Kcnn2

Summary

Gene Symbol: Kcnn2
Description: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
Alias: KCa2.2, SK2, SKCA2, fri, small conductance calcium-activated potassium channel protein 2, small conductance calcium-activated potassium channel subfamily N member 2
Species: mouse
Products:     Kcnn2

Top Publications

  1. Bond C, Sprengel R, Bissonnette J, Kaufmann W, Pribnow D, Neelands T, et al. Respiration and parturition affected by conditional overexpression of the Ca2+-activated K+ channel subunit, SK3. Science. 2000;289:1942-6 pubmed
    ..The results implicate SK3 channels as potential therapeutic targets for disorders such as sleep apnea or sudden infant death syndrome and for regulating uterine contractions during labor. ..
  2. Stackman R, Bond C, Adelman J. Contextual memory deficits observed in mice overexpressing small conductance Ca2+-activated K+ type 2 (KCa2.2, SK2) channels are caused by an encoding deficit. Learn Mem. 2008;15:208-13 pubmed publisher
    ..Transgenic mice overexpressing SK2 channels (SK2+/T mice) exhibit marked deficits in hippocampal memory and synaptic plasticity, as previously ..
  3. Kye M, Spiess J, Blank T. Transcriptional regulation of intronic calcium-activated potassium channel SK2 promoters by nuclear factor-kappa B and glucocorticoids. Mol Cell Biochem. 2007;300:9-17 pubmed
    Small-conductance Ca(2+)-activated K(+) channels (SK) of the SK2 subtype are widely expressed in the central nervous system where they contribute to the control of neuronal excitability...
  4. Hammond R, Bond C, Strassmaier T, Ngo Anh T, Adelman J, Maylie J, et al. Small-conductance Ca2+-activated K+ channel type 2 (SK2) modulates hippocampal learning, memory, and synaptic plasticity. J Neurosci. 2006;26:1844-53 pubmed
    ..Studies of SK channel knock-out mice reveal that of the three apamin-sensitive SK channel subunits (SK1-SK3), only SK2 subunits are necessary for the apamin-sensitive currents in CA1 hippocampal neurons...
  5. Lin M, Lujan R, Watanabe M, Frerking M, Maylie J, Adelman J. Coupled activity-dependent trafficking of synaptic SK2 channels and AMPA receptors. J Neurosci. 2010;30:11726-34 pubmed publisher
    Small conductance Ca(2+)-activated K(+) type 2 (SK2) channels are expressed in the postsynaptic density of CA1 neurons where they are activated by synaptically evoked Ca(2+) influx to limit the size of EPSPs and spine Ca(2+) transients...
  6. Bond C, Herson P, Strassmaier T, Hammond R, Stackman R, Maylie J, et al. Small conductance Ca2+-activated K+ channel knock-out mice reveal the identity of calcium-dependent afterhyperpolarization currents. J Neurosci. 2004;24:5301-6 pubmed
    ..transgenic mice, each lacking one of the three SK channel genes expressed in the CNS, reveals that mice without the SK2 subunit completely lack the apamin-sensitive component of the ImAHP in CA1 neurons, whereas the IsAHP is not ..
  7. Lin M, Lujan R, Watanabe M, Adelman J, Maylie J. SK2 channel plasticity contributes to LTP at Schaffer collateral-CA1 synapses. Nat Neurosci. 2008;11:170-7 pubmed publisher
    ..Small-conductance Ca(2+)-activated K(+) channels (SK2 channels) are functionally coupled with NMDA receptors (NMDARs) in CA1 spines such that their activity modulates ..
  8. Strassmaier T, Bond C, Sailer C, Knaus H, Maylie J, Adelman J. A novel isoform of SK2 assembles with other SK subunits in mouse brain. J Biol Chem. 2005;280:21231-6 pubmed
    The SK2 subtype of small conductance Ca2+-activated K+ channels is widely distributed throughout the central nervous system and modulates neuronal excitability by contributing to the afterhyperpolarization that follows an action ..
