Gene Symbol: Kcnq3
Description: potassium voltage-gated channel, subfamily Q, member 3
Alias: potassium voltage-gated channel subfamily KQT member 3, KQT-like 3, potassium channel subunit alpha KvLQT3, voltage-gated potassium channel subunit Kv7.3
Species: mouse
Products:     Kcnq3

Top Publications

  1. Peters H, Hu H, Pongs O, Storm J, Isbrandt D. Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior. Nat Neurosci. 2005;8:51-60 pubmed
    In humans, mutations in the KCNQ2 or KCNQ3 potassium-channel genes are associated with an inherited epilepsy syndrome...
  2. Anta B, Martín Rodríguez C, Gomis Pèrez C, Calvo L, López Benito S, Calderón García A, et al. Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3). J Biol Chem. 2016;291:19132-45 pubmed publisher
    ..2/3 channel regulation. Our results demonstrate that USP36 binds to and regulates the actions of Nedd4-2 over different substrates affecting their expression and functions. ..
  3. Ballif B, Arnaud L, Arthur W, Guris D, Imamoto A, Cooper J. Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons. Curr Biol. 2004;14:606-10 pubmed
    ..C3G and Rap1 regulate adhesion of fibroblasts and other cell types. Regulation of Crk/CrkL, C3G, and Rap1 by Reelin may be involved in coordinating neuron migrations during brain development. ..
  4. McCormack T, Rudy B, Seldin M. Chromosomal mapping of the potassium channel genes Kcnq2 and Kcnq3 in mouse. Genomics. 1999;56:360-1 pubmed
  5. Kim K, Duignan K, Hawryluk J, Soh H, Tzingounis A. The Voltage Activation of Cortical KCNQ Channels Depends on Global PIP2 Levels. Biophys J. 2016;110:1089-98 pubmed publisher
    ..Further, the sensitivity of this effect on KCNQ3 channels appeared to be higher than that on KCNQ2...
  6. Geiger J, Weber Y, Landwehrmeyer B, Sommer C, Lerche H. Immunohistochemical analysis of KCNQ3 potassium channels in mouse brain. Neurosci Lett. 2006;400:101-4 pubmed
    ..Mutations in KCNQ2/KCNQ3 channels can cause benign familial neonatal convulsions (BFNC)...
  7. Liu W, Devaux J. Calmodulin orchestrates the heteromeric assembly and the trafficking of KCNQ2/3 (Kv7.2/3) channels in neurons. Mol Cell Neurosci. 2014;58:40-52 pubmed publisher
    Mutations in KCNQ2 and KCNQ3 genes are responsible for benign familial neonatal seizures and epileptic encephalopathies...
  8. Singh N, Otto J, Dahle E, Pappas C, Leslie J, Vilaythong A, et al. Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization. J Physiol. 2008;586:3405-23 pubmed publisher
    ..onset and a favourable prognosis, sparing cognitive abilities despite persistent expression of the mutant KCNQ2 or KCNQ3 potassium channels throughout adulthood...
  9. Jin Z, Liang G, Cooper E, Jarlebark L. Expression and localization of K channels KCNQ2 and KCNQ3 in the mammalian cochlea. Audiol Neurootol. 2009;14:98-105 pubmed publisher
    ..By using RT-PCR, we found expression of Kcnq2 in the modiolus and organ of Corti, while Kcnq3 expression was also detected in the cochlear lateral wall...

