Kcnq4

Summary

Gene Symbol: Kcnq4
Description: potassium voltage-gated channel, subfamily Q, member 4
Alias: potassium voltage-gated channel subfamily KQT member 4, KQT-like 4, potassium channel subunit alpha KvLQT4, voltage-gated potassium channel subunit Kv7.4
Species: mouse
Products:     Kcnq4

Top Publications

  1. Beisel K, Nelson N, Delimont D, Fritzsch B. Longitudinal gradients of KCNQ4 expression in spiral ganglion and cochlear hair cells correlate with progressive hearing loss in DFNA2. Brain Res Mol Brain Res. 2000;82:137-49 pubmed
    Mutations in the human KCNQ4 gene were recently found by Kubisch et al. [Cell 96 (1999) 437-446] to cause a non-syndromic, autosomal dominant, progressive hearing loss, DFNA2...
  2. Kharkovets T, Dedek K, Maier H, Schweizer M, Khimich D, Nouvian R, et al. Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness. EMBO J. 2006;25:642-52 pubmed
    b>KCNQ4 is an M-type K+ channel expressed in sensory hair cells of the inner ear and in the central auditory pathway. KCNQ4 mutations underlie human DFNA2 dominant progressive hearing loss...
  3. Heidenreich M, Lechner S, Vardanyan V, Wetzel C, Cremers C, De Leenheer E, et al. KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man. Nat Neurosci. 2011;15:138-45 pubmed publisher
    Mutations inactivating the potassium channel KCNQ4 (K(v)7.4) lead to deafness in humans and mice...
  4. Saul S, Brzezinski J, Altschuler R, Shore S, Rudolph D, Kabara L, et al. Math5 expression and function in the central auditory system. Mol Cell Neurosci. 2008;37:153-69 pubmed
    ..1, Kv3.1b and Kcnq4 potassium channels, and projection patterns within the auditory brainstem...
  5. Salomonsson M, Brasen J, Braunstein T, Hagelqvist P, Holstein Rathlou N, Sorensen C. K(V)7.4 channels participate in the control of rodent renal vascular resting tone. Acta Physiol (Oxf). 2015;214:402-14 pubmed publisher
    ..There is no indication that K(V)7 channels have an effect on agonist-induced renal vasoconstriction while there is a small effect on acetylcholine-induced vasodilation. ..
  6. Iannotti F, Silvestri C, Mazzarella E, Martella A, Calvigioni D, Piscitelli F, et al. The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels. Proc Natl Acad Sci U S A. 2014;111:E2472-81 pubmed publisher
    ..4-bound PIP2 levels in C2C12 cells and inhibits Kv7.4 currents in transfected CHO cells. We suggest that 2-AG is an endogenous repressor of myoblast differentiation via CB1-mediated inhibition of Kv7.4 channels. ..
  7. Pauli Magnus D, Hoch G, Strenzke N, Anderson S, Jentsch T, Moser T. Detection and differentiation of sensorineural hearing loss in mice using auditory steady-state responses and transient auditory brainstem responses. Neuroscience. 2007;149:673-84 pubmed
    ..We then recorded ASSR and ABR from mouse mutants bearing defects of either outer hair cell amplification (KCNQ4-knockout) or inner hair cell synaptic transmission (Bassoon-mutant)...
  8. Oliver D, Knipper M, Derst C, Fakler B. Resting potential and submembrane calcium concentration of inner hair cells in the isolated mouse cochlea are set by KCNQ-type potassium channels. J Neurosci. 2003;23:2141-9 pubmed
    ..Single-cell PCR and immunocytochemistry showed expression of the KCNQ4 subunit in IHCs...
  9. McCallum L, Pierce S, England S, Greenwood I, Tribe R. The contribution of Kv7 channels to pregnant mouse and human myometrial contractility. J Cell Mol Med. 2011;15:577-86 pubmed publisher
    ..Consequently, activation of the encoded channels represents a novel mechanism for treatment of preterm labour...