  9. Nie L, Song H, Chen M, Chiamvimonvat N, Beisel K, Yamoah E, et al. Cloning and expression of a small-conductance Ca(2+)-activated K+ channel from the mouse cochlea: coexpression with alpha9/alpha10 acetylcholine receptors. J Neurophysiol. 2004;91:1536-44 pubmed
    ..Here we report the cloning, characterization, and expression of a complete SK2 cDNA from the mouse cochlea...

More Information

Publications57

  1. Rafizadeh S, Zhang Z, Woltz R, Kim H, Myers R, Lu L, et al. Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel. Proc Natl Acad Sci U S A. 2014;111:9989-94 pubmed publisher
    ..Here, we demonstrate that filamin A, a cytoskeletal protein, augments the trafficking of SK2 channels in cardiac myocytes. The trafficking of SK2 channel is Ca(2+)-dependent...
  2. Johnson S, Adelman J, Marcotti W. Genetic deletion of SK2 channels in mouse inner hair cells prevents the developmental linearization in the Ca2+ dependence of exocytosis. J Physiol. 2007;583:631-46 pubmed
    ..IHCs are shaped by a variety of ion channels including that of the small conductance Ca(2+)-activated K(+) current (SK2), which is only transiently expressed in immature cells...
  3. Ohtsuki G, Piochon C, Adelman J, Hansel C. SK2 channel modulation contributes to compartment-specific dendritic plasticity in cerebellar Purkinje cells. Neuron. 2012;75:108-20 pubmed publisher
    ..Dendritic plasticity is mimicked and occluded by the SK channel blocker apamin and is absent in Purkinje cells from SK2 null mice...
  4. Kakizawa S, Kishimoto Y, Hashimoto K, Miyazaki T, Furutani K, Shimizu H, et al. Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity. EMBO J. 2007;26:1924-33 pubmed
    ..Therefore, JPs support the Ca(2+)-mediated communication between voltage-gated Ca(2+) channels, RyRs and SK channels, which modulates the excitability of PCs and is fundamental to cerebellar LTD and motor functions. ..
  5. Fakira A, Portugal G, Carusillo B, Melyan Z, Morón J. Increased small conductance calcium-activated potassium type 2 channel-mediated negative feedback on N-methyl-D-aspartate receptors impairs synaptic plasticity following context-dependent sensitization to morphine. Biol Psychiatry. 2014;75:105-14 pubmed publisher
    ..role of N-methyl-D-aspartate receptors (NMDARs), AMPARs, and small conductance Ca(2+)-activated potassium type 2 (SK2) channels in LTP induction after context-dependent sensitization to morphine...
  6. Lu L, Timofeyev V, Li N, Rafizadeh S, Singapuri A, Harris T, et al. Alpha-actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel). Proc Natl Acad Sci U S A. 2009;106:18402-7 pubmed publisher
    ..we directly demonstrate that proper membrane localization of a small-conductance Ca(2+)-activated K(+) channel (SK2 or K(Ca)2.2) is dependent on its interacting protein, alpha-actinin2, a major F-actin crosslinking protein...
  7. Abdulkareem Z, Gee J, Cox C, Wann K. Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines. Br J Pharmacol. 2016;173:177-90 pubmed publisher
    ..x channels in migration, blockade of these channels was potently cytotoxic in breast cancer cell lines, pointing to modulation of KCa 2.x channels as a potential therapeutic approach to breast cancer. ..
  8. Grasselli G, He Q, Wan V, Adelman J, Ohtsuki G, Hansel C. Activity-Dependent Plasticity of Spike Pauses in Cerebellar Purkinje Cells. Cell Rep. 2016;14:2546-53 pubmed publisher
    ..Pause plasticity is absent from mice lacking SK2-type potassium channels (SK2(-/-) mice) and in occlusion experiments using the SK channel blocker apamin, while ..
