Jak1

Summary

Gene Symbol: Jak1
Description: Janus kinase 1
Alias: AA960307, BAP004, C130039L05Rik, tyrosine-protein kinase JAK1, JAK-1
Species: mouse
Products:     Jak1

Top Publications

  1. Shang L, Tomasi T. The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons. J Biol Chem. 2006;281:1876-84 pubmed
    ..b>JAK1 interacts with Hsp90 and the CDC37 co-chaperone, and both interactions are destabilized by Hsp90 inhibitors...
  2. Hrabe de Angelis M, Flaswinkel H, Fuchs H, Rathkolb B, Soewarto D, Marschall S, et al. Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet. 2000;25:444-7 pubmed
    ..Our mutant lines are freely accessible to non-commercial users (for information, see http://www.gsf.de/ieg/groups/enu-mouse.html). ..
  3. Nicholson S, Willson T, Farley A, Starr R, Zhang J, Baca M, et al. Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J. 1999;18:375-85 pubmed
    ..Thus, although inhibition of signaling by SOCS-1 and SOCS-3 requires both the SH2 and N-terminal domains, their mechanisms of action appear to be biochemically different. ..
  4. Rodig S, Meraz M, White J, Lampe P, Riley J, Arthur C, et al. Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell. 1998;93:373-83 pubmed
    Herein we report the generation of mice lacking the ubiquitously expressed Janus kinase, Jak1. Jak1-/- mice are runted at birth, fail to nurse, and die perinatally...
  5. Agilan B, Rajendra Prasad N, Kanimozhi G, Karthikeyan R, Ganesan M, Mohana S, et al. Caffeic Acid Inhibits Chronic UVB-Induced Cellular Proliferation Through JAK-STAT3 Signaling in Mouse Skin. Photochem Photobiol. 2016;92:467-74 pubmed publisher
    ..study, chronic UVB irradiation (180 mJ cm(-2) ; weekly thrice for 30 weeks) induces the expression of IL-10 and JAK1 that eventually activates the STAT3 which leads to the transcription of proliferative and antiapoptotic markers ..
  6. Ashino S, Takeda K, Li H, Taylor V, Joetham A, Pine P, et al. Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses. J Allergy Clin Immunol. 2014;133:1162-74 pubmed publisher
    Janus kinases (JAKs) are regulators of signaling through cytokine receptors. The importance of JAK1/3 signaling on TH2 differentiation and development of lung allergic responses has not been investigated...
  7. Yin T, Tsang M, Yang Y. JAK1 kinase forms complexes with interleukin-4 receptor and 4PS/insulin receptor substrate-1-like protein and is activated by interleukin-4 and interleukin-9 in T lymphocytes. J Biol Chem. 1994;269:26614-7 pubmed
    ..tyrosine-phosphorylated protein as 4PS/insulin receptor substrate-1-like (IRS-1L) protein and 130-kDa protein as JAK1 kinase...
  8. Ghoreschi K, Jesson M, Li X, Lee J, Ghosh S, Alsup J, et al. Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). J Immunol. 2011;186:4234-43 pubmed publisher
    ..Furthermore, efficacy in this disease model correlated with the inhibition of both JAK1 and JAK3 signaling pathways...
  9. Boyle K, Zhang J, Nicholson S, Trounson E, Babon J, McManus E, et al. Deletion of the SOCS box of suppressor of cytokine signaling 3 (SOCS3) in embryonic stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylation. Cell Signal. 2009;21:394-404 pubmed publisher
    ..using over-expression studies in cell lines and is thought to involve interactions with both the gp130 receptor and JAK1. Here, we compare the endogenous JAK/STAT signaling pathway downstream of Leukemia Inhibitory Factor (LIF) ..

