Kcnmb2

Summary

Gene Symbol: Kcnmb2
Description: potassium large conductance calcium-activated channel, subfamily M, beta member 2
Alias: 2700049B16Rik, 3110031N04Rik, calcium-activated potassium channel subunit beta-2, BK channel subunit beta-2, BKbeta2, calcium-activated potassium channel, subfamily M subunit beta-2, charybdotoxin receptor subunit beta-2, k(VCA)beta-2, maxi K channel subunit beta-2, slo-beta-2
Species: mouse
Products:     Kcnmb2

Top Publications

  1. Whitt J, Montgomery J, Meredith A. BK channel inactivation gates daytime excitability in the circadian clock. Nat Commun. 2016;7:10837 pubmed publisher
    ..Our study reveals the clock employs inactivation gating as a biophysical switch to set the diurnal variation in suprachiasmatic nucleus excitability that underlies circadian rhythm. ..
  2. Larsen C, Jensen I, Sorensen M, de Bruijn P, Bleich M, Praetorius H, et al. Hyperaldosteronism after decreased renal K+ excretion in KCNMB2 knockout mice. Am J Physiol Renal Physiol. 2016;310:F1035-46 pubmed publisher
    ..1). Here, we report a novel knockout mouse of the ?2-subunit of the KCa1.1 channel (KCNMB2), which displays hyperaldosteronism after decreased renal K(+) excretion...
  3. Martinez Espinosa P, Yang C, González Pérez V, Xia X, Lingle C. Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity. J Gen Physiol. 2014;144:275-95 pubmed publisher
    ..This inactivation is thought to arise from the assembly of up to four β2 auxiliary subunits (encoded by the kcnmb2 gene) with a tetramer of pore-forming Slo1 α subunits...
  4. Shelton E, Ector G, Galindo C, Hooper C, Brown N, Wilkerson I, et al. Transcriptional profiling reveals ductus arteriosus-specific genes that regulate vascular tone. Physiol Genomics. 2014;46:457-66 pubmed publisher
    ..Ion channels that regulate DA tone, including BKCa channels, are promising targets. Specifically, BKCa channel agonists like NS1619 maintain DA patency even in the presence of O2 and may be clinically useful. ..
  5. Larsen C, Praetorius H, Leipziger J, Sorensen M. Intact colonic KCa1.1 channel activity in KCNMB2 knockout mice. Physiol Rep. 2017;5: pubmed publisher
    ..1-?2-subunit (KCNMB2-/-), which apparently is the only ?-subunit of the colonic enterocyte KCa1...