  9. Thorneloe K, Knorn A, Doetsch P, Lashinger E, Liu A, Bond C, et al. Small-conductance, Ca(2+) -activated K+ channel 2 is the key functional component of SK channels in mouse urinary bladder. Am J Physiol Regul Integr Comp Physiol. 2008;294:R1737-43 pubmed publisher
    ..Here we investigated a role for the SK2 member of the SK family (SK1-3) utilizing: 1) mice expressing beta-galactosidase (beta-gal) under the direction of ..
  10. Murthy S, Teodorescu G, Nijholt I, Dolga A, Grissmer S, Spiess J, et al. Identification and characterization of a novel, shorter isoform of the small conductance Ca2+ -activated K+ channel SK2. J Neurochem. 2008;106:2312-21 pubmed publisher
    ..We have identified a novel, shorter isoform of standard SK2 (SK2-std) in mouse brain which we named SK2-sh...
  11. Ballesteros Merino C, Lin M, Wu W, Ferrándiz Huertas C, Cabañero M, Watanabe M, et al. Developmental profile of SK2 channel expression and function in CA1 neurons. Hippocampus. 2012;22:1467-80 pubmed publisher
    We investigated the temporal and spatial expression of SK2 in the developing mouse hippocampus using molecular and biochemical techniques, quantitative immunogold electron microscopy, and electrophysiology...
  12. Herde M, Friauf E, Rust M. Developmental expression of the actin depolymerizing factor ADF in the mouse inner ear and spiral ganglia. J Comp Neurol. 2010;518:1724-41 pubmed publisher
    ..The developmentally regulated ADF expression suggests a temporally restricted function in the stereocilia and, thus, a hitherto undescribed role of ADF...
  13. Zhang Q, Timofeyev V, Lu L, Li N, Singapuri A, Long M, et al. Functional roles of a Ca2+-activated K+ channel in atrioventricular nodes. Circ Res. 2008;102:465-71 pubmed
    ..mouse models with overexpression or null mutation of 1 of a small conductance Ca2+-activated K+ channel isoform, SK2 channel, and demonstrated robust phenotypes of AVN dysfunction in these experimental models...
  14. Dolga A, Netter M, Perocchi F, Doti N, Meissner L, Tobaben S, et al. Mitochondrial small conductance SK2 channels prevent glutamate-induced oxytosis and mitochondrial dysfunction. J Biol Chem. 2013;288:10792-804 pubmed publisher
    Small conductance calcium-activated potassium (SK2/K(Ca)2.2) channels are known to be located in the neuronal plasma membrane where they provide feedback control of NMDA receptor activity...
  15. Fuchs P, Lehar M, Hiel H. Ultrastructure of cisternal synapses on outer hair cells of the mouse cochlea. J Comp Neurol. 2014;522:717-29 pubmed publisher
    ..inhibition of cochlear hair cells via ?9?10-containing ionotropic receptors and associated calcium-activated (SK2) potassium channels, providing the opportunity to examine the ultrastructure of genetically altered cisternal ..
  16. Chan A, van Oers N, Tran A, Turka L, Law C, Ryan J, et al. Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J Immunol. 1994;152:4758-66 pubmed
    ..Thus, the differential expression of these kinases suggests the possibility of different roles for ZAP-70 and Syk in TCR signaling and thymic development. ..
  17. Szatanik M, Vibert N, Vassias I, Guenet J, Eugène D, de Waele C, et al. Behavioral effects of a deletion in Kcnn2, the gene encoding the SK2 subunit of small-conductance Ca2+-activated K+ channels. Neurogenetics. 2008;9:237-48 pubmed publisher
    ..In this report, we describe a deletion in the 5' region of the Kcnn2 gene encoding the SK2 subunit in the mouse neurological frissonnant (fri) mutant...
  18. Davisson M, Cook S, Johnson K, Eicher E. Balding: a new mutation on mouse chromosome 18 causing hair loss and immunological defects. J Hered. 1994;85:134-6 pubmed
  19. Lu L, Zhang Q, Timofeyev V, Zhang Z, Young J, Shin H, et al. Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2. Circ Res. 2007;100:112-20 pubmed
    ..Here, we demonstrate that a small conductance Ca(2+)-activated K(+) channels (SK2 channel), present in a variety of cells, where they integrate changes in intracellular Ca(2+) concentration [Ca(2+)(..
