Kcnma1

Summary

Gene Symbol: Kcnma1
Description: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Alias: 5730414M22Rik, BKCa, MaxiK, Slo, Slo1, mSlo, mSlo1, calcium-activated potassium channel subunit alpha-1, BK channel alpha subunit, BKCA alpha, KCa1.1, calcium-activated potassium channel, subfamily M subunit alpha-1, k(VCA)alpha, maxi K channel, slo homolog, slo-alpha, slowpoke homolog
Species: mouse
Products:     Kcnma1

Top Publications

  1. Chen L, Tian L, MacDonald S, McClafferty H, Hammond M, Huibant J, et al. Functionally diverse complement of large conductance calcium- and voltage-activated potassium channel (BK) alpha-subunits generated from a single site of splicing. J Biol Chem. 2005;280:33599-609 pubmed
  2. Roth M, Rupp M, Hofmann S, Mittal M, Fuchs B, Sommer N, et al. Heme oxygenase-2 and large-conductance Ca2+-activated K+ channels: lung vascular effects of hypoxia. Am J Respir Crit Care Med. 2009;180:353-64 pubmed publisher
    ..It is demonstrated that neither deletion of HO-2 nor BK channels affect acute, sustained, and chronic vascular responses to alveolar hypoxia in the lung. ..
  3. Brunton P, Sausbier M, Wietzorrek G, Sausbier U, Knaus H, Russell J, et al. Hypothalamic-pituitary-adrenal axis hyporesponsiveness to restraint stress in mice deficient for large-conductance calcium- and voltage-activated potassium (BK) channels. Endocrinology. 2007;148:5496-506 pubmed
  4. Li H, Yao J, Tong X, Guo Z, Wu Y, Sun L, et al. Interaction sites between the Slo1 pore and the NH2 terminus of the beta2 subunit, probed with a three-residue sensor. J Biol Chem. 2007;282:17720-8 pubmed
    Calcium- and voltage-gated (BK) K(+) channels encoded by Slo1 play an essential role in nervous systems...
  5. Romanenko V, Nakamoto T, Srivastava A, Melvin J, Begenisich T. Molecular identification and physiological roles of parotid acinar cell maxi-K channels. J Biol Chem. 2006;281:27964-72 pubmed
  6. Pallanck L, Ganetzky B. Cloning and characterization of human and mouse homologs of the Drosophila calcium-activated potassium channel gene, slowpoke. Hum Mol Genet. 1994;3:1239-43 pubmed
  7. Tang Q, Zhang Z, Xia X, Lingle C. Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine. Channels (Austin). 2010;4:22-41 pubmed
    ..The Slo3 channel shares extensive homology with Ca(2+)- and voltage-regulated BK-type Slo1 K(+) channels...
  8. Engel J, Braig C, Ruttiger L, Kuhn S, Zimmermann U, Blin N, et al. Two classes of outer hair cells along the tonotopic axis of the cochlea. Neuroscience. 2006;143:837-49 pubmed
    ..Our findings propose new mechanisms and candidate genes for explaining high and low frequency hearing loss. ..
  9. Ruttiger L, Sausbier M, Zimmermann U, Winter H, Braig C, Engel J, et al. Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BKbeta1-subunit leads to progressive hearing loss. Proc Natl Acad Sci U S A. 2004;101:12922-7 pubmed
    ..loss of KCNQ4 in OHCs, and OHC degeneration requires further investigation, data already suggest human BK-coding slo1 gene mutation as a susceptibility factor for progressive deafness, similar to KCNQ4 potassium channel mutations.
  10. Sausbier M, Zhou X, Beier C, Sausbier U, Wolpers D, Maget S, et al. Reduced rather than enhanced cholinergic airway constriction in mice with ablation of the large conductance Ca2+-activated K+ channel. FASEB J. 2007;21:812-22 pubmed

Detail Information

Publications86

  1. Chen L, Tian L, MacDonald S, McClafferty H, Hammond M, Huibant J, et al. Functionally diverse complement of large conductance calcium- and voltage-activated potassium channel (BK) alpha-subunits generated from a single site of splicing. J Biol Chem. 2005;280:33599-609 pubmed
  2. Roth M, Rupp M, Hofmann S, Mittal M, Fuchs B, Sommer N, et al. Heme oxygenase-2 and large-conductance Ca2+-activated K+ channels: lung vascular effects of hypoxia. Am J Respir Crit Care Med. 2009;180:353-64 pubmed publisher
    ..It is demonstrated that neither deletion of HO-2 nor BK channels affect acute, sustained, and chronic vascular responses to alveolar hypoxia in the lung. ..
