Itgb2

Summary

Gene Symbol: Itgb2
Description: integrin beta 2
Alias: 2E6, AI528527, Cd18, LAD, LCAMB, Lfa1, MF17, integrin beta-2, Mac-1 beta, cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, complement receptor C3 subunit beta, lymphocyte function associated antigen 1, macrophage antigen-1 beta
Species: mouse
Products:     Itgb2

Top Publications

  1. Barlow S, Langston W, Matthews K, Chidlow J, Kevil C. CD18 deficiency protects against multiple low-dose streptozotocin-induced diabetes. Am J Pathol. 2004;165:1849-52 pubmed
    ..Here we report that a gene-targeted deficiency of the beta(2) integrin, CD18, protects against multiple low-dose streptozotocin-induced autoimmune diabetes...
  2. Martin S, Hibino T, Faust A, Kleemann R, Kolb H. Differential expression of ICAM-1 and LFA-1 versus L-selectin and VCAM-1 in autoimmune insulitis of NOD mice and association with both Th1- and Th2-type infiltrates. J Autoimmun. 1996;9:637-43 pubmed
    ..ICAM-1 and LFA-1 expression is seen prior to L-selectin and VCAM-1. However, adhesion molecule expression during Th1 versus Th2 cell infiltration is very similar, suggesting similar adhesion molecule requirements of the two Th subsets. ..
  3. Boyle K, Gyori D, Sindrilaru A, Scharffetter Kochanek K, Taylor P, Mocsai A, et al. Class IA phosphoinositide 3-kinase ? and ? regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae. J Immunol. 2011;186:2978-89 pubmed publisher
    ..Hyphal-induced ROS responses were substantially inhibited by deletion of the common ?2-integrin subunit CD18, with only a minor, redundant role for Dectin-1...
  4. Wu H, Rodgers J, Perrard X, Perrard J, Prince J, Abe Y, et al. Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes. J Immunol. 2004;173:297-306 pubmed
    ..To evaluate the roles of each CD11/CD18 integrin in T cell-APC interactions, we tested the ability of splenocytes of CD11-knockout (KO) mice to respond to ..
  5. Sakurai E, Taguchi H, Anand A, Ambati B, Gragoudas E, Miller J, et al. Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization. Invest Ophthalmol Vis Sci. 2003;44:2743-9 pubmed
    To investigate the role of the leukocyte adhesion molecules CD18 and intercellular adhesion molecule (ICAM)-1 in the development of choroidal neovascularization (CNV)...
  6. Papayannopoulou T, Priestley G, Nakamoto B, Zafiropoulos V, Scott L. Molecular pathways in bone marrow homing: dominant role of alpha(4)beta(1) over beta(2)-integrins and selectins. Blood. 2001;98:2403-11 pubmed
    ..Although early deaths after transplantation can be seen in recipients deficient in CD18 and selectin, these are attributed to septic complications rather than homing defects...
  7. Petrescu M, Larry C, Bowden R, Williams G, Gagen D, Li Z, et al. Neutrophil interactions with keratocytes during corneal epithelial wound healing: a role for CD18 integrins. Invest Ophthalmol Vis Sci. 2007;48:5023-9 pubmed
    To determine the role of keratocytes and leukocyte beta(2) (CD18) integrins in neutrophil (PMN) migration through the corneal stroma after epithelial scrape injury...
  8. Li Z, Burns A, Smith C. Two waves of neutrophil emigration in response to corneal epithelial abrasion: distinct adhesion molecule requirements. Invest Ophthalmol Vis Sci. 2006;47:1947-55 pubmed
    ..Comparisons were made between wild-type (WT) mice and mice with targeted deletions of genes for CD18 (CD18(-/-)) or P- and E-selectin (P/E-sel(-/-)) or in mice with antibody-induced neutropenia...
  9. Gakidis M, Cullere X, Olson T, Wilsbacher J, Zhang B, Moores S, et al. Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol. 2004;166:273-82 pubmed
    ..Thus, Vav proteins play an essential role coupling beta2 to Rho GTPases and regulating multiple integrin-induced events important in leukocyte adhesion and phagocytosis. ..