  20. Xu Y, Tuteja D, Zhang Z, Xu D, Zhang Y, Rodriguez J, et al. Molecular identification and functional roles of a Ca(2+)-activated K+ channel in human and mouse hearts. J Biol Chem. 2003;278:49085-94 pubmed
    ..We confirmed the presence of a small conductance Ca2+-activated K+ channel subtype (SK2) in human and mouse cardiac myocytes using Western blot analysis and reverse transcription-polymerase chain ..
  21. Murthy V, Maison S, Taranda J, Haque N, Bond C, Elgoyhen A, et al. SK2 channels are required for function and long-term survival of efferent synapses on mammalian outer hair cells. Mol Cell Neurosci. 2009;40:39-49 pubmed publisher
    Cochlear hair cells use SK2 currents to shape responses to cholinergic efferent feedback from the brain...
  22. Cueni L, Canepari M, Lujan R, Emmenegger Y, Watanabe M, Bond C, et al. T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites. Nat Neurosci. 2008;11:683-92 pubmed publisher
    ..Sk2-/- (also known as Kcnn2) mice lacked cellular oscillations, showed a greater than threefold reduction in low-frequency rhythms in the ..
  23. Oliveira M, Skinner F, Arshadmansab M, Garcia I, Mello C, Knaus H, et al. Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in pilocarpine-treated epileptic rats. Brain Res. 2010;1348:187-99 pubmed publisher
    ..Western blotting analysis showed a significant reduction in the expression of SK1 and SK2 channels at 10days following status epilepticus (SE), but levels recovered at 1month and at more than 2months after ..
  24. Johnson S, Kuhn S, Franz C, Ingham N, Furness D, Knipper M, et al. Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activity. Proc Natl Acad Sci U S A. 2013;110:8720-5 pubmed publisher
    ..We used a mouse model in which the potassium channel SK2 is normally overexpressed, but can be modulated in vivo using doxycycline...
  25. Sun J, Zhu G, Liu Y, Standley S, Ji A, Tunuguntla R, et al. UBE3A Regulates Synaptic Plasticity and Learning and Memory by Controlling SK2 Channel Endocytosis. Cell Rep. 2015;12:449-61 pubmed publisher
    ..While there is a wealth of information on SK2 gating, kinetics, and Ca(2+) sensitivity, little is known regarding the regulation of SK2 subcellular localization...
  26. Hu L, Kontrogianni Konstantopoulos A. The kinase domains of obscurin interact with intercellular adhesion proteins. FASEB J. 2013;27:2001-12 pubmed publisher
    ..are composed of tandem structural and signaling motifs, including 2 serine/threonine kinase domains, SK1 and SK2, present at the COOH terminus of giant obscurin-B...
  27. Kim G, Luján R, Schwenk J, Kelley M, Aguado C, Watanabe M, et al. Membrane palmitoylated protein 2 is a synaptic scaffold protein required for synaptic SK2-containing channel function. elife. 2016;5: pubmed publisher
    Mouse CA1 pyramidal neurons express apamin-sensitive SK2-containing channels in the post-synaptic membrane, positioned close to NMDA-type (N-methyl-D-aspartate) glutamate receptors...
  28. Deignan J, Lujan R, Bond C, Riegel A, Watanabe M, Williams J, et al. SK2 and SK3 expression differentially affect firing frequency and precision in dopamine neurons. Neuroscience. 2012;217:67-76 pubmed publisher
    ..The present findings show that SK2 was also expressed in DA neurons...
  29. Wimmer R, Astori S, Bond C, Rovó Z, Chatton J, Adelman J, et al. Sustaining sleep spindles through enhanced SK2-channel activity consolidates sleep and elevates arousal threshold. J Neurosci. 2012;32:13917-28 pubmed publisher
    ..3-type Ca(2+) channels and Ca(2+)-dependent small-conductance-type 2 (SK2) K(+) channels, underlies spindle generation...
