Gene Symbol: Izumo
Description: izumo sperm-egg fusion 1
Alias: 1700058F15Rik, Izumo, izumo sperm-egg fusion protein 1, OBF, oocyte binding/fusion factor, sperm-specific protein Izumo
Species: mouse
Products:     Izumo

Top Publications

  1. Inoue N, Hamada D, Kamikubo H, Hirata K, Kataoka M, Yamamoto M, et al. Molecular dissection of IZUMO1, a sperm protein essential for sperm-egg fusion. Development. 2013;140:3221-9 pubmed publisher
  2. Ellerman D, Pei J, Gupta S, Snell W, Myles D, Primakoff P. Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. Mol Reprod Dev. 2009;76:1188-99 pubmed publisher
    b>Izumo, a sperm membrane protein, is essential for gamete fusion in the mouse. It has an Immunoglobulin (Ig) domain and an N-terminal domain for which neither the functions nor homologous sequences are known...
  3. Inoue N, Ikawa M, Okabe M. Putative sperm fusion protein IZUMO and the role of N-glycosylation. Biochem Biophys Res Commun. 2008;377:910-4 pubmed publisher
    b>IZUMO is the mouse sperm protein proven to be essential for fusion with eggs. It contains one immunoglobulin-like domain with a conserved glycosylation site within...
  4. Bianchi E, Doe B, Goulding D, Wright G. Juno is the egg Izumo receptor and is essential for mammalian fertilization. Nature. 2014;508:483-7 pubmed publisher
    ..Our discovery of an essential receptor pair at the nexus of conception provides opportunities for the rational development of new fertility treatments and contraceptives. ..
  5. Satouh Y, Inoue N, Ikawa M, Okabe M. Visualization of the moment of mouse sperm-egg fusion and dynamic localization of IZUMO1. J Cell Sci. 2012;125:4985-90 pubmed publisher
    ..Translocation of IZUMO1 during the fertilization process was clarified, and a fundamental mechanism in mammalian fertilization is postulated...
  6. Inoue N, Ikawa M, Isotani A, Okabe M. The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs. Nature. 2005;434:234-8 pubmed
    ..We have termed the gene Izumo and produced a gene-disrupted mouse line. Izumo-/- mice were healthy but males were sterile...
  7. Wang M, Lv Z, Shi J, Hu Y, Xu C. Immunocontraceptive potential of the Ig-like domain of Izumo. Mol Reprod Dev. 2009;76:794-801 pubmed publisher
    To investigate whether the Ig-like domain of sperm protein Izumo or the other part of the protein could be used as an immunocontraceptive antigen, three partially overlapping cDNA fragments (PA, PB, and PC), together covering entire ..
  8. Inoue N, Kasahara T, Ikawa M, Okabe M. Identification and disruption of sperm-specific angiotensin converting enzyme-3 (ACE3) in mouse. PLoS ONE. 2010;5:e10301 pubmed publisher
  9. Inoue N, Satouh Y, Ikawa M, Okabe M, Yanagimachi R. Acrosome-reacted mouse spermatozoa recovered from the perivitelline space can fertilize other eggs. Proc Natl Acad Sci U S A. 2011;108:20008-11 pubmed publisher
    ..Thus, the concept that acrosome-reacted spermatozoa are unable to bind to the ZP and have lost their fertilizing capacity must be reconsidered...

More Information


  1. Inoue N, Hagihara Y, Wright D, Suzuki T, Wada I. Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm-egg fusion in mice. Nat Commun. 2015;6:8858 pubmed publisher
  2. Fujihara Y, Murakami M, Inoue N, Satouh Y, Kaseda K, Ikawa M, et al. Sperm equatorial segment protein 1, SPESP1, is required for fully fertile sperm in mouse. J Cell Sci. 2010;123:1531-6 pubmed publisher
    ..It was demonstrated that SPESP1 is necessary to produce the fully 'fusion competent' sperm. ..
  3. An G, Huang T, Wang D, Xie Q, Ma L, Chen D. In vitro and in vivo studies evaluating recombinant plasmid pCXN2-mIzumo as a potential immunocontraceptive antigen. Am J Reprod Immunol. 2009;61:227-35 pubmed publisher
    ..b>Izumo cDNA positive bands were detected in sample from mice immunized with pCXN2-mIzumo...
  4. Miranda P, Allaire A, Sosnik J, Visconti P. Localization of low-density detergent-resistant membrane proteins in intact and acrosome-reacted mouse sperm. Biol Reprod. 2009;80:897-904 pubmed publisher
    ..In this study, a subset of these proteins (TEX101, basigin, hexokinase 1, facilitated glucose transporter 3, IZUMO, and SPAM1) and other molecules known to be enriched in membrane rafts (caveolin 2, flotillin 1, flotillin 2, and ..
  5. Chalbi M, Barraud Lange V, Ravaux B, Howan K, Rodriguez N, Soule P, et al. Binding of sperm protein Izumo1 and its egg receptor Juno drives Cd9 accumulation in the intercellular contact area prior to fusion during mammalian fertilization. Development. 2014;141:3732-9 pubmed publisher
  6. Ohto U, Ishida H, Krayukhina E, Uchiyama S, Inoue N, Shimizu T. Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization. Nature. 2016;534:566-9 pubmed publisher
    ..IZUMO1 exhibits an elongated rod-shaped structure comprised of a helical bundle IZUMO domain and an immunoglobulin-like domain that are each firmly anchored to an intervening ?-hairpin region through ..
  7. Young S, Miyata H, Satouh Y, Muto M, Larsen M, Aitken R, et al. CRISPR/Cas9-mediated mutation revealed cytoplasmic tail is dispensable for IZUMO1 function and male fertility. Reproduction. 2016;152:665-672 pubmed
  8. Nishimura H, Gupta S, Myles D, Primakoff P. Characterization of mouse sperm TMEM190, a small transmembrane protein with the trefoil domain: evidence for co-localization with IZUMO1 and complex formation with other sperm proteins. Reproduction. 2011;141:437-51 pubmed publisher
    ..These findings suggest that a mouse sperm protein complex(es) including TMEM190 plays an indirect role(s) in sperm-oocyte fusion. The role(s), if any, is probably dispensable since Tmem190-null male mice were normally fertile. ..
  9. Baker M, Hetherington L, Weinberg A, Naumovski N, Velkov T, Pelzing M, et al. Analysis of phosphopeptide changes as spermatozoa acquire functional competence in the epididymis demonstrates changes in the post-translational modification of Izumo1. J Proteome Res. 2012;11:5252-64 pubmed publisher
    ..A model is advanced suggesting that these phospho-regulations are likely to act as a scaffold for the association of adaptor proteins with Izumo1 as these cells prepare for fertilization. ..
  10. Xue F, Wang L, Liu Y, Tang H, Xu W, Xu C. Vaccination with an Epitope Peptide of IZUMO1 to Induce Contraception in Female Mice. Am J Reprod Immunol. 2016;75:474-85 pubmed publisher
    ..IZUMO1 plays an important role in the fusion of the sperm and ovum during fertilization. Izumo(-/-) mice are infertile...
  11. Nishimura K, Han L, Bianchi E, Wright G, de Sanctis D, Jovine L. The structure of sperm Izumo1 reveals unexpected similarities with Plasmodium invasion proteins. Curr Biol. 2016;26:R661-2 pubmed publisher
    ..These observations suggest a link between the molecular mechanisms underlying host cell invasion by the malaria parasite and gamete membrane fusion at fertilization. ..