jsd

Summary

Gene Symbol: jsd
Description: UTP14B small subunit processome component
Alias: 4932411L21Rik, jsd, U3 small nucleolar RNA-associated protein 14 homolog B, UTP14, U3 small nucleolar ribonucleoprotein, homolog B, juvenile spermatogonial depletion protein
Species: mouse
Products:     jsd

Top Publications

  1. de Rooij D, Okabe M, Nishimune Y. Arrest of spermatogonial differentiation in jsd/jsd, Sl17H/Sl17H, and cryptorchid mice. Biol Reprod. 1999;61:842-7 pubmed
    The nature of the spermatogenic arrest in cryptorchid C57Bl mice and in jsd/jsd and Sl17H/Sl17H mutant mice was identified by studying whole mounts of seminiferous tubules...
  2. Barton D, Yang Feng T, Mason A, Seeburg P, Francke U. Mapping of genes for inhibin subunits alpha, beta A, and beta B on human and mouse chromosomes and studies of jsd mice. Genomics. 1989;5:91-9 pubmed
    ..region of mouse chromosome 1 that carries other genes known to have homologs on human chromosome 2q includes the jsd locus (for juvenile spermatogonial depletion)...
  3. Mizunuma M, Dohmae K, Tajima Y, Koshimizu U, Watanabe D, Nishimune Y. Loss of sperm in juvenile spermatogonial depletion (jsd) mutant mice is ascribed to a defect of intratubular environment to support germ cell differentiation. J Cell Physiol. 1992;150:188-93 pubmed
    C57BL/6(B6)-jsd/jsd mice are sterile due to the defective spermatogenesis in the testes...
  4. Tohda A, Matsumiya K, Tadokoro Y, Yomogida K, Miyagawa Y, Dohmae K, et al. Testosterone suppresses spermatogenesis in juvenile spermatogonial depletion (jsd ) mice. Biol Reprod. 2001;65:532-7 pubmed
    Male juvenile spermatogonial depletion (jsd/jsd) mice are sterile because of a failure of spermatogonial differentiation...
  5. Tadokoro Y, Yomogida K, Ohta H, Tohda A, Nishimune Y. Homeostatic regulation of germinal stem cell proliferation by the GDNF/FSH pathway. Mech Dev. 2002;113:29-39 pubmed
    ..These results suggest that in mammalian testes, GSC proliferation and population size are regulated homeostatically by the GDNF/FSH pathway. ..
  6. Shetty G, Weng C, Porter K, Zhang Z, Pakarinen P, Kumar T, et al. Spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mice with androgen receptor or follicle-stimulating hormone mutations. Endocrinology. 2006;147:3563-70 pubmed
    The jsd mice experience a single wave of spermatogenesis, followed by an arrest of spermatogenesis because of a block in spermatogonial differentiation...
  7. Ohta H, Yomogida K, Tadokoro Y, Tohda A, Dohmae K, Nishimune Y. Defect in germ cells, not in supporting cells, is the cause of male infertility in the jsd mutant mouse: proliferation of spermatogonial stem cells without differentiation. Int J Androl. 2001;24:15-23 pubmed
    C57BL/6 (B6)-jsd/jsd male mice are sterile because of lack of spermatogenesis...
  8. Matsumiya K, Meistrich M, Shetty G, Dohmae K, Tohda A, Okuyama A, et al. Stimulation of spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mutant mice by gonadotropin-releasing hormone antagonist treatment. Endocrinology. 1999;140:4912-5 pubmed
    Male juvenile spermatogonial depletion (jsd) mutant mice are sterile because of spermatogenic failure and so may provide a model for genetically caused human male infertility...
  9. Aoto H, Tsuchida J, Nishina Y, Nishimune Y, Asano A, Tajima S. Isolation of a novel cDNA that encodes a protein localized to the pre-acrosome region of spermatids. Eur J Biochem. 1995;234:8-15 pubmed
    ..As the mutant mouse jsd/jsd, which has a defect in germ cell maturation, barely expressed the transcript, the message was expected to be ..

