Gene Symbol: Itgb1
Description: integrin beta 1 (fibronectin receptor beta)
Alias: 4633401G24Rik, AA409975, AA960159, CD29, Fnrb, Gm9863, gpIIa, integrin beta-1, VLA-4 subunit beta, fibronectin receptor subunit beta
Species: mouse
Products:     Itgb1

Top Publications

  1. Li R, Wu Y, Manso A, Gu Y, Liao P, Israeli S, et al. ?1 integrin gene excision in the adult murine cardiac myocyte causes defective mechanical and signaling responses. Am J Pathol. 2012;180:952-62 pubmed publisher
    ..These results show that ?1 integrin expression is required for proper mechanotransductive and adrenergic responses of the adult heart. ..
  2. Jeanes A, Wang P, Moreno Layseca P, Paul N, Cheung J, Tsang R, et al. Specific ?-containing integrins exert differential control on proliferation and two-dimensional collective cell migration in mammary epithelial cells. J Biol Chem. 2012;287:24103-12 pubmed publisher
    ..These results show that ?1-integrins promote cell cycle in mammary epithelial cells, whereas ?3-integrins are involved in migration. ..
  3. Zhang X, Mernaugh G, Yang D, Gewin L, Srichai M, Harris R, et al. beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity. Development. 2009;136:3357-66 pubmed publisher
    ..Thus beta1 integrins can regulate organ branching morphogenesis during development by mediating growth-factor-dependent signaling in addition to their well-defined role as adhesion receptors. ..
  4. Nodari A, Zambroni D, Quattrini A, Court F, D Urso A, Recchia A, et al. Beta1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelination. J Cell Biol. 2007;177:1063-75 pubmed
    ..Thus, increased activation of Rac1 by beta1 integrins allows Schwann cells to switch from migration/elongation to the extension of radial membranes required for axonal sorting and myelination...
  5. Rebustini I, Patel V, Stewart J, Layvey A, Georges Labouesse E, Miner J, et al. Laminin alpha5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta1 integrin signaling. Dev Biol. 2007;308:15-29 pubmed
    ..These data link changes in basement membrane composition during branching morphogenesis with FGFR expression and signaling. ..
  6. Huck L, Pontier S, Zuo D, Muller W. beta1-integrin is dispensable for the induction of ErbB2 mammary tumors but plays a critical role in the metastatic phase of tumor progression. Proc Natl Acad Sci U S A. 2010;107:15559-64 pubmed publisher
    ..Taken together, these observations suggest that, although beta1-integrin is dispensable for the initiation of ErbB2 tumor induction, it plays a critical role in metastatic phase of tumor progression. ..
  7. Zhang X, Jiang G, Cai Y, Monkley S, Critchley D, Sheetz M. Talin depletion reveals independence of initial cell spreading from integrin activation and traction. Nat Cell Biol. 2008;10:1062-8 pubmed publisher
    ..We suggest that talin is not required for initial cell spreading. However, talin provides the important mechanical linkage between ligand-bound integrins and the actin cytoskeleton required to catalyse focal adhesion-dependent pathways. ..
  8. Shibue T, Weinberg R. Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Proc Natl Acad Sci U S A. 2009;106:10290-5 pubmed publisher
    ..These results demonstrate the critical role of integrin beta(1)-FAK signaling axis in controlling the initial proliferation of micrometastatic cancer cells disseminated in the lungs. ..
  9. Parkash J, Cimino I, Ferraris N, Casoni F, Wray S, Cappy H, et al. Suppression of β1-integrin in gonadotropin-releasing hormone cells disrupts migration and axonal extension resulting in severe reproductive alterations. J Neurosci. 2012;32:16992-7002 pubmed publisher reproduction, Cre/LoxP technology was used to generate GnRH neuron-specific β1-integrin conditional KO (GnRH-Itgb1(-/-)) mice...

