Genomes and Genes
Gene Symbol: Itpr1
Description: inositol 1,4,5-trisphosphate receptor 1
Alias: D6Pas2, Gm10429, IP3R 1, IP3R1, InsP3R, Ip3r, Itpr-1, P400, Pcp-1, Pcp1, insP3R1, opt, wblo, inositol 1,4,5-trisphosphate receptor type 1, IP3 receptor, InsP>3
- Kawaai K, Hisatsune C, Kuroda Y, Mizutani A, Tashiro T, Mikoshiba K. 80K-H interacts with inositol 1,4,5-trisphosphate (IP3) receptors and regulates IP3-induced calcium release activity. J Biol Chem. 2009;284:372-80 pubmed publisher..80K-H directly interacted with IP3R type 1 (IP3R1) in vitro and co-immunoprecipitated with IP3R1 in cell lysates...
- Decuypere J, Monaco G, Kiviluoto S, Oh Hora M, Luyten T, De Smedt H, et al. STIM1, but not STIM2, is required for proper agonist-induced Ca2+ signaling. Cell Calcium. 2010;48:161-7 pubmed publisher..Our data do not provide experimental evidence for the suggestion that STIM proteins would directly control the function of the IP(3) receptor. ..
- Matsumoto M, Nakagawa T, Inoue T, Nagata E, Tanaka K, Takano H, et al. Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor. Nature. 1996;379:168-71 pubmed..b>Type 1 InsP3 receptor (IP3R1) is the major neuronal member of the IP3R family in the central nervous system, predominantly ..
- Yamada M, Miyawaki A, Saito K, Nakajima T, Yamamoto Hino M, Ryo Y, et al. The calmodulin-binding domain in the mouse type 1 inositol 1,4,5-trisphosphate receptor. Biochem J. 1995;308 ( Pt 1):83-8 pubmed..amino acid sequence responsible for the calmodulin (CaM)-binding ability of mouse type 1 Ins(1,4,5)P3 receptor (IP3R1). We expressed various parts of IP3R1 from deleted cDNA and examined their CaM-binding ability...
- Sugawara T, Hisatsune C, Le T, Hashikawa T, Hirono M, Hattori M, et al. Type 1 inositol trisphosphate receptor regulates cerebellar circuits by maintaining the spine morphology of purkinje cells in adult mice. J Neurosci. 2013;33:12186-96 pubmed publisher..Here we show that the calcium channel type 1 inositol trisphosphate receptor (IP3R1) in PCs plays a crucial role in controlling the maintenance of parallel fiber (PF)-PC synaptic circuits in the ..
- Rosemblit N, Moschella M, Ondriasova E, Gutstein D, Ondrias K, Marks A. Intracellular calcium release channel expression during embryogenesis. Dev Biol. 1999;206:163-77 pubmedThe release of intracellular calcium (Ca2+) via either inositol 1,4, 5-trisphosphate receptors (IP3R) or ryanodine receptors (RyR) activates a wide variety of signaling pathways in virtually every type of cell...
- Jiang Q, Thrower E, Chester D, Ehrlich B, Sigworth F. Three-dimensional structure of the type 1 inositol 1,4,5-trisphosphate receptor at 24 A resolution. EMBO J. 2002;21:3575-81 pubmed..A central opening in this domain, which is occluded on the cytoplasmic half, outlines a pathway for calcium flow in the open state of the channel. ..
- Hirota J, Ando H, Hamada K, Mikoshiba K. Carbonic anhydrase-related protein is a novel binding protein for inositol 1,4,5-trisphosphate receptor type 1. Biochem J. 2003;372:435-41 pubmed..This could be due to co-expression of CARP with IP(3)R in Purkinje cells and its inhibitory effects on IP(3) binding. ..
- Ando H, Mizutani A, Kiefer H, Tsuzurugi D, Michikawa T, Mikoshiba K. IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor. Mol Cell. 2006;22:795-806 pubmed..We previously identified an IP3R binding protein, IRBIT, which binds to the IP3 binding domain of IP3R and is dissociated from IP3R in the presence ..
