Jund

Summary

Gene Symbol: Jund
Description: Jun proto-oncogene related gene d
Alias: Jund1, Jun proto-oncogene related gene d1, transcription factor jun-D
Species: mouse

Top Publications

  1. doi Jun and JunD-dependent functions in cell proliferation and stress response
    A Meixner
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria
    Cell Death Differ 17:1409-19. 2010
  2. ncbi JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation
    David E Smart
    Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, UK
    Hepatology 44:1432-40. 2006
  3. ncbi Protein kinase A and AP-1 (c-Fos/JunD) are induced during apoptosis of mouse mammary epithelial cells
    A Marti
    Laboratory for Clinical and Experimental Research, University of Bern, Switzerland
    Oncogene 9:1213-23. 1994
  4. pmc CDK-mediated regulation of cell functions via c-Jun phosphorylation and AP-1 activation
    Tony J Vanden Bush
    Department of Microbiology, The University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 6:e19468. 2011
  5. pmc AP-1 transcription factor JunD confers protection from accelerated nephrotoxic nephritis and control podocyte-specific Vegfa expression
    H Terence Cook
    Centre for Complement and Inflammation Research, Imperial College London, Hammersmith Hospital, London, United Kingdom
    Am J Pathol 179:134-40. 2011
  6. ncbi Targeted disruption of the murine junD gene results in multiple defects in male reproductive function
    D Thepot
    Laboratoire de Biologie Cellulaire et Moleculaire, INRA, Jouy en Josas, France
    Development 127:143-53. 2000
  7. pmc JunD regulates lymphocyte proliferation and T helper cell cytokine expression
    Arabella Meixner
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    EMBO J 23:1325-35. 2004
  8. ncbi Menin suppresses osteoblast differentiation by antagonizing the AP-1 factor, JunD
    Junko Naito
    Division of Endocrinology Metabolism, Neurology and Hematology Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 280:4785-91. 2005
  9. doi Oxidative stress contributes to aging by enhancing pancreatic angiogenesis and insulin signaling
    Gaëlle Laurent
    Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Cell Metab 7:113-24. 2008
  10. ncbi Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1
    A Puga
    Laboratory of Developmental Pharmacology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    DNA Cell Biol 11:269-81. 1992

Scientific Experts

  • Kiflai Bein
  • Mei Qiang
  • T Herdegen
  • Larry I Crawshaw
  • Denise Hilfiker-Kleiner
  • M P Fernandez
  • Wiphawi Hipkaeo
  • Fatima Mechta-Grigoriou
  • Erwin F Wagner
  • Gaëlle Laurent
  • N A Jenkins
  • Jonathan B Weitzman
  • Moshe Yaniv
  • Mutsuko Hara
  • Francesco Paneni
  • Muhammed Kashif
  • Tony J Vanden Bush
  • Mohammad R Ebrahimkhani
  • H Terence Cook
  • Bogdan Mateescu
  • M Ujue Latasa
  • Joseph Przybyszewski
  • A Meixner
  • N G Copeland
  • Jean Pierre David
  • Alexander Akhmedov
  • Elena Ezhkova
  • Derek A Mann
  • Jelena Mann
  • Fiona Oakley
  • Rachana Patel
  • Aya Kawamata
  • Jennifer J Marden
  • M Yaniv
  • O Akhouayri
  • H Zhou
  • Cecile E Malnou
  • Guillaume E Beranger
  • D J Gilbert
  • David E Smart
  • Eggi Arguni
  • Tomohiko Wakayama
  • Shoichi Iseki
  • Miyuki Yamamoto
  • Junko Naito
  • J B Weitzman
  • Etsuko Miyamoto-Sato
  • Romeo Ricci
  • E F Wagner
  • D Thepot
  • Yasuto Ikeo
  • Arabella Meixner
  • Hong Xin
  • J Doyle
  • Evangeline Pillebout
  • John D Short
  • Pengfei Gong
  • Keiko Maeda
  • Shunsuke Kanada
  • Giuseppe Coppolino
  • Chiharu Nishiyama
  • Kanako Fukuyama
  • Ruslan Kubant
