Gene Symbol: Jmjd6
Description: jumonji domain containing 6
Alias: 5730436I23Rik, D11Ertd195e, PSR, PtdSerR, Ptdsr, mKIAA0585, bifunctional arginine demethylase and lysyl-hydroxylase JMJD6, apoptotic cell clearance receptor PtdSerR, histone arginine demethylase JMJD6, jmjC domain-containing protein 6, jumonji domain-containing protein 6, lysyl-hydroxylase JMJD6, peptide-lysine 5-dioxygenase JMJD6, phosphatidylserine receptor
Species: mouse
Products:     Jmjd6

Top Publications

  1. Cikala M, Alexandrova O, David C, Pr schel M, Stiening B, Cramer P, et al. The phosphatidylserine receptor from Hydra is a nuclear protein with potential Fe(II) dependent oxygenase activity. BMC Cell Biol. 2004;5:26 pubmed publisher
    ..Surface exposure of phosphatidylserine is recognised by a specific receptor (phosphatidylserine receptor, PSR) and is required for phagocytosis of apoptotic cells by macrophages and fibroblasts. ..
  2. Unoki M, Masuda A, Dohmae N, Arita K, Yoshimatsu M, Iwai Y, et al. Lysyl 5-hydroxylation, a novel histone modification, by Jumonji domain containing 6 (JMJD6). J Biol Chem. 2013;288:6053-62 pubmed publisher
    b>JMJD6 is reported to hydroxylate lysyl residues of a splicing factor, U2AF65. In this study, we found that JMJD6 hydroxylates histone lysyl residues...
  3. Fadok V, Bratton D, Rose D, Pearson A, Ezekewitz R, Henson P. A receptor for phosphatidylserine-specific clearance of apoptotic cells. Nature. 2000;405:85-90 pubmed
    ..This candidate phosphatidylserine receptor is highly homologous to genes of unknown function in Caenorhabditis elegans and Drosophila melanogaster,..
  4. Li M, Sarkisian M, Mehal W, Rakic P, Flavell R. Phosphatidylserine receptor is required for clearance of apoptotic cells. Science. 2003;302:1560-3 pubmed
    ..Phagocytes lacking the phosphatidylserine receptor (PSR) were defective in removing apoptotic cells...
  5. Kunisaki Y, Masuko S, Noda M, Inayoshi A, Sanui T, Harada M, et al. Defective fetal liver erythropoiesis and T lymphopoiesis in mice lacking the phosphatidylserine receptor. Blood. 2004;103:3362-4 pubmed
    ..The phosphatidylserine receptor (PSR), which specifically binds to phosphatidylserine (PS) exposed on the surface of apoptotic cells, ..
  6. Hahn P, Böse J, Edler S, Lengeling A. Genomic structure and expression of Jmjd6 and evolutionary analysis in the context of related JmjC domain containing proteins. BMC Genomics. 2008;9:293 pubmed publisher
    The jumonji C (JmjC) domain containing gene 6 (Jmjd6, previously known as phosphatidylserine receptor) has misleadingly been annotated to encode a transmembrane receptor for the engulfment of apoptotic cells...
  7. Hahn P, Wegener I, Burrells A, Böse J, Wolf A, Erck C, et al. Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation. PLoS ONE. 2010;5:e13769 pubmed publisher
    ..Here, we report studies to test the involvement of Jumonji domain-containing protein 6 (Jmjd6) in histone lysine demethylation...
  8. Schneider J, Böse J, Bamforth S, Gruber A, Broadbent C, Clarke K, et al. Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique. BMC Dev Biol. 2004;4:16 pubmed
    ..Using this approach we identified cardiac malformations in phosphatidylserine receptor (Ptdsr) deficient embryos...
  9. Klose R, Kallin E, Zhang Y. JmjC-domain-containing proteins and histone demethylation. Nat Rev Genet. 2006;7:715-27 pubmed publisher
    ..Here we analyse the evolutionary relationship between Jumonji C (JmjC)-domain-containing proteins and discuss their cellular functions in relation to their potential enzymatic activities. ..

