Gene Symbol: Itgb4
Description: integrin beta 4
Alias: AA407042, C230078O20, CD104, integrin beta-4
Species: mouse
Products:     Itgb4

Top Publications

  1. Kennel S, Foote L, Falcioni R, Sonnenberg A, Stringer C, Crouse C, et al. Analysis of the tumor-associated antigen TSP-180. Identity with alpha 6-beta 4 in the integrin superfamily. J Biol Chem. 1989;264:15515-21 pubmed
    ..Finally, two different monoclonal antibodies are described, 346-11A and 439-9B, which directly recognize the multiple forms of mouse and human beta 4 proteins, respectively. ..
  2. Staquicini F, Dias Neto E, Li J, Snyder E, Sidman R, Pasqualini R, et al. Discovery of a functional protein complex of netrin-4, laminin gamma1 chain, and integrin alpha6beta1 in mouse neural stem cells. Proc Natl Acad Sci U S A. 2009;106:2903-8 pubmed publisher
    ..Our findings present a unique molecular mechanism mediating astrocytic/neuronal crosstalk that regulates ongoing neurogenesis in the adult olfactory system. ..
  3. Yang X, Pursell B, Lu S, Chang T, Mercurio A. Regulation of beta 4-integrin expression by epigenetic modifications in the mammary gland and during the epithelial-to-mesenchymal transition. J Cell Sci. 2009;122:2473-80 pubmed publisher
    ..Our data indicate that complex epigenetic modifications contribute to the regulation of the beta 4 integrin and E-cadherin. ..
  4. Rhee H, Polak L, Fuchs E. Lhx2 maintains stem cell character in hair follicles. Science. 2006;312:1946-9 pubmed
    ..Using gain- and loss-of-function studies, we uncovered a role for Lhx2 in maintaining the growth and undifferentiated properties of hair follicle progenitors. ..
  5. Guo W, Pylayeva Y, Pepe A, Yoshioka T, Muller W, Inghirami G, et al. Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell. 2006;126:489-502 pubmed
    ..These results indicate that beta 4 integrin promotes tumor progression by amplifying ErbB2 signaling and identify beta 4 as a potential target for molecular therapy of breast cancer. ..
  6. Devenport D, Fuchs E. Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles. Nat Cell Biol. 2008;10:1257-68 pubmed publisher
    ..Finally, we provide in vitro evidence that homotypic intracellular interactions of Celsr1 are required to recruit Vangl2 and Fzd6 to sites of cell-cell contact. ..
  7. DiPersio C, van der Neut R, Georges Labouesse E, Kreidberg J, Sonnenberg A, Hynes R. alpha3beta1 and alpha6beta4 integrin receptors for laminin-5 are not essential for epidermal morphogenesis and homeostasis during skin development. J Cell Sci. 2000;113 ( Pt 17):3051-62 pubmed
    ..These findings show that while alpha3beta1 and alpha6beta4 are both required for integrity of the dermo-epidermal junction, neither one is essential for epidermal morphogenesis during skin development. ..
  8. Yi R, O Carroll D, Pasolli H, Zhang Z, Dietrich F, Tarakhovsky A, et al. Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet. 2006;38:356-62 pubmed
    ..Here we characterize miRNAs in skin, the existence of which was hitherto unappreciated, and demonstrate their differential expression and importance in the morphogenesis of epithelial tissues within this vital organ. ..
  9. van der Neut R, Krimpenfort P, Calafat J, Niessen C, Sonnenberg A. Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null mice. Nat Genet. 1996;13:366-9 pubmed
    ..No evidence was found for impaired T-cell development, nor for defects in myelination in the peripheral nervous system. ..

More Information


  1. Clavel C, Grisanti L, Zemla R, Rezza A, Barros R, Sennett R, et al. Sox2 in the dermal papilla niche controls hair growth by fine-tuning BMP signaling in differentiating hair shaft progenitors. Dev Cell. 2012;23:981-94 pubmed publisher
    ..Collectively, our data identify Sox2 as a key regulator of hair growth that controls progenitor migration by fine-tuning BMP-mediated mesenchymal-epithelial crosstalk...