  • Massimo Volpe
  • Thomas F Luscher
  • Christian M Matter
  • Tomonobu Ito
  • Elena Osto
  • Pavani Mocharla
  • Tadeusz Malinski
  • Enrico Perna
  • Ko Okumura
  • Yoshihiko Usui
  • Naomi Shimokawa
  • Hideoki Ogawa
  • Makoto Nishiyama
  • Sylvie Briand
  • Francesco Cosentino
  • Lucia Rohrer
  • Nao Kitamura
  • Giovanni G Camici
  • Hokuto Yokoyama
  • Sarah Costantino
  • Satish Ranjan
  • Andrea Hellwig
  • Said Hashemolhosseini
  • Hongjie Wang
  • Fabian Bock
  • Juliane Wolter
  • Berend Isermann

Detail Information

Publications73

  1. doi Jun and JunD-dependent functions in cell proliferation and stress response
    A Meixner
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria
    Cell Death Differ 17:1409-19. 2010
    ..Embryos expressing JunD in place of Jun (Jun(d/d)) can develop to term with normal fetal livers, but display cardiac defects as observed in ..
  2. ncbi JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation
    David E Smart
    Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, UK
    Hepatology 44:1432-40. 2006
    b>JunD is implicated in the regulation of hepatic stellate cell (HSC) activation and liver fibrosis via its transcriptional regulation of the tissue inhibitor of metalloproteinases-1 (TIMP-1) gene...
  3. ncbi Protein kinase A and AP-1 (c-Fos/JunD) are induced during apoptosis of mouse mammary epithelial cells
    A Marti
    Laboratory for Clinical and Experimental Research, University of Bern, Switzerland
    Oncogene 9:1213-23. 1994
    ..protein kinase A (PKA) activity was observed from one day post-lactation, paralleled by increased c-fos, junB, junD and to a lesser extent c-jun mRNA levels...
  4. pmc CDK-mediated regulation of cell functions via c-Jun phosphorylation and AP-1 activation
    Tony J Vanden Bush
    Department of Microbiology, The University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 6:e19468. 2011
    ..These findings point to additional roles of CDKs in cell signaling and reveal potential implications for therapeutic manipulations of this kinase pathway...
  5. pmc AP-1 transcription factor JunD confers protection from accelerated nephrotoxic nephritis and control podocyte-specific Vegfa expression
    H Terence Cook
    Centre for Complement and Inflammation Research, Imperial College London, Hammersmith Hospital, London, United Kingdom
    Am J Pathol 179:134-40. 2011
    ..to nephrotoxic nephritis (NTN), allowed us to positionally clone the activator protein-1 transcription factor Jund as a susceptibility gene associated with Crgn...
  6. ncbi Targeted disruption of the murine junD gene results in multiple defects in male reproductive function
    D Thepot
    Laboratoire de Biologie Cellulaire et Moleculaire, INRA, Jouy en Josas, France
    Development 127:143-53. 2000
    b>JunD is one of three mammalian Jun proteins that contribute to the AP-1 transcription factor complex...
  7. pmc JunD regulates lymphocyte proliferation and T helper cell cytokine expression
    Arabella Meixner
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    EMBO J 23:1325-35. 2004
    Transgenic mice broadly expressing JunD (Ubi-junD(m)) appear phenotypically normal, but have strongly reduced numbers of peripheral lymphocytes...
  8. ncbi Menin suppresses osteoblast differentiation by antagonizing the AP-1 factor, JunD
    Junko Naito
    Division of Endocrinology Metabolism, Neurology and Hematology Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 280:4785-91. 2005
    ..The activator protein-1 (AP-1) transcription factor, JunD, is expressed in osteoblasts and has been shown to interact with menin in other cell types...