  3. Brunton P, Sausbier M, Wietzorrek G, Sausbier U, Knaus H, Russell J, et al. Hypothalamic-pituitary-adrenal axis hyporesponsiveness to restraint stress in mice deficient for large-conductance calcium- and voltage-activated potassium (BK) channels. Endocrinology. 2007;148:5496-506 pubmed
  4. Li H, Yao J, Tong X, Guo Z, Wu Y, Sun L, et al. Interaction sites between the Slo1 pore and the NH2 terminus of the beta2 subunit, probed with a three-residue sensor. J Biol Chem. 2007;282:17720-8 pubmed
    Calcium- and voltage-gated (BK) K(+) channels encoded by Slo1 play an essential role in nervous systems...
  5. Romanenko V, Nakamoto T, Srivastava A, Melvin J, Begenisich T. Molecular identification and physiological roles of parotid acinar cell maxi-K channels. J Biol Chem. 2006;281:27964-72 pubmed
  6. Pallanck L, Ganetzky B. Cloning and characterization of human and mouse homologs of the Drosophila calcium-activated potassium channel gene, slowpoke. Hum Mol Genet. 1994;3:1239-43 pubmed
  7. Tang Q, Zhang Z, Xia X, Lingle C. Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine. Channels (Austin). 2010;4:22-41 pubmed
    ..The Slo3 channel shares extensive homology with Ca(2+)- and voltage-regulated BK-type Slo1 K(+) channels...
  8. Engel J, Braig C, Ruttiger L, Kuhn S, Zimmermann U, Blin N, et al. Two classes of outer hair cells along the tonotopic axis of the cochlea. Neuroscience. 2006;143:837-49 pubmed
    ..Our findings propose new mechanisms and candidate genes for explaining high and low frequency hearing loss. ..
  9. Ruttiger L, Sausbier M, Zimmermann U, Winter H, Braig C, Engel J, et al. Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BKbeta1-subunit leads to progressive hearing loss. Proc Natl Acad Sci U S A. 2004;101:12922-7 pubmed
    ..loss of KCNQ4 in OHCs, and OHC degeneration requires further investigation, data already suggest human BK-coding slo1 gene mutation as a susceptibility factor for progressive deafness, similar to KCNQ4 potassium channel mutations.
  10. Sausbier M, Zhou X, Beier C, Sausbier U, Wolpers D, Maget S, et al. Reduced rather than enhanced cholinergic airway constriction in mice with ablation of the large conductance Ca2+-activated K+ channel. FASEB J. 2007;21:812-22 pubmed
  11. Essin K, Gollasch M, Rolle S, Weissgerber P, Sausbier M, Bohn E, et al. BK channels in innate immune functions of neutrophils and macrophages. Blood. 2009;113:1326-31 pubmed publisher
    ..Based on these data, we conclude that the BK channel is not required for NADPH oxidase activity in PMNs or macrophages or for endotoxin-triggered tumor necrosis factor-alpha release and signal transduction BMDMs. ..
  12. Sweet T, Cox D. Measuring the influence of the BKCa {beta}1 subunit on Ca2+ binding to the BKCa channel. J Gen Physiol. 2009;133:139-50 pubmed publisher
    ..Both of these modifications increase the difference in affinity between open and closed, such that Ca(2+) binding at either site has a larger effect on channel opening when beta1 is present. ..
  13. Meredith A, Wiler S, Miller B, Takahashi J, Fodor A, Ruby N, et al. BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output. Nat Neurosci. 2006;9:1041-9 pubmed
    ..BK channel-null mice (Kcnma1(-/-)) have increased SFRs in SCN neurons selectively at night and weak circadian amplitudes in multiple behaviors ..
  14. Weiger T, Holmqvist M, Levitan I, Clark F, Sprague S, Huang W, et al. A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels. J Neurosci. 2000;20:3563-70 pubmed
    ..beta4 may be important for the critical roles played by Slowpoke channels in the regulation of neuronal excitability and neurotransmitter release. ..
  15. Xia X, Zeng X, Lingle C. Multiple regulatory sites in large-conductance calcium-activated potassium channels. Nature. 2002;418:880-4 pubmed
    ..This allows BK channels to serve a variety of physiological roles contingent on the Ca(2+) concentration to which the channels are exposed. ..
  16. Wen D, Cornelius R, Yuan Y, Sansom S. Regulation of BK-? expression in the distal nephron by aldosterone and urine pH. Am J Physiol Renal Physiol. 2013;305:F463-76 pubmed publisher
    ..These data suggest that aldosterone mediates a high-K-induced increase in BK-? and urinary alkalinization increases BK-?4 expression, which promotes the apical localization of BK-?. ..
