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Genomes and Genes
| Itga7SummaryGene Symbol: Itga7 Description: integrin alpha 7 Alias: alpha7, integrin alpha-7 Species: mouse Publications Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophyJachinta E Rooney Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA Proc Natl Acad Sci U S A 106:7991-6 Alpha7 integrin expression is negatively regulated by deltaEF1 during skeletal myogenesisPoonam Jethanandani Department of Cell and Tissue Biology, University of California, San Francisco, California 94143 0640, USA J Biol Chem 280:36037-46 Role for the alpha7beta1 integrin in vascular development and integrityNichole L Flintoff Dye Department of Pharmacology, University of Nevada, Manville Health Science Building, Reno, 89557, USA Dev Dyn 234:11-21 Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocystDan Strumpf Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto M5G 1X5, Ontario, Canada Development 132:2093-102 Alpha7 integrin mediates neurite outgrowth of distinct populations of adult sensory neuronsNatalie J Gardiner School of Biological Sciences, University of Manchester, Manchester, M13 9PT, UK Mol Cell Neurosci 28:229-40 Force transmission, compliance, and viscoelasticity are altered in the alpha7-integrin-null mouse diaphragmM A Lopez Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA Am J Physiol Cell Physiol 288:C282-9 Beta1 integrins in muscle, but not in motor neurons, are required for skeletal muscle innervationMartin Schwander Department of Cell Biology and Institute for Childhood and Neglected Disease, The Scripps Research Institute, La Jolla, California 92037, USA J Neurosci 24:8181-91 Integrins in the mouse myotome: developmental changes and differences between the epaxial and hypaxial lineageFernanda Bajanca Departamento de Biologia Animal, Centro de Biologia Ambiental, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal Dev Dyn 231:402-15 ADP-ribosylation of integrin alpha7 modulates the binding of integrin alpha7beta1 to lamininZhefeng Zhao Department of Biochemistry, Kansas State University, 104 Willard Hall, Manhattan, KS 66506, USA Biochem J 385:309-17 Genetic compensation for sarcoglycan loss by integrin alpha7beta1 in muscleMichael J Allikian Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA J Cell Sci 117:3821-30 | Scientific Experts
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Detail Information
Publications
Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophyJachinta E Rooney
Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA
Proc Natl Acad Sci U S A 106:7991-6
Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA
Proc Natl Acad Sci U S A 106:7991-6
..These findings demonstrate that laminin-111 is a highly potent therapeutic agent for the mdx mouse model of DMD and represents a paradigm for the systemic delivery of extracellular matrix proteins as therapies for genetic diseases...
Alpha7 integrin expression is negatively regulated by deltaEF1 during skeletal myogenesisPoonam Jethanandani
Department of Cell and Tissue Biology, University of California, San Francisco, California 94143 0640, USA
J Biol Chem 280:36037-46
Department of Cell and Tissue Biology, University of California, San Francisco, California 94143 0640, USA
J Biol Chem 280:36037-46
b>Alpha7 integrin levels increase dramatically as myoblasts differentiate to myotubes. A negative regulatory element with putative sites for deltaEF1 is present in the alpha7 proximal promoter region...
Role for the alpha7beta1 integrin in vascular development and integrityNichole L Flintoff Dye
Department of Pharmacology, University of Nevada, Manville Health Science Building, Reno, 89557, USA
Dev Dyn 234:11-21
Department of Pharmacology, University of Nevada, Manville Health Science Building, Reno, 89557, USA
Dev Dyn 234:11-21
..To identify the expression pattern of the alpha7 integrin in these tissues during embryonic development, alpha7 integrin chain knockout mice were generated by a ..
Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocystDan Strumpf
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto M5G 1X5, Ontario, Canada
Development 132:2093-102
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto M5G 1X5, Ontario, Canada
Development 132:2093-102
..Thus, Cdx2 is essential for segregation of the ICM and TE lineages at the blastocyst stage by ensuring repression of Oct4 and Nanog in the TE...