  9. doi Oxidative stress contributes to aging by enhancing pancreatic angiogenesis and insulin signaling
    Gaëlle Laurent
    Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Cell Metab 7:113-24. 2008
    b>JunD, a transcription factor of the AP-1 family, protects cells against oxidative stress. Here, we show that junD(-/-) mice exhibit features of premature aging and shortened life span...
  10. ncbi Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1
    A Puga
    Laboratory of Developmental Pharmacology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    DNA Cell Biol 11:269-81. 1992
    ..These results reveal early events that may lead to the elucidation of the molecular basis of TCDD-induced tumor promotion...
  11. pmc An octamer motif contributes to the expression of the retinoic acid-regulated zinc finger gene Rex-1 (Zfp-42) in F9 teratocarcinoma cells
    B A Hosler
    Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
    Mol Cell Biol 13:2919-28. 1993
    ....
  12. ncbi JunD/AP-1 and STAT3 are the major enhancer molecules for high Bcl6 expression in germinal center B cells
    Eggi Arguni
    Department of Developmental Genetics H2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Int Immunol 18:1079-89. 2006
    ..AP-1-binding elements in the promoter region were the major enhancer elements in GC-derived B lymphoma cells, and JunD/AP-1 was detected in GC B cells...
  13. pmc jun-D: a third member of the jun gene family
    K Ryder
    Howard Hughes Medical Institute Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 86:1500-3. 1989
    ..In resting 3T3 cells, jun-D is expressed at a higher level compared to c-jun and jun-B, and its transcription is stimulated only slightly by serum growth factors. Thus, jun-D appears to be regulated differently than c-jun and jun-B...
  14. ncbi Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite
    Pengfei Gong
    Department of Molecular Genetics, Ochsner Clinic Foundation, 1516 Jefferson Highway, New Orleans, LA 70121, USA
    Arch Biochem Biophys 405:265-74. 2002
    ..Antibody "supershift" experiments identified Nrf2, JunD, and ATF3 in control complexes and the amount of these factors increased significantly in the arsenite-induced ..
  15. ncbi Role of AP-1 in ethanol-induced N-methyl-D-aspartate receptor 2B subunit gene up-regulation in mouse cortical neurons
    Mei Qiang
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurochem 95:1332-41. 2005
    ..The AP-1 DNA-binding complex in control and ethanol-treated nuclear extract was composed of c-Fos, FosB, c-Jun, JunD, and phosphorylated CREB (p-CREB)...
  16. ncbi Retinal photoreceptors are apoptosis-competent in the absence of JunD/AP-1
    F Hafezi
    Cell Death Differ 6:934-6. 1999
  17. pmc Nuclear factor erythroid-derived 2 (Nfe2) regulates JunD DNA-binding activity via acetylation: a novel mechanism regulating trophoblast differentiation
    Muhammed Kashif
    Department of Internal Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    J Biol Chem 287:5400-11. 2012
    ..Here we show that Nfe2 represses JunD DNA-binding activity to the Gcm1 promoter during syncytiotrophoblast differentiation...
  18. pmc Stimulating healthy tissue regeneration by targeting the 5-HT₂B receptor in chronic liver disease
    Mohammad R Ebrahimkhani
    Fibrosis Laboratory, Liver Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Nat Med 17:1668-73. 2011
    ..proliferation, through signaling by mitogen-activated protein kinase 1 (ERK) and the transcription factor JunD. Selective antagonism of 5-HT(2B) enhanced hepatocyte growth in models of acute and chronic liver injury...
  19. pmc JUN-CCAAT/enhancer-binding protein complexes inhibit surfactant-associated protein B promoter activity
    Kiflai Bein
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15219 3130, USA
    Am J Respir Cell Mol Biol 45:436-44. 2011
    ..These findings support the idea that heterodimerization between JUN and C/EBP-α and/or C/EBP-β targets JUN to the Sftpb promoter, thereby mediating its inhibitory regulatory role...