  10. Li Z, Rumbaut R, Burns A, Smith C. Platelet response to corneal abrasion is necessary for acute inflammation and efficient re-epithelialization. Invest Ophthalmol Vis Sci. 2006;47:4794-802 pubmed
    ..Comparisons were made between wild-type (WT) mice and mice with targeted deletions of genes for P-selectin, CD18, or CD54, or mice with antibody-induced neutropenia or thrombocytopenia...

Detail Information

Publications62

  1. Barlow S, Langston W, Matthews K, Chidlow J, Kevil C. CD18 deficiency protects against multiple low-dose streptozotocin-induced diabetes. Am J Pathol. 2004;165:1849-52 pubmed
    ..Here we report that a gene-targeted deficiency of the beta(2) integrin, CD18, protects against multiple low-dose streptozotocin-induced autoimmune diabetes...
  2. Martin S, Hibino T, Faust A, Kleemann R, Kolb H. Differential expression of ICAM-1 and LFA-1 versus L-selectin and VCAM-1 in autoimmune insulitis of NOD mice and association with both Th1- and Th2-type infiltrates. J Autoimmun. 1996;9:637-43 pubmed
    ..ICAM-1 and LFA-1 expression is seen prior to L-selectin and VCAM-1. However, adhesion molecule expression during Th1 versus Th2 cell infiltration is very similar, suggesting similar adhesion molecule requirements of the two Th subsets. ..
  3. Boyle K, Gyori D, Sindrilaru A, Scharffetter Kochanek K, Taylor P, Mocsai A, et al. Class IA phosphoinositide 3-kinase ? and ? regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae. J Immunol. 2011;186:2978-89 pubmed publisher
    ..Hyphal-induced ROS responses were substantially inhibited by deletion of the common ?2-integrin subunit CD18, with only a minor, redundant role for Dectin-1...
  4. Wu H, Rodgers J, Perrard X, Perrard J, Prince J, Abe Y, et al. Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes. J Immunol. 2004;173:297-306 pubmed
    ..To evaluate the roles of each CD11/CD18 integrin in T cell-APC interactions, we tested the ability of splenocytes of CD11-knockout (KO) mice to respond to ..
  5. Sakurai E, Taguchi H, Anand A, Ambati B, Gragoudas E, Miller J, et al. Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization. Invest Ophthalmol Vis Sci. 2003;44:2743-9 pubmed
    To investigate the role of the leukocyte adhesion molecules CD18 and intercellular adhesion molecule (ICAM)-1 in the development of choroidal neovascularization (CNV)...
  6. Papayannopoulou T, Priestley G, Nakamoto B, Zafiropoulos V, Scott L. Molecular pathways in bone marrow homing: dominant role of alpha(4)beta(1) over beta(2)-integrins and selectins. Blood. 2001;98:2403-11 pubmed
    ..Although early deaths after transplantation can be seen in recipients deficient in CD18 and selectin, these are attributed to septic complications rather than homing defects...
  7. Petrescu M, Larry C, Bowden R, Williams G, Gagen D, Li Z, et al. Neutrophil interactions with keratocytes during corneal epithelial wound healing: a role for CD18 integrins. Invest Ophthalmol Vis Sci. 2007;48:5023-9 pubmed
    To determine the role of keratocytes and leukocyte beta(2) (CD18) integrins in neutrophil (PMN) migration through the corneal stroma after epithelial scrape injury...
  8. Li Z, Burns A, Smith C. Two waves of neutrophil emigration in response to corneal epithelial abrasion: distinct adhesion molecule requirements. Invest Ophthalmol Vis Sci. 2006;47:1947-55 pubmed
    ..Comparisons were made between wild-type (WT) mice and mice with targeted deletions of genes for CD18 (CD18(-/-)) or P- and E-selectin (P/E-sel(-/-)) or in mice with antibody-induced neutropenia...
  9. Gakidis M, Cullere X, Olson T, Wilsbacher J, Zhang B, Moores S, et al. Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol. 2004;166:273-82 pubmed
    ..Thus, Vav proteins play an essential role coupling beta2 to Rho GTPases and regulating multiple integrin-induced events important in leukocyte adhesion and phagocytosis. ..