More Information


  1. Roca Cusachs P, Gauthier N, Del Rio A, Sheetz M. Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction. Proc Natl Acad Sci U S A. 2009;106:16245-50 pubmed publisher
  2. Jones R, Li X, Gray P, Kuang J, Clayton F, Samowitz W, et al. Conditional deletion of beta1 integrins in the intestinal epithelium causes a loss of Hedgehog expression, intestinal hyperplasia, and early postnatal lethality. J Cell Biol. 2006;175:505-14 pubmed
    ..This study shows that beta1 integrins are key regulators of proliferation and homeostasis in the intestine and achieve this not through anchorage-dependent effects but by generating Hh expression and signaling. ..
  3. Akhtar N, Streuli C. An integrin-ILK-microtubule network orients cell polarity and lumen formation in glandular epithelium. Nat Cell Biol. 2013;15:17-27 pubmed
    ..We propose that this integrin signalling network controls the delivery of apical components to the correct surface and thereby governs the orientation of polarity and development of lumens. ..
  4. Ieda M, Tsuchihashi T, Ivey K, Ross R, Hong T, Shaw R, et al. Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Dev Cell. 2009;16:233-44 pubmed publisher
    ..These findings reveal a previously unrecognized paracrine function of embryonic cardiac fibroblasts in regulating cardiomyocyte proliferation. ..
  5. Harburger D, Bouaouina M, Calderwood D. Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects. J Biol Chem. 2009;284:11485-97 pubmed publisher
    ..We suggest that kindlins are adaptor proteins that regulate integrin activation, that kindlin expression levels determine their effects, and that kindlins may exert integrin-specific effects. ..
  6. Green J, Berrier A, Pankov R, Yamada K. beta1 integrin cytoplasmic domain residues selectively modulate fibronectin matrix assembly and cell spreading through talin and Akt-1. J Biol Chem. 2009;284:8148-59 pubmed publisher
    ..These results demonstrate distinct mechanisms by which integrins regulate cell spreading and matrix assembly through the beta(1) integrin cytoplasmic tail. ..
  7. Liu J, He X, Qi Y, Tian X, Monkley S, Critchley D, et al. Talin1 regulates integrin turnover to promote embryonic epithelial morphogenesis. Mol Cell Biol. 2011;31:3366-77 pubmed publisher
    ..All together, these results suggest that talin1 binding to integrin promotes epiblast adhesion and morphogenesis in part by preventing integrin ?1 degradation. ..
  8. Larrieu Lahargue F, Welm A, Thomas K, Li D. Netrin-4 activates endothelial integrin {alpha}6{beta}1. Circ Res. 2011;109:770-4 pubmed publisher
    ..The ?6?1 integrin is a netrin-4 receptor in lymphatic endothelium and consequently represents a potential target to inhibit netrin-4-induced metastatic dissemination. ..
  9. Singh P, Chen C, Pal Ghosh S, Stepp M, Sheppard D, Van De Water L. Loss of integrin alpha9beta1 results in defects in proliferation, causing poor re-epithelialization during cutaneous wound healing. J Invest Dermatol. 2009;129:217-28 pubmed publisher
  10. Ramirez N, Zhang Z, Madamanchi A, Boyd K, O Rear L, Nashabi A, et al. The ???? integrin is a metastasis suppressor in mouse models and human cancer. J Clin Invest. 2011;121:226-37 pubmed publisher
    ..Thus, the ?2?1 integrin functionally inhibits breast tumor metastasis, and ?2 expression may serve as an important biomarker of metastatic potential and patient survival. ..
  11. Staniszewska I, Sariyer I, Lecht S, BROWN M, Walsh E, Tuszynski G, et al. Integrin alpha9 beta1 is a receptor for nerve growth factor and other neurotrophins. J Cell Sci. 2008;121:504-13 pubmed publisher
    ..Moreover, alpha9beta1 integrin is a signaling receptor for NGF, which activates the MAPK (Erk1/2) pathway. The alpha9beta1-dependent chemotactic ability of NGF appears to result from the activation of paxillin. ..
