Kat2a

Summary

Gene Symbol: Kat2a
Description: K(lysine) acetyltransferase 2A
Alias: 1110051E14Rik, AW212720, Gcn5, Gcn5l2, mmGCN5, histone acetyltransferase KAT2A, GCN5 general control of amino acid synthesis-like 2, PCAF-B/GCN5, general control of amino acid synthesis 5-like 2, general control of amino acid synthesis protein 5-like 2, general control of amino acid synthesis, yeast homolog-like 2, general control of amino acid synthesis-like 2, histone acetyltransferase GCN5, histone succinyltransferase KAT2A, lysine acetyltransferase 2A
Species: mouse
Products:     Kat2a

Top Publications

  1. Lin W, Srajer G, Evrard Y, Phan H, Furuta Y, Dent S. Developmental potential of Gcn5(-/-) embryonic stem cells in vivo and in vitro. Dev Dyn. 2007;236:1547-57 pubmed
    b>Gcn5 is a prototypical histone acetyltransferase (HAT) that serves as a coactivator for multiple DNA-bound transcription factors...
  2. Chen Y, Gatchel J, Lewis R, Mao C, Grant P, Zoghbi H, et al. Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model. Hum Mol Genet. 2012;21:394-405 pubmed publisher
    ..Previous studies provided conflicting evidence regarding the effects of polyQ-ATXN7 on the activity of Gcn5, the HAT catalytic subunit of SAGA...
  3. Lin W, Zhang Z, Srajer G, Chen Y, Huang M, Phan H, et al. Proper expression of the Gcn5 histone acetyltransferase is required for neural tube closure in mouse embryos. Dev Dyn. 2008;237:928-40 pubmed publisher
    ..Our previous studies demonstrated that Gcn5, a prototypical HAT, is required for mesodermal maintenance in early embryos...
  4. Bu P, Evrard Y, Lozano G, Dent S. Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos. Mol Cell Biol. 2007;27:3405-16 pubmed
    b>Gcn5 was the first transcription-related histone acetyltransferase (HAT) to be identified. However, the functions of this enzyme in mammalian cells remain poorly defined...
  5. Xu W, Edmondson D, Evrard Y, Wakamiya M, Behringer R, Roth S. Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development. Nat Genet. 2000;26:229-32 pubmed
    ..Gcn5 (encoded by Gcn5l2) and Pcaf, mouse histone acetyltransferases, share similar sequences and enzymatic activities...
  6. Xu C, Cole P, Meyers D, Kormish J, Dent S, Zaret K. Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas. Science. 2011;332:963-6 pubmed publisher
    ..These studies reveal a functional "prepattern" of chromatin states within multipotent progenitors and potential targets to modulate cell fate induction. ..
  7. Zhao D, Xu C, Huang H, Qian Y, Jin F. [Expression patterns of GCN5 and HDAC1 in preimplantational mouse embryos and effects of in-vitro cultures on their expressions]. Shi Yan Sheng Wu Xue Bao. 2005;38:513-9 pubmed
    To investigate the expression patterns of histone acetyltransferase (GCN5) and histone deacetylase 1 (HDAC1) in preimplantation mouse embryos and the effects of in-vitro cultures on their expressions, immunocytochemistry was used to ..
  8. Lin W, Zhang Z, Chen C, Behringer R, Dent S. Proper Gcn5 histone acetyltransferase expression is required for normal anteroposterior patterning of the mouse skeleton. Dev Growth Differ. 2008;50:321-30 pubmed publisher
    ..To define the functions of Gcn5, a prototypical HAT, during mouse development, we have created a series of mutant Gcn5 alleles...
  9. Sampley M, Ozcan S. Regulation of insulin gene transcription by multiple histone acetyltransferases. DNA Cell Biol. 2012;31:8-14 pubmed publisher
    ..CREB binding protein (CBP), p300/CBP-associated factor (PCAF), and general control of amino-acid synthesis 5 (GCN5) in regulation of glucose-stimulated insulin gene transcription...

More Information

Publications53

  1. Yi Q, Xu H, Yang K, Wang Y, Tan B, Tian J, et al. Islet-1 induces the differentiation of mesenchymal stem cells into cardiomyocyte-like cells through the regulation of Gcn5 and DNMT-1. Mol Med Rep. 2017;15:2511-2520 pubmed publisher
    ..demonstrated that Islet‑1 upregulated expression of general control of amino acid biosynthesis protein 5 (Gcn5) and enhanced the binding of Gcn5 to the promoters of GATA binding protein 4 (GATA4) and NK2 homeobox 5 (Nkx2.5)...
