Jak3

Summary

Gene Symbol: Jak3
Description: Janus kinase 3
Alias: fae, wil, tyrosine-protein kinase JAK3
Species: mouse
Products:     Jak3

Top Publications

  1. Chang B, Zhao F, He X, Ren H, Braselmann S, Taylor V, et al. JAK3 inhibition significantly attenuates psoriasiform skin inflammation in CD18 mutant PL/J mice. J Immunol. 2009;183:2183-92 pubmed publisher
    b>JAK3, a member of the Janus kinase family, is predominantly expressed in hemopoietic cells and binds specifically to the common gamma chain of a subfamily of cytokine receptors that includes IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21...
  2. Witthuhn B, Silvennoinen O, Miura O, Lai K, Cwik C, Liu E, et al. Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature. 1994;370:153-7 pubmed
    ..Jak-3 activation requires the serine-rich, membrane-proximal domain of the interleukin-2 receptor beta-chain, but does not require the acidic domain that is required for association and activation of Src family kinases. ..
  3. Lv N, Kim E, Song M, Choi H, Moon W, Park S, et al. JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Exp Cell Res. 2009;315:2064-71 pubmed publisher
    JANEX-1/WHI-P131, a selective Janus kinase 3 (JAK3) inhibitor, has been shown to delay the onset of diabetes in the NOD mouse model. However, the molecular mechanism by which JANEX-1 protects pancreatic beta-cells is unknown...
  4. Shi M, Lin T, Appell K, Berg L. Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation. Immunity. 2008;28:763-73 pubmed publisher
    ..Here, we report that a third cytokine signal, mediated by the Janus family tyrosine kinase 3 (Jak3) and signal transducer and activator of transcription 5 (STAT5) pathway, is also required for Th1 cell ..
  5. Soldevila G, Licona I, Salgado A, Ramirez M, Chávez R, García Zepeda E. Impaired chemokine-induced migration during T-cell development in the absence of Jak 3. Immunology. 2004;112:191-200 pubmed
  6. Suzuki K, Nakajima H, Saito Y, Saito T, Leonard W, Iwamoto I. Janus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice. Int Immunol. 2000;12:123-32 pubmed
    ..The Janus family tyrosine kinase 3 (Jak3) is known to be associated with gamma(c), and the reported phenotypes of gamma(c)-deficient (gamma(c)(-)) and Jak3-..
  7. Nosaka T, van Deursen J, Tripp R, Thierfelder W, Witthuhn B, McMickle A, et al. Defective lymphoid development in mice lacking Jak3. Science. 1995;270:800-2 pubmed
    ..Although Jak1, Jak2, and Tyk2 are widely expressed, Jak3 is predominantly expressed in hematopoietic cells and is known to associate only with the common gamma (gamma c) ..
  8. Garcia Zepeda E, Licona Limón I, Jiménez Sólomon M, Soldevila G. Janus kinase 3-deficient T lymphocytes have an intrinsic defect in CCR7-mediated homing to peripheral lymphoid organs. Immunology. 2007;122:247-60 pubmed
    Chemokine-mediated signalling involves the activation of a Janus kinase (Jak) pathway. We have previously shown that Jak3 mediates CCR9 and CXCR4 signalling in response to CCL25 and CXCL12 in BM progenitors and thymocytes...
  9. Yamaoka K, Min B, Zhou Y, Paul W, O Shea J. Jak3 negatively regulates dendritic-cell cytokine production and survival. Blood. 2005;106:3227-33 pubmed
    Cytokines are critical in regulating the development and function of diverse cells. Janus kinase 3 (Jak3) is a tyrosine kinase expressed in hematopoietic cells that associates with the common gamma chain (gammac) and is required for ..

More Information

Publications62

  1. Thomis D, Gurniak C, Tivol E, Sharpe A, Berg L. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science. 1995;270:794-7 pubmed
    ..Specifically, Jak3 has been shown to be associated with the interleukin-2 (IL-2) receptor gamma chain, a component of the receptors ..