  10. Li Z, Rumbaut R, Burns A, Smith C. Platelet response to corneal abrasion is necessary for acute inflammation and efficient re-epithelialization. Invest Ophthalmol Vis Sci. 2006;47:4794-802 pubmed
    ..Comparisons were made between wild-type (WT) mice and mice with targeted deletions of genes for P-selectin, CD18, or CD54, or mice with antibody-induced neutropenia or thrombocytopenia...
  11. Lämmermann T, Bader B, Monkley S, Worbs T, Wedlich Soldner R, Hirsch K, et al. Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature. 2008;453:51-5 pubmed publisher
    ..Myosin II-dependent contraction is only required on passage through narrow gaps, where a squeezing contraction of the trailing edge propels the rigid nucleus. ..
  12. Walzog B, Scharffetter Kochanek K, Gaehtgens P. Impairment of neutrophil emigration in CD18-null mice. Am J Physiol. 1999;276:G1125-30 pubmed
    This study was undertaken to investigate the requirement of beta2-integrins (CD11/CD18) for extravasation of neutrophils in mice...
  13. McMillan S, Sharma R, McKenzie E, Richards H, Zhang J, Prescott A, et al. Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b ?2-integrin-dependent signaling. Blood. 2013;121:2084-94 pubmed publisher
    ..Our findings have implications for the human functional ortholog, siglec-9, and its potential role in regulating inflammatory lung disease. ..
  14. Flick M, LaJeunesse C, Talmage K, Witte D, Palumbo J, Pinkerton M, et al. Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif. J Clin Invest. 2007;117:3224-35 pubmed
    ..Thus, fibrin(ogen) is an important, but context-dependent, determinant of arthritis, and one mechanism linking fibrin(ogen) to joint disease is coupled to alphaMbeta2-mediated inflammatory processes. ..
  15. Anderson K, Boyle K, Davidson K, Chessa T, Kulkarni S, Jarvis G, et al. CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks. Blood. 2008;112:5202-11 pubmed publisher
    ..serum-derived antibodies, and effectively abolished in mouse neutrophils lacking the beta(2)-integrin common chain, CD18. A combination of PI3K isoform-selective inhibitors, mouse knock-outs, and RNA-interference indicated CD18-..
  16. Sarantos M, Zhang H, Schaff U, Dixit N, Hayenga H, Lowell C, et al. Transmigration of neutrophils across inflamed endothelium is signaled through LFA-1 and Src family kinase. J Immunol. 2008;181:8660-9 pubmed
    ..We conclude that dimeric bond clusters of LFA-1/ICAM-1 provide a key outside-in signal for orienting cytoskeletal dynamics that direct PMN extravasation at sites of inflammation. ..
  17. Hoefer I, van Royen N, Rectenwald J, Deindl E, Hua J, Jost M, et al. Arteriogenesis proceeds via ICAM-1/Mac-1- mediated mechanisms. Circ Res. 2004;94:1179-85 pubmed
  18. Schymeinsky J, Sindrilaru A, Frommhold D, Sperandio M, Gerstl R, Then C, et al. The Vav binding site of the non-receptor tyrosine kinase Syk at Tyr 348 is critical for beta2 integrin (CD11/CD18)-mediated neutrophil migration. Blood. 2006;108:3919-27 pubmed
    Leukocyte adhesion via beta(2) integrins (CD11/CD18) activates the tyrosine kinase Syk. We found that Syk was enriched at the lamellipodium during N-formyl-Met-Leu-Phe-induced migration of neutrophil-like differentiated HL-60 cells...
  19. Bullard D, Scharffetter Kochanek K, McArthur M, Chosay J, McBride M, Montgomery C, et al. A polygenic mouse model of psoriasiform skin disease in CD18-deficient mice. Proc Natl Acad Sci U S A. 1996;93:2116-21 pubmed
    Previously, a hypomorphic mutation in CD18 was generated by gene targeting, with homozygous mice displaying increased circulating neutrophil counts, defects in the response to chemically induced peritonitis, and delays in transplantation ..
  20. Wilson R, Ballantyne C, Smith C, Montgomery C, Bradley A, O Brien W, et al. Gene targeting yields a CD18-mutant mouse for study of inflammation. J Immunol. 1993;151:1571-8 pubmed
    b>CD18 is the common beta subunit for the heterodimeric leukocyte integrins that mediate many inflammatory cell adhesion responses including binding to intercellular adhesion molecules 1 and 2...
