Gene Symbol: Itm2a
Description: integral membrane protein 2A
Alias: AW108051, Bricd2a, E25, Itm2, integral membrane protein 2A
Species: mouse
Products:     Itm2a

Top Publications

  1. Deleersnijder W, Hong G, Cortvrindt R, Poirier C, Tylzanowski P, Pittois K, et al. Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction. Molecular cloning and characterization of a gene belonging to a novel multigene family of integral membrane proteins. J Biol Chem. 1996;271:19475-82 pubmed
    ..Homology searches of DNA databanks showed that E25 belongs to a novel multigene family, containing three members both in man and mouse. The mouse E25 gene locus (Itm2) was mapped to the X chromosome.
  2. Pittois K, Wauters J, Bossuyt P, Deleersnijder W, Merregaert J. Genomic organization and chromosomal localization of the Itm2a gene. Mamm Genome. 1999;10:54-6 pubmed
    b>Itm2A is a novel type II integral membrane protein that is involved in osteo- and chondrogenic differentiation...
  3. Yamaza H, Matsuo K, Kiyoshima T, Shigemura N, Kobayashi I, Wada H, et al. Detection of differentially expressed genes in the early developmental stage of the mouse mandible. Int J Dev Biol. 2001;45:675-80 pubmed
    ..5 mandible, and E25, ATPase6, Mum2, Thymosin beta4 and L21 from the E12 mandible to be differentially expressed genes...
  4. Barber T, Barber M, Tomescu O, Barr F, Ruben S, Friedman T. Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma. Genomics. 2002;79:278-84 pubmed
    ..Numerous putative targets of PAX3 and PAX3-FKHR were identified and six genes, Itm2A, Fath, FLT1, TGFA, BVES, and EN2, were examined closely...
  5. Van den Plas D, Merregaert J. In vitro studies on Itm2a reveal its involvement in early stages of the chondrogenic differentiation pathway. Biol Cell. 2004;96:463-70 pubmed
    The Integral membrane protein 2A (Itm2A) is a transmembrane protein belonging to a family composed of at least two other members, Itm2B and Itm2C, all of them having a different expression pattern...
  6. Lagha M, Mayeuf Louchart A, Chang T, Montarras D, Rocancourt D, Zalc A, et al. Itm2a is a Pax3 target gene, expressed at sites of skeletal muscle formation in vivo. PLoS ONE. 2013;8:e63143 pubmed publisher
    ..We show that Itm2a, which encodes a type 2 transmembrane protein, is a direct Pax3 target in vivo, by combining genetic approaches ..
  7. Loebel D, O Rourke M, Steiner K, Banyer J, Tam P. Isolation of differentially expressed genes from wild-type and Twist mutant mouse limb buds. Genesis. 2002;33:103-13 pubmed
  8. Rengaraj D, Gao F, Liang X, Yang Z. Expression and regulation of type II integral membrane protein family members in mouse male reproductive tissues. Endocrine. 2007;31:193-201 pubmed
    Type II Integral membrane protein (Itm2) family consists of three members, Itm2a, Itm2b and Itm2c. ITM2B has been shown to be closely related to human male reproduction...
  9. Mahler M, Bristol I, Sundberg J, Churchill G, Birkenmeier E, Elson C, et al. Genetic analysis of susceptibility to dextran sulfate sodium-induced colitis in mice. Genomics. 1999;55:147-56 pubmed
    ..We conclude that multiple genes control susceptibility to DSS colitis in mice. Possible Dssc candidate genes are discussed in terms of current knowledge of inflammatory bowel disease susceptibility loci in humans. ..

More Information


  1. Garcia M, Ghiani M, Lefort A, Libert F, Strollo S, Vassart G. LGR5 deficiency deregulates Wnt signaling and leads to precocious Paneth cell differentiation in the fetal intestine. Dev Biol. 2009;331:58-67 pubmed publisher
    ..Together, our data identify LGR5 as a negative regulator of the Wnt pathway in the developing intestine. ..
  2. Tai T, Pai S, Ho I. Itm2a, a target gene of GATA-3, plays a minimal role in regulating the development and function of T cells. PLoS ONE. 2014;9:e96535 pubmed publisher
    The integral membrane protein 2a (Itm2a) is one of the BRICHOS domain-containing proteins and is structurally related to Itm2b and Itm2c...
  3. Kihara M, Kiyoshima T, Nagata K, Wada H, Fujiwara H, Hasegawa K, et al. Itm2a expression in the developing mouse first lower molar, and the subcellular localization of Itm2a in mouse dental epithelial cells. PLoS ONE. 2014;9:e103928 pubmed publisher
    b>Itm2a is a type II transmembrane protein with a BRICHOS domain...