More Information


  1. Zhou X, Song M, Chen D, Wei L, Yu S. Potential role of KCNQ/M-channels in regulating neuronal differentiation in mouse hippocampal and embryonic stem cell-derived neuronal cultures. Exp Neurol. 2011;229:471-83 pubmed publisher
    ..It is composed of the molecular counterparts KCNQ2 and KCNQ3 (also named Kv7.2 and Kv7.3) channels and expressed in the soma and dendrites of neurons...
  2. McCallum L, Pierce S, England S, Greenwood I, Tribe R. The contribution of Kv7 channels to pregnant mouse and human myometrial contractility. J Cell Mol Med. 2011;15:577-86 pubmed publisher
    ..In mice, there was a global suppression of all KCNQ isoforms, except KCNQ3, in early pregnancy (n= 6, P < 0...
  3. Zhou X, Wei J, Song M, Francis K, Yu S. Novel role of KCNQ2/3 channels in regulating neuronal cell viability. Cell Death Differ. 2011;18:493-505 pubmed publisher
    ..All these events were attenuated by blocking KCNQ2/3 channels. These findings provide novel evidence that KCNQ2/3 channels could be an important regulator in neuronal apoptosis. ..
  4. Soh H, Pant R, LoTurco J, Tzingounis A. Conditional deletions of epilepsy-associated KCNQ2 and KCNQ3 channels from cerebral cortex cause differential effects on neuronal excitability. J Neurosci. 2014;34:5311-21 pubmed publisher
    KCNQ2 and KCNQ3 potassium channels have emerged as central regulators of pyramidal neuron excitability and spiking behavior...
  5. Wen H, Levitan I. Calmodulin is an auxiliary subunit of KCNQ2/3 potassium channels. J Neurosci. 2002;22:7991-8001 pubmed
    Calmodulin (CaM) was identified as a KCNQ2 and KCNQ3 potassium channel-binding protein, using a yeast two-hybrid screen...
  6. Watanabe H, Nagata E, Kosakai A, Nakamura M, Yokoyama M, Tanaka K, et al. Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability. J Neurochem. 2000;75:28-33 pubmed
    ..Recently, two novel voltage-dependent potassium channel genes, KCNQ2 and KCNQ3, were identified by positional cloning as being responsible for BFNC...
  7. Zhang J, Shapiro M. Activity-dependent transcriptional regulation of M-Type (Kv7) K(+) channels by AKAP79/150-mediated NFAT actions. Neuron. 2012;76:1133-46 pubmed publisher
  8. Zhou P, Yu H, Gu M, Nan F, Gao Z, Li M. Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels. Proc Natl Acad Sci U S A. 2013;110:8726-31 pubmed publisher
    ..Whereas all five potassium channel subtypes (KCNQ1-KCNQ5) are found in the nervous system, KCNQ2 and KCNQ3 are the primary players that mediate M currents...
  9. Pan Z, Kao T, Horvath Z, Lemos J, Sul J, Cranstoun S, et al. A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon. J Neurosci. 2006;26:2599-613 pubmed
    ..Here, antibodies against four different KCNQ2 and KCNQ3 polypeptide epitopes show these subunits concentrated at the axonal initial segment (AIS) and node of Ranvier...
  10. Li S, Kalappa B, Tzounopoulos T. Noise-induced plasticity of KCNQ2/3 and HCN channels underlies vulnerability and resilience to tinnitus. elife. 2015;4: pubmed publisher
    ..Our results highlight KCNQ2/3 and HCN channels as potential targets for designing novel therapeutics that may promote resilience to tinnitus. ..
  11. Tzingounis A, Nicoll R. Contribution of KCNQ2 and KCNQ3 to the medium and slow afterhyperpolarization currents. Proc Natl Acad Sci U S A. 2008;105:19974-9 pubmed publisher
    ..neonatal convulsion (BNFC) is a neurological disorder caused by mutations in the potassium channel genes KCNQ2 and KCNQ3, which are thought to contribute to the medium afterhyperpolarization (mAHP)...
  12. Templin J, Bang S, Soiza Reilly M, Berde C, Commons K. Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas. Brain Res. 2012;1457:1-12 pubmed publisher
    ..The identified genes likely contribute to unique excitable properties of different groups of neurons in the DR and may include novel pharmacologic targets for affective disorders. ..
  13. Schütze S, Orozco I, Jentsch T. KCNQ Potassium Channels Modulate Sensitivity of Skin Down-hair (D-hair) Mechanoreceptors. J Biol Chem. 2016;291:5566-75 pubmed publisher
    ..play an important role in regulating the excitability of neuronal cells, as highlighted by mutations in Kcnq2 and Kcnq3 that underlie certain forms of epilepsy...
  14. Marowsky A, Burgener J, Falck J, Fritschy J, Arand M. Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism. Neuroscience. 2009;163:646-61 pubmed publisher
    ..Our findings suggest that these different enzymes have individual, possibly quite distinct roles in brain function and cerebral EET metabolism. ..
  15. Friedman A, Juarez B, Ku S, Zhang H, Calizo R, Walsh J, et al. KCNQ channel openers reverse depressive symptoms via an active resilience mechanism. Nat Commun. 2016;7:11671 pubmed publisher
    ..These findings identify KCNQ as a target for conceptually novel antidepressants that function through the potentiation of active resilience mechanisms. ..
  16. Li S, Choi V, Tzounopoulos T. Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitus. Proc Natl Acad Sci U S A. 2013;110:9980-5 pubmed publisher
    ..Moreover, our findings point to previously unknown biological targets for designing therapeutic drugs that may prevent the development of tinnitus in humans...