  12. Ozcelik M, Cotter L, Jacob C, Pereira J, Relvas J, Suter U, et al. Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves. J Neurosci. 2010;30:4120-31 pubmed publisher
    ..We conclude that regulation of epithelial-like polarization is a critical determinant of myelin sheath structure and function. ..
  13. Böttcher R, Stremmel C, Meves A, Meyer H, Widmaier M, Tseng H, et al. Sorting nexin 17 prevents lysosomal degradation of ?1 integrins by binding to the ?1-integrin tail. Nat Cell Biol. 2012;14:584-92 pubmed publisher
    ..Our results identify SNX17 as a ?1-integrin-tail-binding protein that interacts with the free Kindlin-binding site in endosomes to stabilize ?1 integrins, resulting in their recycling to the cell surface where they can be reused. ..
  14. Schmidt S, Nakchbandi I, Ruppert R, Kawelke N, Hess M, Pfaller K, et al. Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption. J Cell Biol. 2011;192:883-97 pubmed publisher
    ..These findings show that osteoclasts require their entire integrin repertoire to be regulated by kindlin-3 to orchestrate bone homeostasis. ..
  15. Lamar J, Iyer V, DiPersio C. Integrin alpha3beta1 potentiates TGFbeta-mediated induction of MMP-9 in immortalized keratinocytes. J Invest Dermatol. 2008;128:575-86 pubmed
    ..These findings provide early evidence of a role for alpha3beta1 in augmenting TGFbeta-mediated induction of MMP-9 in immortalized or transformed keratinocytes during skin carcinogenesis. ..
  16. Radakovits R, Barros C, Belvindrah R, Patton B, Muller U. Regulation of radial glial survival by signals from the meninges. J Neurosci. 2009;29:7694-705 pubmed publisher
    ..Our findings demonstrate that attachment of RGC processes at the meninges is important for RGC survival and the control of cortical size. ..
  17. Liang X, Sun Y, Ye M, Scimia M, Cheng H, Martin J, et al. Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality. Circulation. 2009;120:568-76 pubmed publisher
    ..These results demonstrate essential roles for PINCHs in myocardial growth, maturation, remodeling, and function and highlight the importance of studying the role of PINCHs in human cardiac injury and cardiomyopathy. ..
  18. Quach N, Biressi S, Reichardt L, Keller C, Rando T. Focal adhesion kinase signaling regulates the expression of caveolin 3 and beta1 integrin, genes essential for normal myoblast fusion. Mol Biol Cell. 2009;20:3422-35 pubmed publisher
    ..These data suggest that FAK regulation of profusion genes, including caveolin 3 and the beta1D integrin subunit, is essential for morphological muscle differentiation. ..
  19. Zovein A, Luque A, Turlo K, Hofmann J, Yee K, Becker M, et al. Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism. Dev Cell. 2010;18:39-51 pubmed publisher
    ..Loss of beta1 integrin (Itgb1) in nascent endothelium leads to disruption of arterial endothelial cell polarity and lumen formation...
  20. Berti C, Bartesaghi L, Ghidinelli M, Zambroni D, Figlia G, Chen Z, et al. Non-redundant function of dystroglycan and ?1 integrins in radial sorting of axons. Development. 2011;138:4025-37 pubmed publisher
    ..These data identify dystroglycan as a functional laminin 211 receptor during axonal sorting and the key substrate relevant to the pathogenesis of glycosyltransferase congenital muscular dystrophies. ..
  21. Moser M, Nieswandt B, Ussar S, Pozgajova M, Fassler R. Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med. 2008;14:325-30 pubmed publisher
    ..We have therefore identified Kindlin-3 as a novel and essential element for platelet integrin activation in hemostasis and thrombosis. ..