  30. Yi F, Ling T, Lu T, Wang X, Li J, Claycomb W, et al. Down-regulation of the small conductance calcium-activated potassium channels in diabetic mouse atria. J Biol Chem. 2015;290:7016-26 pubmed publisher
    ..We found that in streptozotocin-induced diabetic mice, the expression of SK2 and SK3 isoforms was down-regulated by 85 and 92%, respectively, whereas that of SK1 was not changed...
  31. Ro S, Hatton W, Koh S, Horowitz B. Molecular properties of small-conductance Ca2+-activated K+ channels expressed in murine colonic smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2001;281:G964-73 pubmed
    ..The transcripts encoding these subunits (SK1, SK2, and SK3) were detected in murine proximal colon and other peripheral tissues...
  32. Deardorff A, Romer S, Deng Z, Bullinger K, Nardelli P, Cope T, et al. Expression of postsynaptic Ca2+-activated K+ (SK) channels at C-bouton synapses in mammalian lumbar -motoneurons. J Physiol. 2013;591:875-97 pubmed publisher
    ..labelling of rat, mouse and cat spinal cord, we reveal a differential and overlapping expression of SK2 and SK3 isoforms across specific types of ?-MNs...
  33. Allen D, Nakayama S, Kuroiwa M, Nakano T, Palmateer J, Kosaka Y, et al. SK2 channels are neuroprotective for ischemia-induced neuronal cell death. J Cereb Blood Flow Metab. 2011;31:2302-12 pubmed publisher
    ..CA1 pyramidal neurons, the activity of synaptic small-conductance Ca(2+)-activated K(+) channels type 2 (SK2 channels) provides a negative feedback on N-methyl-D-aspartate receptors (NMDARs), reestablishing Mg(2+) block that ..
  34. Tuteja D, Xu D, Timofeyev V, Lu L, Sharma D, Zhang Z, et al. Differential expression of small-conductance Ca2+-activated K+ channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytes. Am J Physiol Heart Circ Physiol. 2005;289:H2714-23 pubmed
    ..We recently reported for the first time the functional existence of SK2 (KCa2.2) channels in human and mouse cardiac myocytes. Here, we report cloning of SK1 (KCa2.1) and SK3 (KCa2...
  35. Maison S, Parker L, Young L, Adelman J, Zuo J, Liberman M. Overexpression of SK2 channels enhances efferent suppression of cochlear responses without enhancing noise resistance. J Neurophysiol. 2007;97:2930-6 pubmed
    Cochlear hair cells express SK2, a small-conductance Ca(2+)-activated K(+) channel thought to act in concert with Ca(2+)-permeable nicotinic acetylcholine receptors (nAChRs) alpha9 and alpha10 in mediating suppressive effects of the ..
  36. Indriati D, Kamasawa N, Matsui K, Meredith A, Watanabe M, Shigemoto R. Quantitative localization of Cav2.1 (P/Q-type) voltage-dependent calcium channels in Purkinje cells: somatodendritic gradient and distinct somatic coclustering with calcium-activated potassium channels. J Neurosci. 2013;33:3668-78 pubmed publisher
    ..1 clusters were colocalized with two types of calcium-activated potassium channels, BK and SK2, with the nearest neighbor distance of ?40 nm. Calcium nanodomain created by the opening of Ca(v)2...
  37. Tamarina N, Wang Y, Mariotto L, Kuznetsov A, Bond C, Adelman J, et al. Small-conductance calcium-activated K+ channels are expressed in pancreatic islets and regulate glucose responses. Diabetes. 2003;52:2000-6 pubmed
    ..b>SK2 and -3 proteins in mouse islets were detected by immunoblot and immunocytochemistry...
