Kaiso

Summary

Gene Symbol: Kaiso
Description: zinc finger and BTB domain containing 33
Alias: AW260253, E130014G12Rik, Kaiso, Znf-kaiso, transcriptional regulator Kaiso, zinc finger and BTB domain-containing protein 33, zinc finger transcription factor Kaiso
Species: mouse
Products:     Kaiso

Top Publications

  1. Della Ragione F, Tiunova A, Vacca M, Strazzullo M, Gonzalez E, Armstrong J, et al. The X-linked methyl binding protein gene Kaiso is highly expressed in brain but is not mutated in Rett syndrome patients. Gene. 2006;373:83-9 pubmed
    ..We pointed our attention on Kaiso gene...
  2. Daniel J, Spring C, Crawford H, Reynolds A, Baig A. The p120(ctn)-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides. Nucleic Acids Res. 2002;30:2911-9 pubmed
    The p120(ctn)-binding partner Kaiso is a new member of the POZ-zinc finger family of transcription factors implicated in development and cancer...
  3. Spring C, Kelly K, O Kelly I, Graham M, Crawford H, Daniel J. The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the beta-catenin/TCF target gene matrilysin. Exp Cell Res. 2005;305:253-65 pubmed
    The POZ-zinc finger transcription factor Kaiso was first identified as a specific binding partner for the Armadillo catenin and cell adhesion cofactor, p120ctn...
  4. Martín Caballero I, Hansen J, Leaford D, Pollard S, Hendrich B. The methyl-CpG binding proteins Mecp2, Mbd2 and Kaiso are dispensable for mouse embryogenesis, but play a redundant function in neural differentiation. PLoS ONE. 2009;4:e4315 pubmed publisher
    ..Nevertheless, we provide genetic evidence for redundancy of function between methyl-CpG binding proteins in postnatal mice. ..
  5. Prokhortchouk A, Sansom O, Selfridge J, Caballero I, Salozhin S, Aithozhina D, et al. Kaiso-deficient mice show resistance to intestinal cancer. Mol Cell Biol. 2006;26:199-208 pubmed
    b>Kaiso is a BTB domain protein that associates with the signaling molecule p120-catenin and binds to the methylated sequence mCGmCG or the nonmethylated sequence CTGCNA to modulate transcription...
  6. Kim S, Park J, Spring C, Sater A, Ji H, Otchere A, et al. Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin. Nat Cell Biol. 2004;6:1212-20 pubmed
    ..Here we demonstrate that the dual-specificity transcriptional repressor Kaiso, first identified in association with p120-catenin, is required for Xenopus gastrulation movements...
  7. van de Ven R, Tenhagen M, Meuleman W, van Riel J, Schackmann R, Derksen P. Nuclear p120-catenin regulates the anoikis resistance of mouse lobular breast cancer cells through Kaiso-dependent Wnt11 expression. Dis Model Mech. 2015;8:373-84 pubmed publisher
    ..ILC cells show an increase in nuclear p120, which results in relief of transcriptional repression by Kaiso. To identify the Kaiso target genes that control anchorage independence we performed genome-wide mRNA profiling on ..
  8. Arányi T, Faucheux B, Khalfallah O, Vodjdani G, Biguet N, Mallet J, et al. The tissue-specific methylation of the human tyrosine hydroxylase gene reveals new regulatory elements in the first exon. J Neurochem. 2005;94:129-39 pubmed
    ..ascertained that this CpG is contained in a sequence characterized by putative binding sites for the AP2, Sp1 and KAISO factors. Characterization of this sequence shows that these factors specifically bind their respective sites...
  9. Donaldson N, Nordgaard C, Pierre C, Kelly K, Robinson S, Swystun L, et al. Kaiso regulates Znf131-mediated transcriptional activation. Exp Cell Res. 2010;316:1692-705 pubmed publisher
    b>Kaiso is a dual-specificity POZ-ZF transcription factor that regulates gene expression by binding to sequence-specific Kaiso binding sites (KBS) or methyl-CpG dinucleotide pairs...