  2. Gurniak C, Berg L. Murine JAK3 is preferentially expressed in hematopoietic tissues and lymphocyte precursor cells. Blood. 1996;87:3151-60 pubmed
    ..investigated the expression pattern and biochemical characteristics of the murine Janus family tyrosine kinase, JAK3. Previous studies have shown that JAK3 is expressed in lymphoid and myeloid tumor cell lines and in a small number ..
  3. Park S, Saijo K, Takahashi T, Osawa M, Arase H, Hirayama N, et al. Developmental defects of lymphoid cells in Jak3 kinase-deficient mice. Immunity. 1995;3:771-82 pubmed
    b>Jak3 is a tyrosine kinase mediating cytokine receptor signaling through the association with the common gamma chain of the cytokine receptors such as IL-2, IL-4, IL-7, IL-9, and IL-15...
  4. Zyuz kov G, Zhdanov V, Udut E, Miroshnichenko L, Simanina E, Polyakova T, et al. Implication of JAK1, JAK2, and JAK3 in the Realization of Proliferation and Differentiation Potential of Mesenchymal Progenitor Cells In Vitro. Bull Exp Biol Med. 2016;161:224-7 pubmed publisher
    ..Important role of JAK2 and JAK3 in determining the initial level of mitotic activity of progenitor cells was established...
  5. Thomis D, Lee W, Berg L. T cells from Jak3-deficient mice have intact TCR signaling, but increased apoptosis. J Immunol. 1997;159:4708-19 pubmed
    The Jak family tyrosine kinase, Jak3, is involved in signaling through cytokine receptors utilizing the common gamma-chain (gamma(c))...
  6. Chopra M, Langenhorst D, Beilhack A, Serfling E, Patra A. Interleukin-2 critically regulates bone marrow erythropoiesis and prevents anemia development. Eur J Immunol. 2015;45:3362-74 pubmed publisher
  7. Pellegrini S, Dusanter Fourt I. The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs). Eur J Biochem. 1997;248:615-33 pubmed
    ..Recent findings have suggested that the interdependence of JAKs and STATs might not be absolute as originally thought. ..
  8. Thomis D, Berg L. Peripheral expression of Jak3 is required to maintain T lymphocyte function. J Exp Med. 1997;185:197-206 pubmed
    The Jak family tyrosine kinase, Jak3, is involved in signaling through cytokine receptors that utilize the common gamma chain (gammac), such as those for IL-2, IL-4, IL-7, IL-9, and IL-15...
  9. Bhavsar S, Singh Y, Sharma P, Khairnar V, Hosseinzadeh Z, Zhang S, et al. Expression of JAK3 Sensitive Na+ Coupled Glucose Carrier SGLT1 in Activated Cytotoxic T Lymphocytes. Cell Physiol Biochem. 2016;39:1209-28 pubmed publisher
    ..SGLT1 expression, function and regulation in lymphocytes, as well as dual electrode voltage clamp in SGLT1 ± JAK3 expressing Xenopus oocytes to quantify the effect of janus kinase3 (JAK3) on SGLT1 function...
  10. Wu W, Sun X. Janus kinase 3: the controller and the controlled. Acta Biochim Biophys Sin (Shanghai). 2012;44:187-96 pubmed publisher
    ..In particular, JAK3 has unique functions in the lymphoid system such that JAK3 ablation results in phenotypes resembling severe ..
  11. Kumar R, Radhika V, Audigé V, Rane S, Dhanasekaran N. Proliferation-specific genes activated by Galpha(12): a role for PDGFRalpha and JAK3 in Galpha(12)-mediated cell proliferation. Cell Biochem Biophys. 2004;41:63-73 pubmed
    ..Further studies aimed at investigating the critical role of two of such upregulated genes, namely PDGFRalpha and JAK3, indicated that the inhibition of PDGFRalpha or JAK3 activity-attenuated Galpha(12)QL-mediated serum-independent ..
