Gene Symbol: Itih4
Description: inter alpha-trypsin inhibitor, heavy chain 4
Alias: ITI-HC4, Itih-4, PK-120, inter alpha-trypsin inhibitor, heavy chain 4, ITI heavy chain H4, inter-alpha-inhibitor heavy chain 4
Heller D, Gianola K, Leinwand L. A highly conserved mouse gene with a propensity to form pseudogenes in mammals. Mol Cell Biol. 1988;8:2797-803 pubmed
..This gene shows extremely high sequence conservation, extending to chicken, amphibian, and nematode genomes. Surprisingly, the gene appears to exist in only one copy in these organisms. ..
Jean L, Smih F, Olivier E, Soury E, Simon Chazottes D, Guenet J, et al
. Comparative assignments of the genes of the inter-alpha-inhibitor family in human and mouse: ITIH4 is close to ITIH1 and ITIH3, on HSA 3 and MMU 14. Genomics. 1997;41:139-40 pubmed
Cai T, Yu P, Monga S, Mishra B, Mishra L. Identification of mouse itih-4 encoding a glycoprotein with two EF-hand motifs from early embryonic liver. Biochim Biophys Acta. 1998;1398:32-7 pubmed
..These results suggest that itih-4 is a potential regulator for extracellular matrix proteins and plays a role during early embryonic liver development. ..
Weinstein M, Monga S, Liu Y, Brodie S, Tang Y, Li C, et al
. Smad proteins and hepatocyte growth factor control parallel regulatory pathways that converge on beta1-integrin to promote normal liver development. Mol Cell Biol. 2001;21:5122-31 pubmed
..These pathways merge at the beta1-integrin, the level of which was increased by HGF in the cultured mutant livers. HGF treatment reversed the defects in cell proliferation and hepatic architecture in the Smad2(+/-); Smad3(+/-) livers. ..
Bhanumathy C, Tang Y, Monga S, Katuri V, Cox J, Mishra B, et al
. Itih-4, a serine protease inhibitor regulated in interleukin-6-dependent liver formation: role in liver development and regeneration. Dev Dyn. 2002;223:59-69 pubmed
..The markedly high expression of Itih-4 in early liver development and in explants treated with IL-6 suggests a prominent role for Itih-4 at key points in liver formation. ..
Kroczynska B, King Simmons L, Alloza L, Alava M, Elguindi E, Blond S. BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4. Biochem Biophys Res Commun. 2005;338:1467-77 pubmed
..279 (2004) 11432-11443]. Here, we identified a new variant of human inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) that also interacts with the SANT2 domain of HTJ1...
Tang Y, Kitisin K, Jogunoori W, Li C, Deng C, Mueller S, et al
. Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling. Proc Natl Acad Sci U S A. 2008;105:2445-50 pubmed publisher
..generation of mouse knockouts involving a positive regulator of IL-6, Inter-alpha-trypsin inhibitor-heavy chain-4 (ITIH4), resulted in reduction in HCC in elf(+/-) mice...
Kormosh N, Davidova T, Kopyltsov V, Serebryakova M, Kabieva A, Voyushin K, et al
. Conformational changes in inter-?-trypsin inhibitor heavy chain 4 activate its tumor-specific activity in mice with B16 melanoma. Mol Med Rep. 2015;12:4483-4493 pubmed publisher
..study showed conformational changes of two serum albumin proteins and inter???trypsin inhibitor heavy chain 4 (ITIH4) in mice with B16 melanoma compared to tumor?free mice, as determined by differences in the products of ..