
    ..show that the lysine-specific demethylase 1 and repressor element-1 silencing transcription factor corepressor 1 (LSD1/CoREST) histone demethylase complex interacts with BCL11A and is required for full developmental silencing of mouse ..
  4. Musri M, Carmona M, Hanzu F, Kaliman P, Gomis R, Parrizas M. Histone demethylase LSD1 regulates adipogenesis. J Biol Chem. 2010;285:30034-41 pubmed publisher
    ..Knockdown of the H3K4/K9 demethylase LSD1 results in markedly decreased differentiation of 3T3-L1 preadipocytes...
  5. Harris W, Huang X, Lynch J, Spencer G, Hitchin J, Li Y, et al. The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells. Cancer Cell. 2012;21:473-87 pubmed publisher
    Using a mouse model of human MLL-AF9 leukemia, we identified the lysine-specific demethylase KDM1A (LSD1 or AOF2) as an essential regulator of leukemia stem cell (LSC) potential...
  6. Saleque S, Kim J, Rooke H, Orkin S. Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Mol Cell. 2007;27:562-72 pubmed
    ..Prominent among these is the corepressor CoREST, the histone demethylase LSD1, and HDACs 1 and 2. CoREST and LSD1 associate with Gfi-1/1b via the SNAG repression domain...
  7. Fuentes P, Cánovas J, Berndt F, Noctor S, Kukuljan M. CoREST/LSD1 control the development of pyramidal cortical neurons. Cereb Cortex. 2012;22:1431-41 pubmed publisher
    ..the RE-1 silencer of transcription/neural restrictive silencing factor, and requires the histone demethylase LSD1. This reveals the importance of epigenetic control in the execution of neural development programs, specifically in ..
  8. Hino S, Sakamoto A, Nagaoka K, Anan K, Wang Y, Mimasu S, et al. FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure. Nat Commun. 2012;3:758 pubmed publisher
    ..The lysine-specific demethylase-1 (LSD1) is a unique nuclear protein that utilizes flavin adenosine dinucleotide (FAD) as a cofactor...
  9. Macfarlan T, Gifford W, Agarwal S, Driscoll S, Lettieri K, Wang J, et al. Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A. Genes Dev. 2011;25:594-607 pubmed publisher
    ..lines carrying "deletable" and "rescuable" alleles of the lysine-specific demethylase LSD1/KDM1A. In the absence of KDM1A, the murine endogenous retrovirus MuERV-L/MERVL becomes overexpressed and embryonic ..
  10. Hu X, Li X, Valverde K, Fu X, NOGUCHI C, Qiu Y, et al. LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis. Proc Natl Acad Sci U S A. 2009;106:10141-6 pubmed publisher
    ..Here, we show that TAL1 is associated with histone demethylase complexes containing lysine-specific demethylase 1 (LSD1), RE1 silencing transcription factor corepressor (CoREST), histone deacetylase 1 (HDAC1), and histone deacetylase 2 ..
  11. Wang J, Hevi S, Kurash J, Lei H, Gay F, Bajko J, et al. The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation. Nat Genet. 2009;41:125-9 pubmed publisher
    ..Here we study the biological function of lysine-specific demethylase 1 (LSD1, also known as KDM1 and AOF2), which has been shown to demethylate histone H3 on lysine 4 (H3K4) and lysine 9 (H3K9)...
  12. Di Stefano B, Collombet S, Jakobsen J, Wierer M, Sardina J, Lackner A, et al. C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4. Nat Cell Biol. 2016;18:371-81 pubmed publisher
    ..Here we show that C/EBPα post-transcriptionally increases the abundance of several hundred proteins, including Lsd1, Hdac1, Brd4, Med1 and Cdk9, components of chromatin-modifying complexes present at super-enhancers...
  13. Choi J, Jang H, Kim H, Lee J, Kim S, Cho E, et al. Modulation of lysine methylation in myocyte enhancer factor 2 during skeletal muscle cell differentiation. Nucleic Acids Res. 2014;42:224-34 pubmed publisher
    ..We report the reversible lysine methylation of MEF2D by G9a and LSD1 as a regulatory mechanism of MEF2D activity and skeletal muscle differentiation...
  14. Hill J, Quenelle D, Cardin R, Vogel J, Clement C, Bravo F, et al. Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes. Sci Transl Med. 2014;6:265ra169 pubmed publisher
    ..from latency is dependent on a transcriptional coactivator complex that contains two required histone demethylases, LSD1 (lysine-specific demethylase 1) and a member of the JMJD2 family (Jumonji C domain-containing protein 2)...