  20. doi Deletion of the activated protein-1 transcription factor JunD induces oxidative stress and accelerates age-related endothelial dysfunction
    Francesco Paneni
    Cardiology and Cardiovascular Research, Institute of Physiology and University Hospital, Zurich, Switzerland
    Circulation 127:1229-40, e1-21. 2013
    Reactive oxygen species are major determinants of vascular aging. JunD, a member of the activated protein-1 family of transcription factors, is emerging as a major gatekeeper against oxidative stress...
  21. doi Transcriptional regulation of the mouse CD11c promoter by AP-1 complex with JunD and Fra2 in dendritic cells
    Mutsuko Hara
    Atopy Research Center, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    Mol Immunol 53:295-301. 2013
    ..of antibodies against transcription factors revealed that the target region was recognized by a complex including JunD and Fra2, which are transcription factors belonging to the AP-1 family...
  22. pmc JunD protects against chronic kidney disease by regulating paracrine mitogens
    Evangeline Pillebout
    Institut National de la Santé et de la Recherche Médicale U426, Faculte de Medecine, Xavier Bichat, BP416, 16, rue Henri Huchard, 75870 Paris, Cedex 18, France
    J Clin Invest 112:843-52. 2003
    ..Here we used JunD knockout (JunD-/-) mice and an experimental model of chronic renal injury (75% nephron reduction) to explore the ..
  23. ncbi Differential binding of poly(ADP-Ribose) polymerase-1 and JunD/Fra2 accounts for RANKL-induced Tcirg1 gene expression during osteoclastogenesis
    Guillaume E Beranger
    GEPITOS, université Nice Sophia Antipolis, CNRS, UFR de Medecine, Nice, France
    J Bone Miner Res 22:975-83. 2007
    ..7 cells. We identified a mechanism involving PARP-1 inhibition release and JunD/Fra-2 binding, which is responsible for Tcirg1 gene upregulation.
  24. ncbi Expression and localization of the transcription factor JunD in the duct system of mouse submandibular gland
    Wiphawi Hipkaeo
    Department of Histology and Embryology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    J Histochem Cytochem 52:479-90. 2004
    We studied the expression and localization of JunD, a component of the transcription factor activator protein-1 (AP-1), in the mouse submandibular gland with immunoblotting and immunohistochemistry...
  25. ncbi Retinoblastoma (Rb) protein upregulates expression of the Ifi202 gene encoding an interferon-inducible negative regulator of cell growth
    Hong Xin
    Department of Radiation Oncology, Stritch School of Medicine, Loyola University Medical Center, 2160 South First Avenue, Building No 1, Mail Code 114B, Maywood, IL 60153, USA
    Oncogene 22:4775-85. 2003
    ..Importantly, the stimulation by Rb was dependent, in part, on a JunD/AP-1 DNA-binding site present in the 5'-regulatory region of the Ifi202 gene...
  26. ncbi JunD-menin interaction regulates c-Jun-mediated AP-1 transactivation
    Yasuto Ikeo
    Department of Aging Medicine and Geriatrics, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Endocr J 51:333-42. 2004
    ..Although menin has been reported to bind AP-1 transcription factor JunD and suppress its transcriptional activity, little is known about its molecular mechanisms and physiological role...
  27. ncbi JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms
    Jean Pierre David
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Cell Sci 115:4317-25. 2002
    ..from mice carrying a mutant of c-Jun phosphorylation sites (JunAA/JunAA), as well as cells lacking either c-Jun or JunD, which is another JNK substrate, revealed that c-Jun phosphorylation and c-Jun itself, but not JunD, are essential ..
  28. ncbi Coexpression of menin and JunD during the duct cell differentiation in mouse submandibular gland
    Wiphawi Hipkaeo
    Department of Histology and Embryology, Graduate School of Medical Science, Kanazawa University
    Tohoku J Exp Med 214:231-45. 2008
    ..We have demonstrated that the expression of a transcription factor JunD is regulated in association with the androgen-induced differentiation of GCT cells from striated duct (SD) cells...