Alpha7 integrin mediates neurite outgrowth of distinct populations of adult sensory neuronsNatalie J Gardiner
School of Biological Sciences, University of Manchester, Manchester, M13 9PT, UK
Mol Cell Neurosci 28:229-40
School of Biological Sciences, University of Manchester, Manchester, M13 9PT, UK
Mol Cell Neurosci 28:229-40
..Following sciatic nerve crush, alpha7 integrin is expressed by medium-large diameter, NF200-immunoreactive (IR), and medium diameter, CGRP-IR, neurons, ..
Force transmission, compliance, and viscoelasticity are altered in the alpha7-integrin-null mouse diaphragmM A Lopez
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Am J Physiol Cell Physiol 288:C282-9
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Am J Physiol Cell Physiol 288:C282-9
Alpha7beta1 integrin is a transmembrane structural and receptor protein of skeletal muscles, and the absence of alpha7-integrin causes muscular dystrophy...
Beta1 integrins in muscle, but not in motor neurons, are required for skeletal muscle innervationMartin Schwander
Department of Cell Biology and Institute for Childhood and Neglected Disease, The Scripps Research Institute, La Jolla, California 92037, USA
J Neurosci 24:8181-91
Department of Cell Biology and Institute for Childhood and Neglected Disease, The Scripps Research Institute, La Jolla, California 92037, USA
J Neurosci 24:8181-91
..We conclude that Itgb1 expression in muscle, but not in motor neurons, is critical for NMJ development...
Integrins in the mouse myotome: developmental changes and differences between the epaxial and hypaxial lineageFernanda Bajanca
Departamento de Biologia Animal, Centro de Biologia Ambiental, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal
Dev Dyn 231:402-15
Departamento de Biologia Animal, Centro de Biologia Ambiental, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal
Dev Dyn 231:402-15
..Here, we describe the expression patterns of the alpha1, alpha4, alpha5, alpha6, and alpha7 integrin subunits in the mouse myotome and correlate them with the expression of several differentiation markers...
ADP-ribosylation of integrin alpha7 modulates the binding of integrin alpha7beta1 to lamininZhefeng Zhao
Department of Biochemistry, Kansas State University, 104 Willard Hall, Manhattan, KS 66506, USA
Biochem J 385:309-17
Department of Biochemistry, Kansas State University, 104 Willard Hall, Manhattan, KS 66506, USA
Biochem J 385:309-17
The extracellular domain of integrin alpha7 is ADP-ribosylated by an arginine-specific ecto-ADP-ribosyltransferase after adding exogenous NAD+ to intact C2C12 skeletal muscle cells...
Genetic compensation for sarcoglycan loss by integrin alpha7beta1 in muscleMichael J Allikian
Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
J Cell Sci 117:3821-30
Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
J Cell Sci 117:3821-30
..Mice lacking integrin alpha7 develop mild muscle degeneration, while sarcoglycan mutant mice display overt muscle degeneration and muscular ..
The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptorThomas Samson
Lehrstuhl für Experimentelle Medizin I, Nikolaus Fiebiger Zentrum für Molekulare Medizin, Friedrich Alexander Universität Erlangen Nürnberg, Glückstrasse 6, 91054 Erlangen, Germany
J Biol Chem 279:28641-52
Lehrstuhl für Experimentelle Medizin I, Nikolaus Fiebiger Zentrum für Molekulare Medizin, Friedrich Alexander Universität Erlangen Nürnberg, Glückstrasse 6, 91054 Erlangen, Germany
J Biol Chem 279:28641-52
..However, in cardiac and skeletal muscles, FHL2 and FHL3, respectively, are colocalized with alpha(7)beta(1) integrin receptor at the periphery of Z-discs, suggesting a role in mechanical stabilization of muscle cells...
Beta1-integrins are critical for cerebellar granule cell precursor proliferationSandra Blaess
Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
J Neurosci 24:3402-12
Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
J Neurosci 24:3402-12
....
Regulation of alpha7 integrin expression during muscle differentiationJianqiao Xiao
Departments of Stomatology and Anatomy, University of California at San Francisco, San Francisco, California 94143 0422, USA
J Biol Chem 278:49780-8
Departments of Stomatology and Anatomy, University of California at San Francisco, San Francisco, California 94143 0422, USA
J Biol Chem 278:49780-8
Expression of the laminin-binding alpha7 integrin is tightly regulated during myogenic differentiation, reflecting required functions that range from cell motility to formation of stable myotendinous junctions...