  21. Marino J, Tausch B, Dearth C, Manacci M, McLoughlin T, Rakyta S, et al. Beta2-integrins contribute to skeletal muscle hypertrophy in mice. Am J Physiol Cell Physiol. 2008;295:C1026-36 pubmed publisher
    ..the synergist ablation model of hypertrophy and mice deficient in the common beta-subunit of beta(2)-integrins (CD18(-/-)), we found that overloaded muscles of wild-type mice had greater myofiber size, dry muscle mass, and total ..
  22. Mocsai A, Abram C, Jakus Z, Hu Y, Lanier L, Lowell C. Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat Immunol. 2006;7:1326-33 pubmed
    ..Our data show that integrin signaling for the activation of cellular responses in neutrophils and macrophages proceeds by an immunoreceptor-like mechanism. ..
  23. Li Z, Burns A, Smith C. Lymphocyte function-associated antigen-1-dependent inhibition of corneal wound healing. Am J Pathol. 2006;169:1590-600 pubmed
    ..We investigated the contributions of lymphocyte function-associated antigen (LFA)-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) by analyzing wound closure in mice with targeted deletions of CD11a (CD11a-/-) or CD11b (..
  24. Vaisar T, Kassim S, Gomez I, Green P, Hargarten S, Gough P, et al. MMP-9 sheds the beta2 integrin subunit (CD18) from macrophages. Mol Cell Proteomics. 2009;8:1044-60 pubmed publisher
    ..Biochemical studies confirmed that two transmembrane proteins, beta(2) integrin subunit (CD18) and amyloid protein precursor (APP), were enriched in the medium of M9A macrophages...
  25. Jerke U, Rolle S, Purfürst B, Luft F, Nauseef W, Kettritz R. ?2 integrin-mediated cell-cell contact transfers active myeloperoxidase from neutrophils to endothelial cells. J Biol Chem. 2013;288:12910-9 pubmed publisher
    ..Neutrophils and ECs formed intimate contact sites demonstrated by electron microscopy. Blocking CD11b or CD18 ?2 integrin chains, or using neutrophils from CD11b gene-deleted mice, reduced MPO transfer...
  26. Mizgerd J, Kubo H, Kutkoski G, Bhagwan S, Scharffetter Kochanek K, Beaudet A, et al. Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11/CD18 revealed by CD18-deficient mice. J Exp Med. 1997;186:1357-64 pubmed
    To determine the role of CD11/CD18 complexes in neutrophil emigration, inflammation was induced in the skin, lungs, or peritoneum of mutant mice deficient in CD18 (CD18-/- mutants)...
  27. Bowden R, Ding Z, Donnachie E, Petersen T, Michael L, Ballantyne C, et al. Role of alpha4 integrin and VCAM-1 in CD18-independent neutrophil migration across mouse cardiac endothelium. Circ Res. 2002;90:562-9 pubmed
    ..Although leukocyte beta2 integrins (CD18) play a critical role, significant neutrophil emigration persists when CD18 is neutralized or absent...
  28. Scharffetter Kochanek K, Lu H, Norman K, van Nood N, Munoz F, Grabbe S, et al. Spontaneous skin ulceration and defective T cell function in CD18 null mice. J Exp Med. 1998;188:119-31 pubmed
    A null mutation was prepared in the mouse for CD18, the beta2 subunit of leukocyte integrins. Homozygous CD18 null mice develop chronic dermatitis with extensive facial and submandibular erosions...
  29. Papayannopoulou T, Priestley G, Nakamoto B, Zafiropoulos V, Scott L, Harlan J. Synergistic mobilization of hemopoietic progenitor cells using concurrent beta1 and beta2 integrin blockade or beta2-deficient mice. Blood. 2001;97:1282-8 pubmed
    ..When the anti-beta2 (anti-CD11a or anti-CD18) or anti-alpha5/beta1 integrin antibody was combined with anti-alpha4, an augmentation in mobilization was seen ..
  30. Marski M, Kandula S, Turner J, Abraham C. CD18 is required for optimal development and function of CD4+CD25+ T regulatory cells. J Immunol. 2005;175:7889-97 pubmed
    ..LFA-1 (CD11a/CD18) is an adhesion molecule that plays an established role in T cell-mediated cell contact and in T cell activation...
