Kcnj1

Summary

Gene Symbol: Kcnj1
Description: potassium inwardly-rectifying channel, subfamily J, member 1
Alias: Kir1.1, ROMK, Romk2, ATP-sensitive inward rectifier potassium channel 1, ATP-regulated potassium channel ROM-K, inward rectifier K(+) channel Kir1.1, inwardly rectifying potassium channel ROMK-2, potassium channel, inwardly rectifying subfamily J member 1
Species: mouse
Products:     Kcnj1

Top Publications

  1. Zhang C, Wang L, Su X, Zhang J, Lin D, Wang W. ENaC and ROMK activity are inhibited in the DCT2/CNT of TgWnk4PHAII mice. Am J Physiol Renal Physiol. 2017;312:F682-F688 pubmed publisher
    ..Since epithelial Na+ channel (ENaC) and renal outer medullary K+ channel (ROMK or Kir4...
  2. Dong K, Yan Q, Lu M, Wan L, Hu H, Guo J, et al. Romk1 Knockout Mice Do Not Produce Bartter Phenotype but Exhibit Impaired K Excretion. J Biol Chem. 2016;291:5259-69 pubmed publisher
    b>Romk knock-out mice show a similar phenotype to Bartter syndrome of salt wasting and dehydration due to reduced Na-K-2Cl-cotransporter activity...
  3. Lin D, Yue P, Zhang C, Wang W. MicroRNA-194 (miR-194) regulates ROMK channel activity by targeting intersectin 1. Am J Physiol Renal Physiol. 2014;306:F53-60 pubmed publisher
    The aim of the study is to explore the role of miR-194 in mediating the effect of high-K (HK) intake on ROMK channel...
  4. Cantone A, Yang X, Yan Q, Giebisch G, Hebert S, Wang T. Mouse model of type II Bartter's syndrome. I. Upregulation of thiazide-sensitive Na-Cl cotransport activity. Am J Physiol Renal Physiol. 2008;294:F1366-72 pubmed publisher
    b>ROMK-deficient (Romk(-/-)) mice exhibit polyuria, natriuresis, and kaliuresis similar to individuals with type II Bartter's form of hyperprostaglandin E syndrome (HPS; antenatal Bartter's syndrome)...
  5. Dvoryanchikov G, Sinclair M, Perea Martinez I, Wang T, Chaudhari N. Inward rectifier channel, ROMK, is localized to the apical tips of glial-like cells in mouse taste buds. J Comp Neurol. 2009;517:1-14 pubmed publisher
    ..1 and derived from the Kcnj1 gene) help to redistribute K(+)...
  6. Liu Z, Wang H, Huang C. Regulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinase. J Biol Chem. 2009;284:12198-206 pubmed publisher
    ..L-WNK1 inhibits renal K(+) channel ROMK, likely contributing to hyperkalemia in PHAII...
  7. Lu M, Wang T, Yan Q, Yang X, Dong K, Knepper M, et al. Absence of small conductance K+ channel (SK) activity in apical membranes of thick ascending limb and cortical collecting duct in ROMK (Bartter's) knockout mice. J Biol Chem. 2002;277:37881-7 pubmed
    The ROMK (Kir1.1; Kcnj1) gene is believed to encode the apical small conductance K(+) channels (SK) of the thick ascending limb (TAL) and cortical collecting duct (CCD)...
  8. Murthy M, Kurz T, O Shaughnessy K. ROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3?403-459 mutation. Physiol Rep. 2016;4: pubmed publisher
    ..Hence, we explored the impact of CUL3(?403-459) on expression of the distal secretory K channel, ROMK, both in vitro and in vivo...
  9. Lu M, Leng Q, Egan M, Caplan M, Boulpaep E, Giebisch G, et al. CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney. J Clin Invest. 2006;116:797-807 pubmed
    ..1, also known as renal outer medullar K [ROMK]) that is critical for K secretion by cells of the thick ascending limb (TAL) and distal nephron segments ..