  2. Raveh E, Cohen S, Levanon D, Negreanu V, Groner Y, Gat U. Dynamic expression of Runx1 in skin affects hair structure. Mech Dev. 2006;123:842-50 pubmed
    ..The data delineate Runx1 as a novel specific marker of several hair follicle cell types and sheds light on its role in hair morphogenesis and differentiation. ..
  3. Vidal F, Aberdam D, Miquel C, Christiano A, Pulkkinen L, Uitto J, et al. Integrin beta 4 mutations associated with junctional epidermolysis bullosa with pyloric atresia. Nat Genet. 1995;10:229-34 pubmed
    ..The maternal mutation occurs in a donor splice site, and results in in-frame exon skipping involving the cytoplasmic domain of the polypeptide. Our results implicate mutations in the beta 4 integrin gene in some forms of PA-JEB. ..
  4. Dowling J, Yu Q, Fuchs E. Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J Cell Biol. 1996;134:559-72 pubmed
  5. Horsley V, Aliprantis A, Polak L, Glimcher L, Fuchs E. NFATc1 balances quiescence and proliferation of skin stem cells. Cell. 2008;132:299-310 pubmed publisher
    ..Our findings may explain why patients receiving cyclosporine A for immunosuppressive therapy display excessive hair growth, and unveil a functional role for calcium-NFATc1-CDK4 circuitry in governing stem cell quiescence. ..
  6. Nodari A, Previtali S, Dati G, Occhi S, Court F, Colombelli C, et al. Alpha6beta4 integrin and dystroglycan cooperate to stabilize the myelin sheath. J Neurosci. 2008;28:6714-9 pubmed publisher
    ..These data indicate that, similar to its role in skin, alpha6beta4 integrin confers stability to myelin in peripheral nerves. ..
  7. Nikolopoulos S, Blaikie P, Yoshioka T, Guo W, Giancotti F. Integrin beta4 signaling promotes tumor angiogenesis. Cancer Cell. 2004;6:471-83 pubmed
    ..These results provide genetic evidence that alpha6beta4 signaling promotes the onset of the invasive phase of pathological angiogenesis and hence identify a novel target for antiangiogenic therapy. ..
  8. Sumigray K, Chen H, Lechler T. Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis. J Cell Biol. 2011;194:631-42 pubmed publisher
    ..This work reveals essential desmosome-associated components that control cortical microtubule organization and unexpected roles for centrosomal proteins in epidermal function...
  9. Fukumoto S, Miner J, Ida H, Fukumoto E, Yuasa K, Miyazaki H, et al. Laminin alpha5 is required for dental epithelium growth and polarity and the development of tooth bud and shape. J Biol Chem. 2006;281:5008-16 pubmed
  10. Blanpain C, Lowry W, Pasolli H, Fuchs E. Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev. 2006;20:3022-35 pubmed
  11. Vasioukhin V, Bowers E, Bauer C, Degenstein L, Fuchs E. Desmoplakin is essential in epidermal sheet formation. Nat Cell Biol. 2001;3:1076-85 pubmed
    ..DP is therefore required for assembly of functional desmosomes, maintaining cytoskeletal architecture and reinforcing membrane attachments essential for stable intercellular adhesion. ..
  12. Borradori L, Sonnenberg A. Structure and function of hemidesmosomes: more than simple adhesion complexes. J Invest Dermatol. 1999;112:411-8 pubmed
  13. Frijns E, Sachs N, Kreft M, Wilhelmsen K, Sonnenberg A. EGF-induced MAPK signaling inhibits hemidesmosome formation through phosphorylation of the integrin {beta}4. J Biol Chem. 2010;285:37650-62 pubmed publisher
    ..Collectively, these data demonstrate an important role of ?4 phosphorylation on residues Ser-1356 and Ser-1364 in the formation and/or stability of HDs...