Alpha7beta1-integrin regulates mechanotransduction and prevents skeletal muscle injuryMarni D Boppart
Dept of Cell and Developmental Biology, University of Illinois, Urbana, IL 61801, USA
Am J Physiol Cell Physiol 290:C1660-5
Dept of Cell and Developmental Biology, University of Illinois, Urbana, IL 61801, USA
Am J Physiol Cell Physiol 290:C1660-5
..These experiments provide the first evidence that alpha7beta1-integrin is a negative regulator of mechanotransduction in vivo and provides resistance to exercise-induced muscle damage...
Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophyChun Guo
Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
Hum Mol Genet 15:989-98
Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
Hum Mol Genet 15:989-98
..Absence of either dystrophin or alpha7 integrin results in a muscular dystrophy...
Severe muscular dystrophy in mice that lack dystrophin and alpha7 integrinJachinta E Rooney
Department of Pharmacology, University of Nevada, Reno, 89557, USA
J Cell Sci 119:2185-95
Department of Pharmacology, University of Nevada, Reno, 89557, USA
J Cell Sci 119:2185-95
..Mutations in the alpha7 integrin gene cause congenital myopathy in humans and mice...
Valproic acid activates the PI3K/Akt/mTOR pathway in muscle and ameliorates pathology in a mouse model of Duchenne muscular dystrophyPraveen B Gurpur
Department of Cell and Developmental Biology, University of Illinois, B107 CLSL, 601 S Goodwin Ave, Urbana, IL 61801, USA
Am J Pathol 174:999-1008
Department of Cell and Developmental Biology, University of Illinois, B107 CLSL, 601 S Goodwin Ave, Urbana, IL 61801, USA
Am J Pathol 174:999-1008
..Transgenic overexpression of the alpha7 integrin in mdx/utrn(-/-) mice, a model of Duchenne muscular dystrophy ameliorates the disease...
Genetically determined proteolytic cleavage modulates alpha7beta1 integrin functionJianming Liu
Department of Cell and Developmental Biology, University of Illinois, Urbana, Illinois 61801, USA
J Biol Chem 283:35668-78
Department of Cell and Developmental Biology, University of Illinois, Urbana, Illinois 61801, USA
J Biol Chem 283:35668-78
..Here we report a species-specific difference in alpha7 chains that results from an intra-peptide proteolytic cleavage, by a serine protease, at the 603RRQ605 site...
Exercise promotes alpha7 integrin gene transcription and protection of skeletal muscleMarni D Boppart
Department of Kinesiology and Community Health, University of Illinois, Urbana, Illinois, USA
Am J Physiol Regul Integr Comp Physiol 295:R1623-30
Department of Kinesiology and Community Health, University of Illinois, Urbana, Illinois, USA
Am J Physiol Regul Integr Comp Physiol 295:R1623-30
..A single bout of downhill running exercise selectively increased transcription of the alpha7 integrin gene in 5-wk-old wild-type mice 3 h postexercise, and an increased alpha7 chain was detected in muscle ..
Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitroStefan Plantman
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
Mol Cell Neurosci 39:50-62
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
Mol Cell Neurosci 39:50-62
....
Tead4 is required for specification of trophectoderm in pre-implantation mouse embryosNoriyuki Nishioka
Laboratory for Embryonic Induction, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo, Kobe, Hyogo 650 0047, Japan
Mech Dev 125:270-83
Laboratory for Embryonic Induction, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo, Kobe, Hyogo 650 0047, Japan
Mech Dev 125:270-83
....
Deletion of integrin-linked kinase from skeletal muscles of mice resembles muscular dystrophy due to alpha 7 beta 1-integrin deficiencyAnia L Gheyara
Department of Pathology, University of California, San Francisco, San Francisco, California 94143, USA
Am J Pathol 171:1966-77
Department of Pathology, University of California, San Francisco, San Francisco, California 94143, USA
Am J Pathol 171:1966-77
..These findings resemble those seen in humans and mice lacking the alpha 7-integrin subunit and suggest that Ilk may act as a cytoplasmic effector of alpha 7 beta1-integrin in the pathogenesis of these deficiencies...
