Kcnq2

Summary

Gene Symbol: Kcnq2
Description: potassium voltage-gated channel, subfamily Q, member 2
Alias: HNSPC, KQT2, Nmf134, KQT-like 2, potassium channel subunit alpha KvLQT2, potassium voltage-gated channel subfamily KQT member 2, voltage-gated potassium channel subunit Kv7.2
Species: mouse

Top Publications

  1. ncbi KQT2, a new putative potassium channel family produced by alternative splicing. Isolation, genomic structure, and alternative splicing of the putative potassium channels
    M Nakamura
    Pharmaceutical Basic Research Laboratories Aobadai, Japan Tobacco Inc, Kanagawa, Japan
    Receptors Channels 5:255-71. 1998
  2. ncbi A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon
    Zongming Pan
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 26:2599-613. 2006
  3. ncbi KCNQ2 is a nodal K+ channel
    Jérôme J Devaux
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6077, USA
    J Neurosci 24:1236-44. 2004
  4. pmc Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitus
    Shuang Li
    Department of Otolaryngology and Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 110:9980-5. 2013
  5. pmc Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels
    Pingzheng Zhou
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
    Proc Natl Acad Sci U S A 110:8726-31. 2013
  6. pmc Activity-dependent transcriptional regulation of M-Type (Kv7) K(+) channels by AKAP79/150-mediated NFAT actions
    Jie Zhang
    Department of Physiology, MS 7756, University of Texas Health Science Center, San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Neuron 76:1133-46. 2012
  7. doi The contribution of Kv7 channels to pregnant mouse and human myometrial contractility
    Laura A McCallum
    Maternal and Fetal Research Unit, Division of Reproduction and Endocrinology, King s College London, St Thomas Hospital Campus, London, UK
    J Cell Mol Med 15:577-86. 2011
  8. pmc Protein Phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-Type potassium channel activity
    David Kapfhamer
    Ernest Gallo Clinic and Research Center, Emeryville, California 94608, USA
    J Neurosci 30:8830-40. 2010
  9. pmc Novel role of KCNQ2/3 channels in regulating neuronal cell viability
    X Zhou
    Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Cell Death Differ 18:493-505. 2011
  10. pmc The C-terminal domain of ßIV-spectrin is crucial for KCNQ2 aggregation and excitability at nodes of Ranvier
    Jérôme J Devaux
    Département Signalisation Neuronale, CRN2M, UMR 6231, CNRS, Faculte de Medecine Secteur Nord, Université de la Méditerranée Université Paul Cézanne, CS80011, Bd Pierre Dramard, 13344 Marseille Cedex 15, France
    J Physiol 588:4719-30. 2010

Scientific Experts

  • Jérôme J Devaux
  • Jennifer A Kearney
  • Zhe Jin
  • M Nakamura
  • Nanda A Singh
  • David Kapfhamer
  • Wayne N Frankel
  • Shuang Li
  • Pingzheng Zhou
  • James F Otto
  • Jie Zhang
  • X Zhou
  • Xin Zhou
  • Laura A McCallum
  • Carolina Roza
  • Nicole A Hawkins
  • Yan Yang
  • Anastassios V Tzingounis
  • Yvonne G Weber
  • Zongming Pan
  • H Christian Peters
  • H Steve White
  • Hua Wen
  • Min Li
  • Min Gu
  • Fa Jun Nan
  • Haibo Yu
  • Thanos Tzounopoulos
  • Zhaobing Gao
  • Veronica Choi
  • Mark S Shapiro
  • K Francis
  • S P Yu
  • Shan Ping Yu
  • Andrew Escayg
  • Mingke Song
  • Dongdong Chen
  • Stephanie L Pierce
  • Iain A Greenwood
  • Sol Castillejo
  • Jose A Lopez-Garcia
  • Melinda S Martin
  • J Wei
  • Ling Wei
  • Rachel M Tribe
  • Sarah K England
  • M Song
  • H Watanabe
  • Roger A Nicoll
  • T McCormack
  • Zsolt Horvath
  • Holger Lerche
  • Vann Bennett
  • Julia Geiger
  • Katherine Kämpchen
  • Julia Lemos
  • Clemens Sommer
  • Jai Yoon Sul
  • Edward C Cooper
  • Tingching Kao
  • Bernhard Landwehrmeyer
  • Steven S Scherer
  • Stephen D Cranstoun
  • Karen S Wilcox
  • Hua Hu
  • Olaf Pongs
  • Dirk Isbrandt
  • Johan F Storm
  • Verity A Letts
  • Barbara J Beyer
  • TIMOTHY P O'BRIEN
  • Irwin B Levitan
  • A Kosakai
  • K Tanaka
  • E Nagata
  • H Sasai
  • M Yokoyama
  • M F Seldin
  • B Rudy