  15. Kilinc S, Savarino A, Coleman J, Schwob J, Lane R. Lysine-specific demethylase-1 (LSD1) is compartmentalized at nuclear chromocenters in early post-mitotic cells of the olfactory sensory neuronal lineage. Mol Cell Neurosci. 2016;74:58-70 pubmed publisher
    ..The lysine-specific demethylase-1 (LSD1) protein removes activating H3K4 or silencing H3K9 methylation marks at gene promoters and is required for proper ..
  16. Dahl J, Jung I, Aanes H, Greggains G, Manaf A, Lerdrup M, et al. Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition. Nature. 2016;537:548-552 pubmed publisher
    ..Our results provide insight into the onset of the developmental program in mouse embryos and demonstrate a role for broad H3K4me3 domains in MZT. ..
  17. Cui S, Lim K, Shi L, Lee M, Jearawiriyapaisarn N, Myers G, et al. The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice. Blood. 2015;126:386-96 pubmed publisher
    Inhibition of lysine-specific demethylase 1 (LSD1) has been shown to induce fetal hemoglobin (HbF) levels in cultured human erythroid cells in vitro...
  18. Lambrot R, Lafleur C, Kimmins S. The histone demethylase KDM1A is essential for the maintenance and differentiation of spermatogonial stem cells and progenitors. FASEB J. 2015;29:4402-16 pubmed publisher
    ..The histone H3 lysine demethylase KDM1A is expressed in spermatogonia...
  19. Nair V, Ge Y, Balasubramaniyan N, Kim J, Okawa Y, Chikina M, et al. Involvement of histone demethylase LSD1 in short-time-scale gene expression changes during cell cycle progression in embryonic stem cells. Mol Cell Biol. 2012;32:4861-76 pubmed publisher
    The histone demethylase LSD1, a component of the CoREST (corepressor for element 1-silencing transcription factor) corepressor complex, plays an important role in the downregulation of gene expression during development...
  20. Lyons D, Allen W, Goh T, Tsai L, Barnea G, Lomvardas S. An epigenetic trap stabilizes singular olfactory receptor expression. Cell. 2013;154:325-36 pubmed publisher
    ..Here, we identify the transient expression of histone demethylase LSD1 and the OR-dependent expression of adenylyl cyclase 3 (Adcy3) as requirements for initiation and stabilization of ..
  21. Sambeat A, Gulyaeva O, Dempersmier J, Tharp K, Stahl A, Paul S, et al. LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program. Cell Rep. 2016;15:2536-49 pubmed publisher
    ..Here, we identify lysine-specific demethylase 1 (LSD1) as a direct binding partner of Zfp516...
  22. Storm M, Kumpfmueller B, Bone H, Buchholz M, Sanchez Ripoll Y, Chaudhuri J, et al. Zscan4 is regulated by PI3-kinase and DNA-damaging agents and directly interacts with the transcriptional repressors LSD1 and CtBP2 in mouse embryonic stem cells. PLoS ONE. 2014;9:e89821 pubmed publisher
    ..further supported by the fact that protein interaction analyses demonstrate that Zscan4 interacts with both LSD1 and CtBP2 in ESC nuclei...
  23. Wu C, Persaud S, Wei L. Retinoic Acid Induces Ubiquitination-Resistant RIP140/LSD1 Complex to Fine-Tune Pax6 Gene in Neuronal Differentiation. Stem Cells. 2016;34:114-23 pubmed publisher
    ..Here, we identify RIP140 as an immediate retinoic acid (RA)-induced dual-function chaperone for LSD1 (lysine-specific demethylase 1)...
  24. Dalton R, Lyons D, Lomvardas S. Co-opting the unfolded protein response to elicit olfactory receptor feedback. Cell. 2013;155:321-32 pubmed publisher
  25. Coleman J, Lin B, Schwob J. Dissecting LSD1-Dependent Neuronal Maturation in the Olfactory Epithelium. J Comp Neurol. 2017;525:3391-3413 pubmed publisher
    ..The lysine specific demethylase 1 (LSD1) demethylates at both of these lysine residues and has been shown to disrupt neuronal maturation and OR expression ..