Increasing alpha 7 beta 1-integrin promotes muscle cell proliferation, adhesion, and resistance to apoptosis without changing gene expressionJianming Liu
Department of Cell and Developmental Biology, University of Illinois, 601 S Goodwin Ave, B107 Chemical and Life Sciences Laboratory, Urbana, IL 61801, USA
Am J Physiol Cell Physiol 294:C627-40
Department of Cell and Developmental Biology, University of Illinois, 601 S Goodwin Ave, B107 Chemical and Life Sciences Laboratory, Urbana, IL 61801, USA
Am J Physiol Cell Physiol 294:C627-40
..These results support the use of integrin enhancement as a therapy for muscular dystrophy...
Patterns of laminins and integrins in the embryonic ventricular zone of the CNSJustin D Lathia
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
J Comp Neurol 505:630-43
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
J Comp Neurol 505:630-43
....
Placental defects in alpha7 integrin null miceJ V Welser
Department of Pharmacology, University of Nevada, Reno, NV 89557, USA
Placenta 28:1219-28
Department of Pharmacology, University of Nevada, Reno, NV 89557, USA
Placenta 28:1219-28
..Loss of the alpha7 integrin chain results in partial embryonic lethality...
Loss of the alpha7 integrin promotes extracellular signal-regulated kinase activation and altered vascular remodelingJennifer V Welser
Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA
Circ Res 101:672-81
Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA
Circ Res 101:672-81
..In this study, we show that loss of the alpha7 integrin in VSMCs results in activation of the extracellular signal-regulated kinase and translocation of the ..
Cytoplasmic gamma-actin expression in diverse animal models of muscular dystrophyLaurin M Hanft
Department of Physiology, University of Wisconsin, Madison, WI, United States
Neuromuscul Disord 17:569-74
Department of Physiology, University of Wisconsin, Madison, WI, United States
Neuromuscul Disord 17:569-74
..other dystrophic animal models, including mice deficient in beta-sarcoglycan, alpha-dystrobrevin, laminin-2, or alpha7 integrin...
Def-6, a guanine nucleotide exchange factor for Rac1, interacts with the skeletal muscle integrin chain alpha7A and influences myoblast differentiationThomas Samson
Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Biol Chem 282:15730-42
Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Biol Chem 282:15730-42
Integrin alpha7beta1 is the major laminin binding integrin receptor of muscle cells. The alpha7 chain occurs in several splice isoforms, of which alpha7A and alpha7B differ in their intracellular domains only...
Lineage allocation and asymmetries in the early mouse embryoJanet Rossant
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
Philos Trans R Soc Lond B Biol Sci 358:1341-8; discussion 1349
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
Philos Trans R Soc Lond B Biol Sci 358:1341-8; discussion 1349
....
Integrin requirement for hippocampal synaptic plasticity and spatial memoryChi Shing Chan
Department of Molecular and Cellular Biology, Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 23:7107-16
Department of Molecular and Cellular Biology, Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 23:7107-16
..These results demonstrate that several different integrins are involved in physiological plasticity and provide the first evidence of their requirement for behavioral plasticity in vertebrates...
Functional expression of the alpha 7 integrin receptor in differentiated smooth muscle cellsC C Yao
Department of Stomatology, School of Dentistry, University of California San Francisco, 94143, USA
J Cell Sci 110:1477-87
Department of Stomatology, School of Dentistry, University of California San Francisco, 94143, USA
J Cell Sci 110:1477-87
Expression of the alpha7 integrin is developmentally regulated and is thought to be tissue-specific for both skeletal and cardiac muscles...
Differential expression of alpha-6 and other subunits of laminin binding integrins during development of the murine heartB P Hierck
Department of Anatomy and Embryology, Leiden University, The Netherlands
Dev Dyn 206:100-11
Department of Anatomy and Embryology, Leiden University, The Netherlands
Dev Dyn 206:100-11
..This study suggests a distinct role for alpha-6-beta-1 in the heart and provides insight concerning probably important roles of integrins and their extracellular matrix ligands during embryonic development...