More Information

Publications26

  1. Chaudhary R, Pierre C, Nanan K, Wojtal D, Morone S, Pinelli C, et al. The POZ-ZF transcription factor Kaiso (ZBTB33) induces inflammation and progenitor cell differentiation in the murine intestine. PLoS ONE. 2013;8:e74160 pubmed publisher
    Since its discovery, several studies have implicated the POZ-ZF protein Kaiso in both developmental and tumorigenic processes...
  2. Koh D, Yoon J, Kim M, An H, Kim M, Hur M. Kaiso is a key regulator of spleen germinal center formation by repressing Bcl6 expression in splenocytes. Biochem Biophys Res Commun. 2013;442:177-82 pubmed publisher
    b>Kaiso was previously described as a methylated DNA-binding protein and a transcription repressor interacting with the corepressor protein complex NCoR...
  3. Rodova M, Kelly K, VanSaun M, Daniel J, Werle M. Regulation of the rapsyn promoter by kaiso and delta-catenin. Mol Cell Biol. 2004;24:7188-96 pubmed
    ..Analysis of the rapsyn promoter revealed a consensus site for the transcription factor Kaiso within a region that is mutated in a subset of patients with congenital myasthenic syndrome...
  4. Pierre C, Longo J, Mavor M, Milosavljevic S, Chaudhary R, Gilbreath E, et al. Kaiso overexpression promotes intestinal inflammation and potentiates intestinal tumorigenesis in Apc(Min/+) mice. Biochim Biophys Acta. 2015;1852:1846-55 pubmed publisher
    ..One potential contributor to colorectal carcinogenesis is the POZ-ZF transcription factor Kaiso, whose depletion extends lifespan and delays polyp onset in the widely used Apc(Min/+) mouse model of intestinal ..
  5. Na J, Lykke Andersen K, Torres Padilla M, Zernicka Goetz M. Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling. Dev Biol. 2007;302:40-9 pubmed
    ..are coincident with an increase in the active form of beta-catenin, p120catenin transcription and decrease of Kaiso expression, indicating an upregulation of Wnt signaling activity before implantation...
  6. Zhang B, Gu L, Deng D. [Methylation specific binding activity of zinc finger protein Kaiso]. Zhonghua Yu Fang Yi Xue Za Zhi. 2007;41 Suppl:43-6 pubmed
    To compare binding activity of different zinc finger domain of human Kaiso with methylated CpG. pGEX constructs with different human Kaiso domain were generated and then corresponding fusion proteins were induced and purified...
  7. Daniel J, Reynolds A. The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. Mol Cell Biol. 1999;19:3614-23 pubmed
    ..p120 as bait, we conducted a yeast two-hybrid screen and identified a novel transcription factor which we named Kaiso. Kaiso's deduced amino acid sequence revealed an amino-terminal BTB/POZ protein-protein interaction domain and ..
  8. Raghav S, Waszak S, Krier I, Gubelmann C, Isakova A, Mikkelsen T, et al. Integrative genomics identifies the corepressor SMRT as a gatekeeper of adipogenesis through the transcription factors C/EBP? and KAISO. Mol Cell. 2012;46:335-50 pubmed publisher
    ..Promoter-proximal tethering of SMRT in preadipocytes is primarily mediated by KAISO through the conserved TCTCGCGAGA motif...
  9. Koh D, Han D, Ryu H, Choi W, Jeon B, Kim M, et al. KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes. Proc Natl Acad Sci U S A. 2014;111:15078-83 pubmed publisher
    ..Transcription factor KAISO was previously described to repress transcription following binding to methylated DNA...
  10. Defossez P, Kelly K, Filion G, Perez Torrado R, Magdinier F, Menoni H, et al. The human enhancer blocker CTC-binding factor interacts with the transcription factor Kaiso. J Biol Chem. 2005;280:43017-23 pubmed
    ..Using full-length CTCF as bait we recovered Kaiso, a POZ-zinc finger transcription factor, as a specific binding partner...
  11. McMurray E, Schmidt J. Identification of imprinting regulators at the Meg3 differentially methylated region. Genomics. 2012;100:184-94 pubmed publisher
    ..DNA-binding proteins that represent potential regulatory factors were identified in both ES cells and embryos. ..
  12. Zhigalova N, Sokolov A, Prokhortchouk E, Zhenilo S. [S100A3 is a new target gene of Kaiso in mouse skin]. Mol Biol (Mosk). 2015;49:362-5 pubmed
  13. Robinson S, Donaldson Kabwe N, Dvorkin Gheva A, Longo J, He L, Daniel J. The POZ-ZF transcription factor Znf131 is implicated as a regulator of Kaiso-mediated biological processes. Biochem Biophys Res Commun. 2017;493:416-421 pubmed publisher
    ..Znf131 heterodimerizes with the POZ-ZF protein Kaiso, which itself represses a subset of canonical Wnt target genes, including the cell cycle regulator Cyclin D1...
  14. Kelly K, Spring C, Otchere A, Daniel J. NLS-dependent nuclear localization of p120ctn is necessary to relieve Kaiso-mediated transcriptional repression. J Cell Sci. 2004;117:2675-86 pubmed
    ..cadherin adhesive strength at the plasma membrane and interacts with the novel BTB/POZ transcriptional repressor Kaiso in the nucleus...
  15. Kulikov A, Korostina V, Kulikova E, Fursenko D, Akulov A, Moshkin M, et al. Knockout Zbtb33 gene results in an increased locomotion, exploration and pre-pulse inhibition in mice. Behav Brain Res. 2016;297:76-83 pubmed publisher
    The Zbtb33 gene encodes the Kaiso protein-a bimodal transcriptional repressor. Here, the effects of Zbtb33 gene disruption on the brain and behaviour of the Kaiso-deficient (KO) and C57BL/6 (WT) male mice were investigated...
  16. Kelly K, Otchere A, Graham M, Daniel J. Nuclear import of the BTB/POZ transcriptional regulator Kaiso. J Cell Sci. 2004;117:6143-52 pubmed
    b>Kaiso is a BTB/POZ transcription factor that functions in vitro as a transcriptional repressor of the matrix metalloproteinase gene matrilysin and the non-canonical Wnt signaling gene Wnt-11, and as an activator of the acetylcholine-..
  17. Zhao C, Deng Y, Liu L, Yu K, Zhang L, Wang H, et al. Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation. Nat Commun. 2016;7:10883 pubmed publisher
    ..At the differentiation onset, Tcf7l2 interacts with a transcriptional co-repressor Kaiso/Zbtb33 to block β-catenin signalling...