  26. Munehira Y, Yang Z, Gozani O. Systematic Analysis of Known and Candidate Lysine Demethylases in the Regulation of Myoblast Differentiation. J Mol Biol. 2017;429:2055-2065 pubmed publisher
    ..Our analysis identified that LSD1 is the only KDM required for myogenic differentiation and that KDM3B, KDM6A, and KDM8 are the candidate KDMs ..
  27. Pajtler K, Weingarten C, Thor T, Künkele A, Heukamp L, Buttner R, et al. The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastoma. Acta Neuropathol Commun. 2013;1:19 pubmed publisher
    ..We examined the role of the H3K4 modifying enzyme, KDM1A, in medulloblastoma, an enzyme also associated with malignant progression in the closely related tumor, ..
  28. Latos P, Goncalves A, Oxley D, Mohammed H, Turro E, Hemberger M. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Nat Commun. 2015;6:7776 pubmed publisher
    ..Unlike in ES cells, Esrrb interacts in TS cells with the histone demethylase Lsd1 and with the RNA Polymerase II-associated Integrator complex...
  29. Zeng X, Jedrychowski M, Chen Y, Serag S, Lavery G, Gygi S, et al. Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation. Genes Dev. 2016;30:1822-36 pubmed publisher
    ..Our understanding of the molecular mechanisms underlying these switches is incomplete. Here we found that LSD1 (lysine-specific demethylase 1), a histone demethylase, regulates brown adipocyte metabolism in two ways...
  30. Byun S, Kim Y, Zhang Y, Kong B, Guo G, Sadoshima J, et al. A postprandial FGF19-SHP-LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy. EMBO J. 2017;36:1755-1769 pubmed publisher
    ..Partner (SHP) mediates postprandial epigenetic repression of hepatic autophagy by recruiting histone demethylase LSD1 in response to a late fed-state hormone, FGF19 (hFGF19, mFGF15)...
  31. Patel D, Shimomura A, Majumdar S, Holley M, Hashino E. The histone demethylase LSD1 regulates inner ear progenitor differentiation through interactions with Pax2 and the NuRD repressor complex. PLoS ONE. 2018;13:e0191689 pubmed publisher
    The histone demethylase LSD1 plays a pivotal role in cellular differentiation, particularly in silencing lineage-specific genes. However, little is known about how LSD1 regulates neurosensory differentiation in the inner ear...
  32. Upadhyay G, Chowdhury A, Vaidyanathan B, Kim D, Saleque S. Antagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiation. Proc Natl Acad Sci U S A. 2014;111:8071-6 pubmed publisher
    Lysine-specific demethylase 1 (LSD1) demethylates nucleosomal histone H3 lysine 4 (H3K4) residues in collaboration with the corepressor CoREST/REST corepressor 1 (Rcor1) and regulates cell fates by epigenetically repressing gene targets...
  33. Wang J, Saijo K, Skola D, Jin C, Ma Q, Merkurjev D, et al. Histone demethylase LSD1 regulates hematopoietic stem cells homeostasis and protects from death by endotoxic shock. Proc Natl Acad Sci U S A. 2018;115:E244-E252 pubmed publisher
    ..Here, we report that the histone demethylase KDM1A/LSD1, serving as a critical regulator of mammalian hematopoiesis, is a negative regulator of the response to ..
  34. Ancelin K, Syx L, Borensztein M, Ranisavljevic N, Vassilev I, Briseño Roa L, et al. Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation. elife. 2016;5: pubmed publisher
    ..Here, we explore the function of the oocyte-inherited pool of a histone H3K4 and K9 demethylase, LSD1/KDM1A during early mouse development...
  35. Gao Y, Chen X, Wang P, Lu L, Zhao W, Chen C, et al. Regulation of DLK1 by the maternally expressed miR-379/miR-544 cluster may underlie callipyge polar overdominance inheritance. Proc Natl Acad Sci U S A. 2015;112:13627-32 pubmed publisher
    ..Our results suggest that maternal expression of the imprinted miR-379/miR-544 cluster regulates paternal expression of the Dlk1 gene in mice. We therefore propose a miR-based molecular working model for polar overdominance inheritance. ..
  36. Seki M, Masaki H, Arauchi T, Nakauchi H, Sugano S, Suzuki Y. A comparison of the rest complex binding patterns in embryonic stem cells and epiblast stem cells. PLoS ONE. 2014;9:e95374 pubmed publisher
    We detected and characterized the binding sites of the representative Rest complex components Rest, Sin3A, and Lsd1. We compared their binding patterns in mouse embryonic stem (ES) cells and epiblast stem (EpiS) cells...