More Information

Publications22

  1. Jepps T, Chadha P, Davis A, Harhun M, Cockerill G, Olesen S, et al. Downregulation of Kv7.4 channel activity in primary and secondary hypertension. Circulation. 2011;124:602-11 pubmed publisher
    ..Of the 5 KCNQ genes, only the expression of KCNQ4 was reduced (?3.7 fold) in SHRs aorta. Kv7...
  2. Spitzmaul G, Tolosa L, Winkelman B, Heidenreich M, Frens M, Chabbert C, et al. Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models. J Biol Chem. 2013;288:9334-44 pubmed publisher
    ..the kcnq4 (kv7...
  3. Yahata T, Takedatsu H, Dunwoodie S, Braganca J, Swingler T, Withington S, et al. Cloning of mouse Cited4, a member of the CITED family p300/CBP-binding transcriptional coactivators: induced expression in mammary epithelial cells. Genomics. 2002;80:601-13 pubmed
    ..The cited4 gene consisted of only a single exon located on chromosome 4 at 56.5-56.8 cM flanked by marker genes kcnq4 and scml1...
  4. Yeung S, Pucovsky V, Moffatt J, Saldanha L, Schwake M, Ohya S, et al. Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity. Br J Pharmacol. 2007;151:758-70 pubmed
    ..All blood vessels expressed KCNQ1, 4 and 5 with hitherto 'neuronal' KCNQ4 being, surprisingly, the most abundant. The correlated proteins K(v)7.1, K(v)7.4 and K(v)7...
  5. Beisel K, Rocha Sanchez S, Morris K, Nie L, Feng F, Kachar B, et al. Differential expression of KCNQ4 in inner hair cells and sensory neurons is the basis of progressive high-frequency hearing loss. J Neurosci. 2005;25:9285-93 pubmed
    Human KCNQ4 mutations known as DFNA2 cause non-syndromic, autosomal-dominant, progressive high-frequency hearing loss in which the cellular and molecular basis is unclear...
  6. Kharkovets T, Hardelin J, Safieddine S, Schweizer M, El Amraoui A, Petit C, et al. KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway. Proc Natl Acad Sci U S A. 2000;97:4333-8 pubmed
    Mutations in the potassium channel gene KCNQ4 underlie DFNA2, an autosomal dominant form of progressive hearing loss in humans. In the mouse cochlea, the transcript has been found exclusively in the outer hair cells...
  7. Yeung S, Schwake M, Pucovsky V, Greenwood I. Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents. Br J Pharmacol. 2008;155:62-72 pubmed publisher
    ..This study investigated the functional and electrophysiological effects of the Kv7 channel activator, retigabine, on murine portal vein smooth muscle...
  8. Lv P, Wei D, Yamoah E. Kv7-type channel currents in spiral ganglion neurons: involvement in sensorineural hearing loss. J Biol Chem. 2010;285:34699-707 pubmed publisher
    ..Thus, this study provides evidence of the cellular etiology and mechanisms of SGN degeneration in DFNA2...
  9. Iannotti F, Barrese V, Formisano L, Miceli F, Taglialatela M. Specification of skeletal muscle differentiation by repressor element-1 silencing transcription factor (REST)-regulated Kv7.4 potassium channels. Mol Biol Cell. 2013;24:274-84 pubmed publisher
    ..These data suggest that K(v)7.4 plays a permissive role in skeletal muscle differentiation and highlight REST as a crucial transcriptional regulator for this K(+) channel subunit. ..
  10. Xu T, Nie L, Zhang Y, Mo J, Feng W, Wei D, et al. Roles of alternative splicing in the functional properties of inner ear-specific KCNQ4 channels. J Biol Chem. 2007;282:23899-909 pubmed
    The function of the KCNQ4 channel in the auditory setting is crucial to hearing, underpinned by the finding that mutations of the channel result in an autosomal dominant form of nonsyndromic progressive high frequency hearing loss...
  11. Rocha Sanchez S, Morris K, Kachar B, Nichols D, Fritzsch B, Beisel K. Developmental expression of Kcnq4 in vestibular neurons and neurosensory epithelia. Brain Res. 2007;1139:117-25 pubmed
    ..The KCNQ4 voltage-gated M-type potassium channel is thought to set the resting membrane potential in cochlear HCs...
  12. Holt J, Stauffer E, Abraham D, Géléoc G. Dominant-negative inhibition of M-like potassium conductances in hair cells of the mouse inner ear. J Neurosci. 2007;27:8940-51 pubmed
    ..We sought to identify hair-cell conductances mediated by KCNQ4, which, when mutated, causes the dominant progressive hearing loss DFNA2...
  13. Jepps T, Greenwood I, Moffatt J, Sanders K, Ohya S. Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles. Am J Physiol Gastrointest Liver Physiol. 2009;297:G107-15 pubmed publisher
    ..Of KCNQ/K(v)7 members, both KCNQ4/K(v)7.4 and KCNQ5/K(v)7...