More Information

Publications62

  1. Sabrautzki S, Rubio Aliaga I, Hans W, Fuchs H, Rathkolb B, Calzada Wack J, et al. New mouse models for metabolic bone diseases generated by genome-wide ENU mutagenesis. Mamm Genome. 2012;23:416-30 pubmed publisher
    ..All new mutant mouse lines are offered as a resource for the scientific community. ..
  2. Degryse S, de Bock C, Cox L, Demeyer S, Gielen O, Mentens N, et al. JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model. Blood. 2014;124:3092-100 pubmed publisher
    ..JAK3 pseudokinase mutants were dependent on Jak1 kinase activity for cellular transformation, whereas the JAK3 kinase domain mutant could transform cells in a Jak1 ..
  3. Linossi E, Chandrashekaran I, Kolesnik T, Murphy J, Webb A, Willson T, et al. Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1. PLoS ONE. 2013;8:e70536 pubmed publisher
    ..Co-expression of SOCS5 was able to specifically reduce JAK1 and JAK2 (but not JAK3 or TYK2) autophosphorylation and this function required both the conserved JIR and ..
  4. Akifusa S, Kamio N, Shimazaki Y, Yamaguchi N, Nonaka K, Yamashita Y. Involvement of the JAK-STAT pathway and SOCS3 in the regulation of adiponectin-generated reactive oxygen species in murine macrophage RAW 264 cells. J Cell Biochem. 2010;111:597-606 pubmed publisher
    ..These results suggest that the JAK-STAT pathway, which can be suppressed by SOCS3 expression, is involved in gAd-induced ROS and NO generation followed by apoptotic cell death. ..
  5. Cha Y, Moon B, Lee M, Ahn H, Lee H, Lee K, et al. Zap70 functions to maintain stemness of mouse embryonic stem cells by negatively regulating Jak1/Stat3/c-Myc signaling. Stem Cells. 2010;28:1476-86 pubmed publisher
  6. Chuang C, Greenside P, Rogers Z, Brady J, Yang D, Ma R, et al. Molecular definition of a metastatic lung cancer state reveals a targetable CD109-Janus kinase-Stat axis. Nat Med. 2017;23:291-300 pubmed publisher
  7. Aringer M, Cheng A, Nelson J, Chen M, Sudarshan C, Zhou Y, et al. Janus kinases and their role in growth and disease. Life Sci. 1999;64:2173-86 pubmed
    Janus kinases (JAK) play a crucial role in the initial steps of cytokine signaling. Each of the four members (JAK1, JAK2, JAK3, TYK2) of this non-receptor tyrosine kinase family is indispensable for the effects of distinct cytokines...
  8. Brunskill E, Witte D, Yutzey K, Potter S. Novel cell lines promote the discovery of genes involved in early heart development. Dev Biol. 2001;235:507-20 pubmed
    ..The results show that the 1H and ECL-2 cell lines can be used to discover novel genes expressed in the early cardiomyocyte. ..
  9. Wilks A. Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction. Proc Natl Acad Sci U S A. 1989;86:1603-7 pubmed
    ..The PCR library was then screened by DNA sequencing for PTK-related sequences. Two sequences were identified that, on the basis of sequence comparison with known PTKs, may encode representatives of a new class of PTK. ..
  10. Rochman Y, Kashyap M, Robinson G, Sakamoto K, Gomez Rodriguez J, Wagner K, et al. Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling. Proc Natl Acad Sci U S A. 2010;107:19455-60 pubmed publisher
    ..We now demonstrate the role of JAK1 and JAK2 in TSLP-mediated STAT5 phosphorylation in mouse and human primary CD4(+) T cells, in contrast to the known ..
  11. Li Y, He W, Jha K, Klotz K, Kim Y, Mandal A, et al. FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis. J Biol Chem. 2007;282:34104-19 pubmed
    ..Due to its temporal appearance during spermiogenesis and location at the cortex of the fibrous sheath, FSCB is postulated to be involved in the later stages of fibrous sheath assembly...
