Gene Symbol: jumonji
Description: jumonji, AT rich interactive domain 2
Alias: Jmj, jumonji, protein Jumonji, jumonji/ARID domain-containing protein 2
Species: mouse
Products:     jumonji

Top Publications

  1. Shen X, Kim W, Fujiwara Y, Simon M, Liu Y, Mysliwiec M, et al. Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell. 2009;139:1303-14 pubmed publisher
    ..Here we demonstrate that the founding member of the Jumonji family, JMJ (JUMONJI or JARID2), is associated with PRC2, colocalizes with PRC2 and H3K27me3 on chromatin, and ..
  2. Zhang Z, Jones A, Sun C, Li C, Chang C, Joo H, et al. PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming. Stem Cells. 2011;29:229-40 pubmed publisher
  3. Peng J, Valouev A, Swigut T, Zhang J, Zhao Y, Sidow A, et al. Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell. 2009;139:1290-302 pubmed publisher
    ..Here we show that Jarid2/Jumonji, a protein enriched in pluripotent cells and a founding member of the Jumonji C (JmjC) domain protein family, is ..
  4. Pasini D, Cloos P, Walfridsson J, Olsson L, Bukowski J, Johansen J, et al. JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature. 2010;464:306-10 pubmed publisher
    ..Here we show that PRC2 forms a stable complex with the Jumonji- and ARID-domain-containing protein, JARID2 (ref. 4)...
  5. Li G, Margueron R, Ku M, Chambon P, Bernstein B, Reinberg D. Jarid2 and PRC2, partners in regulating gene expression. Genes Dev. 2010;24:368-80 pubmed publisher
    ..We found that Jarid2 associates with PRC2 and stimulates its enzymatic activity in vitro. Jarid2 contains a Jumonji C domain, but is devoid of detectable histone demethylase activity...
  6. Jung J, Mysliwiec M, Lee Y. Roles of JUMONJI in mouse embryonic development. Dev Dyn. 2005;232:21-32 pubmed
    ..In search for the developmentally important genes, the jumonji gene (jmj) was identified by gene trap technology and characterized as a critical nuclear factor for mouse ..
  7. Singh B, Tahara N, Kawakami Y, Das S, Koyano Nakagawa N, Gong W, et al. Etv2-miR-130a-Jarid2 cascade regulates vascular patterning during embryogenesis. PLoS ONE. 2017;12:e0189010 pubmed publisher
    ..These findings demonstrate a critical role for Etv2-miR-130a-Jarid2 in vascular patterning both in vitro and in vivo. ..
  8. Toyoda M, Kojima M, Takeuchi T. Jumonji is a nuclear protein that participates in the negative regulation of cell growth. Biochem Biophys Res Commun. 2000;274:332-6 pubmed
    The jumonji (jmj) gene, obtained by a gene trap strategy, is essential for mouse embryogenesis and is suggested to play important roles in cell growth during development...
  9. da Rocha S, Boeva V, Escamilla Del Arenal M, Ancelin K, Granier C, Matias N, et al. Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome. Mol Cell. 2014;53:301-16 pubmed publisher
    ..Jarid2 thus represents an important intermediate between PRC2 and Xist RNA for the initial targeting of the PRC2 complex to the X chromosome during onset of XCI. ..

More Information


  1. Londhe P, Davie J. Interferon-? resets muscle cell fate by stimulating the sequential recruitment of JARID2 and PRC2 to promoters to repress myogenesis. Sci Signal. 2013;6:ra107 pubmed publisher
    ..We showed that CIITA first interacted with the Jumonji family protein JARID2, a noncatalytic subunit of PRC2, which caused an RNA polymerase II (RNAPII), phosphorylated ..
  2. Takeuchi T, Kojima M, Nakajima K, Kondo S. jumonji gene is essential for the neurulation and cardiac development of mouse embryos with a C3H/He background. Mech Dev. 1999;86:29-38 pubmed
    The recessive mutant mouse jumonji (jmj), obtained by a gene trap strategy, shows neural tube defects in approximately half of homozygous embryos with a BALB/cA and 129/Ola mixed background, but no neural tube defects with BALB/cA, C57BL/..
