Kat2b

Summary

Gene Symbol: Kat2b
Description: K(lysine) acetyltransferase 2B
Alias: A930006P13Rik, AI461839, AW536563, Pcaf, p/CAF, histone acetyltransferase KAT2B, histone acetylase PCAF, histone acetyltransferase PCAF, lysine acetyltransferase 2B, p300/CBP-associated factor
Species: mouse
Products:     Kat2b

Top Publications

  1. Xu W, Edmondson D, Roth S. Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates. Mol Cell Biol. 1998;18:5659-69 pubmed
    ..Thus, the unique amino-terminal domains of mammalian P/CAF and GCN5 may provide additional functions important to recognition of chromatin substrates and the regulation of gene expression. ..
  2. Puri P, Sartorelli V, Yang X, Hamamori Y, Ogryzko V, Howard B, et al. Differential roles of p300 and PCAF acetyltransferases in muscle differentiation. Mol Cell. 1997;1:35-45 pubmed
    b>PCAF is a histone acetyltransferase that associates with p300/CBP and competes with E1A for access to them...
  3. Schiltz R, Nakatani Y. The PCAF acetylase complex as a potential tumor suppressor. Biochim Biophys Acta. 2000;1470:M37-53 pubmed
  4. Gupta P, Park S, Farooqui M, Wei L. Orphan nuclear receptor TR2, a mediator of preadipocyte proliferation, is differentially regulated by RA through exchange of coactivator PCAF with corepressor RIP140 on a platform molecule GRIP1. Nucleic Acids Res. 2007;35:2269-82 pubmed
    ..RA induces the recruitment of histone acetyl transferase-containing/GRIP1/p300/CBP-associated factor (PCAF) complex to the TR2 promoter in undifferentiated cells, whereas it triggers recruitment of histone deacetylase-..
  5. Park S, Hu X, Gupta P, Lin Y, Ha S, Wei L. SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells. Nat Struct Mol Biol. 2007;14:68-75 pubmed
    ..SUMOylation of Tr2 induces an exchange of its coregulators: corepressor Rip140 replaces coactivator Pcaf, which switches Tr2 from an activator to a repressor...
  6. Muth V, Nadaud S, Grummt I, Voit R. Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription. EMBO J. 2001;20:1353-62 pubmed
    ..of the promoter-proximal terminator, we found that TTF-I associates with the p300/CBP-associated factor PCAF, suggesting that TTF-I may target histone acetyltransferase to the rDNA promoter...
  7. Ianari A, Gallo R, Palma M, Alesse E, Gulino A. Specific role for p300/CREB-binding protein-associated factor activity in E2F1 stabilization in response to DNA damage. J Biol Chem. 2004;279:30830-5 pubmed
    ..Our results unveil a differential role of P/CAF and p300 in acetylation-induced stabilization of E2F1, thus supporting a specific role for P/CAF HAT activity in E2F1-dependent apoptosis in response to DNA damage. ..
  8. Jin Y, Zeng S, Lee H, Lu H. MDM2 mediates p300/CREB-binding protein-associated factor ubiquitination and degradation. J Biol Chem. 2004;279:20035-43 pubmed
    ..a negative feedback regulator of the tumor suppressor p53, inhibits p300/CREB-binding protein-associated factor (PCAF)-mediated p53 acetylation. Our further study showed that MDM2 also regulates the stability of PCAF...
  9. Blanco García N, Asensio Juan E, de la Cruz X, Martínez Balbás M. Autoacetylation regulates P/CAF nuclear localization. J Biol Chem. 2009;284:1343-52 pubmed publisher
    ..These results reveal the molecular mechanism of autoacetylation control of P/CAF nuclear translocation and suggest a novel pathway by which P/CAF activity is controlled in vivo. ..

More Information

Publications77

  1. Naeem H, Cheng D, Zhao Q, Underhill C, Tini M, Bedford M, et al. The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation. Mol Cell Biol. 2007;27:120-34 pubmed
    ..Collectively, our data highlight coactivator methylation as an important regulatory mechanism in hormonal signaling. ..
  2. Maurice T, Duclot F, Meunier J, Naert G, Givalois L, Meffre J, et al. Altered memory capacities and response to stress in p300/CBP-associated factor (PCAF) histone acetylase knockout mice. Neuropsychopharmacology. 2008;33:1584-602 pubmed
    ..acts as a transcriptional coactivator with intrinsic histone acetylase activity, the p300/CBP-associated factor (PCAF), is poorly documented...