  14. Ruiz P, Wiles M, Imhof B. Alpha 6 integrins participate in pro-T cell homing to the thymus. Eur J Immunol. 1995;25:2034-41 pubmed
    ..These data suggest that alpha 6 integrins are involved in the homing of pro-T cells to the developing thymus by mediating adhesion of pro-T cells to the vascular endothelium. ..
  15. Morena A, Riccioni S, Marchetti A, Polcini A, Mercurio A, Blandino G, et al. Expression of the beta 4 integrin subunit induces monocytic differentiation of 32D/v-Abl cells. Blood. 2002;100:96-106 pubmed
    ..Overall, the reported findings indicate that alpha 6 beta 4 integrin promotes growth arrest and differentiation by modulating Abl kinases and p73 protein pathway(s). ..
  16. Previtali S, Nodari A, Taveggia C, Pardini C, Dina G, Villa A, et al. Expression of laminin receptors in schwann cell differentiation: evidence for distinct roles. J Neurosci. 2003;23:5520-30 pubmed
    ..These data suggest that the action of laminin is mediated by beta1 integrins during axonal sorting and by dystroglycan, alpha6beta1, and alpha6beta4 integrins during myelination. ..
  17. Richardson R, Mitchell K, Hammond N, Mollo M, Kouwenhoven E, Wyatt N, et al. p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate. PLoS Genet. 2017;13:e1006828 pubmed publisher
  18. Fantauzzo K, Soriano P. PDGFR? regulates craniofacial development through homodimers and functional heterodimers with PDGFR?. Genes Dev. 2016;30:2443-2458 pubmed
    ..Our studies thus uncover a novel mode of signaling for the PDGF family during vertebrate development. ..
  19. Williams S, Ratliff L, Postiglione M, Knoblich J, Fuchs E. Par3-mInsc and G?i3 cooperate to promote oriented epidermal cell divisions through LGN. Nat Cell Biol. 2014;16:758-69 pubmed publisher
    ..Finally, we uncover a developmental switch between delamination-driven early stratification and spindle-orientation-dependent differentiation that occurs around E15, revealing a two-step mechanism underlying epidermal maturation. ..
  20. Maalouf S, Theivakumar S, Owens D. Epidermal ?6?4 integrin stimulates the influx of immunosuppressive cells during skin tumor promotion. J Dermatol Sci. 2012;66:108-18 pubmed publisher
    ..We conclude that aberrant expression of ?6?4 integrin in post-mitotic epidermal keratinocytes stimulates a pro-tumorigenic skin microenvironment by augmenting the influx of immunosuppressive granular cells during tumor promotion. ..
  21. Wolf Yadlin A, Hautaniemi S, Lauffenburger D, White F. Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks. Proc Natl Acad Sci U S A. 2007;104:5860-5 pubmed
    ..Using this approach, it should now be possible to routinely monitor the phosphorylation status of hundreds of nodes across multiple biological conditions. ..
  22. Murgia C, Blaikie P, Kim N, Dans M, Petrie H, Giancotti F. Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain. EMBO J. 1998;17:3940-51 pubmed
  23. Van der Zee C, Kreft M, Beckers G, Kuipers A, Sonnenberg A. Conditional deletion of the Itgb4 integrin gene in Schwann cells leads to delayed peripheral nerve regeneration. J Neurosci. 2008;28:11292-303 pubmed publisher
    ..the integrin alpha6beta4 in peripheral nerve regeneration was investigated in mice by cre-mediated deletion of the Itgb4 (beta4) gene in Schwann cells...
  24. Wang X, Pasolli H, Williams T, Fuchs E. AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis. J Cell Biol. 2008;183:37-48 pubmed publisher
  25. Chen T, Heller E, Beronja S, Oshimori N, Stokes N, Fuchs E. An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration. Nature. 2012;485:104-8 pubmed publisher
    ..Our results validate the RNA interference screen and underscore its power in unearthing new molecules that govern stem cell self-renewal and tissue-regenerative potential. ..