  12. Liu P, Caulder E, Li J, Waeltz P, Margulis A, Wynn R, et al. Combined inhibition of Janus kinase 1/2 for the treatment of JAK2V617F-driven neoplasms: selective effects on mutant cells and improvements in measures of disease severity. Clin Cancer Res. 2009;15:6891-900 pubmed publisher
    ..We tested the efficacy of a selective JAK1/2 inhibitor in cellular and in vivo models of JAK2-driven malignancy...
  13. Liu M, Bao S, Napolitano J, Burris D, Yu L, Tridandapani S, et al. Zinc regulates the acute phase response and serum amyloid A production in response to sepsis through JAK-STAT3 signaling. PLoS ONE. 2014;9:e94934 pubmed publisher
  14. Hanisch U, Lyons S, Prinz M, Nolte C, Weber J, Kettenmann H, et al. Mouse brain microglia express interleukin-15 and its multimeric receptor complex functionally coupled to Janus kinase activity. J Biol Chem. 1997;272:28853-60 pubmed
    ..Microglial IL-15 could thus play a pivotal role in the CNS and may participate in certain CNS and neuroendocrine functions previously ascribed to IL-2. ..
  15. Tang L, Heller M, Meng Z, Yu L, Tang Y, Zhou M, et al. Transforming Growth Factor-β (TGF-β) Directly Activates the JAK1-STAT3 Axis to Induce Hepatic Fibrosis in Coordination with the SMAD Pathway. J Biol Chem. 2017;292:4302-4312 pubmed publisher
    ..Here, we report that JAK1 is a constitutive TGFβRI binding protein and is absolutely required for phosphorylation of STATs in a SMAD-..
  16. Kumar A, Toscani A, Rane S, Reddy E. Structural organization and chromosomal mapping of JAK3 locus. Oncogene. 1996;13:2009-14 pubmed
    ..Partial genomic clones of the JAK1 and JAK2 genes encoding the tyrosine kinase domain were also isolated and compared with JAK3...
  17. Springuel L, Losdyck E, Saussoy P, Turcq B, Mahon F, Knoops L, et al. Loss of mutL homolog-1 (MLH1) expression promotes acquisition of oncogenic and inhibitor-resistant point mutations in tyrosine kinases. Cell Mol Life Sci. 2016;73:4739-4748 pubmed
    ..We previously reported that the IL-9-dependent TS1 cell line sequentially acquired activating substitutions in JAK1 and JAK3 upon successive selections for growth factor independent and JAK inhibitor-resistant cells, suggestive of ..
  18. Witthuhn B, Silvennoinen O, Miura O, Lai K, Cwik C, Liu E, et al. Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature. 1994;370:153-7 pubmed
    ..Jak-3 activation requires the serine-rich, membrane-proximal domain of the interleukin-2 receptor beta-chain, but does not require the acidic domain that is required for association and activation of Src family kinases. ..
  19. Duran A, Rodriguez A, Martin P, Serrano M, Flores J, Leitges M, et al. Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis. EMBO J. 2004;23:4595-605 pubmed
    ..Stat6 tyrosine phosphorylation and Jak1 activation were ablated in the liver of ConA-injected PKCzeta-/- mice and in IL-4-stimulated PKCzeta-/- fibroblasts...
  20. Cha Y, Park K. SHP2 is a downstream target of ZAP70 to regulate JAK1/STAT3 and ERK signaling pathways in mouse embryonic stem cells. FEBS Lett. 2010;584:4241-6 pubmed publisher
    ..a Syk family tyrosine kinase, is expressed in mouse embryonic stem cells (mESCs) and regulates the Janus kinase 1 (JAK1)/signal transducer and activator of transcription 3 (STAT3) signaling through consolidating SHP1 enzymatic activity...