  3. Dilworth F, Seaver K, Fishburn A, Htet S, Tapscott S. In vitro transcription system delineates the distinct roles of the coactivators pCAF and p300 during MyoD/E47-dependent transactivation. Proc Natl Acad Sci U S A. 2004;101:11593-8 pubmed
    The transcriptional coactivators p300 and pCAF are necessary for the myogenic factor MyoD to initiate the expression of skeletal muscle genes...
  4. Rabhi N, Denechaud P, Gromada X, Hannou S, Zhang H, Rashid T, et al. KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response. Cell Rep. 2016;15:1051-1061 pubmed publisher
    ..We show here that germline and ? cell-specific disruption of the lysine acetyltransferase 2B (Kat2b) gene in mice leads to impaired insulin secretion and glucose intolerance...
  5. Mateo F, Vidal Laliena M, Canela N, Zecchin A, Martínez Balbás M, Agell N, et al. The transcriptional co-activator PCAF regulates cdk2 activity. Nucleic Acids Res. 2009;37:7072-84 pubmed publisher
    ..We report here that the transcriptional co-activator PCAF directly interacts with cdk2. This interaction is mainly produced during S and G(2)/M phases of the cell cycle...
  6. Barbacci E, Chalkiadaki A, Masdeu C, Haumaitre C, Lokmane L, Loirat C, et al. HNF1beta/TCF2 mutations impair transactivation potential through altered co-regulator recruitment. Hum Mol Genet. 2004;13:3139-49 pubmed
    ..weakly or not affected, correlated with the loss of association with one of the histone-acetyltransferases CBP or PCAF. In contrast to wild-type HNF1beta, whose transactivation potential depends on the synergistic action of CBP and ..
  7. Xiong Y, Svingen P, Sarmento O, Smyrk T, Dave M, Khanna S, et al. Differential coupling of KLF10 to Sin3-HDAC and PCAF regulates the inducibility of the FOXP3 gene. Am J Physiol Regul Integr Comp Physiol. 2014;307:R608-20 pubmed publisher
    ..and either the Sin3-histone deacetylase complex or the histone acetyltransferase, p300/CBP-associated factor (PCAF)...
  8. Wansa K, Harris J, Yan G, Ordentlich P, Muscat G. The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine. J Biol Chem. 2003;278:24776-90 pubmed
    ..We hypothesize that the NR4A subgroup mediates the genotoxic stress response and suggest that this subgroup may function as sensors that respond to genotoxicity. ..
  9. Suhara W, Yoneyama M, Kitabayashi I, Fujita T. Direct involvement of CREB-binding protein/p300 in sequence-specific DNA binding of virus-activated interferon regulatory factor-3 holocomplex. J Biol Chem. 2002;277:22304-13 pubmed
    ..Furthermore, the critical function of these domains in virus-induced gene activation was demonstrated in vivo by using p300 mutants. ..
  10. Li X, Kato Y, Tsuji Y, Tsunoda Y. The effects of trichostatin A on mRNA expression of chromatin structure-, DNA methylation-, and development-related genes in cloned mouse blastocysts. Cloning Stem Cells. 2008;10:133-42 pubmed publisher
    ..blastocysts developed from TSA-treated SCNT oocytes exhibited similar expression patterns for Hdac1, 2, and 3, CBP, PCAF, and Dnmt3b genes compared with in vitro-developed blastocysts and blastocysts developed from SCNT oocytes without ..
  11. Inoue E, Hanai M, Yamada K, Esashi T, Yamauchi J. Transcriptional coactivator p300/CBP-associated factor and p300/CBP-associated factor type B are required for normal estrogen response of the mouse uterus. Biosci Biotechnol Biochem. 2004;68:2209-11 pubmed
    Mice with targeted gene disruption of one of the estrogen receptor coactivators, p300/CBP-associated factor (PCAF), and its counterpart, PCAF-B, were used to investigate the possible involvement of PCAF and PCAF-B in estrogen receptor-..
  12. Marek R, Coelho C, Sullivan R, Baker Andresen D, Li X, Ratnu V, et al. Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300. J Neurosci. 2011;31:7486-91 pubmed publisher
    ..These data suggest that one function of p300 activity within the ILPFC is to constrain synaptic plasticity, and that a reduction in the function of this HAT is required for the formation of fear extinction memory. ..
