Kcnk9

Summary

Gene Symbol: Kcnk9
Description: potassium channel, subfamily K, member 9
Alias: Task3, TWIK-related acid-sensitive K(+) channel 3, acid-sensitive potassium channel protein TASK-3, potassium channel subfamily K member 9
Species: mouse

Top Publications

  1. pmc An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action
    Daniel S J Pang
    Biophysics Section, Blackett Laboratory, Imperial College, South Kensington, London SW7 2AZ, United Kingdom
    Proc Natl Acad Sci U S A 106:17546-51. 2009
  2. ncbi TASK-3 two-pore domain potassium channels enable sustained high-frequency firing in cerebellar granule neurons
    Stephen G Brickley
    Biophysics Group, Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, United Kingdom
    J Neurosci 27:9329-40. 2007
  3. ncbi TASK-3 knockout mice exhibit exaggerated nocturnal activity, impairments in cognitive functions, and reduced sensitivity to inhalation anesthetics
    Anni Maija Linden
    Institute of Biomedicine, Pharmacology, University of Helsinki, POB 63 Haartmaninkatu 8, 00014 University of Helsinki, Finland
    J Pharmacol Exp Ther 323:924-34. 2007
  4. doi Severe hyperaldosteronism in neonatal Task3 potassium channel knockout mice is associated with activation of the intraadrenal renin-angiotensin system
    Sascha Bandulik
    Department of Medical Cell Biology, University of Regensburg, 93053 Regensburg, Germany
    Endocrinology 154:2712-22. 2013
  5. pmc A new TASK for Dipeptidyl Peptidase-like Protein 6
    Brian M Nadin
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 8:e60831. 2013
  6. doi Kv1.1 channels act as mechanical brake in the senses of touch and pain
    Jizhe Hao
    Aix Marseille Universite, CNRS, Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, UMR 7286, CS80011, Boulevard Pierre Dramard, 13344 Marseille Cedex 15, France
    Neuron 77:899-914. 2013
  7. doi K(+) efflux through two-pore domain K(+) channels is required for mouse embryonic development
    Chang Gi Hur
    Department of Physiology, Institute of Health Sciences, Gyeongsang National University School of Medicine, 90 Chilam, Jinju 660 751, South Korea
    Reproduction 143:625-36. 2012
  8. pmc A role for TASK-1 (KCNK3) channels in the chemosensory control of breathing
    Stefan Trapp
    Department of Anaesthetics, Pain Medicine and Intensive Care, Chelsea and Westminster Hospital, Imperial College London, London SW109NH, United Kingdom
    J Neurosci 28:8844-50. 2008
  9. pmc TASK-3 channel deletion in mice recapitulates low-renin essential hypertension
    Nick A Guagliardo
    Department of Pharmacology, University of Virginia, School of Medicine, Charlottesville, VA 22908, USA
    Hypertension 59:999-1005. 2012
  10. pmc Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas
    J Scott Templin
    Department of Anesthesiology, Perioperative, and Pain Medicine, Children s Hospital, Boston, 300 Longwood Ave, Boston, MA 02115, USA
    Brain Res 1457:1-12. 2012