  12. Regunathan J, Chen Y, Kutlesa S, Dai X, Bai L, Wen R, et al. Differential and nonredundant roles of phospholipase Cgamma2 and phospholipase Cgamma1 in the terminal maturation of NK cells. J Immunol. 2006;177:5365-76 pubmed
    ..Our results strongly demonstrate that PLCgamma1 and PLCgamma2 play nonredundant and obligatory roles in NK cell ontogeny and in its effector functions. ..
  13. Saharinen P, Silvennoinen O. The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction. J Biol Chem. 2002;277:47954-63 pubmed
    ..Here, we found that the JH2 domain negatively regulates the activity of Jak2 and Jak3. Deletion of JH2 resulted in increased tyrosine phosphorylation of the Jak2- and Jak3-JH2 deletion mutants as well ..
  14. Babon J, Lucet I, Murphy J, Nicola N, Varghese L. The molecular regulation of Janus kinase (JAK) activation. Biochem J. 2014;462:1-13 pubmed publisher
    ..This family, comprising JAK1, JAK2, JAK3 and TYK2 (tyrosine kinase 2), was first described more than 20 years ago, but the complexities underlying their ..
  15. Verbsky J, Randolph D, Shornick L, Chaplin D. Nonhematopoietic expression of Janus kinase 3 is required for efficient recruitment of Th2 lymphocytes and eosinophils in OVA-induced airway inflammation. J Immunol. 2002;168:2475-82 pubmed
    Tyrosine kinases of the Janus kinase (Jak) family transduce signals from the type I and type II cytokine receptors. Jak3 is unique in this family because its expression must be induced and is predominantly limited to cells of the lymphoid ..
  16. Goldstein J, Burlion A, Zaragoza B, Sendeyo K, Polansky J, Huehn J, et al. Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression. PLoS ONE. 2016;11:e0153682 pubmed publisher
    The IL-2/JAK3/STAT-5 signaling pathway is involved on the initiation and maintenance of the transcription factor Foxp3 in regulatory T cells (Treg) and has been associated with demethylation of the intronic Conserved Non Coding Sequence-2 ..
  17. Baird A, Lucas J, Berg L. A profound deficiency in thymic progenitor cells in mice lacking Jak3. J Immunol. 2000;165:3680-8 pubmed
    ..We have examined the first wave of developing T cells in Jak3-/-, IL-7-/-, and IL-7Ralpha-/- fetal mice, and have found a near absence of thymic progenitor cells...
  18. Yan J, Schmid E, Hosseinzadeh Z, Honisch S, Shumilina E, Fuchs J, et al. Impact of Janus Kinase 3 on Cellular Ca Release, Store Operated Ca(2+) Entry and Na(+)/Ca(2+) Exchanger Activity in Dendritic Cells. Cell Physiol Biochem. 2015;36:2287-98 pubmed publisher
    Janus kinase 3 (JAK3), a tyrosine kinase mainly expressed in hematopoietic cells, participates in the signaling stimulating cell proliferation...
  19. Ambriz Peña X, García Zepeda E, Meza I, Soldevila G. Jak3 enables chemokine-dependent actin cytoskeleton reorganization by regulating cofilin and Rac/Rhoa GTPases activation. PLoS ONE. 2014;9:e88014 pubmed publisher
    We have previously shown that Jak3 is involved in the signaling pathways of CCR7, CCR9 and CXCR4 in murine T lymphocytes and that Jak3?/? lymphocytes display an intrinsic defect in homing to peripheral lymph nodes...
  20. Imada K, Leonard W. The Jak-STAT pathway. Mol Immunol. 2000;37:1-11 pubmed
    ..Moreover, the recent discovery of the CIS/SOCS/JAB/SSI family of inhibitors has contributed to understanding how this pathway is negatively regulated. ..
  21. Brown M, Nosaka T, Tripp R, Brooks J, van Deursen J, Brenner M, et al. Reconstitution of early lymphoid proliferation and immune function in Jak3-deficient mice by interleukin-3. Blood. 1999;94:1906-14 pubmed
    ..progenitors requires interleukin-7 (IL-7), which functions through gamma(c)-mediated receptor activation of Jak3. Jak3 deficiency is a cause of severe combined immunodeficiency (SCID) in humans and mice...