  2. Winnay J, Hammer G. Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation. Mol Endocrinol. 2006;20:147-66 pubmed
    ..In addition, the current study demonstrates that specific enzymatic activities are capable of regulating distinct facets of a highly ordered transcriptional response...
  3. Wiper Bergeron N, Salem H, Tomlinson J, Wu D, Haché R. Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5. Proc Natl Acad Sci U S A. 2007;104:2703-8 pubmed
    ..Here, we show that C/EBPbeta is acetylated by GCN5 and PCAF within a cluster of lysine residues between amino acids 98-102 and that this acetylation is strongly ..
  4. Xu W, Edmondson D, Roth S. Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates. Mol Cell Biol. 1998;18:5659-69 pubmed
    ..Mouse GCN5 (mmGCN5) and mmP/CAF genes are ubiquitously expressed, but maximum expression levels are found in different, complementary ..
  5. Kim J, Woo A, Chu J, Snow J, Fujiwara Y, Kim C, et al. A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell. 2010;143:313-24 pubmed publisher
    ..The apparent similarity of cancer and ES cell signatures reflects, in large part, the pervasive nature of Myc regulatory networks. ..
  6. Guelman S, Kozuka K, Mao Y, Pham V, Solloway M, Wang J, et al. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Mol Cell Biol. 2009;29:1176-88 pubmed publisher
    ..Here we report the characterization of a novel mammalian HAT complex, which contains the two acetyltransferases GCN5 and ATAC2 as well as other proteins linked to chromatin metabolism...
  7. Jin Q, Zhuang L, Lai B, Wang C, Li W, Dolan B, et al. Gcn5 and PCAF negatively regulate interferon-? production through HAT-independent inhibition of TBK1. EMBO Rep. 2014;15:1192-201 pubmed publisher
    ..Previous studies showed that Gcn5 (Kat2a), a histone acetyltransferase (HAT) with partial functional redundancy with PCAF (Kat2b), and Gcn5/PCAF-mediated ..
  8. Zelin E, Zhang Y, Toogun O, Zhong S, Freeman B. The p23 molecular chaperone and GCN5 acetylase jointly modulate protein-DNA dynamics and open chromatin status. Mol Cell. 2012;48:459-70 pubmed publisher
    ..Here we show that the p23 molecular chaperone initiates disassembly of protein-DNA complexes and that the GCN5 acetyltransferase prolongs the dissociated state through lysine acetylation...
  9. Warrier S, Nuwayhid S, Sabatino J, Sugrue K, Zohn I. Supt20 is required for development of the axial skeleton. Dev Biol. 2017;421:245-257 pubmed publisher
    ..Supt20 interacts with the Gcn5-containing SAGA histone acetylation complex...
  10. Stockinger E, Mao Y, Regier M, Triezenberg S, Thomashow M. Transcriptional adaptor and histone acetyltransferase proteins in Arabidopsis and their interactions with CBF1, a transcriptional activator involved in cold-regulated gene expression. Nucleic Acids Res. 2001;29:1524-33 pubmed
    ..activities of three key components of the yeast Ada and SAGA complexes, namely the histone acetyltransferase (HAT) Gcn5 and the transcriptional adaptor proteins Ada2 and Ada3...
  11. Jing H, Liao L, Su X, Shuai Y, Zhang X, Deng Z, et al. Declining histone acetyltransferase GCN5 represses BMSC-mediated angiogenesis during osteoporosis. FASEB J. 2017;31:4422-4433 pubmed publisher
    ..Jing, H., Liao, L., Su, X., Shuai, Y. Zhang, X., Deng, Z., Jin, Y. Declining histone acetyltransferase GCN5 represses BMSC-mediated angiogenesis during osteoporosis.
  12. Helmlinger D, Hardy S, Abou Sleymane G, Eberlin A, Bowman A, Gansmuller A, et al. Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction. PLoS Biol. 2006;4:e67 pubmed
    ..We previously demonstrated that the SCA7 gene product, ataxin-7 (ATXN7), is a subunit of the GCN5 histone acetyltransferase-containing coactivator complexes TFTC/STAGA...