Scientific Experts

  • Christine L Torborg
  • Denis Burdakov
  • Stephen G Brickley
  • Anni Maija Linden
  • Nick A Guagliardo
  • Anthony L Gotter
  • Florian Lesage
  • Douglas A Bayliss
  • Sascha Bandulik
  • David Penton
  • Jacques Barhanin
  • Thomas Budde
  • Edmund M Talley
  • Xiangdong Chen
  • Sven G Meuth
  • Wendy Gonzalez
  • Jizhe Hao
  • Brian M Nadin
  • Enzo Lalli
  • Philipp Tauber
  • Richard Warth
  • Frank Schweda
  • Xi Huang
  • Chang Gi Hur
  • J Scott Templin
  • Boris Manoury
  • Nicole Bobak
  • S Muhammad
  • Roman M Lazarenko
  • J A Gonzalez
  • Alice Guyon
  • Daniel S J Pang
  • William Wisden
  • Patrick Meuth
  • Stefan Trapp
  • Lucinda A Davies
  • Catherine E Clarke
  • Neil Sen
  • Daniel K Mulkey
  • Nico Ruf
  • Gábor Czirják
  • Leandro Zúñiga
  • Catharina Lavebratt
  • Ines Tegtmeier
  • Patrick Delmas
  • Christina Sterner
  • Michaela Hartmann
  • Barbara Arévalo
  • Françoise Padilla
  • Jacques Noel
  • Francisco V Sepúlveda
  • Mathieu Dandonneau
  • L Pablo Cid
  • Paul J Pfaffinger
  • Maria Isabel Niemeyer
  • Hyun Min Tak
  • Sophia Haubs
  • Abeer El Wakil
  • Seong Keun Cho
  • Jim Berg
  • Mariano Soiza-Reilly
  • William A Weiss
  • Changyong Choe
  • Michael K Cooper
  • Dawon Kang
  • Michael D Taylor
  • Charles B Berde
  • Ji Wang
  • Jaehee Han
  • Eun Jin Kim
  • Chang Woon Kim
  • David H Rowitch
  • Ye He
  • Sook Young Yoon
  • Lu Dang Cong
  • Christopher S Hackett
  • C David James
  • Chin Chiang
  • Sun Jung Bang
  • Tarik Tihan
  • Marc A Shuman
  • Rintaro Hashizume
  • Maria Christina Zennaro
  • Michael J Barnes
  • Young Woo Cho
  • Lily Yeh Jan
  • Yuh Nung Jan
  • Markus Reichold
  • Adrian M Dubuc
  • Kathryn G Commons

