Gene Symbol: Kcnmb4
Description: potassium large conductance calcium-activated channel, subfamily M, beta member 4
Alias: 1700058G18Rik, 2900045G12Rik, calcium-activated potassium channel subunit beta-4, BK channel subunit beta-4, BKbeta4, Slowpoke beta 4, calcium-activated potassium channel, subfamily M subunit beta-4, charybdotoxin receptor subunit beta-4, k(VCA)beta-4, large conductance calcium-dependent potassium ion channel beta 4 subunit, maxi K channel subunit beta-4, slo-beta-4
Species: mouse
Products:     Kcnmb4

Top Publications

  1. Brenner R, Chen Q, Vilaythong A, Toney G, Noebels J, Aldrich R. BK channel beta4 subunit reduces dentate gyrus excitability and protects against temporal lobe seizures. Nat Neurosci. 2005;8:1752-9 pubmed
  2. Wen D, Cornelius R, Yuan Y, Sansom S. Regulation of BK-? expression in the distal nephron by aldosterone and urine pH. Am J Physiol Renal Physiol. 2013;305:F463-76 pubmed publisher
    ..These data suggest that aldosterone mediates a high-K-induced increase in BK-? and urinary alkalinization increases BK-?4 expression, which promotes the apical localization of BK-?. ..
  3. Weiger T, Holmqvist M, Levitan I, Clark F, Sprague S, Huang W, et al. A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels. J Neurosci. 2000;20:3563-70 pubmed
    ..beta4 may be important for the critical roles played by Slowpoke channels in the regulation of neuronal excitability and neurotransmitter release. ..
  4. Holtzclaw J, Grimm P, Sansom S. Intercalated cell BK-alpha/beta4 channels modulate sodium and potassium handling during potassium adaptation. J Am Soc Nephrol. 2010;21:634-45 pubmed publisher
    ..We studied whether BK-beta4-deficient mice (Kcnmb4(-/-)) have altered renal sodium and potassium clearances compared with wild-type mice when fed a regular or ..
  5. Yang C, Zeng X, Zhou Y, Xia X, Lingle C. LRRC52 (leucine-rich-repeat-containing protein 52), a testis-specific auxiliary subunit of the alkalization-activated Slo3 channel. Proc Natl Acad Sci U S A. 2011;108:19419-24 pubmed publisher
    ..Together, LRRC52 and LRRC26 define a new family of auxiliary subunits capable of critically modifying the gating behavior of Slo family channels. ..
  6. Jaffe D, Wang B, Brenner R. Shaping of action potentials by type I and type II large-conductance Ca²+-activated K+ channels. Neuroscience. 2011;192:205-18 pubmed publisher
    ..Finally, we show how the broadening of action potentials conferred by type II BK channels can also indirectly increase the recruitment of SK-type channels decreasing the excitability of the neuron. ..
  7. Whitmire L, Ling L, Bugay V, Carver C, Timilsina S, Chuang H, et al. Downregulation of KCNMB4 expression and changes in BK channel subtype in hippocampal granule neurons following seizure activity. PLoS ONE. 2017;12:e0188064 pubmed publisher
    ..Here, we have investigated changes in BK channels and their accessory ?4 subunit (KCNMB4) in dentate gyrus (DG) granule neurons of the hippocampus, key neurons that regulate excitability of the ..
  8. Deng P, Rotman Z, Blundon J, Cho Y, Cui J, Cavalli V, et al. FMRP regulates neurotransmitter release and synaptic information transmission by modulating action potential duration via BK channels. Neuron. 2013;77:696-711 pubmed publisher
    ..Our results thus suggest major translation-independent presynaptic functions of FMRP that may have important implications for understanding FXS neuropathology. ..
  9. Piwonska M, Wilczek E, Szewczyk A, Wilczynski G. Differential distribution of Ca2+-activated potassium channel beta4 subunit in rat brain: immunolocalization in neuronal mitochondria. Neuroscience. 2008;153:446-60 pubmed publisher
    ..directed against four distinct beta subunits demonstrated the presence of the BK(Ca) channel beta4 subunit (KCNMB4) in the inner membrane of neuronal mitochondria in the rat brain and cultured neurons...