  17. Xie J, McCobb D. Control of alternative splicing of potassium channels by stress hormones. Science. 1998;280:443-6 pubmed
    ..Expression of alternative splice variants of Slo, a gene encoding calcium- and voltage-activated potassium channels, was measured in rat adrenal chromaffin tissue ..
  18. Morrow J, Zakharov S, Liu G, Yang L, Sok A, Marx S. Defining the BK channel domains required for beta1-subunit modulation. Proc Natl Acad Sci U S A. 2006;103:5096-101 pubmed
    ..Although the functional interaction of alpha and beta1 requires the N-terminal tail of alpha, the physical association requires the S1, S2, and S3 transmembrane helices of alpha. ..
  19. van Welie I, du Lac S. Bidirectional control of BK channel open probability by CAMKII and PKC in medial vestibular nucleus neurons. J Neurophysiol. 2011;105:1651-9 pubmed publisher
  20. Sausbier M, Arntz C, Bucurenciu I, Zhao H, Zhou X, Sausbier U, et al. Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice. Circulation. 2005;112:60-8 pubmed
    ..Here we report that deletion of the pore-forming BK channel alpha subunit leads to a significant blood pressure elevation resulting from hyperaldosteronism accompanied by ..
  21. Butler A, Tsunoda S, McCobb D, Wei A, Salkoff L. mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels. Science. 1993;261:221-4 pubmed
    Complementary DNAs (cDNAs) from mSlo, a gene encoding calcium-activated potassium channels, were isolated from mouse brain and skeletal muscle, sequenced, and expressed in Xenopus oocytes...
  22. Li W, Aldrich R. Unique inner pore properties of BK channels revealed by quaternary ammonium block. J Gen Physiol. 2004;124:43-57 pubmed
    ..These features could potentially contribute to the large conductance of BK channels. ..
  23. Sausbier M, Hu H, Arntz C, Feil S, Kamm S, Adelsberger H, et al. Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency. Proc Natl Acad Sci U S A. 2004;101:9474-8 pubmed
    ..These results identify previously unknown roles of potassium channels in mammalian cerebellar function and motor control. In addition, they provide a previously undescribed animal model of cerebellar ataxia. ..
  24. Meredith A, Thorneloe K, Werner M, Nelson M, Aldrich R. Overactive bladder and incontinence in the absence of the BK large conductance Ca2+-activated K+ channel. J Biol Chem. 2004;279:36746-52 pubmed
    ..To address the role of the BK channel in urinary bladder function, the gene mSlo1 for the pore-forming subunit of the BK channel was deleted...
  25. Hu L, Shi J, Ma Z, Krishnamoorthy G, Sieling F, Zhang G, et al. Participation of the S4 voltage sensor in the Mg2+-dependent activation of large conductance (BK) K+ channels. Proc Natl Acad Sci U S A. 2003;100:10488-93 pubmed
    ..These results indicate that the voltage sensor is critical for Mg2+-dependent activation and the coupling between the voltage sensor and channel gate is a converging point for voltage- and Mg2+-dependent activation pathways. ..
  26. Pyott S, Meredith A, Fodor A, Vazquez A, Yamoah E, Aldrich R. Cochlear function in mice lacking the BK channel alpha, beta1, or beta4 subunits. J Biol Chem. 2007;282:3312-24 pubmed
    ..cells, we analyzed the morphology, physiology, and function of these cells from mice lacking the BK channel alpha (Slo-/-) and also the beta1 and beta4 subunits (beta1/4-/-)...
  27. Bao L, Rapin A, Holmstrand E, Cox D. Elimination of the BK(Ca) channel's high-affinity Ca(2+) sensitivity. J Gen Physiol. 2002;120:173-89 pubmed
    ..Estimates of the binding characteristics of the BK(Ca) channel's high-affinity Ca(2+)-binding sites are provided. ..
  28. Imlach W, Finch S, Dunlop J, Meredith A, Aldrich R, Dalziel J. The molecular mechanism of "ryegrass staggers," a neurological disorder of K+ channels. J Pharmacol Exp Ther. 2008;327:657-64 pubmed publisher
    ..to inhibition of BK ion channels, their ability to induce tremor and ataxia in mice deficient in this ion channel (Kcnma1(-/-)) was examined. Our results show that mice lacking Kcnma1 are unaffected by these neurotoxins...