  26. Youssef K, Lapouge G, Bouvrée K, Rorive S, Brohée S, Appelstein O, et al. Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation. Nat Cell Biol. 2012;14:1282-94 pubmed publisher
    ..Deletion of ?-catenin in adult SmoM2-expressing cells prevents EHFP reprogramming and tumour initiation. Finally, human basal cell carcinomas also express genes of the Wnt signalling and EHFP signatures...
  27. Sixt M, Engelhardt B, Pausch F, Hallmann R, Wendler O, Sorokin L. Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis. J Cell Biol. 2001;153:933-46 pubmed
  28. Liadaki K, Casar J, Wessen M, Luth E, Jun S, Gussoni E, et al. ?4 integrin marks interstitial myogenic progenitor cells in adult murine skeletal muscle. J Histochem Cytochem. 2012;60:31-44 pubmed publisher
    ..These findings support the expression of ?4 integrin in interstitial, vessel-associated cells with myogenic activity within adult skeletal muscle. ..
  29. Wadsworth S, Halvorson M, Coligan J. Developmentally regulated expression of the beta 4 integrin on immature mouse thymocytes. J Immunol. 1992;149:421-8 pubmed
  30. Hierck B, Gittenberger de Groot A, Van Iperen L, Brouwer A, Poelmann R. Expression of the beta 4 integrin subunit in the mouse heart during embryonic development: retinoic acid advances beta 4 expression. Dev Dyn. 1996;207:89-103 pubmed
    ..Several hypotheses on the mechanism of beta 4 up-regulation and a possible role for alpha 6 beta 4 in the development of heart malformations after the administration of retinoic acid are discussed. ..
  31. Thorsteinsdottir S, Roelen B, Freund E, Gaspar A, Sonnenberg A, Mummery C. Expression patterns of laminin receptor splice variants alpha 6A beta 1 and alpha 6B beta 1 suggest different roles in mouse development. Dev Dyn. 1995;204:240-58 pubmed
  32. Lee P, Jiang S, Li Y, Yue J, Gou X, Chen S, et al. Phosphorylation of Pkp1 by RIPK4 regulates epidermal differentiation and skin tumorigenesis. EMBO J. 2017;36:1963-1980 pubmed publisher
    ..Taken together, our study presents a global view of phosphoproteomic changes that occur during epidermal differentiation, and identifies RIPK-PKP1 signaling as novel axis involved in skin stratification and tumorigenesis. ..
  33. Dauber K, Perdigoto C, Valdes V, Santoriello F, Cohen I, Ezhkova E. Dissecting the Roles of Polycomb Repressive Complex 2 Subunits in the Control of Skin Development. J Invest Dermatol. 2016;136:1647-1655 pubmed publisher
    ..The strikingly different roles of PRC2 in the formation of three lineages exemplify the complex outcomes that the lack of PRC2 can have in a somatic stem cell system. ..
  34. Ramovs V, Te Molder L, Sonnenberg A. The opposing roles of laminin-binding integrins in cancer. Matrix Biol. 2017;57-58:213-243 pubmed publisher
    ..In this review we discuss the dual role of the laminin-binding integrins ?3?1 and ?6?4 in tumor development and progression, and examine the factors and mechanisms involved in these opposing effects. ..
  35. Yazlovitskaya E, Tseng H, Viquez O, Tu T, Mernaugh G, McKee K, et al. Integrin α3β1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt. Mol Biol Cell. 2015;26:1857-74 pubmed publisher
    ..Thus K63-linked polyubiquitination plays a previously unrecognized role in integrin α3β1-dependent cell signaling required for UB development and may represent a novel mechanism whereby integrins regulate signaling pathways. ..