  21. Zyuz kov G, Zhdanov V, Udut E, Miroshnichenko L, Simanina E, Polyakova T, et al. Implication of JAK1, JAK2, and JAK3 in the Realization of Proliferation and Differentiation Potential of Mesenchymal Progenitor Cells In Vitro. Bull Exp Biol Med. 2016;161:224-7 pubmed publisher
    ..Blockade of JAK3 increased the rate of progenitor element differentiation. JAK1 had no effect on proliferation and differentiation status of progenitor cells.
  22. Hornakova T, Springuel L, Devreux J, Dusa A, Constantinescu S, Knoops L, et al. Oncogenic JAK1 and JAK2-activating mutations resistant to ATP-competitive inhibitors. Haematologica. 2011;96:845-53 pubmed publisher
    Activating mutations in JAK1 and JAK2 have been described in patients with various hematologic malignancies including acute lymphoblastic leukemia and myeloproliferative neoplasms, leading to clinical trials with JAK inhibitors...
  23. Li T, Wang W, Li T. [Regulatory effect of resveratrol on JAK1/STAT3 signal transduction pathway in leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008;16:772-6 pubmed
    ..The results indicated that resveratrol could significantly inhibit the JAK1/STAT3 signal transduction pathway, down-regulate expressions of pJAK1 and pSTAT3 and reduce the phosphorylation of ..
  24. Yasuda T, Fukada T, Nishida K, Nakayama M, Matsuda M, Miura I, et al. Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis. J Clin Invest. 2016;126:2064-76 pubmed publisher
    ..These mice harbor a mutation that results in a single aa substitution in the JAK1 tyrosine kinase that results in hyperactivation, thereby leading to skin serine protease overexpression and ..
  25. Liu Z, Baskaran R, Lea Chou E, Wood L, Chen Y, Karin M, et al. Three distinct signalling responses by murine fibroblasts to genotoxic stress. Nature. 1996;384:273-6 pubmed
    ..These findings show that signals generated by genotoxins are transduced by multiple, independent pathways. Only p53 appears to be a universal sensor of genotoxic stress. ..
  26. Novotny Diermayr V, Lin B, Gu L, Cao X. Modulation of the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction. J Biol Chem. 2005;280:12747-57 pubmed
    ..These studies may open up a link between the oncogenic effect of LMO proteins and their regulatory role in cytokine signaling in general. ..
  27. Huang E, Zhu G, Jiang W, Yang K, Gao Y, Luo Q, et al. Growth hormone synergizes with BMP9 in osteogenic differentiation by activating the JAK/STAT/IGF1 pathway in murine multilineage cells. J Bone Miner Res. 2012;27:1566-75 pubmed publisher
    ..Thus, it is conceivable that the BMP9-GH-IGF axis may be exploited as an innovative strategy to enhance osteogenesis in regenerative medicine. ..
  28. Zyuz kov G, Zhdanov V, Udut E, Miroshnichenko L, Simanina E, Polyakova T, et al. Involvement of JAK1, JAK2, and JAK3 in Stimulation of Functional Activity of Mesenchymal Progenitor Cells by Fibroblast Growth Factor. Bull Exp Biol Med. 2016;162:240-243 pubmed
    ..role of JAK2 and JAK3 in determining the initial level of mitotic activity of progenitor cells and participation of JAK1 in this process under conditions of cytokine stimulation of progenitor cells were demonstrated...
  29. Meares G, Liu Y, Rajbhandari R, Qin H, Nozell S, Mobley J, et al. PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation. Mol Cell Biol. 2014;34:3911-25 pubmed publisher
    ..do not easily succumb to ER stress but rather activate an inflammatory program involving activation of STAT3 in a JAK1-dependent fashion...
  30. Mapes J, Li Q, Kannan A, Anandan L, Laws M, Lydon J, et al. CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy. PLoS Genet. 2017;13:e1006654 pubmed publisher
    ..Proteomic studies further revealed that CUZD1 interacts with a complex containing JAK1/JAK2 and STAT5, downstream transducers of prolactin signaling in the mammary gland...