  13. Jin Q, Yu L, Wang L, Zhang Z, Kasper L, Lee J, et al. Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation. EMBO J. 2011;30:249-62 pubmed publisher
    Histone acetyltransferases (HATs) GCN5 and PCAF (GCN5/PCAF) and CBP and p300 (CBP/p300) are transcription co-activators. However, how these two distinct families of HATs regulate gene activation remains unclear...
  14. Wang L, Wang J, Qu T, Zhang Y, Shen Y. Reversible acetylation of Lin28 mediated by PCAF and SIRT1. Biochim Biophys Acta. 2014;1843:1188-95 pubmed publisher
    ..In this study, we demonstrated that PCAF directly interacted with and acetylated Lin28...
  15. Huang J, Bi Y, Zhu G, He Y, Su Y, He B, et al. Retinoic acid signalling induces the differentiation of mouse fetal liver-derived hepatic progenitor cells. Liver Int. 2009;29:1569-81 pubmed publisher
    ..RA was further shown to induce glycogen synthesis in HP14.5 cells, an important function of mature hepatocytes. Our results strongly suggest that RA signalling may play an important role in regulating hepatic differentiation. ..
  16. Puttagunta R, Tedeschi A, Sória M, Hervera A, Lindner R, Rathore K, et al. PCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system. Nat Commun. 2014;5:3527 pubmed publisher
    ..Here we show through systematic epigenetic studies that the histone acetyltransferase p300/CBP-associated factor (PCAF) promotes acetylation of histone 3 Lys 9 at the promoters of established key regeneration-associated genes ..
  17. Ravnskjaer K, Hogan M, Lackey D, Tora L, Dent S, Olefsky J, et al. Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects. J Clin Invest. 2013;123:4318-28 pubmed publisher
    ..Dephosphorylation of CRTC2 promoted increased H3K9Ac through recruitment of the lysine acetyltransferase 2B (KAT2B) and WD repeat-containing protein 5 (WDR5), a core subunit of histone methyltransferase (HMT) ..
  18. Wilson B, Tremblay A, Deblois G, Sylvain Drolet G, Giguere V. An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha. Mol Endocrinol. 2010;24:1349-58 pubmed publisher
    ..Here we demonstrate that ERRalpha interacts with and is acetylated by p300 coactivator associated factor (PCAF) in vitro and in mouse liver...
  19. Sampley M, Ozcan S. Regulation of insulin gene transcription by multiple histone acetyltransferases. DNA Cell Biol. 2012;31:8-14 pubmed publisher
    ..we investigated the role of the additional HAT proteins CREB binding protein (CBP), p300/CBP-associated factor (PCAF), and general control of amino-acid synthesis 5 (GCN5) in regulation of glucose-stimulated insulin gene ..
  20. Huang S, Qiu Y, Shi Y, Xu Z, Brandt S. P/CAF-mediated acetylation regulates the function of the basic helix-loop-helix transcription factor TAL1/SCL. EMBO J. 2000;19:6792-803 pubmed
    ..These results reveal a novel mechanism by which TAL1 activity is regulated and implicate acetylation of this transcription factor in promotion of erythroid differentiation. ..
  21. Mal A, Sturniolo M, Schiltz R, Ghosh M, Harter M. A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program. EMBO J. 2001;20:1739-53 pubmed
    ..These results provide for a model which postulates that MyoD may be co-dependent on HDAC1 and P/CAF for temporally controlling its transcriptional activity before and after the differentiation of muscle cells. ..
  22. Panda S, Nilsson J, Gekara N. Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes. Immunity. 2015;43:647-59 pubmed publisher
    ..This study identifies MYSM1 as a key negative regulator of the innate immune system that guards against an overzealous self-destructive immune response. ..
  23. Shen M, Zhou T, Xie W, Ling T, Zhu Q, Zong L, et al. The chromatin remodeling factor CSB recruits histone acetyltransferase PCAF to rRNA gene promoters in active state for transcription initiation. PLoS ONE. 2013;8:e62668 pubmed publisher
    ..Here we show that a complex consisting of CSB, RNA polymerase I and histone acetyltransferase PCAF is present at the rDNA promoters in active state...