Detail Information

Publications29

  1. pmc An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action
    Daniel S J Pang
    Biophysics Section, Blackett Laboratory, Imperial College, South Kensington, London SW7 2AZ, United Kingdom
    Proc Natl Acad Sci U S A 106:17546-51. 2009
    ..These results imply a previously unexpected role for TASK-3 channels in the cellular mechanisms underlying these behaviors and suggest that endogenous modulators of these channels may regulate theta oscillations...
  2. ncbi TASK-3 two-pore domain potassium channels enable sustained high-frequency firing in cerebellar granule neurons
    Stephen G Brickley
    Biophysics Group, Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, United Kingdom
    J Neurosci 27:9329-40. 2007
    ....
  3. ncbi TASK-3 knockout mice exhibit exaggerated nocturnal activity, impairments in cognitive functions, and reduced sensitivity to inhalation anesthetics
    Anni Maija Linden
    Institute of Biomedicine, Pharmacology, University of Helsinki, POB 63 Haartmaninkatu 8, 00014 University of Helsinki, Finland
    J Pharmacol Exp Ther 323:924-34. 2007
    ..Overall, our results suggest important contributions of TASK-3 channels in the neuronal circuits regulating circadian rhythms, cognitive functions, and mediating specific pharmacological effects...
  4. doi Severe hyperaldosteronism in neonatal Task3 potassium channel knockout mice is associated with activation of the intraadrenal renin-angiotensin system
    Sascha Bandulik
    Department of Medical Cell Biology, University of Regensburg, 93053 Regensburg, Germany
    Endocrinology 154:2712-22. 2013
    b>Task3 K(+) channels are highly expressed in the adrenal cortex and contribute to the angiotensin II and K(+) sensitivity of aldosterone-producing glomerulosa cells...
  5. pmc A new TASK for Dipeptidyl Peptidase-like Protein 6
    Brian M Nadin
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 8:e60831. 2013
    ....
  6. doi Kv1.1 channels act as mechanical brake in the senses of touch and pain
    Jizhe Hao
    Aix Marseille Universite, CNRS, Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, UMR 7286, CS80011, Boulevard Pierre Dramard, 13344 Marseille Cedex 15, France
    Neuron 77:899-914. 2013
    ..By balancing the activity of excitatory mechanotransducers, Kv1.1 acts as a mechanosensitive brake that regulates mechanical sensitivity of fibers associated with mechanical perception...
  7. doi K(+) efflux through two-pore domain K(+) channels is required for mouse embryonic development
    Chang Gi Hur
    Department of Physiology, Institute of Health Sciences, Gyeongsang National University School of Medicine, 90 Chilam, Jinju 660 751, South Korea
    Reproduction 143:625-36. 2012
    ..05). RT-PCR data showed that members of the K(2P) channel family, specifically KCNK2, KCNK10, KCNK4, KCNK3, and KCNK9, were expressed in mouse oocytes and embryos...
  8. pmc A role for TASK-1 (KCNK3) channels in the chemosensory control of breathing
    Stefan Trapp
    Department of Anaesthetics, Pain Medicine and Intensive Care, Chelsea and Westminster Hospital, Imperial College London, London SW109NH, United Kingdom
    J Neurosci 28:8844-50. 2008
    ..TASK-1 channels therefore play a key role in the control of ventilation by peripheral chemoreceptors...
  9. pmc TASK-3 channel deletion in mice recapitulates low-renin essential hypertension
    Nick A Guagliardo
    Department of Pharmacology, University of Virginia, School of Medicine, Charlottesville, VA 22908, USA
    Hypertension 59:999-1005. 2012
    ..Our studies establish a model of LREH and suggest that loss of TASK channel activity may be one mechanism that advances the syndrome of low renin hypertension...
  10. pmc Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas
    J Scott Templin
    Department of Anesthesiology, Perioperative, and Pain Medicine, Children s Hospital, Boston, 300 Longwood Ave, Boston, MA 02115, USA
    Brain Res 1457:1-12. 2012
    ..The identified genes likely contribute to unique excitable properties of different groups of neurons in the DR and may include novel pharmacologic targets for affective disorders...
  11. pmc Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics
    Xi Huang
    Howard Hughes Medical Institute, San Francisco, CA 94158, USA
    Genes Dev 26:1780-96. 2012
    ....
  12. ncbi Task3 potassium channel gene invalidation causes low renin and salt-sensitive arterial hypertension
    David Penton
    University of Regensburg, 93053 Regensburg, Germany
    Endocrinology 153:4740-8. 2012
    Task1 and Task3 potassium channels (Task: tandem of P domains in a weak inward rectifying K(+) channel-related acid-sensitive K(+) channel) are believed to control the membrane voltage of aldosterone-producing adrenal glomerulosa cells...
  13. pmc An extracellular ion pathway plays a central role in the cooperative gating of a K(2P) K+ channel by extracellular pH
    Wendy Gonzalez
    Centro de Estudios Cientificos CECS, 5110466 Valdivia, Chile
    J Biol Chem 288:5984-91. 2013
    ..Cooperativity, and therefore steep dependence of TASK-3 K(+) channel activity on extracellular pH, is dependent on an effect of the permeant ion on the channel pH(o) sensors...
  14. pmc Contractile and electrophysiological properties of pulmonary artery smooth muscle are not altered in TASK-1 knockout mice
    Boris Manoury
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    J Physiol 589:3231-46. 2011
    ..The Em was, however, depolarised in comparison with other species.Mouse IKN was much smaller than in rat and showed no sensitivity to pH. The results imply that TASK-1 does not form a functional channel in mouse PASMCs...
  15. pmc TASK-3 as a potential antidepressant target
    Anthony L Gotter
    Department of Neuroscience, Merck Research Laboratories, West Point, PA, USA
    Brain Res 1416:69-79. 2011