  36. Ritie L, Spenlé C, Lacroute J, Bolcato Bellemin A, Lefebvre O, Bole Feysot C, et al. Abnormal Wnt and PI3Kinase signaling in the malformed intestine of lama5 deficient mice. PLoS ONE. 2012;7:e37710 pubmed publisher
    ..Thus deregulated adhesion to laminin-511 may be instrumental in diseases such as human pathologies of the gut where laminin-511 is abnormally expressed as it is shown here. ..
  37. Viquez O, Yazlovitskaya E, Tu T, Mernaugh G, Secades P, McKee K, et al. Integrin alpha6 maintains the structural integrity of the kidney collecting system. Matrix Biol. 2017;57-58:244-257 pubmed publisher
    ..These data give a mechanistic explanation for the association between kidney collecting system abnormalities in patients and epidermolysis bullosa. ..
  38. Zent R, Bush K, Pohl M, Quaranta V, Koshikawa N, Wang Z, et al. Involvement of laminin binding integrins and laminin-5 in branching morphogenesis of the ureteric bud during kidney development. Dev Biol. 2001;238:289-302 pubmed
    ..These data may help to partially explain the renal phenotype seen in integrin alpha3 and alpha3/alpha6 subunit-deficient animals. ..
  39. Fan J, Cai B, Zeng M, Hao Y, Giancotti F, Fu B. Integrin ?4 signaling promotes mammary tumor cell adhesion to brain microvascular endothelium by inducing ErbB2-mediated secretion of VEGF. Ann Biomed Eng. 2011;39:2223-2241 pubmed publisher
    ..Our results indicate that ?4 signaling regulates VEGF expression by the mammary tumor cells thereby enhancing their adhesion to microvascular endothelium. ..
  40. Kashimata M, Gresik E. Epidermal growth factor system is a physiological regulator of development of the mouse fetal submandibular gland and regulates expression of the alpha6-integrin subunit. Dev Dyn. 1997;208:149-61 pubmed
  41. Davies D, Holley M. Differential expression of alpha 3 and alpha 6 integrins in the developing mouse inner ear. J Comp Neurol. 2002;445:122-32 pubmed
  42. Yoshioka T, Otero J, Chen Y, Kim Y, Koutcher J, Satagopan J, et al. ?4 Integrin signaling induces expansion of prostate tumor progenitors. J Clin Invest. 2013;123:682-99 pubmed publisher
    ..These findings indicate that the ?4 integrin promotes prostate tumorigenesis by amplifying ErbB2 and c-Met signaling in tumor progenitor cells. ..
  43. Sumigray K, Zhou K, Lechler T. Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption. PLoS ONE. 2014;9:e101824 pubmed publisher
    ..These data demonstrate that desmosome disruption results in extensive transcriptional and posttranslational changes that alter the activity of other cell adhesion structures...
  44. Lee S, Kong Y, Weatherbee S. Forward genetics identifies Kdf1/1810019J16Rik as an essential regulator of the proliferation-differentiation decision in epidermal progenitor cells. Dev Biol. 2013;383:201-13 pubmed publisher
  45. Georges Labouesse E, Mark M, Messaddeq N, Gansmuller A. Essential role of alpha 6 integrins in cortical and retinal lamination. Curr Biol. 1998;8:983-6 pubmed
    ..These observations are particularly significant given the recent report that human patients suffering from epidermolysis bullosa can carry mutations in ITGA6, the gene encoding the alpha 6 integrin chain [8,9]. ..
  46. Ezhkova E, Pasolli H, Parker J, Stokes N, Su I, Hannon G, et al. Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell. 2009;136:1122-35 pubmed publisher
    ..They maintain their proliferative potential and globally repressing undesirable differentiation programs while selectively establishing a specific terminal differentiation program in a stepwise fashion. ..
  47. Shiojiri N, Sugiyama Y. Immunolocalization of extracellular matrix components and integrins during mouse liver development. Hepatology. 2004;40:346-55 pubmed
    ..Supplementary material for this article can be found on the HEPATOLOGY website ( ..