  31. Dixit N, Yamayoshi I, Nazarian A, Simon S. Migrational guidance of neutrophils is mechanotransduced via high-affinity LFA-1 and calcium flux. J Immunol. 2011;187:472-81 pubmed publisher
    ..We demonstrate how the shear stress of blood flow can transduce distinct outside-in signals at focal sites of high-affinity LFA-1 that provide contact-mediated guidance for neutrophil emigration. ..
  32. Coxon A, Rieu P, Barkalow F, Askari S, Sharpe A, von Andrian U, et al. A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity. 1996;5:653-66 pubmed
    In mice selectively deficient in CD11b/CD18, a beta 2 integrin, chemoattractant-induced leukocyte adhesion to microvascular endothelium in vivo was reduced...
  33. Sumagin R, Prizant H, Lomakina E, Waugh R, Sarelius I. LFA-1 and Mac-1 define characteristically different intralumenal crawling and emigration patterns for monocytes and neutrophils in situ. J Immunol. 2010;185:7057-66 pubmed publisher
    ..Using function-blocking Abs, we show that these different crawling patterns were due to CD11a/CD18 (LFA-1)- versus CD11b/CD18 (Mac-1)-mediated crawling...
  34. Moser M, Bauer M, Schmid S, Ruppert R, Schmidt S, Sixt M, et al. Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells. Nat Med. 2009;15:300-5 pubmed publisher
    ..leukocytes is the hallmark of a rare autosomal recessive leukocyte adhesion deficiency syndrome in humans called LAD-III, characterized by severe bleeding and impaired adhesion of leukocytes to inflamed endothelia...
  35. Lu H, Smith C, Perrard J, Bullard D, Tang L, Shappell S, et al. LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice. J Clin Invest. 1997;99:1340-50 pubmed
    ..Our results demonstrate that Mac-1 plays a critical role in mediating binding of neutrophils to fibrinogen and neutrophil degranulation, but is not necessary for effective neutrophil emigration, which is more dependent upon LFA-1...
  36. Rosenkranz A, Mayadas T. Leukocyte-endothelial cell interactions - lessons from knockout mice. Exp Nephrol. 1999;7:125-36 pubmed
    ..Second, we discuss models of experimental glomerulonephritis and what we have learned about leukocyte adhesion receptors in the pathogenesis of glomerulonephritis through studies in knockout mice. ..
  37. Ding Z, Babensee J, Simon S, Lu H, Perrard J, Bullard D, et al. Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. J Immunol. 1999;163:5029-38 pubmed
    ..in embryonic stem cells, and neutrophil function was compared in vitro and in vivo with Mac-1-deficient, CD18-deficient, and wild-type mice...
  38. Watts G, Beurskens F, Martin Padura I, Ballantyne C, Klickstein L, Brenner M, et al. Manifestations of inflammatory arthritis are critically dependent on LFA-1. J Immunol. 2005;174:3668-75 pubmed
    ..Using mice deficient in all beta2 integrins (CD18 null mice), we demonstrate that expression of these heterodimeric adhesion molecules is critical for arthritis ..
  39. Kandula S, Abraham C. LFA-1 on CD4+ T cells is required for optimal antigen-dependent activation in vivo. J Immunol. 2004;173:4443-51 pubmed
    ..allows for segregation of the migration and activation defects through the adoptive transfer of LFA-1-deficient (CD18(-/-)) CD4(+) T cells from DO11.10 Ag-specific TCR transgenic mice into wild-type BALB/c mice...
  40. Kevil C, Hicks M, He X, Zhang J, Ballantyne C, Raman C, et al. Loss of LFA-1, but not Mac-1, protects MRL/MpJ-Fas(lpr) mice from autoimmune disease. Am J Pathol. 2004;165:609-16 pubmed
    ..The phenotype of the LFA-1-deficient mice was similar to that observed in beta(2) integrin-deficient (CD18-null) MRL/MpJ-Fas(lpr) mice, suggesting a lack of redundancy among the beta(2) integrin family members and other ..
  41. Asaduzzaman M, Zhang S, Lavasani S, Wang Y, Thorlacius H. LFA-1 and MAC-1 mediate pulmonary recruitment of neutrophils and tissue damage in abdominal sepsis. Shock. 2008;30:254-9 pubmed publisher
    ..Thus, these novel findings suggest that LFA-1 or Mac-1 may serve as targets to protect against lung injury in polymicrobial sepsis. ..