  29. pmc Distinct functions of junD in cardiac hypertrophy and heart failure
    Romeo Ricci
    Institute of Molecular Pathology, A 1030 Vienna, Austria
    Genes Dev 19:208-13. 2005
    ..Here we show that mice lacking junD develop less adaptive hypertrophy in heart after mechanical pressure overload, while cardiomyocyte-specific ..
  30. ncbi Lack of JunD promotes pressure overload-induced apoptosis, hypertrophic growth, and angiogenesis in the heart
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Circulation 112:1470-7. 2005
    The Jun family of activator protein 1 (AP-1) transcription factors (c-Jun, JunB, and JunD) is involved in fundamental biological processes such as proliferation, apoptosis, tumor angiogenesis, and hypertrophy...
  31. doi Polymeric black tea polyphenols induce phase II enzymes via Nrf2 in mouse liver and lungs
    Rachana Patel
    Advanced Centre for Treatment, Research, and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai 410 208, India
    Free Radic Biol Med 44:1897-911. 2008
    ....
  32. pmc Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells
    Elena Ezhkova
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Cell 136:1122-35. 2009
    ..They maintain their proliferative potential and globally repressing undesirable differentiation programs while selectively establishing a specific terminal differentiation program in a stepwise fashion...
  33. doi JunD suppresses bone formation and contributes to low bone mass induced by estrogen depletion
    Aya Kawamata
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, 101 0062, Tokyo, Japan
    J Cell Biochem 103:1037-45. 2008
    b>JunD is an activator protein-1 (AP-1) component though its function in skeletal system is still not fully understood. To elucidate the role of JunD in the regulation of bone metabolism, we analyzed JunD-deficient mice...
  34. doi Dietary energy restriction, in part through glucocorticoid hormones, mediates the impact of 12-O-tetradecanoylphorbol-13-acetate on jun D and fra-1 in Sencar mouse epidermis
    Joseph Przybyszewski
    Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA
    Mol Carcinog 49:592-602. 2010
    ..In summary, our study supports potential roles for jun D, jun B, and fra-1 in the DER regulation of AP-1 function in the Sencar mouse skin carcinogenesis model...
  35. ncbi Heterodimerization with Jun family members regulates c-Fos nucleocytoplasmic traffic
    Cecile E Malnou
    Institut de Genetique Moleculaire de Montpellier, CNRS, UMR5535, 1919 Route de Mende, Montpellier F 34293, France
    J Biol Chem 282:31046-59. 2007
    c-Fos proto-oncoprotein forms AP-1 transcription complexes with heterodimerization partners such as c-Jun, JunB, and JunD. Thereby, it controls essential cell functions and exerts tumorigenic actions...
  36. ncbi Role of c-Fos/JunD in protecting stress-induced cell death
    H Zhou
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai JiaoTong University School of Medicine, Shanghai, China
    Cell Prolif 40:431-44. 2007
    ..The purpose of the current study was to investigate the role of c-Fos and JunD in stress-induced cell death.
  37. ncbi Differential mechanisms of transcriptional regulation of the mouse osteocalcin gene by Jun family members
    O Akhouayri
    Genetics Unit, Shriners Hospital for Children, 1529 Cedar Avenue, Montreal, Quebec, Canada H3G 1A6
    Calcif Tissue Int 80:123-31. 2007
    ..that control the transcription of osteocalcin, including activator protein 1 (AP-1) family members such as the Fra2/JunD heterodimer...
  38. pmc Oral methylthioadenosine administration attenuates fibrosis and chronic liver disease progression in Mdr2-/- mice
    M Ujue Latasa
    Division of Hepatology and Gene Therapy, CIMA, University of Navarra, Pamplona, Spain
    PLoS ONE 5:e15690. 2010
    ....
  39. pmc JunD protects the liver from ischemia/reperfusion injury by dampening AP-1 transcriptional activation
    Jennifer J Marden
    Molecular and Cellular Biology Interdisciplinary Graduate Program, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 283:6687-95. 2008
    ..b>JunD is a major component of the AP-1 complex following liver ischemia/reperfusion (I/R) injury; however, its precise ..