  37. Nam H, Boo K, Kim D, Han D, Choe H, Kim C, et al. Phosphorylation of LSD1 by PKC? is crucial for circadian rhythmicity and phase resetting. Mol Cell. 2014;53:791-805 pubmed publisher
    ..Here, we provide evidence that the lysine-specific demethylase 1 (LSD1) is phosphorylated by protein kinase C? (PKC?) in a circadian manner and the phosphorylated LSD1 forms a complex ..
  38. Rusconi F, Paganini L, Braida D, Ponzoni L, Toffolo E, Maroli A, et al. LSD1 Neurospecific Alternative Splicing Controls Neuronal Excitability in Mouse Models of Epilepsy. Cereb Cortex. 2015;25:2729-40 pubmed publisher
    ..Lysine-specific demethylase 1 (LSD1/KDM1A) is a ubiquitously expressed histone H3Lys4 demethylase that acts as a transcriptional co-repressor in complex ..
  39. Kim Y, Fang S, Byun S, Seok S, Kemper B, Kemper J. Farnesoid X receptor-induced lysine-specific histone demethylase reduces hepatic bile acid levels and protects the liver against bile acid toxicity. Hepatology. 2015;62:220-31 pubmed publisher
    ..Here, we show that lysine-specific histone demethylase1 (LSD1) is directly induced by BA-activated farnesoid X receptor, is recruited to the BA synthetic genes Cyp7a1 and Cyp8b1 ..
  40. Guo Y, Fu X, Jin Y, Sun J, Liu Y, Huo B, et al. Histone demethylase LSD1-mediated repression of GATA-2 is critical for erythroid differentiation. Drug Des Devel Ther. 2015;9:3153-62 pubmed publisher
    ..Stable LSD1-knockdown cell lines were established by growing murine erythroleukemia (MEL) or mouse embryonic stem cells ..
  41. Zhang F, Xu D, Yuan L, Sun Y, Xu Z. Epigenetic regulation of Atrophin1 by lysine-specific demethylase 1 is required for cortical progenitor maintenance. Nat Commun. 2014;5:5815 pubmed publisher
    Lysine-specific demethylase 1 (LSD1) is involved in gene regulation and development; however, its precise function, molecular targets and underlying mechanisms during development are poorly understood...
  42. Yokoyama A, Igarashi K, Sato T, Takagi K, Otsuka I M, Shishido Y, et al. Identification of myelin transcription factor 1 (MyT1) as a subunit of the neural cell type-specific lysine-specific demethylase 1 (LSD1) complex. J Biol Chem. 2014;289:18152-62 pubmed publisher
    ..In this study we aimed to isolate the histone demethylase lysine-specific demethylase 1 (LSD1) complex from neural cells by biochemical purification...
  43. Ricq E, Hooker J, Haggarty S. Activity-dependent Regulation of Histone Lysine Demethylase KDM1A by a Putative Thiol/Disulfide Switch. J Biol Chem. 2016;291:24756-24767 pubmed
    ..proteins such as histones is catalyzed by several classes of enzymes, including the FAD-dependent amine oxidases KDM1A/B...
  44. Tosic M, Allen A, Willmann D, Lepper C, Kim J, Duteil D, et al. Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells. Nat Commun. 2018;9:366 pubmed publisher
    ..Here, we show that elevated levels of lysine-specific demethylase 1 (Kdm1a, also known as Lsd1) have a beneficial effect on muscle regeneration and recovery after injury, since Lsd1 ..
  45. Liang J, Wan M, Zhang Y, Gu P, Xin H, Jung S, et al. Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nat Cell Biol. 2008;10:731-9 pubmed publisher
    ..Our data collectively suggest that Nanog and Oct4 associate with unique repressor complexes on their target genes to control ES cell fate. ..
  46. Scionti I, Hayashi S, Mouradian S, Girard E, Esteves de Lima J, Morel V, et al. LSD1 Controls Timely MyoD Expression via MyoD Core Enhancer Transcription. Cell Rep. 2017;18:1996-2006 pubmed publisher
    ..Here, we demonstrate that the histone demethylase LSD1/KDM1a is recruited on the MyoD core enhancer upon muscle differentiation...