More Information

Publications33

  1. Bailey M, Cantone A, Yan Q, MacGregor G, Leng Q, Amorim J, et al. Maxi-K channels contribute to urinary potassium excretion in the ROMK-deficient mouse model of Type II Bartter's syndrome and in adaptation to a high-K diet. Kidney Int. 2006;70:51-9 pubmed
    ..1; Kcnj1), mediating potassium recycling in the thick ascending limb of Henle's loop (TAL) and potassium secretion in the ..
  2. Lu M, Dong K, Egan M, Giebisch G, Boulpaep E, Hebert S. Mouse cystic fibrosis transmembrane conductance regulator forms cAMP-PKA-regulated apical chloride channels in cortical collecting duct. Proc Natl Acad Sci U S A. 2010;107:6082-7 pubmed publisher
    ..and modulate the activity of a variety of apical membrane proteins, including the renal outer medullary potassium (ROMK) K(+) channel...
  3. Rossier B, Staub O, Hummler E. Genetic dissection of sodium and potassium transport along the aldosterone-sensitive distal nephron: importance in the control of blood pressure and hypertension. FEBS Lett. 2013;587:1929-41 pubmed publisher
    ..This will allow to design rational strategies for the treatment of hypertension and for the development of the next generation of diuretics. ..
  4. Wang W. Regulation of ROMK (Kir1.1) channels: new mechanisms and aspects. Am J Physiol Renal Physiol. 2006;290:F14-9 pubmed
    This brief review attempts to provide an overview regarding recent developments in the regulation of ROMK channels...
  5. Gallazzini M, Karim Z, Bichara M. Regulation of ROMK (Kir 1.1) channel expression in kidney thick ascending limb by hypertonicity: role of TonEBP and MAPK pathways. Nephron Physiol. 2006;104:126-35 pubmed
    ..assessed the mechanisms by which hypertonicity caused by NaCl enhances the renal outer medullary potassium channel (ROMK) mRNA abundance in rat kidney medullary thick ascending limb (MTAL) and in cultured mouse TAL cells...
  6. Suzuki T, Nakamura K, Mayanagi T, Sobue K, Kubokawa M. Na+/H+ exchange regulatory factor 1 is required for ROMK1 K+ channel expression in the surface membrane of cultured M-1 cortical collecting duct cells. Biochem Biophys Res Commun. 2017;489:116-122 pubmed publisher
    The ROMK1 K+ channel, a member of the ROMK channel family, is the major candidate for the K+ secretion pathway in the renal cortical collecting duct (CCD)...
  7. Renigunta A, Renigunta V, Saritas T, Decher N, Mutig K, Waldegger S. Tamm-Horsfall glycoprotein interacts with renal outer medullary potassium channel ROMK2 and regulates its function. J Biol Chem. 2011;286:2224-35 pubmed publisher
    ..library and identified THGP as a potential interaction partner of the renal outer medullary potassium channel (ROMK2), a key player in the process of salt reabsorption along the TAL...
  8. Boim M, Ho K, Shuck M, Bienkowski M, Block J, Slightom J, et al. ROMK inwardly rectifying ATP-sensitive K+ channel. II. Cloning and distribution of alternative forms. Am J Physiol. 1995;268:F1132-40 pubmed
    The rat ROMK gene encodes inwardly rectifying, ATP-regulated K+ channels [K. Ho, C. G. Nichols, W. J. Lederer, J. Lytton, P. M. Vassilev, M. V. Kanazirska, and S. C. Hebert. Nature Lond. 362: 31-38, 1993; H. Zhou, S. S. Tate, and L. G...
  9. Yoo D, Kim B, Campo C, Nance L, King A, Maouyo D, et al. Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A. J Biol Chem. 2003;278:23066-75 pubmed
    The Kir1.1 (ROMK) subtypes of inward rectifier K+ channels mediate potassium secretion and regulate sodium chloride reabsorption in the kidney...
  10. Yan Q, Yang X, Cantone A, Giebisch G, Hebert S, Wang T. Female ROMK null mice manifest more severe Bartter II phenotype on renal function and higher PGE2 production. Am J Physiol Regul Integr Comp Physiol. 2008;295:R997-R1004 pubmed publisher
    b>ROMK null mice with a high survival rate and varying severity of hydronephrosis provide a good model to study type II Bartter syndrome pathophysiology (26)...
  11. Lu M, Wang T, Yan Q, Wang W, Giebisch G, Hebert S. ROMK is required for expression of the 70-pS K channel in the thick ascending limb. Am J Physiol Renal Physiol. 2004;286:F490-5 pubmed
    ..Loss-of-function mutations in the K channel, ROMK (Kir1.1; KCNJ1), cause Bartter syndrome, a genetically heterogeneous disorder characterized by severe reduction in salt ..
  12. Elvira B, Munoz C, Borras J, Chen H, Warsi J, Ajay S, et al. SPAK and OSR1 dependent down-regulation of murine renal outer medullary K channel ROMK1. Kidney Blood Press Res. 2014;39:353-60 pubmed publisher
    ..Similarly, ROMK1 activity and ROMK1-HA protein abundance were significantly down-regulated by wild-type OSR1 and (T185E)OSR1, but not by (D164A)OSR1. ROMK1 protein abundance and activity are down-regulated by SPAK and OSR1. ..