  40. ncbi Translational regulation of the JunD messenger RNA
    John D Short
    Department of Cell Biology and Biochemistry and the Southwest Cancer Center at University Medical Center, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    J Biol Chem 277:32697-705. 2002
    b>JunD, a member of the Jun family of nuclear transcription proteins, dimerizes with Fos family members or other Jun proteins (c-Jun or JunB) to form the activator protein 1 (AP-1) transcription factor...
  41. ncbi Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins
    J Doyle
    Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, 37831 8077, USA
    Genomics 35:227-30. 1996
    ..These data define the established relationships between these homologous mouse and human regions in further detail and provide new tools for linking cloned genes to phenotypes in both species...
  42. ncbi Molecular cloning, analysis, and chromosomal localization of a mouse genomic sequence related to the human papillomavirus type 18 E5 region
    T Kahn
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Mol Carcinog 6:88-99. 1992
    ..The data suggest that there may be several cellular counterparts to the viral E5 proteins...
  43. pmc JunD mutants with spontaneously acquired transforming potential have enhanced transactivating activity in combination with Fra-2
    T Kameda
    Department of Tumor Virus Research, University of Tokyo, Japan
    Proc Natl Acad Sci U S A 90:9369-73. 1993
    Although a replication-competent retrovirus that carries junD has no transforming activity in chicken embryo fibroblasts, we have isolated mutant viruses that have spontaneously acquired transforming activity...
  44. ncbi Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras
    C M Pfarr
    Departement des Biotechnologies, Institut Pasteur, Paris, France
    Cell 76:747-60. 1994
    As NIH 3T3 fibroblasts become quiescent, the level of c-Jun protein decreases while JunD accumulates...
  45. ncbi Structural organization of the mouse glycophorin A gene
    M Terajima
    Department of Cell Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai
    J Biochem 116:1105-10. 1994
    ..The upstream regulatory region of the mouse gene consists of multiple motifs for DNA binding factors that may be required for its erythroid-specific expression...
  46. ncbi Characterization of human and mouse cartilage oligomeric matrix protein
    G Newton
    Division of Vascular Research, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Genomics 24:435-9. 1994
    ..1. These data confirm and extend the known regions of homology between human and mouse chromosomes and establish that COMP, like thrombospondin-1, -2, -3, and -4, is present in the human and mouse genomes...
  47. ncbi Tissue-specific expression of the fos-related transcription factor fra-2 during mouse development
    D Carrasco
    Department of Molecular Biology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000
    Oncogene 10:1069-79. 1995
    ..The pattern of fra-2 expression is distinct from that observed for other fos related genes, suggesting that fra-2 has a unique role in cellular differentiation during fetal development...
  48. ncbi Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development
    J C Cross
    Department of Anatomy, University of California, San Francisco 94143, USA
    Development 121:2513-23. 1995
    ..These data demonstrate a role for HLH factors in regulating trophoblast development and indicate a positive role for Hxt in promoting the formation of trophoblast giant cells...
  49. ncbi DNA binding activities of three murine Jun proteins: stimulation by Fos
    Y Nakabeppu
    Howard Hughes Medical Institute Laboratory, Baltimore, Maryland
    Cell 55:907-15. 1988
    ..If there are functional differences between them, they are likely to involve other activities of the Jun proteins...
  50. pmc Characterization of junD: a new member of the jun proto-oncogene family
    S I Hirai
    Department de Biologie Moleculaire, CNRS, Institut Pasteur, Paris, France
    EMBO J 8:1433-9. 1989
    ..Two of them were carrying c-jun and junB sequences respectively, whereas the sequence of the third group of clones (junD) was distinct from these two and from v-jun...
  51. ncbi Chromosomal localization of the three members of the jun proto-oncogene family in mouse and man
    M G Mattei
    INSERM U242, Hopital d Enfants de la Timone, Marseille, France
    Oncogene 5:151-6. 1990
    ..Finally, the present data identify a new segmental homology between mouse and human chromosomes...