  48. Horsley V, O Carroll D, Tooze R, Ohinata Y, Saitou M, Obukhanych T, et al. Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland. Cell. 2006;126:597-609 pubmed
  49. DiPersio C, Hodivala Dilke K, Jaenisch R, Kreidberg J, Hynes R. alpha3beta1 Integrin is required for normal development of the epidermal basement membrane. J Cell Biol. 1997;137:729-42 pubmed
    ..Our findings support a novel role for alpha3beta1 in establishment and/or maintenance of basement membrane integrity, while alpha6beta4 is required for stable adhesion of the epidermis to the basement membrane through hemidesmosomes. ..
  50. Nikolopoulos S, Blaikie P, Yoshioka T, Guo W, Puri C, Tacchetti C, et al. Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migration. Mol Cell Biol. 2005;25:6090-102 pubmed
    ..These findings provide evidence that beta4 signaling promotes epidermal growth and wound healing through a previously unrecognized effect on nuclear translocation of NF-kappaB and mitogen-activated protein kinases. ..
  51. Falk M, Salmivirta K, Durbeej M, Larsson E, Ekblom M, Vestweber D, et al. Integrin alpha 6B beta 1 is involved in kidney tubulogenesis in vitro. J Cell Sci. 1996;109 ( Pt 12):2801-10 pubmed
    ..could be detected by immunofluorescence on all cell types of embryonic mouse kidney, but we could not detect integrin beta 4 subunit in embryonic kidney by immunofluorescence or by in situ hybridization...
  52. Byrd K, Lough K, Patel J, Descovich C, Curtis T, Williams S. LGN plays distinct roles in oral epithelial stratification, filiform papilla morphogenesis and hair follicle development. Development. 2016;143:2803-17 pubmed publisher
    ..Thus, LGN has crucial tissue-specific functions in patterning surface ectoderm and its appendages by controlling division orientation. ..
  53. Sun C, Liu X, Qi L, Xu J, Zhao J, Zhang Y, et al. Modulation of vascular endothelial cell senescence by integrin ?4. J Cell Physiol. 2010;225:673-81 pubmed publisher
    ..Our findings provide new clues illustrating the mechanism of VEC senescence. Integrin ?4 might be a potential target for therapy in cardiovascular diseases...
  54. Yi R, Poy M, Stoffel M, Fuchs E. A skin microRNA promotes differentiation by repressing 'stemness'. Nature. 2008;452:225-9 pubmed publisher
    ..Our findings suggest that miR-203 defines a molecular boundary between proliferative basal progenitors and terminally differentiating suprabasal cells, ensuring proper identity of neighbouring layers. ..
  55. Böse K, Nischt R, Page A, Bader B, Paulsson M, Smyth N. Loss of nidogen-1 and -2 results in syndactyly and changes in limb development. J Biol Chem. 2006;281:39620-9 pubmed
    ..Further, in certain animals more severe changes in bone formation occur, providing evidence for the interplay between growth factors and the extracellular matrix. ..
  56. Wang D, Zhang Z, O Loughlin E, Wang L, Fan X, Lai E, et al. MicroRNA-205 controls neonatal expansion of skin stem cells by modulating the PI(3)K pathway. Nat Cell Biol. 2013;15:1153-63 pubmed publisher
    ..Our findings reveal an essential role for miR-205 in maintaining the expansion of skin SCs by antagonizing negative regulators of PI(3)K signalling. ..
  57. Kostan J, Gregor M, Walko G, Wiche G. Plectin isoform-dependent regulation of keratin-integrin alpha6beta4 anchorage via Ca2+/calmodulin. J Biol Chem. 2009;284:18525-36 pubmed publisher
  58. Oikawa T, Kamiya A, Kakinuma S, Zeniya M, Nishinakamura R, Tajiri H, et al. Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells. Gastroenterology. 2009;136:1000-11 pubmed publisher
    ..These results suggest that Sall4 plays a crucial role in controlling the lineage commitment of hepatoblasts not only inhibiting their differentiation into hepatocytes but also driving their differentiation toward cholangiocytes. ..