  24. Wei W, Coelho C, Li X, Marek R, Yan S, Anderson S, et al. p300/CBP-associated factor selectively regulates the extinction of conditioned fear. J Neurosci. 2012;32:11930-41 pubmed
    ..Here we demonstrate, in C57BL/6 mice, that the activity of p300/CBP-associated factor (PCAF) within the infralimbic prefrontal cortex is required for long-term potentiation and is necessary for the formation ..
  25. Chatterjee T, Idelman G, Blanco V, Blomkalns A, Piegore M, Weintraub D, et al. Histone deacetylase 9 is a negative regulator of adipogenic differentiation. J Biol Chem. 2011;286:27836-47 pubmed publisher
    ..These findings provide new insights into mechanisms of adipogenic differentiation and document a critical regulatory role for HDAC9 in adipogenic differentiation through a deacetylase-independent mechanism. ..
  26. Lv L, Xu Y, Zhao D, Li F, Wang W, Sasaki N, et al. Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization. Mol Cell. 2013;52:340-52 pubmed publisher
    ..Hence, K433 acetylation links cell proliferation and transformation to the switch of PKM2 from a cytoplasmic metabolite kinase to a nuclear protein kinase. ..
  27. Bastiaansen A, Ewing M, de Boer H, van der Pouw Kraan T, De Vries M, Peters E, et al. Lysine acetyltransferase PCAF is a key regulator of arteriogenesis. Arterioscler Thromb Vasc Biol. 2013;33:1902-10 pubmed publisher
    ..Transcriptional coactivator p300-CBP-associated factor (PCAF) has histone acetylating activity and promotes transcription of multiple inflammatory genes...
  28. Xiong Y, Khanna S, Grzenda A, Sarmento O, Svingen P, Lomberk G, et al. Polycomb antagonizes p300/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent manner. J Biol Chem. 2012;287:34372-85 pubmed publisher
    ..These results provide insight into chromatin remodeling events key to phenotypic features of distinct T cell populations. ..
  29. Jin Q, Wang C, Kuang X, Feng X, Sartorelli V, Ying H, et al. Gcn5 and PCAF regulate PPAR? and Prdm16 expression to facilitate brown adipogenesis. Mol Cell Biol. 2014;34:3746-53 pubmed publisher
    The acetyltransferase Gcn5 is critical for embryogenesis and shows partial functional redundancy with its homolog PCAF. However, the tissue- and cell lineage-specific functions of Gcn5 and PCAF are still not well defined...
  30. Kurooka H, Honjo T. Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5. J Biol Chem. 2000;275:17211-20 pubmed
    ..Here we show that mouse Notch1 RAMIC interacts with two conserved HATs, mouse PCAF and GCN5, and recruits each of the HATs to RBP-J...
  31. Cherasse Y, Maurin A, Chaveroux C, Jousse C, Carraro V, Parry L, et al. The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP. Nucleic Acids Res. 2007;35:5954-65 pubmed
    ..Using a tandem affinity purification (TAP) tag approach, we identified p300/CBP-associated factor (PCAF) as a novel interaction partner of ATF4 in leucine-starved cells...
  32. Craig J, Earle E, Canham P, Wong L, Anderson M, Choo K. Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns. Hum Mol Genet. 2003;12:3109-21 pubmed
    ..a neocentromere, and the active centromere of a dicentric chromosome, with six of these proteins (Sin3A, PCAF, MYST, MBD2, ORC2, P300/CBP) being demonstrated at mammalian centromeres for the first time...
  33. Yamauchi T, Yamauchi J, Kuwata T, Tamura T, Yamashita T, Bae N, et al. Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesis. Proc Natl Acad Sci U S A. 2000;97:11303-6 pubmed
    b>PCAF plays a role in transcriptional activation, cell-cycle arrest, and cell differentiation in cultured cells...
  34. Yamaguchi Y, Kurokawa M, Imai Y, Izutsu K, Asai T, Ichikawa M, et al. AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues. J Biol Chem. 2004;279:15630-8 pubmed
    ..Taken together, these data indicate that acetylation of AML1 through p300 is a critical manner of posttranslational modification and identify a novel mechanism for regulating the function of AML1. ..
  35. Sánchez Molina S, Oliva J, García Vargas S, Valls E, Rojas J, Martínez Balbás M. The histone acetyltransferases CBP/p300 are degraded in NIH 3T3 cells by activation of Ras signalling pathway. Biochem J. 2006;398:215-24 pubmed
    ..These findings support a novel mechanism for modulating other signalling transduction pathways that require these common co-activators. ..