  47. Zhou A, Lin K, Zhang S, Chen Y, Zhang N, Xue J, et al. Nuclear GSK3? promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22. Nat Cell Biol. 2016;18:954-966 pubmed publisher
    ..Here, we show that nuclear GSK3? is responsible for the accumulation of the histone demethylase KDM1A and critically regulates histone H3K4 methylation during tumorigenesis...
  48. Siklenka K, Erkek S, Godmann M, Lambrot R, McGraw S, Lafleur C, et al. Disruption of histone methylation in developing sperm impairs offspring health transgenerationally. Science. 2015;350:aab2006 pubmed publisher
    ..We generated transgenic mice in which overexpression of the histone H3 lysine 4 (H3K4) demethylase KDM1A (also known as LSD1) during spermatogenesis reduced H3K4 dimethylation in sperm...
  49. Myrick D, Christopher M, Scott A, Simon A, Donlin Asp P, Kelly W, et al. KDM1A/LSD1 regulates the differentiation and maintenance of spermatogonia in mice. PLoS ONE. 2017;12:e0177473 pubmed publisher
    ..Here, we investigated the function of the H3K4me2 demethylase KDM1A/LSD1 during spermatogenesis in developing and adult mice...
  50. Pojoga L, Williams J, Yao T, Kumar A, Raffetto J, do Nascimento G, et al. Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension. Am J Physiol Heart Circ Physiol. 2011;301:H1862-71 pubmed publisher
    ..was thought to be irreversible, but recent evidence suggests that lysine-specific demethylase-1 (LSD1, Kdm1a) induces demethylation of histone H3 lysine 4 (H3K4) or H3K9 and thereby alters gene transcription...
  51. Ceballos Chávez M, Rivero S, García Gutiérrez P, Rodríguez Paredes M, Garcia Dominguez M, Bhattacharya S, et al. Control of neuronal differentiation by sumoylation of BRAF35, a subunit of the LSD1-CoREST histone demethylase complex. Proc Natl Acad Sci U S A. 2012;109:8085-90 pubmed publisher
    The LSD1-CoREST histone demethylase complex is required to repress neuronal genes in nonneuronal tissues...
  52. Cui S, Tanabe O, Sierant M, Shi L, Campbell A, Lim K, et al. Compound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic β-type globin genes. Blood. 2015;125:1477-87 pubmed publisher
  53. Dovey O, Foster C, Cowley S. Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation. Proc Natl Acad Sci U S A. 2010;107:8242-7 pubmed publisher
  54. Duteil D, Tosic M, Willmann D, Georgiadi A, Kanouni T, Schüle R. Lsd1 prevents age-programed loss of beige adipocytes. Proc Natl Acad Sci U S A. 2017;114:5265-5270 pubmed publisher
    ..Lysine-specific demethylase 1 (Lsd1) is an epigenetic eraser enzyme positively regulating differentiation and function of adipocytes...
  55. Yin F, Lan R, Zhang X, Zhu L, Chen F, Xu Z, et al. LSD1 regulates pluripotency of embryonic stem/carcinoma cells through histone deacetylase 1-mediated deacetylation of histone H4 at lysine 16. Mol Cell Biol. 2014;34:158-79 pubmed publisher
    b>LSD1 is essential for the maintenance of pluripotency of embryonic stem (ES) or embryonic carcinoma/teratocarcinoma (EC) cells. We have previously developed novel LSD1 inhibitors that selectively inhibit ES/EC cells...
  56. Wasson J, Simon A, Myrick D, Wolf G, Driscoll S, Pfaff S, et al. Maternally provided LSD1/KDM1A enables the maternal-to-zygotic transition and prevents defects that manifest postnatally. elife. 2016;5: pubmed publisher
    ..In C. elegans, LSD1/KDM1A enables this transition by removing H3K4me2 and preventing the transgenerational inheritance of transcription ..
  57. Mosammaparast N, Kim H, Laurent B, Zhao Y, Lim H, Majid M, et al. The histone demethylase LSD1/KDM1A promotes the DNA damage response. J Cell Biol. 2013;203:457-70 pubmed publisher
    ..We report a role for the histone demethylase LSD1/KDM1A in the DNA damage response (DDR). We show that LSD1 is recruited directly to sites of DNA damage...