  52. ncbi Different members of the jun proto-oncogene family exhibit distinct patterns of expression in response to type beta transforming growth factor
    L Li
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    J Biol Chem 265:1556-62. 1990
    ..The rapid transcriptional induction of junB is among the earliest and most dramatic responses to TGF-beta yet described and suggests that junB may mediate certain of the diverse biological effects of this growth factor...
  53. ncbi Genetic mapping in the mouse of four loci related to the jun family of transcriptional activators
    M Shapiro
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    Somat Cell Mol Genet 17:341-7. 1991
    ..Probes for jun D identified two genetic loci; one, Jund-1, is near Junb on Chr 8, and a second, previously unidentified locus termed Jund-2, was mapped to Chr 2.
  54. ncbi junD mRNA expression differs from c-jun and junB mRNA expression during male germinal cell differentiation
    A A Alcivar
    Department of Biology, Tufts University, Medford, Massachusetts 02155
    Mol Reprod Dev 30:187-93. 1991
    The members of the jun family of protooncogenes (junB, c-jun, and junD) share a high degree of sequence homology and function as transcriptional regulators...
  55. pmc MEF2B is a potent transactivator expressed in early myogenic lineages
    J D Molkentin
    Hamon Center for Basic Cancer Research, The University of Texas Southwestern Medical Center at Dallas, 75235 9148, YSA
    Mol Cell Biol 16:3814-24. 1996
    ....
  56. ncbi Molecular characterization of mouse and rat CPP32 beta gene encoding a cysteine protease resembling interleukin-1 beta converting enzyme and CED-3
    T S Juan
    Department of Developmental Hematology, Amgen, Inc, Thousand Oaks, California 91320, USA
    Oncogene 13:749-55. 1996
    ..Mouse interspecific backcross mapping allowed localization of CPP32 beta to the central region of mouse chromosome 8, linked to Scvr, Lpl, Jund1 and Mlr.
  57. ncbi Influence of ethanol on thermoregulation: mapping quantitative trait loci
    L I Crawshaw
    Department of Biology, Portland State University, Portland, 97207, USA
    Physiol Genomics 7:159-69. 2001
    ..To our knowledge, this is the first report of QTLs that underlie changes in regulation as well as the disruption of a physiological regulatory system...
  58. ncbi JunD protects cells from p53-dependent senescence and apoptosis
    J B Weitzman
    Unite des Virus Oncogenes CNRS URA1644 Pasteur Institute, Paris, France
    Mol Cell 6:1109-19. 2000
    b>JunD is the most broadly expressed member of the Jun family and the AP-1 transcription factor complex. Primary fibroblasts lacking JunD displayed p53-dependent growth arrest, upregulated p19(Arf) expression, and premature senescence...
  59. ncbi Novel human and mouse annexin A10 are linked to the genome duplications during early chordate evolution
    R O Morgan
    Faculty of Medicine, University of Oviedo, Oviedo, E 33006, Spain
    Genomics 60:40-9. 1999
    ....
  60. pmc Functions of c-Jun in liver and heart development
    R Eferl
    Department of Pathology, University of Graz, A 8036 Graz, Austria
    J Cell Biol 145:1049-61. 1999
    ....
  61. ncbi Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins
    T Herdegen
    Institute of Pharmacology, University of Kiel, Hospitalstrasse 4, 24105, Kiel
    Brain Res Brain Res Rev 28:370-490. 1998
    This article reviews findings up to the end of 1997 about the inducible transcription factors (ITFs) c-Jun, JunB, JunD, c-Fos, FosB, Fra-1, Fra-2, Krox-20 (Egr-2) and Krox-24 (NGFI-A, Egr-1, Zif268); and the constitutive transcription ..
  62. ncbi Two proteins translated by alternative usage of initiation codons in mRNA encoding a JunD transcriptional regulator
    S Okazaki
    Department of Gene Regulation, University of Tokyo, Japan
    Biochem Biophys Res Commun 250:347-53. 1998
    The junD gene encodes one component of the transcription factor, AP-1. Since two forms of JunD protein have been reported, we analyzed here the molecular mechanisms involved in the isoform production...