  36. Scoville D, Cyphert H, Liao L, Xu J, Reynolds A, Guo S, et al. MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function. Diabetes. 2015;64:3772-83 pubmed publisher
    ..We propose that MLL3 and MLL4 are broadly required for controlling MAFA and MAFB transactivation during development and postnatally. ..
  37. Beharry A, Judge A. Differential expression of HDAC and HAT genes in atrophying skeletal muscle. Muscle Nerve. 2015;52:1098-101 pubmed publisher
    ..The mRNA levels of Hdac2, Hdac4, Hdac6, Sirt1, p300, Cbp, and Pcaf increased, and Hdac7 decreased in skeletal muscle in each experimental model of muscle atrophy...
  38. Buryskova M, Pospisek M, Grothey A, Simmet T, Burysek L. Intracellular interleukin-1alpha functionally interacts with histone acetyltransferase complexes. J Biol Chem. 2004;279:4017-26 pubmed
    ..that the IL-1alpha precursor interacts via its N-terminal peptide (IL-1NTP) with histone acetyltransferases p300, PCAF, Gcn5 and with the adaptor component Ada3, and that it integrates into the PCAF...
  39. Peng C, Zhang W, Zhao W, Zhu J, Huang X, Tian J. Alcohol-induced histone H3K9 hyperacetylation and cardiac hypertrophy are reversed by a histone acetylases inhibitor anacardic acid in developing murine hearts. Biochimie. 2015;113:1-9 pubmed publisher
    ..Binding of p300, CBP, PCAF, SRC1, except GCN5, were increased to the NKX2.5 promoter in fetal mouse hearts exposed to alcohol...
  40. Xu C, Cole P, Meyers D, Kormish J, Dent S, Zaret K. Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas. Science. 2011;332:963-6 pubmed publisher
    ..These studies reveal a functional "prepattern" of chromatin states within multipotent progenitors and potential targets to modulate cell fate induction. ..
  41. Phan H, Xu A, Coco C, Srajer G, Wyszomierski S, Evrard Y, et al. GCN5 and p300 share essential functions during early embryogenesis. Dev Dyn. 2005;233:1337-47 pubmed
    ..b>PCAF and GCN5 physically interact with p300 and CBP in vitro...
  42. Benlhabib H, Mendelson C. Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia. Mol Cell Biol. 2011;31:1949-58 pubmed publisher
    ..we observed that the developmental induction of SP-A was associated with increased recruitment of TTF-1, NF-?B, PCAF, and CBP, as well as enhanced acetylation and decreased methylation of histone H3K9 at the TBE...
  43. Sun C, Wang M, Liu X, Luo L, Li K, Zhang S, et al. PCAF improves glucose homeostasis by suppressing the gluconeogenic activity of PGC-1α. Cell Rep. 2014;9:2250-62 pubmed publisher
    ..Here, we show that PCAF is a pivotal acetyltransferase for acetylating PGC-1α in both fasted and diabetic states...
  44. Mazza D, Infante P, Colicchia V, Greco A, Alfonsi R, Siler M, et al. PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress. Cell Death Differ. 2013;20:1688-97 pubmed publisher
    ..This inhibition is dependent on the p53-mediated elevation of the acetyltransferase p300/CBP-associated factor (PCAF). Notably, we identify PCAF as a novel E3 ubiquitin ligase of Gli1...
  45. Duclot F, Meffre J, Jacquet C, Gongora C, Maurice T. Mice knock out for the histone acetyltransferase p300/CREB binding protein-associated factor develop a resistance to amyloid toxicity. Neuroscience. 2010;167:850-63 pubmed publisher
    p300/CREB binding protein-associated factor (PCAF) regulates gene expression by acting through histone acetylation and as a transcription coactivator...
  46. Kimbrel E, Lemieux M, Xia X, Davis T, Rebel V, Kung A. Systematic in vivo structure-function analysis of p300 in hematopoiesis. Blood. 2009;114:4804-12 pubmed publisher
    ..Our results suggest that, in distinct contrast to other organ systems, HAT activity does not provide a critical function for hematopoietic development and emphasizes the importance of enzyme-independent functions of p300. ..