  22. Lathia J, Patton B, Eckley D, Magnus T, Mughal M, Sasaki T, et al. Patterns of laminins and integrins in the embryonic ventricular zone of the CNS. J Comp Neurol. 2007;505:630-43 pubmed
  23. Lluri G, Langlois G, Soloway P, Jaworski D. Tissue inhibitor of metalloproteinase-2 (TIMP-2) regulates myogenesis and beta1 integrin expression in vitro. Exp Cell Res. 2008;314:11-24 pubmed
    ..Elucidating the role of TIMP-2 in myogenesis in vitro may lead to new therapeutic options for the use of TIMP-2 in myopathies and muscular dystrophies in vivo. ..
  24. Benninger Y, Thurnherr T, Pereira J, Krause S, Wu X, Chrostek Grashoff A, et al. Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development. J Cell Biol. 2007;177:1051-61 pubmed
    ..Our results indicate that although cdc42 is required for normal Schwann cell proliferation, rac1 regulates Schwann cell process extension and stabilization, allowing efficient radial sorting of axon bundles...
  25. Chen X, Abair T, Ibanez M, Su Y, Frey M, Dise R, et al. Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation. Mol Cell Biol. 2007;27:3313-26 pubmed
  26. Longmate W, Monichan R, Chu M, Tsuda T, Mahoney M, DiPersio C. Reduced fibulin-2 contributes to loss of basement membrane integrity and skin blistering in mice lacking integrin ?3?1 in the epidermis. J Invest Dermatol. 2014;134:1609-1617 pubmed publisher
    ..Our findings indicate a role for integrin ?3?1 in BM stability through fibulin-2 induction, both in neonatal skin and in adult wounds. ..
  27. Liu Y, Chattopadhyay N, Qin S, Szekeres C, Vasylyeva T, Mahoney Z, et al. Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis. Development. 2009;136:843-53 pubmed publisher
    ..Together, these results demonstrate how signals from integrins and growth factor receptors can be integrated to regulate the expression of an important family of signaling molecules so as to regulate morphogenetic events. ..
  28. Vjugina U, Zhu X, Oh E, Bracero N, Evans J. Reduction of mouse egg surface integrin alpha9 subunit (ITGA9) reduces the egg's ability to support sperm-egg binding and fusion. Biol Reprod. 2009;80:833-41 pubmed publisher
    ..RNA interference attempts to knockdown ITGA9's likely beta partner, beta(1) (ITGB1), resulted in reduced Itgb1 mRNA but no reduction in ITGB1 surface protein...
  29. Piwko Czuchra A, Koegel H, Meyer H, Bauer M, Werner S, Brakebusch C, et al. Beta1 integrin-mediated adhesion signalling is essential for epidermal progenitor cell expansion. PLoS ONE. 2009;4:e5488 pubmed publisher
    ..These data demonstrate that expression of beta1 integrins is critically important for the expansion of epidermal progenitor cells to maintain epidermal homeostasis. ..
  30. King S, Worth D, Scales T, Monypenny J, Jones G, Parsons M. ?1 integrins regulate fibroblast chemotaxis through control of N-WASP stability. EMBO J. 2011;30:1705-18 pubmed publisher
    ..This represents a novel mechanism by which integrins cooperate with growth factor receptors to promote localised signalling and directed cell motility. ..
  31. Phillips J, Almeida E, Hill E, Aguirre J, Rivera M, Nachbandi I, et al. Role for beta1 integrins in cortical osteocytes during acute musculoskeletal disuse. Matrix Biol. 2008;27:609-18 pubmed publisher
  32. McCall Culbreath K, Li Z, Zutter M. Crosstalk between the alpha2beta1 integrin and c-met/HGF-R regulates innate immunity. Blood. 2008;111:3562-70 pubmed publisher
    ..These findings suggest that crosstalk between c-met and the alpha2beta1 integrin may contribute to mast-cell activation in autoimmune and inflammatory disorders. ..