  22. Ono A, Hattori S, Kariya R, Iwanaga S, Taura M, Harada H, et al. Comparative study of human hematopoietic cell engraftment into BALB/c and C57BL/6 strain of rag-2/jak3 double-deficient mice. J Biomed Biotechnol. 2011;2011:539748 pubmed publisher
    ..In this study, we generated Rag-2/Jak3 double-deficient (Rag-2?/?Jak3?/?) mice with a C57/BL6 and Balb/c genetic background and compared the human ..
  23. Dure M, Macian F. IL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genes. Mol Immunol. 2009;46:999-1006 pubmed publisher
    ..In this study we show that IL-2 receptor signaling mediated through JAK3 and mTOR inhibits the expression of anergy-inducing genes independently of any effect on cell cycle progression...
  24. Mishra J, Verma R, Alpini G, Meng F, Kumar N. Role of Janus Kinase 3 in Predisposition to Obesity-associated Metabolic Syndrome. J Biol Chem. 2015;290:29301-12 pubmed publisher
    ..Previously, we reported that Jak3 was essential for mucosal differentiation and enhanced colonic barrier functions and its loss in mice resulted in ..
  25. Bellanger D, Jacquemin V, Chopin M, Pierron G, Bernard O, Ghysdael J, et al. Recurrent JAK1 and JAK3 somatic mutations in T-cell prolymphocytic leukemia. Leukemia. 2014;28:417-9 pubmed publisher
  26. Umbach A, Luo D, Bhavsar S, Hosseinzadeh Z, Lang F. Intestinal Na+ loss and volume depletion in JAK3-deficient mice. Kidney Blood Press Res. 2013;37:514-20 pubmed publisher
    The Janus kinase 3 JAK3 participates in the signaling of immune cells...
  27. Gozalo Sanmillan S, McNally J, Lin M, Chambers C, Berg L. Cutting edge: two distinct mechanisms lead to impaired T cell homeostasis in Janus kinase 3- and CTLA-4-deficient mice. J Immunol. 2001;166:727-30 pubmed
    ..To address this possibility, we examined the TCR repertoire of peripheral T cells in Jak3(-/-) and CTLA-4(-/-) mice using complementarity-determining region 3 spectratype analysis...
  28. Springuel L, Hornakova T, Losdyck E, Lambert F, Leroy E, Constantinescu S, et al. Cooperating JAK1 and JAK3 mutants increase resistance to JAK inhibitors. Blood. 2014;124:3924-31 pubmed publisher
    ..Here, we show that this transforming event results from activating mutations either in JAK1, JAK3, or in both kinases...
  29. Dupaul Chicoine J, Arabzadeh A, Dagenais M, Douglas T, Champagne C, Morizot A, et al. The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity. Immunity. 2015;43:751-63 pubmed publisher
    ..Our results define a regulatory signaling circuit within the innate immune system linking inflammasome activation to effective NK-cell-mediated tumor attack required to suppress colorectal cancer growth in the liver. ..
  30. Doles J, Storer M, Cozzuto L, Roma G, Keyes W. Age-associated inflammation inhibits epidermal stem cell function. Genes Dev. 2012;26:2144-53 pubmed publisher
    ..Collectively, this study reveals a role for the aging epidermis in the disruption of cytokine and stem cell homeostasis, suggesting that stem cell decline during aging may be part of broader tumor-suppressive mechanisms...
  31. Junttila I, Mizukami K, Dickensheets H, Meier Schellersheim M, Yamane H, Donnelly R, et al. Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity. J Exp Med. 2008;205:2595-608 pubmed publisher
    ..These findings provide an explanation for IL-13's principal function as an "effector" cytokine and IL-4's principal role as an "immunoregulatory" cytokine. ..
  32. Tibbles H, Vassilev A, Wendorf H, Schonhoff D, Zhu D, Lorenz D, et al. Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation. J Biol Chem. 2001;276:17815-22 pubmed
    Here we provide experimental evidence that identifies JAK3 as one of the regulators of platelet function. Treatment of platelets with thrombin induced tyrosine phosphorylation of the JAK3 target substrates STAT1 and STAT3...