  58. Shao G, Chen J, Zhang L, Huang P, Lu H, Jin J, et al. Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development. In Vitro Cell Dev Biol Anim. 2014;50:603-13 pubmed publisher
    ..examined the dynamic changes of H3K4me and its key regulators (Ash1l, Ash2l, Kmt2a, Kmt2b, Kmt2c, Setd1a, Setd7, Kdm1a, Kdm1b, Kdm5a, Kdm5b, Kdm5c, and Kdm5d) in mouse oocytes and preimplantation embryos...
  59. Vacik T, Stubbs J, Lemke G. A novel mechanism for the transcriptional regulation of Wnt signaling in development. Genes Dev. 2011;25:1783-95 pubmed publisher
    ..Specific elimination of dnTcf7l2 in Xenopus results in headless embryos, a phenotype consistent with a fundamental role for this regulator in forebrain development. ..
  60. Christopher M, Myrick D, Barwick B, Engstrom A, Porter Stransky K, Boss J, et al. LSD1 protects against hippocampal and cortical neurodegeneration. Nat Commun. 2017;8:805 pubmed publisher
    ..the mechanisms that maintain differentiated cells, here we inducibly delete the histone demethylase LSD1/KDM1A in adult mice...
  61. Kim J, Singh A, Takata Y, Lin K, Shen J, Lu Y, et al. LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice. Nat Commun. 2015;6:10116 pubmed publisher
    ..Here we show that LSD1, a lysine demethylase, regulates histone H3 lysine 4 di-methylation (H3K4me2) in mouse oocytes and is essential for ..
  62. Wang J, Telese F, Tan Y, Li W, Jin C, He X, et al. LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control. Nat Neurosci. 2015;18:1256-64 pubmed publisher
    We found that a neuron-specific isoform of LSD1, LSD1n, which results from an alternative splicing event, acquires a new substrate specificity, targeting histone H4 Lys20 methylation, both in vitro and in vivo...
  63. Grimaldi P, Pucci M, Di Siena S, Di Giacomo D, Pirazzi V, Geremia R, et al. The faah gene is the first direct target of estrogen in the testis: role of histone demethylase LSD1. Cell Mol Life Sci. 2012;69:4177-90 pubmed publisher
    ..Moreover, the histone demethylase LSD1 was found to be associated with ERE2/3 sites and to play a role in mediating E(2) induction of FAAH expression...
  64. Chen Y, Kim J, Zhang R, Yang X, Zhang Y, Fang J, et al. Histone Demethylase LSD1 Promotes Adipocyte Differentiation through Repressing Wnt Signaling. Cell Chem Biol. 2016;23:1228-1240 pubmed publisher
    ..By screening a collection of epigenetic compounds, we found that Lysine-Specific Demethylase 1 (LSD1) inhibitors repress brown adipocyte differentiation...
  65. Liu L, Souto J, Liao W, Jiang Y, Li Y, Nishinakamura R, et al. Histone lysine-specific demethylase 1 (LSD1) protein is involved in Sal-like protein 4 (SALL4)-mediated transcriptional repression in hematopoietic stem cells. J Biol Chem. 2013;288:34719-28 pubmed publisher
    ..Here, we demonstrate that LSD1, a histone lysine demethylase, also participates in the trans-repressive effects of SALL4...
  66. Vyas R, Meredith D, Lane R. Lysine-specific demethylase-1 (LSD1) depletion disrupts monogenic and monoallelic odorant receptor (OR) expression in an olfactory neuronal cell line. Mol Cell Neurosci. 2017;82:1-11 pubmed publisher
    ..The lysine-specific demethylase-1 (LSD1) protein removes activating H3K4 or silencing H3K9 methylation marks in a variety of developmental contexts, and is ..
  67. Patrick N, Griggs C, Icenogle A, Gilpatrick M, Kadiyala V, Jaime Frias R, et al. Class I lysine deacetylases promote glucocorticoid-induced transcriptional repression through functional interaction with LSD1. J Steroid Biochem Mol Biol. 2017;167:1-13 pubmed publisher
    ..nucleosomes with no corresponding change in H3K4Me3, suggesting the activation of the lysine demethylase, LSD1/KDM1A. Depletion of LSD1 expression via siRNA restored Dex-mediated repression in the presence of KDAC inhibitors, ..
  68. Hanzu F, Musri M, Sánchez Herrero A, Claret M, Esteban Y, Kaliman P, et al. Histone demethylase KDM1A represses inflammatory gene expression in preadipocytes. Obesity (Silver Spring). 2013;21:E616-25 pubmed publisher
    ..Previously it was shown that histone demethylase KDM1A is required for adipogenesis...