  29. Sprossmann F, Pankert P, Sausbier U, Wirth A, Zhou X, Madlung J, et al. Inducible knockout mutagenesis reveals compensatory mechanisms elicited by constitutive BK channel deficiency in overactive murine bladder. FEBS J. 2009;276:1680-97 pubmed publisher
    ..Thus, constitutive and inducible deletion of BK channel activity unmasks compensatory mechanisms that are relevant for urinary bladder relaxation. ..
  30. Oliver D, Taberner A, Thurm H, Sausbier M, Arntz C, Ruth P, et al. The role of BKCa channels in electrical signal encoding in the mammalian auditory periphery. J Neurosci. 2006;26:6181-9 pubmed
    Large-conductance voltage- and Ca(2+)-activated K+ channels (BKCa) are involved in shaping spiking patterns in many neurons...
  31. Singh H, Lu R, Bopassa J, Meredith A, Stefani E, Toro L. MitoBK(Ca) is encoded by the Kcnma1 gene, and a splicing sequence defines its mitochondrial location. Proc Natl Acad Sci U S A. 2013;110:10836-41 pubmed publisher
    The large-conductance Ca(2+)- and voltage-activated K(+) channel (BK(Ca), MaxiK), which is encoded by the Kcnma1 gene, is generally expressed at the plasma membrane of excitable and nonexcitable cells...
  32. Nehrke K, Quinn C, Begenisich T. Molecular identification of Ca2+-activated K+ channels in parotid acinar cells. Am J Physiol Cell Physiol. 2003;284:C535-46 pubmed
    ..with the intermediate and maxi-K classes of Ca(2+)-activated K(+) channels, typified by the mIK1 (Kcnn4) and mSlo (Kcnma1) genes, respectively. The presence of mIK1 mRNA was established in acinar cells by in situ hybridization...
  33. Shi J, Krishnamoorthy G, Yang Y, Hu L, Chaturvedi N, Harilal D, et al. Mechanism of magnesium activation of calcium-activated potassium channels. Nature. 2002;418:876-80 pubmed
    ..These results indicate distinct structural pathways for Mg(2+)- and Ca(2+)-dependent activation and suggest a possible mechanism for the coupling between Mg(2+) binding and channel opening. ..
  34. Cui J, Aldrich R. Allosteric linkage between voltage and Ca(2+)-dependent activation of BK-type mslo1 K(+) channels. Biochemistry. 2000;39:15612-9 pubmed
    ..We studied three point mutations in the putative voltage sensor S4 or S4-S5 linker regions in the mslo1 BK channels to explore the relationship between voltage and Ca(2+) in activating the channel...
  35. Dufer M, Neye Y, Horth K, Krippeit Drews P, Hennige A, Widmer H, et al. BK channels affect glucose homeostasis and cell viability of murine pancreatic beta cells. Diabetologia. 2011;54:423-32 pubmed publisher
    ..In addition, BK channels are part of a defence mechanism against apoptosis and oxidative stress. ..
  36. Singh H, Li M, Hall L, Chen S, Sukur S, Lu R, et al. MaxiK channel interactome reveals its interaction with GABA transporter 3 and heat shock protein 60 in the mammalian brain. Neuroscience. 2016;317:76-107 pubmed publisher
    ..with rabbit immunoglobulin G (IgG) and with anti-MaxiK antibodies in wild type and MaxiK channel knockout mice (Kcnma1(-/-)), respectively...
  37. Duncan P, Tabak J, Ruth P, Bertram R, Shipston M. Glucocorticoids Inhibit CRH/AVP-Evoked Bursting Activity of Male Murine Anterior Pituitary Corticotrophs. Endocrinology. 2016;157:3108-21 pubmed publisher
    ..Thus, we have established that glucocorticoids can modulate multiple properties of corticotroph electrical excitability through both BK-dependent and BK-independent mechanisms. ..
  38. Semenova N, Abarca Heidemann K, Loranc E, Rothberg B. Bimane fluorescence scanning suggests secondary structure near the S3-S4 linker of BK channels. J Biol Chem. 2009;284:10684-93 pubmed publisher
    ..Our results suggest a working hypothesis for the secondary structure of the BK channel S3-S4 region, and places residues Leu-204, Gly-205, and Leu-206 within the extracellular end of the S4 helix. ..
  39. Marino M, Beny J, Peyter A, Diaceri G, Tolsa J. Perinatal hypoxia enhances cyclic adenosine monophosphate-mediated BKCa channel activation in adult murine pulmonary artery. J Cardiovasc Pharmacol. 2011;57:154-65 pubmed publisher
    ..In summary, perinatal hypoxia enhanced cAMP-mediated BK(Ca) channels activation in adult murine PA, suggesting that this pathway could be a potential target for modulating adult pulmonary vascular tone after perinatal hypoxia. ..