- Mohler P, Davis J, Davis L, Hoffman J, Michaely P, Bennett V. Inositol 1,4,5-trisphosphate receptor localization and stability in neonatal cardiomyocytes requires interaction with ankyrin-B. J Biol Chem. 2004;279:12980-7 pubmed..These new results provide the first physiological evidence of a molecular partner required for early post-translational stability of InsP(3)R. ..
- Furuichi T, Yoshikawa S, Miyawaki A, Wada K, Maeda N, Mikoshiba K. Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400. Nature. 1989;342:32-8 pubmedCloning and expression of functional P400 protein from cerebellar Purkinje neurons shows that this protein is a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
- Street V, Bosma M, Demas V, Regan M, Lin D, Robinson L, et al. The type 1 inositol 1,4,5-trisphosphate receptor gene is altered in the opisthotonos mouse. J Neurosci. 1997;17:635-45 pubmed..Genetic and molecular data presented here demonstrate that the type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) protein, which serves as an IP3-gated channel to release calcium from intracellular stores, is altered in the opt ..
- Fissore R, Longo F, Anderson E, Parys J, Ducibella T. Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes. Biol Reprod. 1999;60:49-57 pubmedIn mammalian fertilization, inositol 1,4,5-trisphosphate receptor (IP3R)-dependent Ca2+ release is a crucial signaling event that originates from the vicinity of sperm-egg interaction and spreads as a wave throughout the egg cytoplasm...
- Knight M, Kennerson M, Anney R, Matsuura T, Nicholson G, Salimi Tari P, et al. Spinocerebellar ataxia type 15 (sca15) maps to 3p24.2-3pter: exclusion of the ITPR1 gene, the human orthologue of an ataxic mouse mutant. Neurobiol Dis. 2003;13:147-57 pubmed..6-cM region flanked by the markers D3S3630 and D3S1304. The mouse syntenic region contains two ataxic mutants, itpr1-/- and opt, affecting the inositol 1,4,5-triphosphate type 1 receptor, ITPR1 gene...
- Bauer P, Hudec R, Ozaki S, Okuno M, Ebisui E, Mikoshiba K, et al. Genetic ablation and chemical inhibition of IP3R1 reduce mutant huntingtin aggregation. Biochem Biophys Res Commun. 2011;416:13-7 pubmed publisher..Previously, it has been shown that inhibition of the inositol 1,4,5-trisphosphate receptor type 1 (IP3R1) activity reduced aggregation of pathogenic polyQ proteins...
- Zhang S, Mizutani A, Hisatsune C, Higo T, Bannai H, Nakayama T, et al. Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cells. J Biol Chem. 2003;278:4048-56 pubmed..1N blocks the localization of co-expressed IP(3)R1 at the basolateral membrane domain. These data indicate that 4.1N is required for IP(3)R1 translocation to the basolateral membrane domain in polarized MDCK cells. ..
- Liu X, Lee K, Herbison A. Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels. Endocrinology. 2008;149:4605-14 pubmed publisher..involved, GnRH neurons were treated with antagonists of phospholipase C (PLC), inositol-trisphosphate receptors (IP3R), and ERK1/2 before kisspeptin exposure...
- Jurkovicova D, Sedlakova B, Lacinova L, Kopacek J, Sulova Z, Sedlak J, et al. Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line. Ann N Y Acad Sci. 2008;1148:421-7 pubmed publisher..that, while in mouse kidney tissue hypoxia elevates mRNA for inositol 1,4,5-trisphosphate receptors (IP3R) type 1 (IP3R1) and ryanodine receptors (RyR) type 2 (RyR2), in culture of HEK 293 cells the gene expression of all IP3Rs ..