  63. ncbi Erythroid Krüppel-like transcription factor (Eklf) maps to a region of mouse chromosome 8 syntenic with human chromosome 19
    N A Jenkins
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research and Development Center, Maryland 21702, USA
    Mamm Genome 9:174-6. 1998
  64. ncbi A linkage map of mouse chromosome 8: further definition of homologous linkage relationships between mouse chromosome 8 and human chromosomes 8, 16, and 19
    T A Howard
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Genomics 10:207-13. 1991
    ..5 cM-Plat-26.3 cM-Crryps/Mel/Jund-3.5 cM-Junb/Ucp-10.5 cM-Mt-1-27.2 cM-Acta2-0.9 cM-Aprt...
  65. ncbi Absence of a persistently elevated 37 kDa fos-related antigen and AP-1-like DNA-binding activity in the brains of kainic acid-treated fosB null mice
    A Mandelzys
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Neurosci 17:5407-15. 1997
    ..By comparing wild-type and fosB-null mice treated with kainic acid, we establish that the complexes comprise JunD in association with an approximately 37 kDa Delta-FosB species...
  66. ncbi Mutations in the Cacnl1a4 calcium channel gene are associated with seizures, cerebellar degeneration, and ataxia in tottering and leaner mutant mice
    J Doyle
    Biology Division, Oak Ridge National Laboratory, Tennessee 37831 8077, USA
    Mamm Genome 8:113-20. 1997
    ....
  67. ncbi JunD phosphorylation, and expression of AP-1 DNA binding activity modulated by serum growth factors in quiescent murine 3T3T cells
    H Wang
    Department of Pathology, The University of Tennessee College of Medicine, Memphis 38163, USA
    Oncogene 13:2639-47. 1996
    b>JunD has been implicated as a negative regulator of cell proliferation. If and how JunD is regulated by growth factors however has not been well investigated...
  68. ncbi A polymorphic interstitial telomere array near the center of mouse chromosome 8
    C H Yen
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Mamm Genome 7:218-21. 1996
  69. ncbi Mapping of the genes encoding mouse prostaglandin D, E, and F and prostacyclin receptors
    T O Ishikawa
    Banyu Tsukuba Research Institute Merck, Japan
    Genomics 32:285-8. 1996
    ..Ptgdr mapped to proximal Chr 14, Ptgfr mapped to distal Chr 3, Ptgerepl mapped to middle Chr 8, and Ptgir mapped to proximal Chr 7...
  70. ncbi Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1
    G Rao
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Oncogene 12:1165-72. 1996
    ....
  71. ncbi Structure, chromosome mapping, and expression of the mouse Lyl-1 gene
    S S Kuo
    Department of Pathology, Stanford University School of Medicine, California 94305
    Oncogene 6:961-8. 1991
    ..We conclude that LYL1 has the properties of a lineage- and differentiation-specific HLH protein that contributes to T-cell neoplasia through its deregulated expression following chromosomal translocation...
  72. ncbi Modified expression of testicular gap-junction connexin 43 during normal spermatogenic cycle and in altered spermatogenesis
    C Batias
    INSERM CJF 95 04, EA 1760, IFR 50, Faculte de Medecine, Nice, France
    Cell Tissue Res 298:113-21. 1999
    ..The present study represents one of the first in vivo examples of alteration of seminiferous tubule Cx43 in testes with impaired spermatogenesis...
  73. pmc Cell-free cotranslation and selection using in vitro virus for high-throughput analysis of protein-protein interactions and complexes
    Etsuko Miyamoto-Sato
    Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama 223 8522, Japan
    Genome Res 15:710-7. 2005
    ..Thus, we consider that this simple IVV selection system based on cell-free cotranslation could be applicable to high-throughput and comprehensive analysis of PPI and complexes in large-scale settings involving parallel bait proteins...