  40. Sakai Y, Sokolowski B. The large conductance calcium-activated potassium channel affects extrinsic and intrinsic mechanisms of apoptosis. J Neurosci Res. 2015;93:745-54 pubmed publisher
    ..These data suggest that BK is part of a larger complex of proteins that protects against apoptosis by interacting with proapoptotic proteins, such as p53 and FADD. ..
  41. Li B, Jie W, Huang L, Wei P, Li S, Luo Z, et al. Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling. Nat Neurosci. 2014;17:1055-63 pubmed publisher
  42. Müller C, Más Gómez N, Ruth P, Strauss O. CaV1.3 L-type channels, maxiK Ca(2+)-dependent K(+) channels and bestrophin-1 regulate rhythmic photoreceptor outer segment phagocytosis by retinal pigment epithelial cells. Cell Signal. 2014;26:968-78 pubmed publisher
    ..3 L-type Ca(2+) channels (Ca1.3(-/-)) and maxiK Ca(2+)-dependent K(+) channels (BK(-/-))...
  43. Lu R, Lukowski R, Sausbier M, Zhang D, Sisignano M, Schuh C, et al. BKCa channels expressed in sensory neurons modulate inflammatory pain in mice. Pain. 2014;155:556-65 pubmed publisher
    Large conductance calcium-activated potassium (BKCa) channels are important regulators of neuronal excitability...
  44. McCartney C, McClafferty H, Huibant J, Rowan E, Shipston M, Rowe I. A cysteine-rich motif confers hypoxia sensitivity to mammalian large conductance voltage- and Ca-activated K (BK) channel alpha-subunits. Proc Natl Acad Sci U S A. 2005;102:17870-6 pubmed
    ..Because STREX splice-variant expression is tissue-specific and dynamically controlled, alternative splicing of BK channels provides a mechanism to control the plasticity of cellular responses to hypoxia. ..
  45. Li W, Aldrich R. State-dependent block of BK channels by synthesized shaker ball peptides. J Gen Physiol. 2006;128:423-41 pubmed
    ..Furthermore, our results from two BK channel mutations demonstrate that similar types of interactions between ball peptides and channels are shared by BK and other K(+) channel types. ..
  46. Zhao C, Wang L, Netoff T, Yuan L. Dendritic mechanisms controlling the threshold and timing requirement of synaptic plasticity. Hippocampus. 2011;21:288-97 pubmed publisher
    ..In conclusion, dendritic A-type and Ca(2+) -activated K(+) channels dually regulate the timing-dependence and thresholds of synaptic plasticity in an additive way. ..
  47. Sun X, Shi J, Delaloye K, Yang X, Yang H, Zhang G, et al. The interface between membrane-spanning and cytosolic domains in Ca²+-dependent K+ channels is involved in ? subunit modulation of gating. J Neurosci. 2013;33:11253-61 pubmed publisher
    ..among the voltage sensing domain (VSD), the cytosolic domain (CTD), and the pore gate domain (PGD) of the Slo1 ?-subunit, and is further regulated by accessory ? subunits (?1-?4)...
  48. Hafidi A, Beurg M, Dulon D. Localization and developmental expression of BK channels in mammalian cochlear hair cells. Neuroscience. 2005;130:475-84 pubmed
    The expression of Slo channels (alpha subunits of BK channels) was investigated in the developing mouse cochlea using a polyclonal antibody against the C-terminal part of the protein (residues 1098-1196)...
  49. Sørensen M, Matos J, Sausbier M, Sausbier U, Ruth P, Praetorius H, et al. Aldosterone increases KCa1.1 (BK) channel-mediated colonic K+ secretion. J Physiol. 2008;586:4251-64 pubmed publisher
    ..Taken together, these data strongly suggest that aldosterone-induced K(+) secretion occurs via increased expression of luminal BK channels. ..
  50. Higgins J, Tal A, Sun X, Hauck S, Hao J, Kosofosky B, et al. Temporal and spatial mouse brain expression of cereblon, an ionic channel regulator involved in human intelligence. J Neurogenet. 2010;24:18-26 pubmed publisher
    ..An mRNA variant (human SITE 2 INSERT or mouse strex) of the BK(Ca) gene (KCNMA1) that is normally expressed during embryonic development is aberrantly expressed in mutCRBN human lymphoblastoid ..