- Michikawa T, Hirota J, Kawano S, Hiraoka M, Yamada M, Furuichi T, et al. Calmodulin mediates calcium-dependent inactivation of the cerebellar type 1 inositol 1,4,5-trisphosphate receptor. Neuron. 1999;23:799-808 pubmedThe dependency of purified mouse cerebellar type 1 inositol 1,4,5-trisphosphate receptor (IP3R1)/Ca2+ channel function on cytoplasmic Ca2+ was examined...
- Sammels E, Devogelaere B, Mekahli D, Bultynck G, Missiaen L, Parys J, et al. Polycystin-2 activation by inositol 1,4,5-trisphosphate-induced Ca2+ release requires its direct association with the inositol 1,4,5-trisphosphate receptor in a signaling microdomain. J Biol Chem. 2010;285:18794-805 pubmed publisher
- Nakagawa S, Watanabe M, Inoue Y. Regional variation in expression of calbindin and inositol 1,4,5-trisphosphate receptor type 1 mRNAs in the cerebellum of the staggerer mutant mouse. Eur J Neurosci. 1996;8:1401-7 pubmed
- Wang P, Tang M, Gao L, Luo H, Wang G, Ma X, et al. Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development. J Cell Biochem. 2013;114:1852-62 pubmed publisher..In addition, we noticed that RyR- and IP3R-mediated ICR coexisted in early-stage ventricular cells and RyRs functionally dominated...
- Son S, Byun J, Roh S, Kim S, Mook Jung I. Reduced IRE1? mediates apoptotic cell death by disrupting calcium homeostasis via the InsP3 receptor. Cell Death Dis. 2014;5:e1188 pubmed publisher..This dysregulation is caused by an accelerated ER-to-cytosolic efflux of Ca(2+) through the InsP3 receptor (InsP3R)...
- Ouyang K, Leandro Gomez Amaro R, Stachura D, Tang H, Peng X, Fang X, et al. Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia. Nat Commun. 2014;5:4814 pubmed publisher..In the absence of IP3R-mediated Ca(2+) signalling, repression of key Notch transcriptional targets--including Hes1--fail to occur in post ├..
- Yuan Q, Yang J, Santulli G, Reiken S, Wronska A, Kim M, et al. Maintenance of normal blood pressure is dependent on IP3R1-mediated regulation of eNOS. Proc Natl Acad Sci U S A. 2016;113:8532-7 pubmed publisher..EC-specific type 1 1,4,5-trisphosphate receptor knockout (IP3R1(-/-)) mice are hypertensive and display blunted vasodilation in response to acetylcholine (ACh)...
- Stavermann M, Buddrus K, St John J, Ekberg J, Nilius B, Deitmer J, et al. Temperature-dependent calcium-induced calcium release via InsP3 receptors in mouse olfactory ensheathing glial cells. Cell Calcium. 2012;52:113-23 pubmed publisher..The results suggest that InsP(3) receptors mediate Ca(2+)-induced Ca(2+) release in OECs, and that this Ca(2+) release is temperature-sensitive and can be suppressed at temperatures above 28┬░C. ..
- Chakraborty R, Park H, Hanif A, Sidhu C, Iuvone P, Pardue M. ON pathway mutations increase susceptibility to form-deprivation myopia. Exp Eye Res. 2015;137:79-83 pubmed publisher..Retinal DA levels were similar between the different genotypes. Our results indicate that reduced retinal DA metabolism/turnover may be associated with increased susceptibility to myopia in mice with ON pathway defect mutations. ..
- Butler M, Ma H, Yang F, Belcher J, Le Y, Mikoshiba K, et al. Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency. J Biol Chem. 2017;292:11189-11205 pubmed publisher..These results thus identify a novel molecular link between Ca2+ homeostasis and cone degeneration, thereby revealing novel therapeutic targets to preserve cones in inherited retinal degenerative diseases. ..
- Hamada K, Miyata T, Mayanagi K, Hirota J, Mikoshiba K. Two-state conformational changes in inositol 1,4,5-trisphosphate receptor regulated by calcium. J Biol Chem. 2002;277:21115-8 pubmedInositol 1,4,5-trisphosphate receptor (IP3R) is a highly controlled calcium (Ca2+) channel gated by inositol 1,4,5-trisphosphate (IP3)...