More Information

Publications26

  1. Yomogida K, Ohtani H, Harigae H, Ito E, Nishimune Y, Engel J, et al. Developmental stage- and spermatogenic cycle-specific expression of transcription factor GATA-1 in mouse Sertoli cells. Development. 1994;120:1759-66 pubmed
    ..In contrast, virtually every Sertoli cell in mutant W/Wv, jsd/jsd or cryptorchid mice (all of which lack significant numbers of germ cells) expresses GATA-1, thus showing that ..
  2. Kojima Y, Kominami K, Dohmae K, Nonomura N, Miki T, Okuyama A, et al. Cessation of spermatogenesis in juvenile spermatogonial depletion (jsd/jsd) mice. Int J Urol. 1997;4:500-7 pubmed
    Mice homozygous for the jsd (juvenile spermatogonial depletion) allele are sterile because they become azoospermic. The onset of such azoospermia was investigated by histologic analysis of sections of testes from jsd/jsd mice...
  3. Tohda A, Okuno T, Matsumiya K, Okabe M, Kishikawa H, Dohmae K, et al. Restoration of spermatogenesis and fertility in azoospermic mutant mice by suppression and reelevation of testosterone followed by intracytoplasmic sperm injection. Biol Reprod. 2002;66:85-90 pubmed
    ..Male mice homozygous for the mutant juvenile spermatogonial depletion (jsd) gene show spermatogonial arrest and an elevated intratesticular testosterone level like many other experimental ..
  4. Wang G, Weng C, Shao S, Zhou W, De Gendt K, Braun R, et al. Androgen receptor in Sertoli cells is not required for testosterone-induced suppression of spermatogenesis, but contributes to Sertoli cell organization in Utp14b jsd mice. J Androl. 2009;30:338-48 pubmed publisher
    ..androgen receptor (AR) maintains the arrest of spermatogonial differentiation in juvenile spermatogonial depletion (jsd mutation in the Utp14b gene) mutant adult male mice...
  5. Shetty G, Shao S, Weng C. p53-dependent apoptosis in the inhibition of spermatogonial differentiation in juvenile spermatogonial depletion (Utp14bjsd) mice. Endocrinology. 2008;149:2773-81 pubmed publisher
    In adult male mice homozygous for the juvenile spermatogonial depletion (Utp14b jsd) mutation in the Utp14b gene, type A spermatogonia proliferate, but in the presence of testosterone and at scrotal temperatures, these spermatogonia ..
  6. Rohozinski J, Bishop C. The mouse juvenile spermatogonial depletion (jsd) phenotype is due to a mutation in the X-derived retrogene, mUtp14b. Proc Natl Acad Sci U S A. 2004;101:11695-700 pubmed
    The recessive juvenile spermatogonial depletion (jsd) mutation results in a single wave of spermatogenesis, followed by failure of type A spermatogonia to differentiate, resulting in adult male sterility...
  7. Bolden Tiller O, Chiarini Garcia H, Poirier C, Alves Freitas D, Weng C, Shetty G, et al. Genetic factors contributing to defective spermatogonial differentiation in juvenile spermatogonial depletion (Utp14bjsd) mice. Biol Reprod. 2007;77:237-46 pubmed
    Male mice that are homozygous for the juvenile spermatogonial depletion (jsd) mutation in the Utp14b gene undergo several waves of spermatogenesis...
  8. Song H, Bettegowda A, Oliver D, Yan W, Phan M, de Rooij D, et al. shRNA off-target effects in vivo: impaired endogenous siRNA expression and spermatogenic defects. PLoS ONE. 2015;10:e0118549 pubmed publisher
    ..Our study serves as a warning for those using shRNA approaches to investigate gene functions in vivo. ..
  9. Shetty G, Porter K, Zhou W, Shao S, Weng C, Meistrich M. Androgen suppression-induced stimulation of spermatogonial differentiation in juvenile spermatogonial depletion mice acts by elevating the testicular temperature. Endocrinology. 2011;152:3504-14 pubmed publisher
    ..the block in spermatogonial differentiation in adult mice homozygous for the juvenile spermatogonial depletion (jsd) mutation has been a conundrum...
  10. Zhou W, Wang G, Small C, Liu Z, Weng C, Yang L, et al. Gene expression alterations by conditional knockout of androgen receptor in adult sertoli cells of Utp14b(jsd/jsd) (jsd) mice. Biol Reprod. 2010;83:759-66 pubmed publisher
    ..these limitations and identify AR-regulated genes in adult Sertoli cells, we compared gene expression in adult jsd (Utp14b(jsd/jsd), juvenile spermatogonial depletion) mouse testes and with that in SCARKO-jsd mouse testes, since ..
  11. Beamer W, Cunliffe Beamer T, Shultz K, Langley S, Roderick T. Juvenile spermatogonial depletion (jsd): a genetic defect of germ cell proliferation of male mice. Biol Reprod. 1988;38:899-908 pubmed
    Adult C57BL/6J male mice homozygous for the mutant gene, juvenile spermatogonial depletion (jsd/jsd), show azoosper4ia and testes reduced to one-third normal size, but are otherwise phenotypically normal...
  12. Shetty G, Weng C. Cryptorchidism rescues spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mice. Endocrinology. 2004;145:126-33 pubmed
    Male mice homozygous for jsd mutation undergo an initial wave of spermatogenesis, but spermatogonial differentiation ceases a few weeks after birth; at that point the tubules show only type A spermatogonia and Sertoli cells...
  13. Cooke H, Saunders P. Mouse models of male infertility. Nat Rev Genet. 2002;3:790-801 pubmed
    ..Targeted mutagenesis in the mouse provides a powerful method to analyse these steps and has provided new insights into the origins of male infertility. ..
  14. Boettger Tong H, Rohozinski J, Agoulnik A, Dohmae K, Nishimune Y, Levy N, et al. Identification and sequencing the juvenile spermatogonial depletion critical interval on mouse chromosome 1 reveals the presence of eight candidate genes. Biochem Biophys Res Commun. 2001;288:1129-35 pubmed
    In mice, the recessive, non-pleiotropic, juvenile spermatogonial depletion (jsd) mutation results in a single wave of spermatogenesis, followed by failure of type A spermatogonial stem cells to differentiate, rendering adult males ..
  15. Zhao M, Rohozinski J, Sharma M, Ju J, Braun R, Bishop C, et al. Utp14b: a unique retrogene within a gene that has acquired multiple promoters and a specific function in spermatogenesis. Dev Biol. 2007;304:848-59 pubmed
    ..for male fertility, and a mutation in its sequence results in the sterile juvenile spermatogonial depletion (jsd) phenotype...
  16. Bradley J, Baltus A, Skaletsky H, Royce Tolland M, Dewar K, Page D. An X-to-autosome retrogene is required for spermatogenesis in mice. Nat Genet. 2004;36:872-6 pubmed
    We identified the gene carrying the juvenile spermatogonial depletion mutation (jsd), a recessive spermatogenic defect mapped to mouse chromosome 1 (refs. 1,2)...
  17. Shetty G, Wilson G, Huhtaniemi I, Boettger Tong H, Meistrich M. Testosterone inhibits spermatogonial differentiation in juvenile spermatogonial depletion mice. Endocrinology. 2001;142:2789-95 pubmed
    The juvenile spermatogonial depletion (jsd) mutation results in spermatogonial arrest after the first wave of spermatogenesis...