  3. Takahashi M, Kojima M, Nakajima K, Suzuki Migishima R, Takeuchi T. Functions of a jumonji-cyclin D1 pathway in the coordination of cell cycle exit and migration during neurogenesis in the mouse hindbrain. Dev Biol. 2007;303:549-60 pubmed
    ..cells and cell clusters expressing neural progenitor or proneural marker genes in the MZ of the hindbrain of jumonji (jmj) mutant embryos...
  4. Landeira D, Bağci H, Malinowski A, Brown K, Soza Ried J, Feytout A, et al. Jarid2 Coordinates Nanog Expression and PCP/Wnt Signaling Required for Efficient ESC Differentiation and Early Embryo Development. Cell Rep. 2015;12:573-86 pubmed publisher
    ..5 blastocysts. These data describe a previously unrecognized role for Jarid2 in regulating a core pluripotency and Wnt/PCP signaling circuit that is important for ESC differentiation and for pre-implantation development. ..
  5. Pereira R, Martinez G, Engel I, Cruz Guilloty F, Barboza B, Tsagaratou A, et al. Jarid2 is induced by TCR signalling and controls iNKT cell maturation. Nat Commun. 2014;5:4540 pubmed publisher
    ..Our results establish Jarid2 as a novel player in iNKT cell maturation that regulates PLZF expression by modulating H3K9 methylation. ..
  6. Trokovic R, Jukkola T, Saarimäki J, Peltopuro P, Naserke T, Weisenhorn D, et al. Fgfr1-dependent boundary cells between developing mid- and hindbrain. Dev Biol. 2005;278:428-39 pubmed
    ..The slowly proliferating boundary cells are necessary for development of the characteristic isthmic constriction. They may also contribute to compartmentalization of this brain region. ..
  7. Jones A, Wang H. Polycomb repressive complex 2 in embryonic stem cells: an overview. Protein Cell. 2010;1:1056-62 pubmed publisher
    ..PRC2 in embryonic stem cells and explore the role of the newly identified mESC specific PRC2 regulatory subunits Jarid2 (jumonji, AT rich interactive domain 2), Mtf2 (metal response element binding transcription factor 2) and esPRC2p48.
  8. Yamaji M, Ueda J, Hayashi K, Ohta H, Yabuta Y, Kurimoto K, et al. PRDM14 ensures naive pluripotency through dual regulation of signaling and epigenetic pathways in mouse embryonic stem cells. Cell Stem Cell. 2013;12:368-82 pubmed publisher
    ..PRDM14 exerts these effects by recruiting polycomb repressive complex 2 (PRC2) specifically to key targets and repressing their expression. ..
  9. Juriloff D, Gunn T, Harris M, Mah D, Wu M, Dewell S. Multifactorial genetics of exencephaly in SELH/Bc mice. Teratology. 2001;64:189-200 pubmed
    ..The high risk of exencephaly in SELH/Bc mice is caused by the cumulative effect of two to three semidominant genes. Candidate genes include Msx2, Madh5, Ptch, and Irx1 (Chr 13) and Actb and Rac1 (Chr 5). ..
  10. Kitajima K, Kojima M, Kondo S, Takeuchi T. A role of jumonji gene in proliferation but not differentiation of megakaryocyte lineage cells. Exp Hematol. 2001;29:507-14 pubmed
    In this study, megakaryocytopoiesis was investigated in the recessive mutant mouse, jumonji, obtained by a gene-trap strategy...
  11. Lee Y, Song A, Baker R, Micales B, Conway S, Lyons G. Jumonji, a nuclear protein that is necessary for normal heart development. Circ Res. 2000;86:932-8 pubmed
    b>Jumonji (jmj) was cloned in a gene trap screen to identify and mutagenize genes important for heart development. To investigate the role of jmj in heart development, we generated mice homozygous for the jmj mutation...
  12. Mysliwiec M, Bresnick E, Lee Y. Endothelial Jarid2/Jumonji is required for normal cardiac development and proper Notch1 expression. J Biol Chem. 2011;286:17193-204 pubmed publisher
    Jarid2/Jumonji critically regulates developmental processes including cardiovascular development. Jarid2 knock-out mice exhibit cardiac defects including hypertrabeculation with noncompaction of the ventricular wall...
  13. Nakajima K, Inagawa M, Uchida C, Okada K, Tane S, Kojima M, et al. Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway. Development. 2011;138:1771-82 pubmed publisher
    ..inhibition of differentiation and enhanced expression of cyclin D1 in cardiomyocytes of mice with mutant jumonji (Jmj, Jarid2), which encodes the repressor of cyclin D1...