- Devogelaere B, Nadif Kasri N, Derua R, Waelkens E, Callewaert G, Missiaen L, et al. Binding of IRBIT to the IP3 receptor: determinants and functional effects. Biochem Biophys Res Commun. 2006;343:49-56 pubmedIRBIT has previously been shown to interact with the inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) in an IP3-sensitive way...
- Tateishi Y, Hattori M, Nakayama T, Iwai M, Bannai H, Nakamura T, et al. Cluster formation of inositol 1,4,5-trisphosphate receptor requires its transition to open state. J Biol Chem. 2005;280:6816-22 pubmed..We also found that GFP-IP(3)R1 clusters colocalized with ERp44, a luminal protein of endoplasmic reticulum that inhibits its channel activity. This is the first example of ligand-induced clustering of a ligand-gated channel protein. ..
- Hibi T, Mizutani M, Baba A, Hattori M. Splicing variations in the ligand-binding domain of ApoER2 results in functional differences in the binding properties to Reelin. Neurosci Res. 2009;63:251-8 pubmed publisher..Therefore, proteolytic cleavage of Reelin and alternative splicing of ApoER2 may be involved in the fine regulation of Reelin signaling. ..
- Shanmughapriya S, Rajan S, Hoffman N, Zhang X, Guo S, Kolesar J, et al. Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU. Sci Signal. 2015;8:ra23 pubmed publisher..uptake was reduced in chicken DT40 B lymphocytes lacking either the ER-localized inositol trisphosphate receptor (IP3R), which releases Ca2+ from the ER, or Orai1 or STIM1, components of the PM-localized Ca2+ -permeable channel ..
- Assefa Z, Bultynck G, Szlufcik K, Nadif Kasri N, Vermassen E, Goris J, et al. Caspase-3-induced truncation of type 1 inositol trisphosphate receptor accelerates apoptotic cell death and induces inositol trisphosphate-independent calcium release during apoptosis. J Biol Chem. 2004;279:43227-36 pubmed..B-lymphocytes were used to investigate the functional relevance of type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) and its cleavage by caspase-3 in apoptosis...
- Geiselh├Âringer A, Werner M, Sigl K, Smital P, W├Ârner R, Acheo L, et al. IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP kinase. EMBO J. 2004;23:4222-31 pubmed..We conclude that cGMP-dependent relaxation of hormone receptor-triggered smooth muscle contraction essentially depends on the interaction of cGKI-IRAG with IP(3)RI. ..
- Fujimoto T, Shirasawa S. Identification of KRAP-expressing cells and the functional relevance of KRAP to the subcellular localization of IP3R in the stomach and kidney. Int J Mol Med. 2012;30:1287-93 pubmed publisher..These findings demonstrate that KRAP physically associates with IP(3)Rs and regulates the proper localization of IP(3)Rs in the mucous cells and the chief cells of the stomach and in the proximal tubular cells of the kidneys. ..
- Wojcikiewicz R, Xu Q, Webster J, Alzayady K, Gao C. Ubiquitination and proteasomal degradation of endogenous and exogenous inositol 1,4,5-trisphosphate receptors in alpha T3-1 anterior pituitary cells. J Biol Chem. 2003;278:940-7 pubmed
- Fukuda N, Shirasu M, Sato K, Ebisui E, Touhara K, Mikoshiba K. Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors. Eur J Neurosci. 2008;27:2665-75 pubmed publisher..Our findings suggest that IP3R2 and IP3R3 mediate nasal mucus secretion, which is important for the maintenance of nasal tissue as well as the perception of odors. ..