More Information


  1. Cui P, Qin B, Liu N, Pan G, Pei D. Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals. Exp Cell Res. 2004;293:154-63 pubmed
    ..A specific receptor for phosphatidylserine (PSR) has recently been identified by phage display and shown to mediate phosphatidylserine dependent phagocytosis...
  2. Böse J, Gruber A, Helming L, Schiebe S, Wegener I, Hafner M, et al. The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal. J Biol. 2004;3:15 pubmed
    ..The phosphatidylserine receptor (Ptdsr) on phagocytes has been implicated in the recognition and engulfment of apoptotic cells and in ..
  3. Williamson P, Schlegel R. Hide and seek: the secret identity of the phosphatidylserine receptor. J Biol. 2004;3:14 pubmed
    ..identified using phage display, but the phenotypes of knockout mice lacking this presumptive receptor, as well as the location of the protein within cells, cast doubt on the assignment of this protein as the phosphatidylserine receptor.
  4. Mitchell J, Cvetanovic M, Tibrewal N, Patel V, Colamonici O, Li M, et al. The presumptive phosphatidylserine receptor is dispensable for innate anti-inflammatory recognition and clearance of apoptotic cells. J Biol Chem. 2006;281:5718-25 pubmed
    The role of the presumptive phosphatidylserine receptor (PSR) in the recognition and engulfment of apoptotic cells, and the antiinflammatory response they exert, has been of great interest...
  5. Böttger A, Islam M, Chowdhury R, Schofield C, Wolf A. The oxygenase Jmjd6--a case study in conflicting assignments. Biochem J. 2015;468:191-202 pubmed publisher
    ..Jmjd6 was initially assigned a role as the phosphatidylserine receptor responsible for engulfment of apoptotic cells but this now seems unlikely...
  6. Wang F, He L, Huangyang P, Liang J, Si W, Yan R, et al. JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. PLoS Biol. 2014;12:e1001819 pubmed publisher
    Jumonji domain-containing 6 (JMJD6) is a member of the Jumonji C domain-containing family of proteins...
  7. Qi J, Qin T, Xu L, Zhang K, Yang G, Li J, et al. TNFSF15 inhibits vasculogenesis by regulating relative levels of membrane-bound and soluble isoforms of VEGF receptor 1. Proc Natl Acad Sci U S A. 2013;110:13863-8 pubmed publisher
    ..the Flt1 gene in favor of sFlt1 production by down-regulating nuclear protein Jumonji domain-containing protein 6 (Jmjd6), thus alleviating Jmjd6-inhibited sFlt1 expression...
  8. Hu Y, Belaghzal H, Hsiao W, Qi J, Bradner J, Guertin D, et al. Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6. Nucleic Acids Res. 2015;43:7790-804 pubmed publisher
    Jumonji domain-containing protein 6 (JMJD6) is a nuclear protein involved in histone modification, transcription and RNA processing...
  9. Yanagihara T, Sanematsu F, Sato T, Uruno T, Duan X, Tomino T, et al. Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus. Nat Commun. 2015;6:8820 pubmed publisher
    ..Here, we show that Jmjd6, a dioxygenase that catalyses lysyl hydroxylation of splicing regulatory proteins, is critical for Aire expression...
  10. Yanagihara T, Tomino T, Uruno T, Fukui Y. Thymic epithelial cell-specific deletion of Jmjd6 reduces Aire protein expression and exacerbates disease development in a mouse model of autoimmune diabetes. Biochem Biophys Res Commun. 2017;489:8-13 pubmed publisher
    ..We previously showed that Jmjd6, a lysyl hydroxylase for splicing regulatory proteins, is important for Aire protein expression and that ..
  11. Brower C, Rosen C, Jones R, Wadas B, Piatkov K, Varshavsky A. Liat1, an arginyltransferase-binding protein whose evolution among primates involved changes in the numbers of its 10-residue repeats. Proc Natl Acad Sci U S A. 2014;111:E4936-45 pubmed publisher
  12. Boeckel J, Guarani V, Koyanagi M, Roexe T, Lengeling A, Schermuly R, et al. Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1. Proc Natl Acad Sci U S A. 2011;108:3276-81 pubmed publisher
    ..Here, we demonstrate that silencing of Jumonji domain-containing protein 6 (Jmjd6) impairs angiogenic functions of endothelial cells by changing the gene expression and modulating the splicing of ..
  13. Monks J, Rosner D, Geske F, Lehman L, Hanson L, Neville M, et al. Epithelial cells as phagocytes: apoptotic epithelial cells are engulfed by mammary alveolar epithelial cells and repress inflammatory mediator release. Cell Death Differ. 2005;12:107-14 pubmed
    ..apoptotic cells in vitro, utilizing many of the same receptors used by macrophages, including the phosphatidylserine receptor (PSR), CD36, the vitronectin receptor alpha(v)beta3, and CD91...
  14. Todt J, Hu B, Punturieri A, Sonstein J, Polak T, Curtis J. Activation of protein kinase C beta II by the stereo-specific phosphatidylserine receptor is required for phagocytosis of apoptotic thymocytes by resident murine tissue macrophages. J Biol Chem. 2002;277:35906-14 pubmed