Laminins promote the locomotion of skeletal myoblasts via the alpha 7 integrin receptorC C Yao
Department of Stomatology, School of Dentistry, University of California San Francisco 94143 0512, USA
J Cell Sci 109:3139-50
Department of Stomatology, School of Dentistry, University of California San Francisco 94143 0512, USA
J Cell Sci 109:3139-50
..These results established that alpha 7 beta 1 receptor can promote myoblast adhesion and motility on a restricted number of laminin isoforms and may be important in myogenic precursor recruitment during regeneration and differentiation...
Distinct alpha 7A beta 1 and alpha 7B beta 1 integrin expression patterns during mouse development: alpha 7A is restricted to skeletal muscle but alpha 7B is expressed in striated muscle, vasculature, and nervous systemT Velling
Department of Animal Physiology, Uppsala University, Sweden
Dev Dyn 207:355-71
Department of Animal Physiology, Uppsala University, Sweden
Dev Dyn 207:355-71
..We conclude that the alpha 7A and alpha 7B integrin variants are expressed in a developmentally regulated, tissue-specific pattern suggesting different functions for the two splice forms...
Identification and characterization of the cell type-specific and developmentally regulated alpha7 integrin gene promoterB L Ziober
Department of Stomatology, University of California, San Francisco, California 94143 0512, USA
J Biol Chem 271:22915-22
Department of Stomatology, University of California, San Francisco, California 94143 0512, USA
J Biol Chem 271:22915-22
Expression of alpha7 is mainly confined to skeletal and cardiac muscle in which it appears to be the major laminin-binding integrin. When myoblasts differentiate to myotubes, alpha7 mRNA and protein expression is up-regulated...
Differential expression of laminin chain-specific mRNA transcripts during mouse preimplantation embryo developmentC Shim
Department of Molecular Biology, Seoul National University, South Korea
Mol Reprod Dev 44:44-55
Department of Molecular Biology, Seoul National University, South Korea
Mol Reprod Dev 44:44-55
..The uterine environment enclosing the preimplantation embryos appears, therefore, to play an important role in the regulation of laminin gene expression during blastocyst development...
Synaptic integrins in developing, adult, and mutant muscle: selective association of alpha1, alpha7A, and alpha7B integrins with the neuromuscular junctionP T Martin
Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, Missouri 63110, USA
Dev Biol 174:125-39
Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, Missouri 63110, USA
Dev Biol 174:125-39
..alpha1 chain was selectively associated with presynaptic cells (Schwann cells and/or nerve terminals), while alpha7 was present on both synaptic and extrasynaptic portions of the muscle fiber surface...
A new isoform of the laminin receptor integrin alpha 7 beta 1 is developmentally regulated in skeletal muscleG Collo
Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037
J Biol Chem 268:19019-24
Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037
J Biol Chem 268:19019-24
..Splicing of alpha 7B mRNA in C2C12 occurred shortly after myogenin expression and could be an indicator of progression through the program of skeletal muscle differentiation...
Developmental regulation of integrin expression at the time of implantation in the mouse embryoA E Sutherland
Department of Stomatology, University of California San Francisco 94143
Development 119:1175-86
Department of Stomatology, University of California San Francisco 94143
Development 119:1175-86
..abstract truncated at 400 words)..
Alternative extracellular and cytoplasmic domains of the integrin alpha 7 subunit are differentially expressed during developmentB L Ziober
Department of Stomatology and Anatomy, University of California, San Francisco 94143
J Biol Chem 268:26773-83
Department of Stomatology and Anatomy, University of California, San Francisco 94143
J Biol Chem 268:26773-83
....
Processing of ADP-ribosylated integrin alpha 7 in skeletal muscle myotubesA Zolkiewska
Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1434, USA
J Biol Chem 270:9227-33
Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1434, USA
J Biol Chem 270:9227-33
b>Integrin alpha 7 is a major substrate in skeletal muscle cells for the cell surface, glycosylphosphatidylinositol-anchored, arginine-specific ADP-ribosyltransferase...
Expression of a developmentally regulated antigen on the surface of skeletal and cardiac muscle cellsS J Kaufman
J Cell Biol 100:1977-87
J Cell Biol 100:1977-87
..We conclude that H36 is a muscle-specific, developmentally regulated cell-surface antigen that may have a role in myoblast differentiation and that can be used to determine the embryonic lineages of skeletal and cardiac muscle...