- Garcia K, Shah T, Garcia J. Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice. Am J Physiol Cell Physiol. 2004;287:C1048-57 pubmed
- Walensky L, Snyder S. Inositol 1,4,5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm. J Cell Biol. 1995;130:857-69 pubmed..Western blotting using a polyclonal antibody directed against purified brain IP3 receptor (IP3R) identified a specific 260 kD band in 1% Triton X-100 extracts of rat, hamster, mouse and dog sperm...
- Fujii S, Matsumoto M, Igarashi K, Kato H, Mikoshiba K. Synaptic plasticity in hippocampal CA1 neurons of mice lacking type 1 inositol-1,4,5-trisphosphate receptors. Learn Mem. 2000;7:312-20 pubmed..To evaluate the role of the type 1 inositol-1,4,5-trisphosphate receptor (IP3R1) in hippocampal synaptic plasticity, we studied LTP, LTD, DP, and LTP suppression of the field excitatory ..
- Xia L, Zhang D, Wang C, Wei F, Hu Y. PC-PLC is involved in osteoclastogenesis induced by TNF-? through upregulating IP3R1 expression. FEBS Lett. 2012;586:3341-8 pubmed publisher..We found that TNF-? increased the expression of IP3R1 and promoted osteoclastogenesis in RANKL-induced mouse BMMs...
- Meisler M, Kearney J, Ottman R, Escayg A. Identification of epilepsy genes in human and mouse. Annu Rev Genet. 2001;35:567-88 pubmed..The development of pharmaceuticals directed towards specific epilepsy genotypes can be anticipated, and the introduction of patient mutations into the mouse genome will provide models for testing these targeted therapies. ..
- Furuichi T, Yoshikawa S, Mikoshiba K. Nucleotide sequence of cDNA encoding P400 protein in the mouse cerebellum. Nucleic Acids Res. 1989;17:5385-6 pubmed
- Hayashi M, Monkawa T, Yoshida T, Sasamura H, Matsumoto M, Inoue T, et al. Intracellular calcium concentration in the inositol trisphosphate receptor type 1 knockout mouse. J Am Soc Nephrol. 1999;10:2094-101 pubmed..To examine the role of IP3 receptor type I in the regulation of intracellular calcium concentration ([Ca2+]i) of glomerular cells, [Ca2+]i was ..
- Cai W, Hisatsune C, Nakamura K, Nakamura T, Inoue T, Mikoshiba K. Activity-dependent expression of inositol 1,4,5-trisphosphate receptor type 1 in hippocampal neurons. J Biol Chem. 2004;279:23691-8 pubmed..showing that synaptic activity regulates the level of expression of inositol 1,4,5-trisphosphate receptor type 1 (IP3R1) in neurons...
- Wang Q, Wang Y, Downey G, Plotnikov S, McCulloch C. A ternary complex comprising FAK, PTP├Ä┬▒ and IP3 receptor 1 functionally engages focal adhesions and the endoplasmic reticulum to mediate IL-1-induced Ca2+ signalling in fibroblasts. Biochem J. 2016;473:397-410 pubmed publisher..We examined the spatial restriction of Ca(2+) release through the inositol 1,4,5-triphosphate receptor 1 (IP3R1) in response to interleukin-1 (IL-1) and the functions of the adhesion-associated proteins, focal adhesion kinase (..
- Verbert L, Lee B, Kocks S, Assefa Z, Parys J, Missiaen L, et al. Caspase-3-truncated type 1 inositol 1,4,5-trisphosphate receptor enhances intracellular Ca2+ leak and disturbs Ca2+ signalling. Biol Cell. 2008;100:39-49 pubmed
- Miyata T, Nakajima K, Aruga J, Takahashi S, Ikenaka K, Mikoshiba K, et al. Distribution of a reeler gene-related antigen in the developing cerebellum: an immunohistochemical study with an allogeneic antibody CR-50 on normal and reeler mice. J Comp Neurol. 1996;372:215-28 pubmed..The spatiotemporal expressions of the CR-50 antigen in the cerebellum are consistent with the possibility that this antigen is involved in cell-cell interactions related to the histogenetic assembly of Purkinje cells. ..