  38. Lane P, Searle A, Beechey C, Eicher E. Chromosome 18 of the house mouse. J Hered. 1981;72:409-12 pubmed
    ..They occupy a total genetic length of 35 cM. The positions of the breakpoints of the two reciprocal translocations T(10;18) 18H and T(7;18) 5OH are discussed and shown to be closely linked to the sy locus. ..
  39. García Negredo G, Soto D, Llorente J, Morató X, Galenkamp K, Gómez Soler M, et al. Coassembly and coupling of SK2 channels and mGlu5 receptors. J Neurosci. 2014;34:14793-802 pubmed publisher
    ..Here, we show that mGlu5 receptors and SK2 channels coassemble in heterologous coexpression systems and in rat brain...
  40. Kong J, Adelman J, Fuchs P. Expression of the SK2 calcium-activated potassium channel is required for cholinergic function in mouse cochlear hair cells. J Physiol. 2008;586:5471-85 pubmed publisher
    ..is mediated by 'nicotinic' cholinergic receptors functionally coupled to calcium-activated, small conductance (SK2) potassium channels...
  41. Li N, Timofeyev V, Tuteja D, Xu D, Lu L, Zhang Q, et al. Ablation of a Ca2+-activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation. J Physiol. 2009;587:1087-100 pubmed publisher
    ..We have recently reported the functional existence of SK2 channels in human and mouse cardiac myocytes...
  42. Allen D, Bond C, Lujan R, Ballesteros Merino C, Lin M, Wang K, et al. The SK2-long isoform directs synaptic localization and function of SK2-containing channels. Nat Neurosci. 2011;14:744-9 pubmed publisher
    ..The Sk2 gene (also known as Kcnn2) encodes two isoforms that differ only in the length of their N-terminal domains...
  43. Tuteja D, Rafizadeh S, Timofeyev V, Wang S, Zhang Z, Li N, et al. Cardiac small conductance Ca2+-activated K+ channel subunits form heteromultimers via the coiled-coil domains in the C termini of the channels. Circ Res. 2010;107:851-9 pubmed publisher
    ..Three isoforms of SK channel subunits (SK1, SK2, and SK3) are found to be expressed...
  44. Sailer C, Kaufmann W, Marksteiner J, Knaus H. Comparative immunohistochemical distribution of three small-conductance Ca2+-activated potassium channel subunits, SK1, SK2, and SK3 in mouse brain. Mol Cell Neurosci. 2004;26:458-69 pubmed
    ..central nervous system, we performed immunohistochemistry using sequence-specific antibodies directed against SK1, SK2, and SK3 proteins...
  45. Callizot N, Guenet J, Baillet C, Warter J, Poindron P. The frissonnant mutant mouse, a model of dopamino-sensitive, inherited motor syndrome. Neurobiol Dis. 2001;8:447-58 pubmed
    The frissonnant (fri) mutation is an autosomic recessive mutation which spontaneously appeared in the stock of C3H mice. fri mutant mice have locomotor instability and rapid tremor...
  46. Sargin D, Oliver D, Lambe E. Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels. elife. 2016;5: pubmed publisher
    ..of small-conductance Ca2+-activated K+ (SK) channels and reveals an important role for both SK2 and SK3 channels in normal regulation of 5-HT neuronal excitability...
  47. Moruno Manchon J, Uzor N, Blasco Conesa M, Mannuru S, Putluri N, Furr Stimming E, et al. Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease. Hum Mol Genet. 2017;26:1305-1317 pubmed publisher
    ..Sphingosine kinases 1 (SK1) and 2 (SK2) synthesize sphingosine-1-phosphate (S1P), a bioactive lipid messenger critically involved in many vital cellular ..
  48. Honrath B, Matschke L, Meyer T, Magerhans L, Perocchi F, Ganjam G, et al. SK2 channels regulate mitochondrial respiration and mitochondrial Ca2+ uptake. Cell Death Differ. 2017;24:761-773 pubmed publisher
    ..respiration and complex I activity upon pharmacological activation and overexpression of mitochondrial SK2 channels resulting in reduced mitochondrial ROS formation...