More Information


  1. Nehrke K, Quinn C, Begenisich T. Molecular identification of Ca2+-activated K+ channels in parotid acinar cells. Am J Physiol Cell Physiol. 2003;284:C535-46 pubmed
    ..RT-PCR analysis revealed the presence of two mSlo beta-subunits (Kcnmb1 and Kcnmb4) in parotid tissue...
  2. Seidel K, Derst C, Salzmann M, Höltje M, Priller J, Markgraf R, et al. Expression of the voltage- and Ca2+-dependent BK potassium channel subunits BK?1 and BK?4 in rodent astrocytes. Glia. 2011;59:893-902 pubmed publisher
    ..Thus, BK?4 expression in astrocytes likely participates in regulating astrocytic voltage gradients and maintaining K(+) homeostasis, hence enabling astrocytes to fulfill their complex regulatory influence on proper brain function. ..
  3. Petrik D, Brenner R. Regulation of STREX exon large conductance, calcium-activated potassium channels by the beta4 accessory subunit. Neuroscience. 2007;149:789-803 pubmed
  4. Pyott S, Meredith A, Fodor A, Vazquez A, Yamoah E, Aldrich R. Cochlear function in mice lacking the BK channel alpha, beta1, or beta4 subunits. J Biol Chem. 2007;282:3312-24 pubmed
    ..These findings reveal the fundamentally different contribution of BK channels to nonmammalian and mammalian hearing and suggest that BK channels should be considered a target in the prevention of noise-induced hearing loss. ..
  5. Wen D, Cornelius R, Rivero Hernandez D, Yuan Y, Li H, Weinstein A, et al. Relation between BK-?/?4-mediated potassium secretion and ENaC-mediated sodium reabsorption. Kidney Int. 2014;86:139-45 pubmed publisher
  6. Bugaj V, Sansom S, Wen D, Hatcher L, Stockand J, Mironova E. Flow-sensitive K+-coupled ATP secretion modulates activity of the epithelial Na+ channel in the distal nephron. J Biol Chem. 2012;287:38552-8 pubmed publisher
    ..Impaired sodium excretion resulting form loss of normal purinergic regulation of ENaC in BK-?4 null mice likely contributes to their elevated blood pressure. ..
  7. Whitt J, Montgomery J, Meredith A. BK channel inactivation gates daytime excitability in the circadian clock. Nat Commun. 2016;7:10837 pubmed publisher
    ..Our study reveals the clock employs inactivation gating as a biophysical switch to set the diurnal variation in suprachiasmatic nucleus excitability that underlies circadian rhythm. ..
  8. Wang B, Bugay V, Ling L, Chuang H, Jaffe D, Brenner R. Knockout of the BK ?4-subunit promotes a functional coupling of BK channels and ryanodine receptors that mediate a fAHP-induced increase in excitability. J Neurophysiol. 2016;116:456-65 pubmed publisher
  9. Yang C, Zeng X, Xia X, Lingle C. Interactions between beta subunits of the KCNMB family and Slo3: beta4 selectively modulates Slo3 expression and function. PLoS ONE. 2009;4:e6135 pubmed publisher
  10. Martin G, Hendrickson L, Penta K, Friesen R, Pietrzykowski A, Tapper A, et al. Identification of a BK channel auxiliary protein controlling molecular and behavioral tolerance to alcohol. Proc Natl Acad Sci U S A. 2008;105:17543-8 pubmed publisher
  11. Petrik D, Wang B, Brenner R. Modulation by the BK accessory ?4 subunit of phosphorylation-dependent changes in excitability of dentate gyrus granule neurons. Eur J Neurosci. 2011;34:695-704 pubmed publisher
    ..By opposing BK channel activation, the ?4 subunit plays an important role in moderating firing frequency regardless of changes in phosphorylation status. ..
  12. Nishimura I, Ui Tei K, Saigo K, Ishii H, Sakuma Y, Kato M. 17beta-estradiol at physiological concentrations augments Ca(2+) -activated K+ currents via estrogen receptor beta in the gonadotropin-releasing hormone neuronal cell line GT1-7. Endocrinology. 2008;149:774-82 pubmed
    ..In conclusion, E2 at physiological concentrations augments K(Ca) currents through ERbeta in the GT1-7 GnRH neuronal cell line and increases the expression of the BK channel subunit mRNAs, alpha and beta4. ..
  13. Myrick L, Deng P, Hashimoto H, Oh Y, Cho Y, Poidevin M, et al. Independent role for presynaptic FMRP revealed by an FMR1 missense mutation associated with intellectual disability and seizures. Proc Natl Acad Sci U S A. 2015;112:949-56 pubmed publisher
    ..These results reveal a presynaptic- and translation-independent function of FMRP that is linked to a specific subset of FXS phenotypes. ..