    Modulation of TASK-3 (Kcnk9) potassium channels affect neurotransmitter release in thalamocortical centers and other sleep-related nuclei having the capacity to regulate arousal cycles and REM sleep changes associated with mood disorders ..
  16. doi Volume regulation of murine T lymphocytes relies on voltage-dependent and two-pore domain potassium channels
    Nicole Bobak
    University of Muenster, Department of neurology Inflammatory disorders of the nervous system and neurooncology, Domagkstr, 13, 48149 Muenster, Germany
    Biochim Biophys Acta 1808:2036-44. 2011
    ..This study explores a putative role of the newly identified K(2P) channels (TASK1, TASK2, TASK3 and TRESK) along with the voltage-gated potassium channel K(V)1...
  17. pmc TASK channels are not required to mount an aldosterone secretory response to metabolic acidosis in mice
    Nick A Guagliardo
    University of Virginia, Department of Pharmacology, 1340 Jefferson Park Ave, Charlottesville, VA 22908, USA
    Mol Cell Endocrinol 336:47-52. 2011
    ..Thus, we conclude that TASK channels are not required for the stimulation of aldosterone production by protons but their inhibition by physiological acidosis may contribute to full expression of the steroidogenic response...
  18. pmc Motoneuronal TASK channels contribute to immobilizing effects of inhalational general anesthetics
    Roman M Lazarenko
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908 0735, USA
    J Neurosci 30:7691-704. 2010
    ....
  19. ncbi Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose
    Denis Burdakov
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom
    Neuron 50:711-22. 2006
    ..These results reveal an unexpected energy-sensing pathway in neurons that regulate states of consciousness and energy balance...
  20. ncbi Membrane resting potential of thalamocortical relay neurons is shaped by the interaction among TASK3 and HCN2 channels
    Sven G Meuth
    Neurologische Klinik, Bayerische Julius Maximilians Universität, Wurzburg, Germany
    J Neurophysiol 96:1517-29. 2006
    ..RT-PCR experiments revealed the expression of TASK1, TASK3, and HCN1-4...
  21. ncbi TASK-like conductances are present within hippocampal CA1 stratum oriens interneuron subpopulations
    Christine L Torborg
    Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 26:7362-7. 2006
    TASK-1 (KCNK3) and TASK-3 (KCNK9) are members of the two-pore domain potassium channel family and form either homomeric or heteromeric open-rectifier (leak) channels...
  22. ncbi Sequence-based bioinformatic prediction and QUASEP identify genomic imprinting of the KCNK9 potassium channel gene in mouse and human
    Nico Ruf
    Max Delbrueck Center for Molecular Medicine, D 13125 Berlin, Germany
    Hum Mol Genet 16:2591-9. 2007
    ..Allele-Specific Expression by Pyrosequencing (QUASEP) and discovered maternal-specific imprinted expression of the Kcnk9 gene as well as strain-dependent preferential expression of the Rarres1 gene in E11...
  23. ncbi TASK channels determine pH sensitivity in select respiratory neurons but do not contribute to central respiratory chemosensitivity
    Daniel K Mulkey
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 27:14049-58. 2007
    ..Furthermore, they indicate that a non-TASK K+ current contributes to chemosensitivity of RTN neurons, which are profoundly pH-sensitive and capable of driving respiratory output in response to local pH changes in vivo...
  24. pmc TASK channel deletion in mice causes primary hyperaldosteronism
    Lucinda A Davies
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 105:2203-8. 2008
    ..Our studies establish an animal model of nontumorigenic primary hyperaldosteronism and identify TASK channels as a possible therapeutic target for primary hyperaldosteronism...
  25. doi The M1P1 loop of TASK3 K2P channels apposes the selectivity filter and influences channel function
    Catherine E Clarke
    Medway School of Pharmacy, Universities of Kent and Greenwich at Medway, Central Avenue, Chatham Maritime, Kent ME4 4TB, United Kingdom
    J Biol Chem 283:16985-92. 2008
    ..The TASK (TASK1, TASK3, and TASK5) subfamily of K2P channels is regulated by a number of different pharmacological and physiological ..
  26. doi Glucose inhibition persists in hypothalamic neurons lacking tandem-pore K+ channels
    Alice Guyon
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6097, Universite de Nice Sophia Antipolis, 06560 Valbonne, France
    J Neurosci 29:2528-33. 2009
    ..and halothane, and resistance to ruthenium red designated the tandem-pore K(+) (K(2P)) channel subunit TASK3 as part of the glucose-induced channel...
  27. pmc Deletion of TASK1 and TASK3 channels disrupts intrinsic excitability but does not abolish glucose or pH responses of orexin/hypocretin neurons
    J A Gonzalez
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1 PD, UK
    Eur J Neurosci 30:57-64. 2009
    ..It was recently proposed that TASK (TWIK-related acid-sensitive potassium) channels [TASK1 (K(2P)3.1) and/or TASK3 (K(2P)9...
  28. doi Expression of the kcnk3 potassium channel gene lessens the injury from cerebral ischemia, most likely by a general influence on blood pressure
    S Muhammad
    Department of Pharmacology, University of Heidelberg, Heidelberg, Germany
    Neuroscience 167:758-64. 2010
    ..Nevertheless, a consequence of having TASK-1 channels expressed (in various non-neuronal tissues and organs) is that neuronal damage is lessened when stroke occurs...
  29. ncbi Zinc and mercuric ions distinguish TRESK from the other two-pore-domain K+ channels
    Gábor Czirják
    Department of Physiology, Semmelweis University, Budapest, Hungary, H 1444
    Mol Pharmacol 69:1024-32. 2006
    ..Thus, both Zn2+ and Hg2+ are expected to inhibit endogenous TRESK in isolated mouse cells, and these ions can be applied to identify the calcineurin-activated 2PK+ channel in its natural environment...