  31. Kumamoto T, Fujii M, Hou D. Myricetin directly targets JAK1 to inhibit cell transformation. Cancer Lett. 2009;275:17-26 pubmed publisher
    b>JAK1/STAT3 pathway has been suggested to play a role in cell transformation and carcinogenesis...
  32. Hirata N, Yanagawa Y, Iwabuchi K, Onoe K. Selective regulation of interleukin-10 production via Janus kinase pathway in murine conventional dendritic cells. Cell Immunol. 2009;258:9-17 pubmed publisher
    ..LY294002, a specific inhibitor of PI3K, markedly inhibited the DC production of IL-10. Thus, JAK-PI3K axis appeared to be responsible for the IL-10 production by DCs. ..
  33. Sun L, Ma K, Wang H, Xiao F, Gao Y, Zhang W, et al. JAK1-STAT1-STAT3, a key pathway promoting proliferation and preventing premature differentiation of myoblasts. J Cell Biol. 2007;179:129-38 pubmed
    ..We demonstrate that Janus kinase 1 (JAK1) is required for myoblast proliferation and that it also functions as a checkpoint to prevent myoblasts from ..
  34. Knoops L, Hornakova T, Royer Y, Constantinescu S, Renauld J. JAK kinases overexpression promotes in vitro cell transformation. Oncogene. 2008;27:1511-9 pubmed
    ..Microarray analysis pointed to JAK1 overexpression as a key genetic event in this transformation...
  35. Finidori J, Kelly P. Cytokine receptor signalling through two novel families of transducer molecules: Janus kinases, and signal transducers and activators of transcription. J Endocrinol. 1995;147:11-23 pubmed
  36. Larner A, Finbloom D. Protein tyrosine phosphorylation as a mechanism which regulates cytokine activation of early response genes. Biochim Biophys Acta. 1995;1266:278-87 pubmed
  37. Quelle F, Thierfelder W, Witthuhn B, Tang B, Cohen S, Ihle J. Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor. J Biol Chem. 1995;270:20775-80 pubmed
    ..Co-expression of Stat1 with Tyk2, Jak1, or Jak2 resulted in the specific tyrosine phosphorylation of Stat1 at Tyr701, the residue phosphorylated in ..
  38. Yang X, Chung D, Cepko C. Molecular cloning of the murine JAK1 protein tyrosine kinase and its expression in the mouse central nervous system. J Neurosci. 1993;13:3006-17 pubmed
    ..clone to screen a mouse eye cDNA library, a full-length cDNA of a cytoplasmic tyrosine kinase, the homolog of human JAK1, was obtained...
  39. Pritchard M, Baker E, Callen D, Sutherland G, Wilks A. Two members of the JAK family of protein tyrosine kinases map to chromosomes 1p31.3 and 9p24. Mamm Genome. 1992;3:36-8 pubmed
    A member of a new class of protein tyrosine kinases, JAK1, has been mapped to 1p31.3 by in situ hybridization and Southern blot analysis of a panel of mouse-human hybrid cell lines...
  40. Domanski P, Yan H, Witte M, Krolewski J, Colamonici O. Homodimerization and intermolecular tyrosine phosphorylation of the Tyk-2 tyrosine kinase. FEBS Lett. 1995;374:317-22 pubmed
    ..The formation of the Tyk-2 homodimer is independent of both tyrosine phosphorylation and the presence of the tyrosine kinase domain. ..
  41. Carniti C, Gimondi S, Vendramin A, Recordati C, Confalonieri D, Bermema A, et al. Pharmacologic Inhibition of JAK1/JAK2 Signaling Reduces Experimental Murine Acute GVHD While Preserving GVT Effects. Clin Cancer Res. 2015;21:3740-9 pubmed publisher
    ..We examined the effect of JAK1/JAK2 modulation by ruxolitinib in a mouse model of fully MHC mismatched bone marrow transplant comprising in vivo ..