  14. Mysliwiec M, Carlson C, Tietjen J, Hung H, Ansari A, Lee Y. Jarid2 (Jumonji, AT rich interactive domain 2) regulates NOTCH1 expression via histone modification in the developing heart. J Biol Chem. 2012;287:1235-41 pubmed publisher
    Jarid2/Jumonji, the founding member of the Jmj factor family, critically regulates various developmental processes, including cardiovascular development...
  15. Scapoli L, Martinelli M, Pezzetti F, Palmieri A, Girardi A, Savoia A, et al. Expression and association data strongly support JARID2 involvement in nonsyndromic cleft lip with or without cleft palate. Hum Mutat. 2010;31:794-800 pubmed publisher
    ..Understanding the molecular role of JARID2 within facial development may offer additional information to further unravel the complex genetics of CL/P...
  16. Cooper S, Grijzenhout A, Underwood E, Ancelin K, Zhang T, Nesterova T, et al. Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2. Nat Commun. 2016;7:13661 pubmed publisher
    ..Our findings ascribe a critical function to Jarid2 and define a key mechanism that links PRC1 and PRC2 in the establishment of Polycomb domains. ..
  17. Hosako H, Martin G, Barrier M, Chen Y, Ivanov I, Mirkes P. Gene and microRNA expression in p53-deficient day 8.5 mouse embryos. Birth Defects Res A Clin Mol Teratol. 2009;85:546-55 pubmed publisher
    ..Our data have identified genes and miRNAs that may be involved in the mechanisms underlining NTDs and begin to define the developmental role of p53 in the etiology of NTDs. ..
  18. Mysliwiec M, Kim T, Lee Y. Characterization of zinc finger protein 496 that interacts with Jumonji/Jarid2. FEBS Lett. 2007;581:2633-40 pubmed
    Jumonij (JMJ)/Jarid2 plays important roles in embryonic development and functions as a transcriptional repressor...
  19. Takeuchi T, Yamazaki Y, Katoh Fukui Y, Tsuchiya R, Kondo S, Motoyama J, et al. Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation. Genes Dev. 1995;9:1211-22 pubmed
    A mouse mutation, termed jumonji (jmj), was generated by a gene trap strategy...
  20. Shen W, Plachez C, Mongi A, Richards L. Identification of candidate genes at the corticoseptal boundary during development. Gene Expr Patterns. 2006;6:471-81 pubmed
    ..An RNase Protection Assay (RPA) revealed that the expression of G39F8, G24F3 and LZIP increase markedly in the telencephalon at E16 and continue to be expressed until at least P0, during the period when the corpus callosum is forming. ..
  21. Jung J, Kim T, Lyons G, Kim H, Lee Y. Jumonji regulates cardiomyocyte proliferation via interaction with retinoblastoma protein. J Biol Chem. 2005;280:30916-23 pubmed
    b>Jumonji (JMJ) can function as a transcriptional repressor and plays critical roles in embryonic development including heart development in mice...
  22. Kaneko S, Bonasio R, Saldaña Meyer R, Yoshida T, Son J, Nishino K, et al. Interactions between JARID2 and noncoding RNAs regulate PRC2 recruitment to chromatin. Mol Cell. 2014;53:290-300 pubmed publisher
    ..Our findings show that lncRNAs facilitate JARID2-PRC2 interactions on chromatin and suggest a mechanism by which lncRNAs contribute to PRC2 recruitment. ..
  23. Fisher C, Marks H, Cho L, Andrews R, Wormald S, Carroll T, et al. An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers. Nucleic Acids Res. 2017;45:e174 pubmed publisher
    ..Our strategy to generate null mutant mouse ES cells is applicable to thousands of genes and repurposes existing IKMC Intermediate Vectors. ..
  24. Xu M, Zuo D, Liu X, Fan H, Chen Q, Deng S, et al. MiR-155 contributes to Th17 cells differentiation in dextran sulfate sodium (DSS)-induced colitis mice via Jarid2. Biochem Biophys Res Commun. 2017;488:6-14 pubmed publisher
    ..This study suggests that miR-155 plays a host-damaging role during DSS-induced colitis mice and induces Th17 differentiation by targeting Jarid2. ..
