Gene Symbol: Katna1
Description: katanin p60 (ATPase-containing) subunit A1
Alias: katanin p60 ATPase-containing subunit A1, katanin p60 subunit A1, lipotransin, p60 katanin
Vale R. AAA proteins. Lords of the ring. J Cell Biol. 2000;150:F13-9 pubmed
Karabay A, Yu W, Solowska J, Baird D, Baas P. Axonal growth is sensitive to the levels of katanin, a protein that severs microtubules. J Neurosci. 2004;24:5778-88 pubmed
..Other neurons are relatively unaffected by overexpression. Collectively, these observations indicate that axonal growth is sensitive to the levels of P60-katanin, but that other factors contribute to modulating this sensitivity. ..
Yu W, Solowska J, Qiang L, Karabay A, Baird D, Baas P. Regulation of microtubule severing by katanin subunits during neuronal development. J Neurosci. 2005;25:5573-83 pubmed
Iwaya N, Akiyama K, Goda N, Tenno T, Fujiwara Y, Hamada D, et al
. Effect of Ca2+ on the microtubule-severing enzyme p60-katanin. Insight into the substrate-dependent activation mechanism. FEBS J. 2012;279:1339-52 pubmed publisher
..Our model can explain how Ca(2+) regulates both severing and ATP hydrolysis activity, because the Ca(2+) -binding site on the N-terminal domain moves close to the AAA domain during MT severing. ..
Toyo oka K, Sasaki S, Yano Y, Mori D, Kobayashi T, Toyoshima Y, et al
. Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. Hum Mol Genet. 2005;14:3113-28 pubmed
..Our results suggest that NDEL1 is essential for mitotic cell division and neuronal migration not only via regulation of cytoplasmic dynein function but also by modulation of katanin p60 localization and function. ..
Koshimizu Y, Ohtomi M. Regulation of katanin-P60 levels by LECT2 adjusts microtubular morphology. Neuroreport. 2010;21:646-50 pubmed publisher
..Our results suggest that LECT2 regulates neuritic extension through microtubular morphallaxis through the control of katanin-P60 levels. ..
Lacroix B, Van Dijk J, Gold N, Guizetti J, Aldrian Herrada G, Rogowski K, et al
. Tubulin polyglutamylation stimulates spastin-mediated microtubule severing. J Cell Biol. 2010;189:945-54 pubmed publisher
..Our study reveals a novel control mechanism for microtubule mass and stability, which is of fundamental importance to cellular physiology and might have implications for diseases related to microtubule severing. ..
Yang W, Guo X, Thein S, Xu F, Sugii S, Baas P, et al
. Regulation of adipogenesis by cytoskeleton remodelling is facilitated by acetyltransferase MEC-17-dependent acetylation of ?-tubulin. Biochem J. 2013;449:605-12 pubmed publisher
Jiang K, Rezabkova L, Hua S, Liu Q, Capitani G, Altelaar A, et al
. Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex. Nat Cell Biol. 2017;19:480-492 pubmed publisher
..We propose that the ASPM-katanin complex controls microtubule disassembly at spindle poles and that misregulation of this process can lead to microcephaly. ..