Detail Information

Publications24

  1. ncbi KQT2, a new putative potassium channel family produced by alternative splicing. Isolation, genomic structure, and alternative splicing of the putative potassium channels
    M Nakamura
    Pharmaceutical Basic Research Laboratories Aobadai, Japan Tobacco Inc, Kanagawa, Japan
    Receptors Channels 5:255-71. 1998
    ..Eleven mouse cDNA clones homologous to the new human putative K+ channel (designated HNSPC, which we recently reported) were isolated from the brain cDNA libraries...
  2. ncbi A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon
    Zongming Pan
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 26:2599-613. 2006
    ..Here, antibodies against four different KCNQ2 and KCNQ3 polypeptide epitopes show these subunits concentrated at the axonal initial segment (AIS) and node of ..
  3. ncbi KCNQ2 is a nodal K+ channel
    Jérôme J Devaux
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6077, USA
    J Neurosci 24:1236-44. 2004
    Mutations in the gene encoding the K+ channel KCNQ2 cause neonatal epilepsy and myokymia, indicating that KCNQ2 regulates the excitability of CNS neurons and motor axons, respectively...
  4. pmc Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitus
    Shuang Li
    Department of Otolaryngology and Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 110:9980-5. 2013
    ..Moreover, our findings point to previously unknown biological targets for designing therapeutic drugs that may prevent the development of tinnitus in humans...
  5. pmc Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels
    Pingzheng Zhou
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
    Proc Natl Acad Sci U S A 110:8726-31. 2013
    ..Whereas all five potassium channel subtypes (KCNQ1-KCNQ5) are found in the nervous system, KCNQ2 and KCNQ3 are the primary players that mediate M currents...
  6. pmc Activity-dependent transcriptional regulation of M-Type (Kv7) K(+) channels by AKAP79/150-mediated NFAT actions
    Jie Zhang
    Department of Physiology, MS 7756, University of Texas Health Science Center, San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Neuron 76:1133-46. 2012
    M-type K(+) channels, encoded by KCNQ2-KCNQ5 genes, play key roles in regulation of neuronal excitability; however, less is known about the mechanisms controlling their transcriptional expression...
  7. doi The contribution of Kv7 channels to pregnant mouse and human myometrial contractility
    Laura A McCallum
    Maternal and Fetal Research Unit, Division of Reproduction and Endocrinology, King s College London, St Thomas Hospital Campus, London, UK
    J Cell Mol Med 15:577-86. 2011
    ..Consequently, activation of the encoded channels represents a novel mechanism for treatment of preterm labour...
  8. pmc Protein Phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-Type potassium channel activity
    David Kapfhamer
    Ernest Gallo Clinic and Research Center, Emeryville, California 94608, USA
    J Neurosci 30:8830-40. 2010
    ..The M-type potassium channel subunit, KCNQ2, is a putative GSK3beta substrate...
  9. pmc Novel role of KCNQ2/3 channels in regulating neuronal cell viability
    X Zhou
    Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Cell Death Differ 18:493-505. 2011
    ..The present investigation examined a possible role of the KCNQ2/3 channel or M-channel (also named Kv7.2/7.3 channels) in the pro-apoptotic process...
  10. pmc The C-terminal domain of ßIV-spectrin is crucial for KCNQ2 aggregation and excitability at nodes of Ranvier
    Jérôme J Devaux
    Département Signalisation Neuronale, CRN2M, UMR 6231, CNRS, Faculte de Medecine Secteur Nord, Université de la Méditerranée Université Paul Cézanne, CS80011, Bd Pierre Dramard, 13344 Marseille Cedex 15, France
    J Physiol 588:4719-30. 2010
    ..Axon and myelin structure in the PNS were unaffected in quivering-3J mice. Of interest, KCNQ2 subunit aggregates were undetectable at PNS and CNS nodes, whereas Nav and Kv1.1/Kv1...
  11. pmc Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus
    Nicole A Hawkins
    Neuroscience Graduate Program, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Neurobiol Dis 41:655-60. 2011
    ..GEFS+, we used mouse models to study the effect of combining the human GEFS+ mutation SCN1A-R1648H with SCN2A, KCNQ2, and SCN8A mutations...
  12. pmc Potential role of KCNQ/M-channels in regulating neuronal differentiation in mouse hippocampal and embryonic stem cell-derived neuronal cultures
    Xin Zhou
    Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Exp Neurol 229:471-83. 2011
    ..It is composed of the molecular counterparts KCNQ2 and KCNQ3 (also named Kv7.2 and Kv7.3) channels and expressed in the soma and dendrites of neurons...
  13. pmc Accumulation of Kv7.2 channels in putative ectopic transduction zones of mice nerve-end neuromas
    Carolina Roza
    Dpto, Fisiologia, Edificio de Medicina Universidad de Alcalá, Madrid, Spain
    Mol Pain 7:58. 2011
    ..We hypothesized that after nerve damage, accumulation of Kv7 channels in afferent fibers may increase M-type currents which then acquired a more important role at regulating fiber excitability...
  14. pmc Contribution of KCNQ2 and KCNQ3 to the medium and slow afterhyperpolarization currents
    Anastassios V Tzingounis
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA
    Proc Natl Acad Sci U S A 105:19974-9. 2008
    ..familial neonatal convulsion (BNFC) is a neurological disorder caused by mutations in the potassium channel genes KCNQ2 and KCNQ3, which are thought to contribute to the medium afterhyperpolarization (mAHP)...
  15. pmc Expression and localization of K channels KCNQ2 and KCNQ3 in the mammalian cochlea
    Zhe Jin
    Center for Hearing and Communication Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Audiol Neurootol 14:98-105. 2009
    ..Here, we describe Kcnq2/3 gene expression and distribution of M channel subunits KCNQ2 and 3 in the cochlea...
  16. ncbi Chromosomal mapping of the potassium channel genes Kcnq2 and Kcnq3 in mouse
    T McCormack
    Department of Physiology, New York University Medical Center, New York, New York 10016, USA
    Genomics 56:360-1. 1999
  17. ncbi Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability
    H Watanabe
    Pharmaceutical Frontier Research Laboratories, Japan Tobacco, Yokohama Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    J Neurochem 75:28-33. 2000
    ..Recently, two novel voltage-dependent potassium channel genes, KCNQ2 and KCNQ3, were identified by positional cloning as being responsible for BFNC...
  18. ncbi Calmodulin is an auxiliary subunit of KCNQ2/3 potassium channels
    Hua Wen
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 22:7991-8001. 2002
    Calmodulin (CaM) was identified as a KCNQ2 and KCNQ3 potassium channel-binding protein, using a yeast two-hybrid screen...
  19. ncbi Spontaneous deletion of epilepsy gene orthologs in a mutant mouse with a low electroconvulsive threshold
    Yan Yang
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Hum Mol Genet 12:975-84. 2003
    ..Two of these genes, Kcnq2 and Chrna4, are known to be mutated in human epilepsy families...
  20. ncbi Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior
    H Christian Peters
    Institut für Neurale Signalverarbeitung, Zentrum fur Molekulare Neurobiologie Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Nat Neurosci 8:51-60. 2005
    In humans, mutations in the KCNQ2 or KCNQ3 potassium-channel genes are associated with an inherited epilepsy syndrome...
  21. ncbi Severe epilepsy resulting from genetic interaction between Scn2a and Kcnq2
    Jennifer A Kearney
    Department of Human Genetics, 4909 Buhl Building 0618, 1241 E Catherine Street, Ann Arbor, MI 48109 0618, USA
    Hum Mol Genet 15:1043-8. 2006
    ..The voltage-gated potassium channel Kcnq2 is responsible for generating M current (I(KM)) that is thought to control excitability and limit repetitive ..
  22. ncbi A spontaneous mutation involving Kcnq2 (Kv7.2) reduces M-current density and spike frequency adaptation in mouse CA1 neurons
    James F Otto
    Anticonvulsant Drug Development Program, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    J Neurosci 26:2053-9. 2006
    ..Mutations in two subunits (KCNQ2 and KCNQ3; Kv7.2 and Kv7...
  23. ncbi Immunohistochemical analysis of KCNQ2 potassium channels in adult and developing mouse brain
    Yvonne G Weber
    Department of Neurology of the University of Ulm, Germany
    Brain Res 1077:1-6. 2006
    ..BFNC is caused by loss-of-function mutations in the potassium channels KCNQ2 and KCNQ3 which can well explain the resulting neuronal hyperexcitability...
  24. pmc Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization
    Nanda A Singh
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    J Physiol 586:3405-23. 2008
    ..weeks of onset and a favourable prognosis, sparing cognitive abilities despite persistent expression of the mutant KCNQ2 or KCNQ3 potassium channels throughout adulthood...