  51. Benkusky N, Korovkina V, Brainard A, England S. Myometrial maxi-K channel beta1 subunit modulation during pregnancy and after 17beta-estradiol stimulation. FEBS Lett. 2002;524:97-102 pubmed
    ..These findings verify that beta1 subunit transcript is regulated in mouse myometrium during gestation and estrogens may contribute to this increase. ..
  52. Wang W, Zhang X, Gao Q, Lawas M, Yu L, Cheng X, et al. A voltage-dependent K+ channel in the lysosome is required for refilling lysosomal Ca2+ stores. J Cell Biol. 2017;216:1715-1730 pubmed publisher
    ..LysoKVCa is encoded molecularly by SLO1 proteins known for forming plasma membrane BK channels...
  53. Hei H, Gao J, Dong J, Tao J, Tian L, Pan W, et al. BK Knockout by TALEN-Mediated Gene Targeting in Osteoblasts: KCNMA1 Determines the Proliferation and Differentiation of Osteoblasts. Mol Cells. 2016;39:530-5 pubmed publisher
  54. Dabertrand F, Nelson M, Brayden J. Acidosis dilates brain parenchymal arterioles by conversion of calcium waves to sparks to activate BK channels. Circ Res. 2012;110:285-94 pubmed publisher
    ..However, the role of this pathway in the brain microcirculation is not known...
  55. Qian X, Niu X, Magleby K. Intra- and intersubunit cooperativity in activation of BK channels by Ca2+. J Gen Physiol. 2006;128:389-404 pubmed
    ..Ca(2+) response for eight possible subunit configurations of the high-affinity Ca(2+) sensors as well as for three additional configurations from a previous study. ..
  56. Chen X, Kovalchuk Y, Adelsberger H, Henning H, Sausbier M, Wietzorrek G, et al. Disruption of the olivo-cerebellar circuit by Purkinje neuron-specific ablation of BK channels. Proc Natl Acad Sci U S A. 2010;107:12323-8 pubmed publisher
    ..Taken together, our results establish an essential role of BK channels of PNs for both cerebellar motor coordination and feedback regulation in the olivo-cerebellar loop. ..
  57. Nagai T, Ito M, Nakamichi N, Mizoguchi H, Kamei H, Fukakusa A, et al. The rewards of nicotine: regulation by tissue plasminogen activator-plasmin system through protease activated receptor-1. J Neurosci. 2006;26:12374-83 pubmed
    ..Targeting the tPA-plasmin-PAR1 system would provide new therapeutic approaches to the treatment of nicotine dependence. ..
  58. Harraz O, Brett S, Zechariah A, Romero M, Puglisi J, Wilson S, et al. Genetic ablation of CaV3.2 channels enhances the arterial myogenic response by modulating the RyR-BKCa axis. Arterioscler Thromb Vasc Biol. 2015;35:1843-51 pubmed publisher
    ..arterial constriction through a feedback response involving the large-conductance Ca(2+)-activated K(+) channel (BKCa). Here, we used wild-type and CaV3.2 knockout (CaV3.2(-/-)) mice to definitively test whether CaV3...
  59. Cordeiro B, Terentyev D, Clements R. BKCa channel activation increases cardiac contractile recovery following hypothermic ischemia/reperfusion. Am J Physiol Heart Circ Physiol. 2015;309:H625-33 pubmed publisher
    Mitochondrial Ca(2+)-activated large-conductance K(+) (BKCa) channels are thought to provide protection during ischemic insults in the heart. Rottlerin (mallotoxin) has been implicated as a potent BKCa activator...
  60. Ikebe C, Ohashi K, Fujimori T, Bernard O, Noda T, Robertson E, et al. Mouse LIM-kinase 2 gene: cDNA cloning, genomic organization, and tissue-specific expression of two alternatively initiated transcripts. Genomics. 1997;46:504-8 pubmed
    ..Limk2a and Limk2b transcripts were expressed at different ratios in a variety of mouse tissues. ..
  61. Indriati D, Kamasawa N, Matsui K, Meredith A, Watanabe M, Shigemoto R. Quantitative localization of Cav2.1 (P/Q-type) voltage-dependent calcium channels in Purkinje cells: somatodendritic gradient and distinct somatic coclustering with calcium-activated potassium channels. J Neurosci. 2013;33:3668-78 pubmed publisher
    ..Calcium nanodomain created by the opening of Ca(v)2.1 channels likely activates the two channels that limit the extent of depolarization. ..
  62. Fezai M, Ahmed M, Hosseinzadeh Z, Lang F. Up-Regulation of the Large-Conductance Ca2+-Activated K+ Channel by Glycogen Synthase Kinase GSK3?. Cell Physiol Biochem. 2016;39:1031-9 pubmed publisher
    ..GSK3ß may up-regulate BK channels, an effect disrupted by Lithium or additional expression of PKB and possibly participating in the regulation of cell volume and excitability. ..