  59. Heller B, Ghidinelli M, Voelkl J, Einheber S, Smith R, Grund E, et al. Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system. J Cell Biol. 2014;204:1219-36 pubmed publisher
    ..These results identify functionally and spatially distinct PI 3-K pathways: an early, pro-myelinating pathway driven by axonal Neuregulin1 and a later-acting, laminin-integrin-dependent pathway that negatively regulates myelination. ..
  60. Abdel Ghany M, Cheng H, Elble R, Pauli B. Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth. J Biol Chem. 2002;277:34391-400 pubmed
    ..For the first time, beta(4) integrin ligation to its novel CLCA-adhesion partner is shown to be associated with FAK complexing, activation, and signaling to promote early, intravascular, metastatic growth. ..
  61. Mokkapati S, Fleger Weckmann A, Bechtel M, Koch M, Breitkreutz D, Mayer U, et al. Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain. J Biol Chem. 2011;286:1911-8 pubmed publisher
  62. Foote H, Sumigray K, Lechler T. FRAP analysis reveals stabilization of adhesion structures in the epidermis compared to cultured keratinocytes. PLoS ONE. 2013;8:e71491 pubmed publisher
    ..Our data demonstrate that there are additional mechanisms for stabilizing junctions in tissues that are not modeled by cell culture. ..
  63. Frei R, Dowling J, Carenini S, Fuchs E, Martini R. Myelin formation by Schwann cells in the absence of beta4 integrin. Glia. 1999;27:269-74 pubmed
    ..Based on both approaches, we conclude that myelination by Schwann cells can occur in the absence of beta4 integrin demonstrating that this Schwann cell component is dispensable for myelin formation in peripheral nerves. ..
  64. Grisanti L, Clavel C, Cai X, Rezza A, Tsai S, Sennett R, et al. Tbx18 targets dermal condensates for labeling, isolation, and gene ablation during embryonic hair follicle formation. J Invest Dermatol. 2013;133:344-53 pubmed publisher
  65. Danussi C, Petrucco A, Wassermann B, Pivetta E, Modica T, Del Bel Belluz L, et al. EMILIN1-?4/?9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation. J Cell Biol. 2011;195:131-45 pubmed publisher
    ..In addition, EMILIN1 is identified as a novel ligand for keratinocyte ?9?1 integrin, suggesting prospective roles for this receptor-ligand pair in skin homeostasis. ..
  66. Li H, Huang S, Wang S, Wang L, Qi L, Zhang Y, et al. Relationship between annexin A7 and integrin ?4 in autophagy. Int J Biochem Cell Biol. 2013;45:2605-11 pubmed publisher
  67. Ruzinova M, Schoer R, Gerald W, Egan J, Pandolfi P, Rafii S, et al. Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors. Cancer Cell. 2003;4:277-89 pubmed
    ..Inhibition of these factors phenocopies loss of Id in in vivo angiogenesis assays. ..
  68. Carroll D, Carroll J, Leong C, Cheng F, Brown M, Mills A, et al. p63 regulates an adhesion programme and cell survival in epithelial cells. Nat Cell Biol. 2006;8:551-61 pubmed
    ..Our results implicate p63 as a key regulator of cellular adhesion and survival in basal cells of the mammary gland and other stratified epithelial tissues. ..
  69. Sánchez Aparicio P, Martinez de Velasco A, Niessen C, Borradori L, Kuikman I, Hulsman E, et al. The subcellular distribution of the high molecular mass protein, HD1, is determined by the cytoplasmic domain of the integrin beta 4 subunit. J Cell Sci. 1997;110 ( Pt 2):169-78 pubmed
  70. Gomez M, Navarro P, Quintanilla M, Cano A. Expression of alpha 6 beta 4 integrin increases during malignant conversion of mouse epidermal keratinocytes: association of beta 4 subunit to the cytokeratin fraction. Exp Cell Res. 1992;201:250-61 pubmed
    ..These results, together with those regarding the organization of both cellular components in drug-treated cells, support the existence of a close association between alpha 6 beta 4 and the intermediate filaments of the cytoskeleton. ..