  13. Atanassov B, Evrard Y, Multani A, Zhang Z, Tora L, Devys D, et al. Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance. Mol Cell. 2009;35:352-64 pubmed publisher
    ..Here, we show that deletion of Gcn5 leads to telomere dysfunction in mouse and human cells...
  14. Swarnalatha M, Singh A, Kumar V. Promoter occupancy of MLL1 histone methyltransferase seems to specify the proliferative and apoptotic functions of E2F1 in a tumour microenvironment. J Cell Sci. 2013;126:4636-46 pubmed publisher
    ..Thus, the temporally regulated promoter occupancy of histone methyltransferase could be a regulatory mechanism associated with the diverse cellular functions of the E2F family of transcription factors. ..
  15. Dominy J, Lee Y, Jedrychowski M, Chim H, Jurczak M, Camporez J, et al. The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis. Mol Cell. 2012;48:900-13 pubmed publisher
    ..gluconeogenic gene expression is dependent upon its acetylation state, which is controlled by the acetyltransferase GCN5 and the deacetylase Sirt1...
  16. Tavares C, Sharabi K, Dominy J, Lee Y, Isasa M, Orozco J, et al. The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1? Transcriptional Coactivator. J Biol Chem. 2016;291:10635-45 pubmed publisher
    ..Here, we show that methionine and derived-sulfur metabolites in the transamination pathway activate the GCN5 acetyltransferase promoting acetylation of the transcriptional coactivator PGC-1? to control hepatic ..
  17. Orpinell M, Fournier M, Riss A, Nagy Z, Krebs A, Frontini M, et al. The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. EMBO J. 2010;29:2381-94 pubmed publisher
    ..Here, we show that the Gcn5-containing histone acetyl transferase complex, Ada Two A containing (ATAC), controls mitotic progression through ..
  18. Ravnskjaer K, Hogan M, Lackey D, Tora L, Dent S, Olefsky J, et al. Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects. J Clin Invest. 2013;123:4318-28 pubmed publisher
    ..Administration of a small-molecule KAT2B antagonist lowered circulating blood glucose concentrations in insulin resistance, suggesting that this enzyme may be a useful target for diabetes treatment. ..
  19. Zhang P, Liu Y, Jin C, Zhang M, Tang F, Zhou Y. Histone Acetyltransferase GCN5 Regulates Osteogenic Differentiation of Mesenchymal Stem Cells by Inhibiting NF-κB. J Bone Miner Res. 2016;31:391-402 pubmed publisher
    As the most well-studied histone acetyltransferase (HAT) in yeast and mammals, general control nonderepressible 5 (GCN5) was documented to play essential roles in various developmental processes...
  20. Gao B, Kong Q, Zhang Y, Yun C, Dent S, Song J, et al. The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation. J Immunol. 2017;198:3927-3938 pubmed publisher
    ..In this study, we conditionally deleted Gcn5 (encoded by the Kat2a gene) specifically in T lymphocytes by crossing floxed Gcn5 and Lck-Cre mice, and demonstrated ..
  21. Wang Y, Yun C, Gao B, Xu Y, Zhang Y, Wang Y, et al. The Lysine Acetyltransferase GCN5 Is Required for iNKT Cell Development through EGR2 Acetylation. Cell Rep. 2017;20:600-612 pubmed publisher
    ..We found that the histone acetyltransferase general control non-derepressible 5 (GCN5) is essential for iNKT cell development during the maturation stage...
  22. Cantù C, Valenta T, Hausmann G, Vilain N, Aguet M, Basler K. The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription. Development. 2013;140:2377-86 pubmed publisher
    ..does not affect the transcription of nearby genes; rather, it is important for the recruitment of the histone acetyltransferase Gcn5 to chromatin, consistent with a testis-specific and Wnt-unrelated role for Pygo2 as a chromatin ..
  23. Philp A, Chen A, Lan D, Meyer G, Murphy A, Knapp A, et al. Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise. J Biol Chem. 2011;286:30561-70 pubmed publisher
    ..in parallel with reduced nuclear abundance of the acetyltransferase, general control of amino-acid synthesis 5 (GCN5), as well as reduced association between GCN5 and nuclear PGC-1?...