  63. Sokolowski S, Harvey M, Sakai Y, Jordan A, Sokolowski B. The large conductance calcium-activated K(+) channel interacts with the small GTPase Rab11b. Biochem Biophys Res Commun. 2012;426:221-5 pubmed publisher
    ..These data suggest that this small GTPase regulates BK in a slow recycling process through the endocytic compartment and to the plasmalemma. ..
  64. Tanimoto N, Sothilingam V, Euler T, Ruth P, Seeliger M, Schubert T. BK channels mediate pathway-specific modulation of visual signals in the in vivo mouse retina. J Neurosci. 2012;32:4861-6 pubmed publisher
    ..These findings demonstrate that BK channels modulate visual responses in vivo at the bipolar cell level at intermediate stimulus conditions. ..
  65. Lee U, Shi J, Cui J. Modulation of BK channel gating by the ß2 subunit involves both membrane-spanning and cytoplasmic domains of Slo1. J Neurosci. 2010;30:16170-9 pubmed publisher
    ..BK channels are composed of four Slo1 subunits, which contain the voltage-sensing and pore-gate domains in the membrane and Ca(2+) binding sites in the ..
  66. Li Y, Hu H, Tian J, Zhu M, O Neil R. Dynamic coupling between TRPV4 and Ca2+-activated SK1/3 and IK1 K+ channels plays a critical role in regulating the K+-secretory BK channel in kidney collecting duct cells. Am J Physiol Renal Physiol. 2017;312:F1081-F1089 pubmed publisher
    The large-conductance Ca2+-activated K+ channel, BK (KCNMA1), is expressed along the connecting tubule (CNT) and cortical collecting duct (CCD) where it underlies flow- and Ca2+-dependent K+ ..
  67. Halm S, Bottomley M, Almutairi M, Di Fulvio M, Halm D. Survival and growth of C57BL/6J mice lacking the BK channel, Kcnma1: lower adult body weight occurs together with higher body fat. Physiol Rep. 2017;5: pubmed publisher
    ..Mice made null for the gene (Kcnma1) producing the BK channel (BKKO) exhibit numerous deficits in physiological functions...
  68. Zhou Y, Tang Q, Xia X, Lingle C. Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix. J Gen Physiol. 2010;135:481-94 pubmed publisher
    ..metabolite, paxilline, is widely used as a potent and relatively specific blocker of Ca(2+)- and voltage-activated Slo1 (or BK) K(+) channels. The pH-regulated Slo3 K(+) channel, a Slo1 homologue, is resistant to blockade by paxilline...
  69. Nelson A, Faulstich M, Moghadam S, Onori K, Meredith A, du Lac S. BK Channels Are Required for Multisensory Plasticity in the Oculomotor System. Neuron. 2017;93:211-220 pubmed publisher
    ..Activity-dependent regulation of intrinsic excitability may be a general mechanism for adaptive control of behavioral output in multisensory circuits. ..
  70. Lynch F, Withers S, Yao Z, Werner M, Edwards G, Weston A, et al. Perivascular adipose tissue-derived adiponectin activates BK(Ca) channels to induce anticontractile responses. Am J Physiol Heart Circ Physiol. 2013;304:H786-95 pubmed publisher
    ..Small mesenteric arteries from wild-type and large-conductance Ca(2+)-activated K(+) (BKCa) channel knockout mice were mounted on a wire myograph in the presence and absence of PVAT, and contractile ..
  71. Martinez Espinosa P, Yang C, González Pérez V, Xia X, Lingle C. Knockout of the BK ?2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity. J Gen Physiol. 2014;144:275-95 pubmed publisher
    ..from the assembly of up to four ?2 auxiliary subunits (encoded by the kcnmb2 gene) with a tetramer of pore-forming Slo1 ? subunits...
  72. Huang J, Luo Y, Hao Y, Zhang Y, Chen P, Xu J, et al. Cellular mechanism underlying hydrogen sulfide induced mouse tracheal smooth muscle relaxation: role of BKCa. Eur J Pharmacol. 2014;741:55-63 pubmed publisher
    ..TSM induced by NaHS was abrogated by iberiotoxin (IbTX), the large conductance calcium activated potassium channel (BKCa) blocker...