Skeletal myoblasts utilize a novel beta 1-series integrin and not alpha 6 beta 1 for binding to the E8 and T8 fragments of lamininH von Der Mark
Max Planck Society Clinical Research Group for Rheumatology, University of Erlangen Nürnberg, Germany
J Biol Chem 266:23593-601
Max Planck Society Clinical Research Group for Rheumatology, University of Erlangen Nürnberg, Germany
J Biol Chem 266:23593-601
..However, there were distinctive differences; in particular, 2 residues were deleted in comparison with alpha 6...
Spatial and temporal expression of the beta1D integrin during mouse developmentA van Der Flier
Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam
Dev Dyn 210:472-86
Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam
Dev Dyn 210:472-86
..The switch from the beta1A to the beta1D subunit in cardiac muscle cells coincides with the expression of alpha7. In adults there is a distinct concentration of beta1D at the myotendinous junctions of muscle fibers and at ..
Altered expression of the alpha7beta1 integrin in human and murine muscular dystrophiesB L Hodges
Department of Cell and Structural Biology, University of Illinois, Urbana, USA
J Cell Sci 110:2873-81
Department of Cell and Structural Biology, University of Illinois, Urbana, USA
J Cell Sci 110:2873-81
..Becker muscular dystrophies indicates that the increase in the alpha7beta1 integrin is regulated at the level of alpha7 gene transcription...
Differential onset of expression of alpha 7 and beta 1D integrins during mouse heart and skeletal muscle developmentM Brancaccio
Department of Genetics, Biology and Medical Chemistry, University of Torino, Italy
Cell Adhes Commun 5:193-205
Department of Genetics, Biology and Medical Chemistry, University of Torino, Italy
Cell Adhes Commun 5:193-205
..In conclusion these data show that the expression of the beta 1D muscle specific integrin during development occurs much earlier in heart than in skeletal muscle and it can dimerize with different alpha subunits...
Expression of laminin receptors in schwann cell differentiation: evidence for distinct rolesStefano C Previtali
Neuropathology Unit, Department of Neuroscience and DIBIT, San Raffaele Scientific Institute, 20132 Milan, Italy
J Neurosci 23:5520-30
Neuropathology Unit, Department of Neuroscience and DIBIT, San Raffaele Scientific Institute, 20132 Milan, Italy
J Neurosci 23:5520-30
..These data suggest that the action of laminin is mediated by beta1 integrins during axonal sorting and by dystroglycan, alpha6beta1, and alpha6beta4 integrins during myelination...
Schwann cells synthesize alpha7beta1 integrin which is dispensable for peripheral nerve development and myelinationS C Previtali
Neuropathology Unit, San Raffaele Scientific Institute, Milan, Italy
Mol Cell Neurosci 23:210-8
Neuropathology Unit, San Raffaele Scientific Institute, Milan, Italy
Mol Cell Neurosci 23:210-8
..The expression of alpha7 appears postnatally, such that alpha7beta1 is the last laminin receptor expressed by differentiating Schwann cells...
TGF-beta 1 regulates adhesion of mucosal mast cell homologues to laminin-1 through expression of integrin alpha 7Anne Rosbottom
Department of Veterinary Pathology, University of Edinburgh, Roslin, Midlothian, UK EH25 9RG
J Immunol 169:5689-95
Department of Veterinary Pathology, University of Edinburgh, Roslin, Midlothian, UK EH25 9RG
J Immunol 169:5689-95
..05), demonstrating a novel role for this molecule in adhesion of a hemopoietic cell to laminin-1...
An intrinsic distinction in neuromuscular junction assembly and maintenance in different skeletal musclesSan Pun
Friedrich Miescher Institute, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
Neuron 34:357-70
Friedrich Miescher Institute, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
Neuron 34:357-70
..Our results show that postsynaptic differentiation processes intrinsic to FaSyn and DeSyn muscles influence the formation of NMJs during development and their maintenance in the adult...