  25. Toyoda M, Shirato H, Nakajima K, Kojima M, Takahashi M, Kubota M, et al. jumonji downregulates cardiac cell proliferation by repressing cyclin D1 expression. Dev Cell. 2003;5:85-97 pubmed
    ..Here, we demonstrate a negative relationship between the spatiotemporal patterns of jumonji (jmj) expression and cardiac myocyte proliferation...
  26. Anzai H, Kamiya A, Shirato H, Takeuchi T, Miyajima A. Impaired differentiation of fetal hepatocytes in homozygous jumonji mice. Mech Dev. 2003;120:791-800 pubmed
    Homozygous jumonji (jmj(-)/jmj(-)) mice were previously shown to exhibit hepatic hypoplasia and defective hematopoiesis in the liver and die at around embryonic day 15.5 (E15.5), suggesting that jmj is essential for liver development...
  27. Kinkel S, Galeev R, Flensburg C, Keniry A, Breslin K, Gilan O, et al. Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2. Blood. 2015;125:1890-900 pubmed publisher
    ..These data implicate Jarid2 as an important component of PRC2 that has a central role in coordinating HSPC function. ..
  28. Escobar T, Kanellopoulou C, Kugler D, Kilaru G, Nguyen C, Nagarajan V, et al. miR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve polycomb-mediated repression. Immunity. 2014;40:865-79 pubmed publisher
    ..Thus, miR-155 contributes to Th17 cell function by suppressing the inhibitory effects of Jarid2. ..
  29. Voss A, Thomas T, Gruss P. Efficiency assessment of the gene trap approach. Dev Dyn. 1998;212:171-80 pubmed
    ..Evidently, gene trapping does not always provide all three of the features mentioned above. In this paper, we discuss the efficiency of gene trapping and ways in which some problems may be overcome. ..
  30. Takeuchi T. jumonji gene maps to mouse chromosome 13. Genomics. 1997;45:240-2 pubmed
  31. Iseki H, Nakachi Y, Hishida T, Yamashita Sugahara Y, Hirasaki M, Ueda A, et al. Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells. Stem Cells. 2016;34:322-33 pubmed publisher
    ..Our findings provide an insight into the important roles of JARID2 during reprogramming and suggest that the JARID2-associated protein network contributes to overcoming reprogramming barriers. ..
  32. Mejetta S, Morey L, Pascual G, Kuebler B, Mysliwiec M, Lee Y, et al. Jarid2 regulates mouse epidermal stem cell activation and differentiation. EMBO J. 2011;30:3635-46 pubmed publisher
    ..We conclude that Jarid2 is required for the scheduled proliferation of epidermal stem and progenitor cells necessary to maintain epidermal homeostasis. ..
  33. Kim T, Kraus J, Chen J, Lee Y. JUMONJI, a critical factor for cardiac development, functions as a transcriptional repressor. J Biol Chem. 2003;278:42247-55 pubmed
    b>JUMONJI (JMJ) is a nuclear factor that is critical for normal cardiovascular development, evidenced by the analysis of jmj homozygous mutant mice. However, the molecular function of JMJ remains to be elucidated...
  34. Takahashi M, Kojima M, Nakajima K, Suzuki Migishima R, Motegi Y, Yokoyama M, et al. Cardiac abnormalities cause early lethality of jumonji mutant mice. Biochem Biophys Res Commun. 2004;324:1319-23 pubmed
    b>jumonji (jmj) mutant mice, obtained by a gene trap strategy, showed several morphological abnormalities including neural tube and cardiac defects, and died in utero around embryonic day 11.5 (E11.5)...
  35. Barth J, Clark C, Fresco V, Knoll E, Lee B, Argraves W, et al. Jarid2 is among a set of genes differentially regulated by Nkx2.5 during outflow tract morphogenesis. Dev Dyn. 2010;239:2024-33 pubmed publisher
    ..5 overexpression. Given the role of Jarid2 as a regulator of early cardiac proliferation, these findings highlight Jarid2 as one of several potential mediators of the critical role played by Nkx2.5 during OFT morphogenesis. ..
  36. Mysliwiec M, Chen J, Powers P, Bartley C, Schneider M, Lee Y. Generation of a conditional null allele of jumonji. Genesis. 2006;44:407-11 pubmed
    The jumonji (jmj) gene plays important roles in multiple organ development in mouse, including cardiovascular development...