  71. Ray S, Foote H, Lechler T. beta-Catenin protects the epidermis from mechanical stresses. J Cell Biol. 2013;202:45-52 pubmed publisher
    ..These data demonstrate that a complete understanding of the functions of cell adhesion proteins must take into account their roles in response to mechanical stresses. ..
  72. Franco M, Muratori C, Corso S, Tenaglia E, Bertotti A, Capparuccia L, et al. The tetraspanin CD151 is required for Met-dependent signaling and tumor cell growth. J Biol Chem. 2010;285:38756-64 pubmed publisher
    ..These results indicate that CD151 controls Met-dependent neoplastic growth by enhancing receptor signaling through ?4 integrin-mediated pathways, independent of cell-substrate adhesion. ..
  73. Folgueras A, Guo X, Pasolli H, Stokes N, Polak L, Zheng D, et al. Architectural niche organization by LHX2 is linked to hair follicle stem cell function. Cell Stem Cell. 2013;13:314-27 pubmed publisher
    ..These findings suggest that niche organization underlies the requirement for LHX2 in hair follicle structure and function. ..
  74. Hierck B, Thorsteinsdottir S, Niessen C, Freund E, Iperen L, Feyen A, et al. Variants of the alpha 6 beta 1 laminin receptor in early murine development: distribution, molecular cloning and chromosomal localization of the mouse integrin alpha 6 subunit. Cell Adhes Commun. 1993;1:33-53 pubmed
  75. Sigle R, Gil S, Bhattacharya M, Ryan M, Yang T, Brown T, et al. Globular domains 4/5 of the laminin alpha3 chain mediate deposition of precursor laminin 5. J Cell Sci. 2004;117:4481-94 pubmed
    ..We conclude that the G4/5 domain in the alpha3 chain facilitates deposition of precursor laminin 5 into the PBM in epidermal wounds. ..
  76. Zhang H, Pasolli H, Fuchs E. Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin. Proc Natl Acad Sci U S A. 2011;108:2270-5 pubmed publisher
    ..Finally, we identify Cyr61 as a target of YAP in MKs and demonstrate a requirement for TEA domain (TEAD) transcriptional factors to comediate YAP functions in MKs. ..
  77. Chen Y, Zhang H, Han F, Yue L, Qiao C, Zhang Y, et al. The depletion of MARVELD1 leads to murine placenta accreta via integrin ?4-dependent trophoblast cell invasion. J Cell Physiol. 2017;: pubmed publisher
    ..The integrin ?4 rescue assay also supported the results. In conclusion, this study found that MARVELD1 mediated the invasion of trophoblast cells via regulating the expression of integrin ?4 during placenta development. ..
  78. Li J, Sun H, Feltri M, Mercurio A. Integrin β4 regulation of PTHrP underlies its contribution to mammary gland development. Dev Biol. 2015;407:313-20 pubmed publisher
    ..To address this problem, we generated and analyzed itgb4(flox/flox)MMTV-Cre(-) and itgb4(flox/flox)MMTV-Cre(+) mice...
  79. Sachs N, Claessen N, Aten J, Kreft M, Teske G, Koeman A, et al. Blood pressure influences end-stage renal disease of Cd151 knockout mice. J Clin Invest. 2012;122:348-58 pubmed publisher
  80. Kennel S, Godfrey V, Ch ang L, Lankford T, Foote L, Makkinje A. The beta 4 subunit of the integrin family is displayed on a restricted subset of endothelium in mice. J Cell Sci. 1992;101 ( Pt 1):145-50 pubmed
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