  13. Liu B, Yang L, Lu X, Song X, Li X, Chen G, et al. Lovastatin-Induced Phosphatidylinositol-4-Phosphate 5-Kinase Diffusion from Microvilli Stimulates ROMK Channels. J Am Soc Nephrol. 2015;26:1576-87 pubmed publisher
    ..1 (Kcnj1; the gene locus for renal outer medullary K(+) [ROMK1] channels)...
  14. Yu G, Cheng M, Wang W, Zhao R, Liu Z. Involvement of WNK1-mediated potassium channels in the sexual dimorphism of blood pressure. Biochem Biophys Res Commun. 2017;485:255-260 pubmed publisher
    ..Western blot analyses of mouse kidney extract revealed a significant decrease in renal outer medullary potassium (ROMK) channel expression, while large-conductance Ca2+-activated K+ (BK) channel and Na-K-2Cl ..
  15. Kahle K, Wilson F, Leng Q, Lalioti M, O Connell A, Dong K, et al. WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion. Nat Genet. 2003;35:372-6 pubmed
    ..By expression in Xenopus laevis oocytes, we show that WNK4 also inhibits the renal K+ channel ROMK. This inhibition is independent of WNK4 kinase activity and is mediated by clathrin-dependent endocytosis of ROMK, ..
  16. Fang L, Garuti R, Kim B, Wade J, Welling P. The ARH adaptor protein regulates endocytosis of the ROMK potassium secretory channel in mouse kidney. J Clin Invest. 2009;119:3278-89 pubmed publisher
    Renal outer medullary potassium (ROMK) channels are exquisitely regulated to adjust renal potassium excretion and maintain potassium balance...
  17. Zhang Y, Lin D, Wang Z, Jin Y, Yang B, Wang W. K restriction inhibits protein phosphatase 2B (PP2B) and suppression of PP2B decreases ROMK channel activity in the CCD. Am J Physiol Cell Physiol. 2008;294:C765-73 pubmed publisher
    ..We also used patch-clamp technique to study the effect of inhibiting PP2B on renal outer medullary K (ROMK) channels in the CCD...
  18. Fang L, Li D, Welling P. Hypertension resistance polymorphisms in ROMK (Kir1.1) alter channel function by different mechanisms. Am J Physiol Renal Physiol. 2010;299:F1359-64 pubmed publisher
    The renal outer medullary K(+) (ROMK) channel plays a critical role in renal sodium handling...
  19. Yamauchi K, Yang S, Ohta A, Sohara E, Rai T, Sasaki S, et al. Apical localization of renal K channel was not altered in mutant WNK4 transgenic mice. Biochem Biophys Res Commun. 2005;332:750-5 pubmed
    ..study using Xenopus oocytes showed that wild-type WNK4 expression inhibited surface expression of renal K channel (ROMK) and that a disease-causing mutant further decreased the surface expression...
  20. Fodstad H, Gonzalez Rodriguez E, Bron S, Gaeggeler H, Guisan B, Rossier B, et al. Effects of mineralocorticoid and K+ concentration on K+ secretion and ROMK channel expression in a mouse cortical collecting duct cell line. Am J Physiol Renal Physiol. 2009;296:F966-75 pubmed publisher
    ..CCD) plays a key role in regulated K(+) secretion, which is mediated mainly through renal outer medullary K(+) (ROMK) channels located in the apical membrane...
  21. Wade J, Fang L, Coleman R, Liu J, Grimm P, Wang T, et al. Differential regulation of ROMK (Kir1.1) in distal nephron segments by dietary potassium. Am J Physiol Renal Physiol. 2011;300:F1385-93 pubmed publisher
    b>ROMK channels are well-known to play a central role in renal K secretion, but the absence of highly specific and avid-ROMK antibodies has presented significant roadblocks toward mapping the extent of expression along the entire distal ..
  22. Alaynick W, Way J, Wilson S, Benson W, Pei L, Downes M, et al. ERRgamma regulates cardiac, gastric, and renal potassium homeostasis. Mol Endocrinol. 2010;24:299-309 pubmed publisher
    ..These findings suggest a potential role for genetic polymorphisms at the ERRgamma locus and ERRgamma modulators in the etiology and treatment of renal, gastric, and cardiac dysfunction. ..
  23. Wagner C, Loffing Cueni D, Yan Q, Schulz N, Fakitsas P, Carrel M, et al. Mouse model of type II Bartter's syndrome. II. Altered expression of renal sodium- and water-transporting proteins. Am J Physiol Renal Physiol. 2008;294:F1373-80 pubmed publisher
    ..Mutations in the ROMK channel cause type II antenatal Bartter's syndrome that presents with maternal polyhydramnios and postnatal life-..
  24. Lorenz J, Baird N, Judd L, Noonan W, Andringa A, Doetschman T, et al. Impaired renal NaCl absorption in mice lacking the ROMK potassium channel, a model for type II Bartter's syndrome. J Biol Chem. 2002;277:37871-80 pubmed
    b>ROMK is an apical K(+) channel expressed in the thick ascending limb of Henle (TALH) and throughout the distal nephron of the kidney...