  33. Bunting K, Sangster M, Ihle J, Sorrentino B. Restoration of lymphocyte function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer. Nat Med. 1998;4:58-64 pubmed
    Janus kinase-3 (JAK3) deficiency has recently been identified as a cause of severe combined immunodeficiency (SCID) in humans. We used a mouse model of Jak3-deficient SCID to test a gene therapy approach for treatment of this disease...
  34. Baird A, Thomis D, Berg L. T cell development and activation in Jak3-deficient mice. J Leukoc Biol. 1998;63:669-77 pubmed
    b>Jak3, a member of the Janus family of tyrosine kinases, participates in signaling through cytokine receptors that contain the common gamma-chain, including the receptors for interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15...
  35. Eynon E, Livak F, Kuida K, Schatz D, Flavell R. Distinct effects of Jak3 signaling on alphabeta and gammadelta thymocyte development. J Immunol. 1999;162:1448-59 pubmed
    Janus kinase 3 (Jak3) plays a central role in the transduction of signals mediated by the IL-2 family of cytokine receptors...
  36. Moriggl R, Sexl V, Piekorz R, Topham D, Ihle J. Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells. Immunity. 1999;11:225-30 pubmed
    ..Here we demonstrate that activation of the Stat5 proteins by tyrosine phosphorylation is uniquely contributed by cytokine receptor signaling and specifically does not occur through the T cell receptor complex. ..
  37. Yeh T, Pellegrini S. The Janus kinase family of protein tyrosine kinases and their role in signaling. Cell Mol Life Sci. 1999;55:1523-34 pubmed
    ..Here, recent progress is reviewed, with particular emphasis on structure-function studies aimed at revealing how this family of tyrosine kinases is regulated. ..
  38. Matsumoto M. Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting. J Med Invest. 1999;46:141-50 pubmed
  39. Bhavsar S, Gu S, Bobbala D, Lang F. Janus kinase 3 is expressed in erythrocytes, phosphorylated upon energy depletion and involved in the regulation of suicidal erythrocyte death. Cell Physiol Biochem. 2011;27:547-56 pubmed publisher
    ..Janus kinase 3, a tyrosine kinase expressed in haematopoetic tissues, plays a decisive role in T-lymphocyte survival. JAK3 deficiency leads to (Severe) Combined Immunodeficiency (SCID) resulting from enhanced lymphocyte apoptosis...
  40. Saijo K, Park S, Ishida Y, Arase H, Saito T. Crucial role of Jak3 in negative selection of self-reactive T cells. J Exp Med. 1997;185:351-6 pubmed
    b>Jak3 mediates growth signals through cytokine receptors such as interleukin-2 (IL-2), IL-4, and IL-7, and its deficiency results in autosomal recessive SCID in mice and humans...
  41. Yao Z, Cui Y, Watford W, Bream J, Yamaoka K, Hissong B, et al. Stat5a/b are essential for normal lymphoid development and differentiation. Proc Natl Acad Sci U S A. 2006;103:1000-5 pubmed
    ..Mutations of the IL-7 receptor, gammac, or its associated kinase, Jak3, are the major cause of human severe combined immunodeficiency...
  42. Umbach A, Zhang B, Daniel C, Fajol A, Velic A, Hosseinzadeh Z, et al. Janus kinase 3 regulates renal 25-hydroxyvitamin D 1α-hydroxylase expression, calcitriol formation, and phosphate metabolism. Kidney Int. 2015;87:728-37 pubmed publisher
    ..INFγ-signaling includes Janus kinase 3 (JAK3) but a role of JAK3 in the regulation of 1α-hydroxylase expression and mineral metabolism has not been shown...
  43. Warsi J, Elvira B, Bissinger R, Hosseinzadeh Z, Lang F. Regulation of Voltage-Gated K+ Channel Kv1.5 by the Janus Kinase JAK3. J Membr Biol. 2015;248:1061-70 pubmed publisher
    The tyrosine kinase Janus kinase 3 (JAK3) participates in the regulation of cell proliferation and apoptosis. The kinase further influences ion channels and transport proteins...