  24. Martinez Cerdeno V, Lemen J, Chan V, Wey A, Lin W, Dent S, et al. N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells. PLoS ONE. 2012;7:e39456 pubmed publisher
    Here we examine the functions of the Myc cofactor and histone acetyltransferase, GCN5/KAT2A, in neural stem and precursor cells (NSC) using a conditional knockout approach driven by nestin-cre...
  25. Goswami R, Kaplan M. Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells. J Immunol. 2012;189:3026-33 pubmed publisher
    ..In the absence of PU.1, there is decreased association of Gcn5 and p300/CBP associated factor and increased association of histone deacetylases at the Il9 locus in Th9 cells...
  26. Miyoshi K, Cui Y, Riedlinger G, Robinson P, Lehoczky J, Zon L, et al. Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse. Genomics. 2001;71:150-5 pubmed
    ..Within this region we identified the genes encoding m-Stats 3, 5a, and 5b, Cnp1, Hcrt/Orexin, Ptrf, GCN5, mDj11, and four new genes...
  27. Inoue E, Hanai M, Yamada K, Esashi T, Yamauchi J. Transcriptional coactivator p300/CBP-associated factor and p300/CBP-associated factor type B are required for normal estrogen response of the mouse uterus. Biosci Biotechnol Biochem. 2004;68:2209-11 pubmed
    ..These observations suggest that PCAF and PCAF-B are required for estrogen-dependent normal growth of the uterus via estrogen receptor-mediated transcriptional regulations. ..
  28. Ablack J, Cohen M, Thillainadesan G, Fonseca G, Pelka P, Torchia J, et al. Cellular GCN5 is a novel regulator of human adenovirus E1A-conserved region 3 transactivation. J Virol. 2012;86:8198-209 pubmed publisher
    ..The N terminus of E1A binds GCN5, a cellular lysine acetyltransferase (KAT)...
  29. Liu X, Zhao D, Zheng Y, Wang L, Qian Y, Xu C, et al. Expression of histone acetyltransferase GCN5 and histone deacetylase 1 in the cultured mouse preimplantation embryos. Curr Pharm Des. 2014;20:1772-7 pubmed
    ..of the abnormal expression patterns of many genes in the embryos in vitro, the expression of histone acetyltransferase GCN5 and histone deacetylase 1 (HDAC1) were detected in mouse preimplantation embryos...
  30. Yamauchi T, Yamauchi J, Kuwata T, Tamura T, Yamashita T, Bae N, et al. Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesis. Proc Natl Acad Sci U S A. 2000;97:11303-6 pubmed
    ..In this report, we present evidence for the in vivo function of PCAF and the closely related PCAF-B/GCN5. Mice lacking PCAF are developmentally normal without a distinct phenotype...
  31. Kikuchi H, Nakayama M, Kuribayashi F, Imajoh Ohmi S, Nishitoh H, Takami Y, et al. GCN5 is essential for IRF-4 gene expression followed by transcriptional activation of Blimp-1 in immature B cells. J Leukoc Biol. 2014;95:399-404 pubmed publisher
    ..b>GCN5, one of the most important histone acetyltransferases, is involved in epigenetic events for transcriptional ..
  32. Cui Y, Li M, Walton K, Sun K, Hanover J, Furth P, et al. The Stat3/5 locus encodes novel endoplasmic reticulum and helicase-like proteins that are preferentially expressed in normal and neoplastic mammary tissue. Genomics. 2001;78:129-34 pubmed
    ..Immunofluorescence studies demonstrated that LGP1 is located in the nuclear envelope and the endoplasmic reticulum. LGP2 is a cytoplasmic protein of 678 amino acids. ..
  33. Wilde J, Siegenthaler J, Dent S, Niswander L. Diencephalic Size Is Restricted by a Novel Interplay Between GCN5 Acetyltransferase Activity and Retinoic Acid Signaling. J Neurosci. 2017;37:2565-2579 pubmed publisher
    ..Here we demonstrate that mice lacking enzymatic activity of the acetyltransferase GCN5 ((Gcn5hat/hat )), which were previously characterized with respect to their exencephalic ..
  34. Phan H, Xu A, Coco C, Srajer G, Wyszomierski S, Evrard Y, et al. GCN5 and p300 share essential functions during early embryogenesis. Dev Dyn. 2005;233:1337-47 pubmed
    Previous studies revealed that deletion of genes encoding the histone acetyltransferases GCN5, p300, or CBP results in embryonic lethality in mice. PCAF and GCN5 physically interact with p300 and CBP in vitro...