  73. Werner M, Meredith A, Aldrich R, Nelson M. Hypercontractility and impaired sildenafil relaxations in the BKCa channel deletion model of erectile dysfunction. Am J Physiol Regul Integr Comp Physiol. 2008;295:R181-8 pubmed publisher
    ..One important target of PKGI in smooth muscle is the large-conductance, Ca2+ -activated potassium (BKCa) channel...
  74. Gao N, Wang H, Zhang X, Yang Z. The inhibitory effect of angiotensin II on BKCa channels in podocytes via oxidative stress. Mol Cell Biochem. 2015;398:217-22 pubmed publisher
    ..study was to investigate the effects of oxidative stress on the large conductance, Ca(2+)-activated K(+) channels (BKCa)...
  75. Strauß O, Reichhart N, Gómez N, Müller C. Contribution of Ion Channels in Calcium Signaling Regulating Phagocytosis: MaxiK, Cav1.3 and Bestrophin-1. Adv Exp Med Biol. 2016;854:739-44 pubmed publisher
    ..Thus we suggest that mutant bestrophin-1 leads to an impaired regulation of the POS phagocytosis by the RPE which would explain the fast lipofuscin accumulation in Best patients. ..
  76. Wang S, Ikeda M, Guggino W. The cytoplasmic tail of large conductance, voltage- and Ca2+-activated K+ (MaxiK) channel is necessary for its cell surface expression. J Biol Chem. 2003;278:2713-22 pubmed publisher
    The large conductance, voltage- and Ca(2+)-activated K(+) channel (MaxiK) is expressed in several renal segments and functions in cell volume regulation and flow-mediated K(+) secretion...
  77. Montgomery J, Meredith A. Genetic activation of BK currents in vivo generates bidirectional effects on neuronal excitability. Proc Natl Acad Sci U S A. 2012;109:18997-9002 pubmed publisher
    ..Alteration of BK currents in Tg-BK(R207Q) SCN neurons increased firing at night but decreased firing during the day, demonstrating that BK currents generate bidirectional effects on neuronal firing under distinct conditions. ..
  78. Kim E, Suh J, Chiu Y, Dryer S. Regulation of podocyte BK(Ca) channels by synaptopodin, Rho, and actin microfilaments. Am J Physiol Renal Physiol. 2010;299:F594-604 pubmed publisher
    Mechanosensitive large-conductance Ca(2+)-activated K(+) channels encoded by the Slo1 gene (BK(Ca) channels) are expressed in podocytes...
  79. Yang H, Shi J, Zhang G, Yang J, Delaloye K, Cui J. Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains. Nat Struct Mol Biol. 2008;15:1152-9 pubmed publisher
    ..These results suggest that the VSD and the cytoplasmic domains from different subunits may interact during channel gating, and the packing of VSD or the RCK1 domain to the pore in BK channels differ from that in Kv1.2 or MthK channels. ..
  80. Yang C, González Pérez V, Mukaibo T, Melvin J, Xia X, Lingle C. Knockout of the LRRC26 subunit reveals a primary role of LRRC26-containing BK channels in secretory epithelial cells. Proc Natl Acad Sci U S A. 2017;114:E3739-E3747 pubmed publisher
    ..Finally, LRRC26 KO mimics the effect of SLO1/BK KO in reducing [K+] in saliva...
  81. Ambroisine M, Favre J, Oliviero P, Rodriguez C, Gao J, Thuillez C, et al. Aldosterone-induced coronary dysfunction in transgenic mice involves the calcium-activated potassium (BKCa) channels of vascular smooth muscle cells. Circulation. 2007;116:2435-43 pubmed
    ..Because calcium-activated potassium (BKCa) channels are essential for vascular smooth muscle cell (VSMC) relaxation, we hypothesized that aldosterone alters ..
  82. Lu S, Ma S, Wang Y, Huang T, Zhu Z, Zhao G. Mus musculus-microRNA-449a ameliorates neuropathic pain by decreasing the level of KCNMA1 and TRPA1, and increasing the level of TPTE. Mol Med Rep. 2017;16:353-360 pubmed publisher
    ..cation channel subfamily A member 1 (TRPA1), and calcium‑activated potassium channel subunit α‑1 (KCNMA1) and increased the level of transmembrane phosphatase with tension homology (TPTE) in the DRG cells (P<0.05)...
  83. Liao Y, Kristiansen A, Oksvold C, Tuvnes F, Gu N, Rundén Pran E, et al. Neuronal Ca2+-activated K+ channels limit brain infarction and promote survival. PLoS ONE. 2010;5:e15601 pubmed publisher
    ..middle cerebral artery occlusion (MCAO) in mice lacking BK channels (homozygous mice lacking the BK channel alpha subunit, BK(-/-))...