  47. Jin Q, Zhuang L, Lai B, Wang C, Li W, Dolan B, et al. Gcn5 and PCAF negatively regulate interferon-? production through HAT-independent inhibition of TBK1. EMBO Rep. 2014;15:1192-201 pubmed publisher
    ..studies showed that Gcn5 (Kat2a), a histone acetyltransferase (HAT) with partial functional redundancy with PCAF (Kat2b), and Gcn5/PCAF-mediated histone H3K9 acetylation (H3K9ac) are enriched on the active IFNB gene promoter...
  48. de Jong R, Ewing M, De Vries M, Karper J, Bastiaansen A, Peters H, et al. The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development. PLoS ONE. 2017;12:e0185820 pubmed publisher
    Genetic P300/CBP-associated factor (PCAF) variation affects restenosis-risk in patients...
  49. Kung A, Rebel V, Bronson R, Ch Ng L, Sieff C, Livingston D, et al. Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev. 2000;14:272-7 pubmed
    ..Thus, a full complement of CBP, but not p300, is required for normal hematopoietic differentiation. These results also provide the first experimental evidence for the hypothesis that CBP has tumor-suppressing activity. ..
  50. Zhao J, Gong A, Zhou R, Liu J, Eischeid A, Chen X. Downregulation of PCAF by miR-181a/b provides feedback regulation to TNF-?-induced transcription of proinflammatory genes in liver epithelial cells. J Immunol. 2012;188:1266-74 pubmed publisher
    ..treatment of human and mouse cholangiocytes and hepatocytes downregulated expression of p300/CBP-associated factor (PCAF), a coactivator and an acetyltransferase that promotes histone acetylation and gene transcription...
  51. Duclot F, Jacquet C, Gongora C, Maurice T. Alteration of working memory but not in anxiety or stress response in p300/CBP associated factor (PCAF) histone acetylase knockout mice bred on a C57BL/6 background. Neurosci Lett. 2010;475:179-83 pubmed publisher
    P300/CBP associated factor (PCAF) acts as an acetyltransferase that acetylates specific lysine residues in histones, thereby remodelling chromatin structure...
  52. Takahashi N, Kawada T, Yamamoto T, Goto T, Taimatsu A, Aoki N, et al. Overexpression and ribozyme-mediated targeting of transcriptional coactivators CREB-binding protein and p300 revealed their indispensable roles in adipocyte differentiation through the regulation of peroxisome proliferator-activated receptor gamma. J Biol Chem. 2002;277:16906-12 pubmed
    ..These data suggest that both CBP and p300 are indispensable for the full activation of PPARgamma and adipocyte differentiation and that CBP and p300 do not mutually complement in the process. ..
  53. Park S, Huang W, Persaud S, Wei L. RIP140 in thyroid hormone-repression and chromatin remodeling of Crabp1 gene during adipocyte differentiation. Nucleic Acids Res. 2009;37:7085-94 pubmed publisher
    ..On the basal promoter, RIP140 replaces coactivators GRIP1 and PCAF and forms a repressive complex with CtBP1, HDAC3 and G9a...
  54. Doi M, Hirayama J, Sassone Corsi P. Circadian regulator CLOCK is a histone acetyltransferase. Cell. 2006;125:497-508 pubmed
    ..Identification of CLOCK as a novel type of DNA binding HAT reveals that chromatin remodeling is crucial for the core clock mechanism and identifies unforeseen links between histone acetylation and cellular physiology. ..
  55. Jethanandani P, Kramer R. Alpha7 integrin expression is negatively regulated by deltaEF1 during skeletal myogenesis. J Biol Chem. 2005;280:36037-46 pubmed
    ..These findings suggest that deltaEF1 has a role in suppressing integrin expression in myoblasts by displacing MYOD and competing for p300/CBP co-activator. ..
  56. Wan W, You Z, Xu Y, Zhou L, Guan Z, Peng C, et al. mTORC1 Phosphorylates Acetyltransferase p300 to Regulate Autophagy and Lipogenesis. Mol Cell. 2017;68:323-335.e6 pubmed publisher
    ..These results uncover p300 as a direct target of mTORC1 and suggest that the mTORC1-p300 pathway plays a pivotal role in cell metabolism by coordinately controlling cell anabolism and catabolism...