  35. Lee D, Goldberg A. Muscle Wasting in Fasting Requires Activation of NF-κB and Inhibition of AKT/Mechanistic Target of Rapamycin (mTOR) by the Protein Acetylase, GCN5. J Biol Chem. 2015;290:30269-79 pubmed publisher
    ..Knockdown of GCN5 with shRNA or a dominant-negative GCN5 or overexpression of SIRT1 decreased p65K310 acetylation and muscle wasting ..
  36. Kurooka H, Honjo T. Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5. J Biol Chem. 2000;275:17211-20 pubmed
    ..Here we show that mouse Notch1 RAMIC interacts with two conserved HATs, mouse PCAF and GCN5, and recruits each of the HATs to RBP-J...
  37. Buryskova M, Pospisek M, Grothey A, Simmet T, Burysek L. Intracellular interleukin-1alpha functionally interacts with histone acetyltransferase complexes. J Biol Chem. 2004;279:4017-26 pubmed
    ..the IL-1alpha precursor interacts via its N-terminal peptide (IL-1NTP) with histone acetyltransferases p300, PCAF, Gcn5 and with the adaptor component Ada3, and that it integrates into the PCAF.p300 complex in a non-destructive manner...
  38. Childress P, Stayrook K, Alvarez M, Wang Z, Shao Y, Hernandez Buquer S, et al. Genome-Wide Mapping and Interrogation of the Nmp4 Antianabolic Bone Axis. Mol Endocrinol. 2015;29:1269-85 pubmed publisher
    ..These data suggest that Nmp4 suppresses bone anabolism, in part, by regulating IGF-binding protein expression. Changes in Nmp4 status may lead to improvements in osteoprogenitor response to therapeutic cues. ..
  39. Jin Q, Wang C, Kuang X, Feng X, Sartorelli V, Ying H, et al. Gcn5 and PCAF regulate PPAR? and Prdm16 expression to facilitate brown adipogenesis. Mol Cell Biol. 2014;34:3746-53 pubmed publisher
    The acetyltransferase Gcn5 is critical for embryogenesis and shows partial functional redundancy with its homolog PCAF. However, the tissue- and cell lineage-specific functions of Gcn5 and PCAF are still not well defined...
  40. Stilling R, Rönicke R, Benito E, Urbanke H, Capece V, Burkhardt S, et al. K-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation. EMBO J. 2014;33:1912-27 pubmed publisher
    ..of all known histone acetyltransferases (HATs) in the hippocampal CA1 region and find that K-acetyltransferase 2a (Kat2a)--a HAT that has not been studied for its role in memory function so far--shows highest expression...
  41. Tao Y, Wu Q, Guo X, Zhang Z, Shen Y, Wang F. MBD5 regulates iron metabolism via methylation-independent genomic targeting of Fth1 through KAT2A in mice. Br J Haematol. 2014;166:279-91 pubmed publisher
    ..Histone H4 acetylation of the Fth1 promoter was reduced in the intestine of Mbd5(-/-) mice and further analysis showed that histone acetyltransferase KAT2A was essential for MBD5-induced Fth1 transcription.
  42. Jin Q, Yu L, Wang L, Zhang Z, Kasper L, Lee J, et al. Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation. EMBO J. 2011;30:249-62 pubmed publisher
    Histone acetyltransferases (HATs) GCN5 and PCAF (GCN5/PCAF) and CBP and p300 (CBP/p300) are transcription co-activators. However, how these two distinct families of HATs regulate gene activation remains unclear...
  43. Kueh A, Dixon M, Voss A, Thomas T. HBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic development. Mol Cell Biol. 2011;31:845-60 pubmed publisher
    ..In conclusion, the primary role of HBO1 in development is that of a transcriptional activator, which is indispensable for H3K14 acetylation and for the normal expression of essential genes regulating embryonic development. ..
  44. Fang S, Tsang S, Jones R, Ponugoti B, Yoon H, Wu S, et al. The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP. J Biol Chem. 2008;283:35086-95 pubmed publisher
    ..While similar results were observed with a related acetylase, CBP, GCN5 did not enhance FXR transactivation, and its recruitment to the promoter was not increased by FXR agonists, ..