  44. Mayack S, Berg L. Cutting edge: an alternative pathway of CD4+ T cell differentiation is induced following activation in the absence of gamma-chain-dependent cytokine signals. J Immunol. 2006;176:2059-63 pubmed
    ..Using murine CD4(+) T cells lacking the Jak3 tyrosine kinase, we show that activation of these cells in the absence of gamma-chain-dependent cytokine signals ..
  45. Warsi J, Hosseinzadeh Z, Dong L, Pakladok T, Umbach A, Bhavsar S, et al. Effect of Janus kinase 3 on the peptide transporters PEPT1 and PEPT2. J Membr Biol. 2013;246:885-92 pubmed publisher
    The tyrosine kinase Janus kinase 3 (JAK3) contributes to signaling regulating the proliferation and apoptosis of lymphocytes and tumor cells...
  46. Smith I, Roberts B, Beharry A, Godinez G, Payan D, Kinsella T, et al. Janus kinase inhibition prevents cancer- and myocardial infarction-mediated diaphragm muscle weakness in mice. Am J Physiol Regul Integr Comp Physiol. 2016;310:R707-10 pubmed publisher
    ..These experiments implicate JAK1/3 signaling in cancer- and MI-mediated diaphragm weakness in mice, and provide a compelling case for further investigation. ..
  47. Bell B, Kitajima M, Larson R, Stoklasek T, Dang K, Sakamoto K, et al. The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses. Nat Immunol. 2013;14:364-71 pubmed publisher
    ..Our results show that the TSLP-STAT5 axis in DCs is a critical component for the promotion of type 2 immunity at barrier surfaces. ..
  48. de Totero D, Meazza R, Capaia M, Fabbi M, Azzarone B, Balleari E, et al. The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways. Blood. 2008;111:517-24 pubmed
    ..of IL-15 and IL-21, which are closely related to IL-2 and share the usage of the common gamma chain and of its JAK3-associated pathway...
  49. Finbloom D, Larner A. Regulation of the Jak/STAT signalling pathway. Cell Signal. 1995;7:739-45 pubmed
  50. Brummett A, Navratil A, Bryan J, Woolard M. Janus kinase 3 activity is necessary for phosphorylation of cytosolic phospholipase A2 and prostaglandin E2 synthesis by macrophages infected with Francisella tularensis live vaccine strain. Infect Immun. 2014;82:970-82 pubmed publisher
    ..In this study, we show that cPLA2, p38 mitogen-activated protein kinase (MAPK), and Janus kinase 3 (JAK3) signaling are necessary for F. tularensis-induced PGE2 production...
  51. Murata Y, Yamashita A, Saito T, Sugamura K, Hamuro J. The conversion of redox status of peritoneal macrophages during pathological progression of spontaneous inflammatory bowel disease in Janus family tyrosine kinase 3(-/-) and IL-2 receptor gamma(-/-) mice. Int Immunol. 2002;14:627-36 pubmed
    ..Oxidative macrophages (OMp) with reduced GSH dominated initially at a younger age in both mice. OMp-dominated JAK3 or IL-2R gamma chain-deficient mice showed shortened life longevity compared with wild-type littermates...
  52. Iseki M, Takaki S, Takatsu K. Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. Biochem Biophys Res Commun. 2000;272:45-54 pubmed
    ..These results suggest that APS is a member of the Lnk family adaptor protein and likely plays a role in signaling in B cells. ..
  53. Kariya R, Taura M, Suzu S, Kai H, Katano H, Okada S. HIV protease inhibitor Lopinavir induces apoptosis of primary effusion lymphoma cells via suppression of NF-?B pathway. Cancer Lett. 2014;342:52-9 pubmed publisher
    ..In a PEL xenograft mouse model, LPV significantly inhibited the growth and invasion of PEL cells. These results suggest that LPV may have promise for the treatment and prevention of PEL, which occurs in HIV/AIDS patients. ..