  57. Zhang P, Liu Y, Jin C, Zhang M, Lv L, Zhang X, et al. Histone H3K9 Acetyltransferase PCAF Is Essential for Osteogenic Differentiation Through Bone Morphogenetic Protein Signaling and May Be Involved in Osteoporosis. Stem Cells. 2016;34:2332-41 pubmed publisher
    ..However, the molecular mechanisms are poorly understood. Here, we show that histone H3K9 acetyltransferase PCAF plays a critical role in osteogenic differentiation of MSCs...
  58. Xu W, Edmondson D, Evrard Y, Wakamiya M, Behringer R, Roth S. Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development. Nat Genet. 2000;26:229-32 pubmed
    ..Gcn5 (encoded by Gcn5l2) and Pcaf, mouse histone acetyltransferases, share similar sequences and enzymatic activities...
  59. Cao D, Wang Z, Zhang C, Oh J, Xing W, Li S, et al. Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol Cell Biol. 2005;25:364-76 pubmed
    ..These findings point to myocardin as a nexus for positive and negative regulation of smooth muscle gene expression by changes in chromatin acetylation. ..
  60. Hiesberger T, Shao X, Gourley E, Reimann A, Pontoglio M, Igarashi P. Role of the hepatocyte nuclear factor-1beta (HNF-1beta) C-terminal domain in Pkhd1 (ARPKD) gene transcription and renal cystogenesis. J Biol Chem. 2005;280:10578-86 pubmed
    ..Expression of HNF-1alpha in proximal tubules may protect against cystogenesis. ..
  61. Gupta P, Ho P, Huq M, Ha S, Park S, Khan A, et al. Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression. Proc Natl Acad Sci U S A. 2008;105:11424-9 pubmed publisher
    ..Dephosphorylated TR2 recruits coactivator PCAF and functions as an activator for its target gene Oct4...
  62. Ge X, Jin Q, Zhang F, Yan T, Zhai Q. PCAF acetylates {beta}-catenin and improves its stability. Mol Biol Cell. 2009;20:419-27 pubmed publisher
    ..However, the effect of a key acetyltransferase p300/CBP-associated factor (PCAF) on beta-catenin signaling is largely unknown...
  63. Kemper J, Xiao Z, Ponugoti B, Miao J, Fang S, Kanamaluru D, et al. FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states. Cell Metab. 2009;10:392-404 pubmed publisher
    ..Small molecules that inhibit FXR acetylation by targeting SIRT1 or p300 may be promising therapeutic agents for metabolic disorders. ..
  64. van Loosdregt J, Vercoulen Y, Guichelaar T, Gent Y, Beekman J, Van Beekum O, et al. Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization. Blood. 2010;115:965-74 pubmed publisher
    ..Manipulating Foxp3 acetylation levels could therefore provide a new therapeutic strategy to control inappropriate (auto)immune responses. ..
  65. Chen Q, Dowhan D, Liang D, Moore D, Overbeek P. CREB-binding protein/p300 co-activation of crystallin gene expression. J Biol Chem. 2002;277:24081-9 pubmed
    ..In a promoter-specific fashion, co-activation can be modulated by Prox-1 and/or Sox-1. This modulation may help to specify the endogenous levels of crystallin gene expression. ..
  66. Kurinna S, Stratton S, Tsai W, Akdemir K, Gu W, Singh P, et al. Direct activation of forkhead box O3 by tumor suppressors p53 and p73 is disrupted during liver regeneration in mice. Hepatology. 2010;52:1023-32 pubmed publisher
    ..p53, TA-p73, and p300 binding and Foxo3 expression decrease during liver regeneration, and this suggests a critical growth control mechanism mediated by these transcription factors in vivo. ..
  67. Mizuguchi Y, Specht S, Lunz J, Isse K, Corbitt N, Takizawa T, et al. Cooperation of p300 and PCAF in the control of microRNA 200c/141 transcription and epithelial characteristics. PLoS ONE. 2012;7:e32449 pubmed publisher
    ..We show that the deacetylase inhibitor TSA as well as P300 and PCAF can cause a shift towards epithelial characteristics in HUCCT-1-SPRR2a cells...
  68. Wang C, Yang S, Wang Z, Tan J, Xing S, Chen D, et al. PCAF acetylates Runx2 and promotes osteoblast differentiation. J Bone Miner Metab. 2013;31:381-9 pubmed publisher
    ..Here we reported that p300/CBP-associated factor (PCAF) directly binds to Runx2 and acetylates Runx2, leading to an increase in its transcriptional activity...