Trophoblast-specific expression and function of the integrin alpha 7 subunit in the peri-implantation mouse embryoE Klaffky
Department of Cell Biology, University of Virginia Health System, Charlottesville, Virginia 22908 0732, USA
Dev Biol 239:161-75
Department of Cell Biology, University of Virginia Health System, Charlottesville, Virginia 22908 0732, USA
Dev Biol 239:161-75
..We have identified integrin alpha 7 beta 1 as a major receptor for trophoblast-laminin interactions during implantation and yolk sac placenta ..
Alternative splice variants of alpha 7 beta 1 integrin selectively recognize different laminin isoformsHelga von der Mark
Friedrich Alexander Universität Erlangen Nürnberg, Nikolaus Fiebiger Zentrum für Molekulare Medizin, Department of Experimental Medicine I, 91054 Erlangen, Germany
J Biol Chem 277:6012-6
Friedrich Alexander Universität Erlangen Nürnberg, Nikolaus Fiebiger Zentrum für Molekulare Medizin, Department of Experimental Medicine I, 91054 Erlangen, Germany
J Biol Chem 277:6012-6
....
Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitisM Sixt
Interdisciplinary Center for Clinical Research IZKF, Nikolaus Fiebiger Center, University of Erlangen Nuremberg, Glückstr 6, 91054 Erlangen, Germany
J Cell Biol 153:933-46
Interdisciplinary Center for Clinical Research IZKF, Nikolaus Fiebiger Center, University of Erlangen Nuremberg, Glückstr 6, 91054 Erlangen, Germany
J Cell Biol 153:933-46
....
Impaired axonal regeneration in alpha7 integrin-deficient miceA Werner
Department of Neuromorphology, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
J Neurosci 20:1822-30
Department of Neuromorphology, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
J Neurosci 20:1822-30
..b>alpha7 and beta1 subunits were present on the axons and their growth cones in the regenerating facial nerve...
Organization of the myotendinous junction is dependent on the presence of alpha7beta1 integrinN Miosge
Zentrum Anatomie, Abteilung Histologie, Universität Göttingen, Germany
Lab Invest 79:1591-9
Zentrum Anatomie, Abteilung Histologie, Universität Göttingen, Germany
Lab Invest 79:1591-9
..receptor alpha7beta1 is enriched at the myotendinous junctions, and mice with a targeted inactivation of the alpha7 gene develop a form of muscular dystrophy that primarily affects this structure...
Activation of c-Raf-1 kinase signal transduction pathway in alpha(7) integrin-deficient miceG Saher
Max Planck Institut für Biochemie, Am Klopferspitz 18a, D 82152 Martinsried, Germany
J Biol Chem 274:27651-7
Max Planck Institut für Biochemie, Am Klopferspitz 18a, D 82152 Martinsried, Germany
J Biol Chem 274:27651-7
....
Secondary reduction of alpha7B integrin in laminin alpha2 deficient congenital muscular dystrophy supports an additional transmembrane link in skeletal muscleR D Cohn
Department of Pediatrics, University of Essen, Germany
J Neurol Sci 163:140-52
Department of Pediatrics, University of Essen, Germany
J Neurol Sci 163:140-52
..The main binding partners of the alpha7 integrin are laminin-1 (alpha1-beta1-gamma1), laminin-2 (alpha2-beta1-gamma1) and laminin-4 (alpha2-beta2-gamma1)...
Cre-loxP-mediated inactivation of the alpha6A integrin splice variant in vivo: evidence for a specific functional role of alpha6A in lymphocyte migration but not in heart developmentC Gimond
Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
J Cell Biol 143:253-66
Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
J Cell Biol 143:253-66
..Nevertheless, the expression of alpha6A might be necessary for optimal lymphocyte migration on laminin in certain pathological conditions...
H36-alpha 7 is a novel integrin alpha chain that is developmentally regulated during skeletal myogenesisW K Song
Department of Cell and Structural Biology, University of Illinois, Urbana 61801
J Cell Biol 117:643-57
Department of Cell and Structural Biology, University of Illinois, Urbana 61801
J Cell Biol 117:643-57
..We conclude that H36-alpha 7 is a novel alpha integrin laminin binding protein whose expression is developmentally regulated during skeletal myogenesis...