  42. Wang X, Gao M, Schouteden S, Roebroek A, Eggermont K, Van Veldhoven P, et al. Hematopoietic stem/progenitor cells directly contribute to arteriosclerotic progression via integrin ?2. Stem Cells. 2015;33:1230-40 pubmed publisher
    ..migration toward ICAM-1 in vitro, and homing to injured arteries in vivo, all of which were blocked with an anti-CD18 blocking antibody...
  43. Threadgill D, Womack J. Mapping HSA 3 loci in cattle: additional support for the ancestral synteny of HSA 3 and 21. Genomics. 1991;11:1143-8 pubmed
    ..FIM3, SI, and CP mapped to bovine syntenic group U10, while RAF1 and GPX1 mapped to U12. ..
  44. Park Min K, Lee E, Moskowitz N, Lim E, Lee S, Lorenzo J, et al. Negative regulation of osteoclast precursor differentiation by CD11b and ?2 integrin-B-cell lymphoma 6 signaling. J Bone Miner Res. 2013;28:135-49 pubmed publisher
    ..In this study we investigated regulation of osteoclast differentiation by the ?2 integrin CD11b/CD18 that is expressed on myeloid lineage osteoclast precursors...
  45. Shih Y, Wang M, Yang T, Zhou J, Lee D, Lee P, et al. ?(2)-Integrin and Notch-1 differentially regulate CD34(+)CD31(+) cell plasticity in vascular niches. Cardiovasc Res. 2012;96:296-307 pubmed publisher
  46. Lefort C, Rossaint J, Moser M, Petrich B, Zarbock A, Monkley S, et al. Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. Blood. 2012;119:4275-82 pubmed publisher
    ..We conclude that talin-1 and kindlin-3 serve distinct functions in LFA-1 activation...
  47. Kadono T, Venturi G, Steeber D, Tedder T. Leukocyte rolling velocities and migration are optimized by cooperative L-selectin and intercellular adhesion molecule-1 functions. J Immunol. 2002;169:4542-50 pubmed
    ..Pretreatment of lymphocytes with an anti-CD18 mAb eliminated the increase in rolling, and all rolling was blocked by anti-L-selectin mAb...
  48. Marski M, Ye A, Abraham C. CD18 is required for intestinal T cell responses at multiple immune checkpoints. J Immunol. 2007;178:2104-12 pubmed
    ..that allows for segregation of T cell migration and activation through the adoptive transfer of LFA-1-deficient (CD18(-/-)) CD4(+) T cells from DO11.10 TCR transgenic mice into wild-type BALB/c mice...
  49. Schack L, Stapulionis R, Christensen B, Kofod Olsen E, Skov Sørensen U, Vorup Jensen T, et al. Osteopontin enhances phagocytosis through a novel osteopontin receptor, the alphaXbeta2 integrin. J Immunol. 2009;182:6943-50 pubmed publisher
    ..We identify the integrin alpha(X)beta(2) (CD11c/CD18), which is highly expressed on the cell surface of monocytes, as a novel OPN receptor...
  50. Nolte t Hoen E, Buschow S, Anderton S, Stoorvogel W, Wauben M. Activated T cells recruit exosomes secreted by dendritic cells via LFA-1. Blood. 2009;113:1977-81 pubmed publisher
    ..These results imply that DC exosomes secreted in the extracellular milieu during cognate T-cell-DC interactions are targeted to T cells activated in that microenvironment. ..
  51. Ranganathan S, Cao C, Catania J, Migliorini M, Zhang L, Strickland D. Molecular basis for the interaction of low density lipoprotein receptor-related protein 1 (LRP1) with integrin alphaMbeta2: identification of binding sites within alphaMbeta2 for LRP1. J Biol Chem. 2011;286:30535-41 pubmed publisher
    ..Indeed, we further demonstrate that the soluble form of LRP1 (sLRP1) inhibits ?(M)?(2)-mediated adhesion of cells to fibrinogen. These studies suggest that sLRP1 may attenuate inflammation by modulating integrin function. ..