  33. Conti F, Monkley S, Wood M, Critchley D, Muller U. Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions. Development. 2009;136:3597-606 pubmed publisher
    ..We conclude that talin 1 and 2 are crucial for skeletal muscle development, where they regulate myoblast fusion, sarcomere assembly and the maintenance of MTJs. ..
  34. Missan D, Chittur S, DiPersio C. Regulation of fibulin-2 gene expression by integrin ?3?1 contributes to the invasive phenotype of transformed keratinocytes. J Invest Dermatol. 2014;134:2418-2427 pubmed publisher
    ..These findings demonstrate a prominent role for ?3?1 in immortalized/transformed keratinocytes in regulating fibulin-2 and other genes that promote matrix remodeling and invasion. ..
  35. Planas Paz L, Strilic B, Goedecke A, Breier G, Fassler R, Lammert E. Mechanoinduction of lymph vessel expansion. EMBO J. 2012;31:788-804 pubmed publisher
    ..Thus, we propose a new and physiologically relevant mode of VEGFR3 activation, which is based on mechanotransduction and is essential for normal development and fluid homeostasis in a mammalian embryo...
  36. Naipauer J, Gattelli A, Degese M, Slomiansky V, Wertheimer E, LaMarre J, et al. The use of alternative polyadenylation sites renders integrin ?1 (Itgb1) mRNA isoforms with differential stability during mammary gland development. Biochem J. 2013;454:345-57 pubmed publisher
    ..Characterization of the full-length mRNA encoding the ?1 subunit (Itgb1) revealed an alternative functional cleavage and polyadenylation site that yields a new Itgb1 mRNA isoform 578 bp ..
  37. Gupton S, Gertler F. Integrin signaling switches the cytoskeletal and exocytic machinery that drives neuritogenesis. Dev Cell. 2010;18:725-36 pubmed publisher
    ..These regulated changes and coordination of cytoskeletal and exocytic machinery may be used in other physiological contexts involving cell motility and morphogenesis. ..
  38. Jensen K, Collins C, Nascimento E, Tan D, Frye M, Itami S, et al. Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis. Cell Stem Cell. 2009;4:427-39 pubmed publisher
    ..Our results suggest that Lrig1-positive cells constitute a previously unidentified reservoir of adult mouse interfollicular epidermal stem cells. ..
  39. Baessler K, Lee Y, Sampson N. Beta1 integrin is an adhesion protein for sperm binding to eggs. ACS Chem Biol. 2009;4:357-66 pubmed publisher
    ..Therefore, the mechanisms by which sperm fertilize wild-type and beta(1) knockout eggs are different. ..
  40. Margadant C, Raymond K, Kreft M, Sachs N, Janssen H, Sonnenberg A. Integrin alpha3beta1 inhibits directional migration and wound re-epithelialization in the skin. J Cell Sci. 2009;122:278-88 pubmed publisher
    ..We suggest that integrin alpha3beta1 delays keratinocyte migration during wound re-epithelialization, by binding to the laminin-332 that is newly deposited on the wound bed. ..
  41. Kren A, Baeriswyl V, Lehembre F, Wunderlin C, Strittmatter K, Antoniadis H, et al. Increased tumor cell dissemination and cellular senescence in the absence of beta1-integrin function. EMBO J. 2007;26:2832-42 pubmed
    ..The results indicate a critical role of beta(1)-integrin function in mediating metastatic dissemination and preventing tumor cell senescence. ..
  42. Tanjore H, Zeisberg E, Gerami Naini B, Kalluri R. Beta1 integrin expression on endothelial cells is required for angiogenesis but not for vasculogenesis. Dev Dyn. 2008;237:75-82 pubmed
    ..These results indicate that beta1 integrin expression on vascular endothelial cells is crucial for embryonic angiogenesis but dispensable for vasculogenesis. ..
  43. Belvindrah R, Graus Porta D, Goebbels S, Nave K, Muller U. Beta1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex. J Neurosci. 2007;27:13854-65 pubmed
    ..We conclude that beta1 integrins in radial glia are required for the proper development of the cerebral cortex, whereas beta1 integrins in migrating neurons are not essential for glial-guided migration and reelin signaling. ..