  42. Works M, Yin F, Yin C, Yiu Y, Shew K, Tran T, et al. Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axis. J Immunol. 2014;193:3278-87 pubmed publisher
    ..In this study, we report the activity of SAR-20347, a small molecule inhibitor with specificity for JAK1 and tyrosine kinase 2 (TYK2) over other JAK family members...
  43. Pellegrini S, Dusanter Fourt I. The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs). Eur J Biochem. 1997;248:615-33 pubmed
    ..Recent findings have suggested that the interdependence of JAKs and STATs might not be absolute as originally thought. ..
  44. Babon J, Lucet I, Murphy J, Nicola N, Varghese L. The molecular regulation of Janus kinase (JAK) activation. Biochem J. 2014;462:1-13 pubmed publisher
    ..This family, comprising JAK1, JAK2, JAK3 and TYK2 (tyrosine kinase 2), was first described more than 20 years ago, but the complexities ..
  45. Hao A, Novotny Diermayr V, Bian W, Lin B, Lim C, Jing N, et al. The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities. Mol Biol Cell. 2005;16:1569-83 pubmed
    ..We found that Isl1 not only forms a complex with Jak1 and Stat3 but also triggers the tyrosine phosphorylation of Jak1 and its kinase activity, thereby elevating the ..
  46. Keil E, Finkenstädt D, Wufka C, Trilling M, Liebfried P, Strobl B, et al. Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation. Blood. 2014;123:520-9 pubmed publisher
    ..loop mutant uncover an essential scaffolding function of Jak2 within the IFNGR receptor complex and reveal that Jak1 can mediate a semi-redundant function for IFNGR signal transduction...
  47. Proietti C, Salatino M, Rosemblit C, Carnevale R, Pecci A, Kornblihtt A, et al. Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells. Mol Cell Biol. 2005;25:4826-40 pubmed
    ..In addition, MPA induced rapid, nongenomic Stat3, Jak1, and Jak2 tyrosine phosphorylation in C4HD and T47D cells...
  48. Pérez Rivero G, Cascio G, Soriano S, Sanz A, de Guinoa J, Rodríguez Frade J, et al. Janus kinases 1 and 2 regulate chemokine-mediated integrin activation and naïve T-cell homing. Eur J Immunol. 2013;43:1745-57 pubmed publisher
    ..Reduced JAK1 and JAK2 expression impaired naïve T-cell migration in response to gradients of the chemokines CXCL12 and CCL21...
  49. Van Nguyen T, Angkasekwinai P, Dou H, Lin F, Lu L, Cheng J, et al. SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation. Mol Cell. 2012;45:210-21 pubmed publisher
    ..These results demonstrate a crucial role of SENP1 in the regulation of STAT5 activation during early lymphoid development. ..
  50. Naggert J, Harris T, North M. The genetics of obesity. Curr Opin Genet Dev. 1997;7:398-404 pubmed
    ..These genes have led to new insights into the etiology of obesity and provide promising targets for therapeutic intervention. ..
  51. Kono D, Owens D, Wechsler A. Jak3 maps to chromosome 8. Mamm Genome. 1996;7:476-7 pubmed
  52. Hellgren G, Jansson J, Carlsson L, Carlsson B. The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver. Growth Horm IGF Res. 1999;9:212-8 pubmed
    ..In addition, growth hormone (GH) stimulates tyrosine phosphorylation of Jak1 and Jak3 in certain cell lines, while the effect on Tyk2 has not been analysed...
  53. Stahl N, Boulton T, Farruggella T, Ip N, Davis S, Witthuhn B, et al. Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components. Science. 1994;263:92-5 pubmed
    ..Unlike other cytokine receptors studied to date, the receptors for the CNTF cytokine family utilize all known members of the Jak-Tyk family, but induce distinct patterns of Jak-Tyk phosphorylation in different cell lines. ..