  52. Smith S, Barnum S. Differential expression of beta 2-integrins and cytokine production between gammadelta and alphabeta T cells in experimental autoimmune encephalomyelitis. J Leukoc Biol. 2008;83:71-9 pubmed
    ..These results suggest unique roles for beta 2-integrins in the trafficking of gammadelta versus alphabeta T cells during EAE and that gammadelta T cells infiltrate the CNS rapidly, producing cytokines, which modulate acute disease. ..
  53. Christensen J, Marker O, Thomsen A. T-cell-mediated immunity to lymphocytic choriomeningitis virus in beta2-integrin (CD18)- and ICAM-1 (CD54)-deficient mice. J Virol. 1996;70:8997-9002 pubmed
  54. Reichardt P, Patzak I, Jones K, Etemire E, Gunzer M, Hogg N. A role for LFA-1 in delaying T-lymphocyte egress from lymph nodes. EMBO J. 2013;32:829-43 pubmed publisher
    ..Thus, we identify a novel function for LFA-1 in guiding T cells at the critical point of LN egress when they either exit or return into the LN for further interactions. ..
  55. Thom S, Bhopale V, Mancini D, Milovanova T. Actin S-nitrosylation inhibits neutrophil beta2 integrin function. J Biol Chem. 2008;283:10822-34 pubmed publisher
    ..We conclude that cytoskeletal changes triggered by hyperoxia inhibit beta(2) integrin-dependent neutrophil adhesion. ..
  56. Coelho F, Natale D, Soriano S, Hons M, Swoger J, Mayer J, et al. Naive B-cell trafficking is shaped by local chemokine availability and LFA-1-independent stromal interactions. Blood. 2013;121:4101-9 pubmed publisher
    ..Our data provide an overview of the contribution of prototype GPCRs and integrins during naive B-cell migration and shed light on the local chemokine availability that these cells compute. ..
  57. Wang H, Peters T, Kess D, Sindrilaru A, Oreshkova T, Van Rooijen N, et al. Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation. J Clin Invest. 2006;116:2105-14 pubmed
    The CD18 hypomorphic (CD18hypo) PL/J mouse model clinically resembling human psoriasis is characterized by reduced expression of the common chain of beta2 integrins (CD11/CD18) to only 2-16% of WT levels...
  58. Schramm R, Schaefer T, Menger M, Thorlacius H. Acute mast cell-dependent neutrophil recruitment in the skin is mediated by KC and LFA-1: inhibitory mechanisms of dexamethasone. J Leukoc Biol. 2002;72:1122-32 pubmed
    ..Thus, this study elucidates important interactions between chemokines and adhesion molecules in mast cell-dependent neutrophil recruitment and provides new insight into mechanisms of dexamethasone in skin inflammation. ..
  59. Krebs P, Crozat K, Popkin D, Oldstone M, Beutler B. Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice. Blood. 2011;117:6582-8 pubmed publisher
    ..We show that neither the integrin CD18, which is involved in adhesion between antigen-presenting cells and effector T cells, nor tumor necrosis factor (..
  60. Bonig H, Priestley G, Oehler V, Papayannopoulou T. Hematopoietic progenitor cells (HPC) from mobilized peripheral blood display enhanced migration and marrow homing compared to steady-state bone marrow HPC. Exp Hematol. 2007;35:326-34 pubmed
    ..The data suggest increased motility as a converging endpoint of complex changes seen in MPB HPC which is likely responsible for their favorable homing. ..
  61. Xu H, Guan H, Zu G, Bullard D, Hanson J, Slater M, et al. The role of ICAM-1 molecule in the migration of Langerhans cells in the skin and regional lymph node. Eur J Immunol. 2001;31:3085-93 pubmed
    ..This study indicates that ICAM-1 regulates the migration of dendritic cells into regional lymph nodes but not into or out of the skin. ..
  62. Jörger A, Liu L, Fehlner K, Weisser T, Cheng Z, Lu M, et al. Impact of NKT Cells and LFA-1 on Liver Regeneration under Subseptic Conditions. PLoS ONE. 2016;11:e0168001 pubmed publisher
    ..A subseptic situation negatively alters hepatocyte proliferation. Within this scenario, we suggest an important impact of NKT cells and postulate a critical function for LFA-1 during processes of liver regeneration. ..