  37. Shirato H, Ogawa S, Nakajima K, Inagawa M, Kojima M, Tachibana M, et al. A jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9. J Biol Chem. 2009;284:733-9 pubmed publisher
    ..Previously, we identified the jumonji (jmj, Jarid2) gene, the jmjC domain, and a Jmj family...
  38. Nath A, Krauthammer M, Li P, Davidov E, Butler L, Copel J, et al. Proteomic-based detection of a protein cluster dysregulated during cardiovascular development identifies biomarkers of congenital heart defects. PLoS ONE. 2009;4:e4221 pubmed publisher
    ..The proteins detected by mass spectrometry (WNT16, ST14, Pcsk1, Jumonji, Morca2a, TRPC5, and others) were validated by Western blotting and immunoflorescent staining of the yolk sac and ..
  39. Baker R, Haendel M, Swanson B, Shambaugh J, Micales B, Lyons G. In vitro preselection of gene-trapped embryonic stem cell clones for characterizing novel developmentally regulated genes in the mouse. Dev Biol. 1997;185:201-14 pubmed
    ..These results also highlight the utility of ES cell differentiation in vitro as a method with which to study the molecular mechanisms regulating the specification and commitment of a variety of cell and tissue types. ..
  40. Berge Lefranc J, Jay P, Massacrier A, Cau P, Mattei M, Bauer S, et al. Characterization of the human jumonji gene. Hum Mol Genet. 1996;5:1637-41 pubmed
    While constructing a cDNA library of human embryos, we have isolated a clone homologous to jumonji, a mouse gene required for neural tube formation...
  41. Motoyama J, Kitajima K, Kojima M, Kondo S, Takeuchi T. Organogenesis of the liver, thymus and spleen is affected in jumonji mutant mice. Mech Dev. 1997;66:27-37 pubmed
    The recessive mutant mouse jumonji (jmj), obtained by a gene trap strategy, shows neural tube defects in approximately half of homozygotes with a Balb/cA and 129/Ola mixed background...
  42. Son J, Shen S, Margueron R, Reinberg D. Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatin. Genes Dev. 2013;27:2663-77 pubmed publisher
    ..Our findings allow us to propose a model in which PRC2-Ezh2 is important for the de novo establishment of H3K27me3 in dividing cells, whereas PRC2-Ezh1 is required for its maintenance in resting cells. ..
  43. Kitajima K, Kojima M, Nakajima K, Kondo S, Hara T, Miyajima A, et al. Definitive but not primitive hematopoiesis is impaired in jumonji mutant mice. Blood. 1999;93:87-95 pubmed
    A novel gene, jumonji was identified by a mouse gene trap strategy. The jumonji gene encodes a protein containing a putative DNA binding domain...
  44. Bleckmann S, Blendy J, Rudolph D, Monaghan A, Schmid W, Schutz G. Activating transcription factor 1 and CREB are important for cell survival during early mouse development. Mol Cell Biol. 2002;22:1919-25 pubmed
    ..5 due to massive apoptosis. These results indicate that CREB and ATF1 act in concert to mediate signals essential for maintaining cell viability during early embryonic development. ..
  45. Hunkapiller J, Shen Y, Diaz A, Cagney G, McCleary D, Ramalho Santos M, et al. Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal. PLoS Genet. 2012;8:e1002576 pubmed publisher
    ..Thus, Pcl3 is a component of PRC2 critical for ESC self-renewal, histone methylation, and recruitment of PRC2 to a subset of its genomic sites. ..
  46. Kim T, Chen J, Sadoshima J, Lee Y. Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors. Mol Cell Biol. 2004;24:10151-60 pubmed
    Mice with a homozygous knockout of the jumonji (jmj) gene showed abnormal heart development and defective regulation of cardiac-specific genes, including the atrial natriuretic factor (ANF)...
  47. Klassen S, Rabkin S. Nitric oxide induces gene expression of Jumonji and retinoblastoma 2 protein while reducing expression of atrial natriuretic peptide precursor type B in cardiomyocytes. Folia Biol (Praha). 2008;54:65-70 pubmed
    b>Jumonji (JMJ, Jarid2), a prototypical member of the jumonji domain-containing protein family, plays a major role in embryonic cardiac development, but its role in the developed heart is unclear...