  44. Petrich B, Marchese P, Ruggeri Z, Spiess S, Weichert R, Ye F, et al. Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med. 2007;204:3103-11 pubmed
    ..These data establish that platelet talin plays a crucial role in hemostasis and provide the first proof that talin is required for the activation and function of mammalian alpha2beta1 and alphaIIbbeta3 integrins in vivo. ..
  45. Taddei I, Deugnier M, Faraldo M, Petit V, Bouvard D, Medina D, et al. Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells. Nat Cell Biol. 2008;10:716-22 pubmed publisher
  46. Millon Fremillon A, Bouvard D, Grichine A, Manet Dupé S, Block M, Albiges Rizo C. Cell adaptive response to extracellular matrix density is controlled by ICAP-1-dependent beta1-integrin affinity. J Cell Biol. 2008;180:427-41 pubmed publisher
    ..Our results clarify the function of ICAP-1 in cell adhesion and highlight the central role it plays in the cell's integrated response to the extracellular microenvironment. ..
  47. Bentmann A, Kawelke N, Moss D, Zentgraf H, Bala Y, Berger I, et al. Circulating fibronectin affects bone matrix, whereas osteoblast fibronectin modulates osteoblast function. J Bone Miner Res. 2010;25:706-15 pubmed publisher
    ..A novel role for liver-derived circulating fibronectin thus was defined and delineated from that of locally produced fibronectin. ..
  48. Nodari A, Previtali S, Dati G, Occhi S, Court F, Colombelli C, et al. Alpha6beta4 integrin and dystroglycan cooperate to stabilize the myelin sheath. J Neurosci. 2008;28:6714-9 pubmed publisher
    ..These data indicate that, similar to its role in skin, alpha6beta4 integrin confers stability to myelin in peripheral nerves. ..
  49. Rantala J, Pouwels J, Pellinen T, Veltel S, Laasola P, Mattila E, et al. SHARPIN is an endogenous inhibitor of ?1-integrin activation. Nat Cell Biol. 2011;13:1315-24 pubmed publisher
    ..Therefore, SHARPIN inhibits the critical switching of ?1-integrins from inactive to active conformations. ..
  50. Messina A, Ferraris N, Wray S, Cagnoni G, Donohue D, Casoni F, et al. Dysregulation of Semaphorin7A/?1-integrin signaling leads to defective GnRH-1 cell migration, abnormal gonadal development and altered fertility. Hum Mol Genet. 2011;20:4759-74 pubmed publisher
    ..In conclusion, we have identified Sema7A as a gene implicated in the normal development of the GnRH-1 system in mice and as a genetic marker for the elucidation of some forms of GnRH-1 deficiency in humans. ..
  51. Kruger M, Moser M, Ussar S, Thievessen I, Luber C, Forner F, et al. SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. Cell. 2008;134:353-64 pubmed publisher
    ..The SILAC-mouse approach is a versatile tool by which to quantitatively compare proteomes from knockout mice and thereby determine protein functions under complex in vivo conditions. ..
  52. Baudoin C, Goumans M, Mummery C, Sonnenberg A. Knockout and knockin of the beta1 exon D define distinct roles for integrin splice variants in heart function and embryonic development. Genes Dev. 1998;12:1202-16 pubmed
    ..We propose that beta1D is less efficient than beta1A in mediating the signaling that regulates cell motility and responses of the cells to mechanical stress. ..
  53. Yang J, Hynes R. Fibronectin receptor functions in embryonic cells deficient in alpha 5 beta 1 integrin can be replaced by alpha V integrins. Mol Biol Cell. 1996;7:1737-48 pubmed
    ..Finally, our data suggested possible roles for alpha V integrins in replacing the role of alpha 5 beta 1 in FN matrix assembly in vitro and in FN-dependent embryonic functions in vivo. ..