Gene Symbol: Itga6
Description: integrin alpha 6
Alias: 5033401O05Rik, AI115430, Cd49f, VLA-6, integrin alpha-6, CD49 antigen-like family member F
Species: mouse
Products:     Itga6

Top Publications

  1. Ruiz P, Wiles M, Imhof B. Alpha 6 integrins participate in pro-T cell homing to the thymus. Eur J Immunol. 1995;25:2034-41 pubmed
    ..These data suggest that alpha 6 integrins are involved in the homing of pro-T cells to the developing thymus by mediating adhesion of pro-T cells to the vascular endothelium. ..
  2. Kennel S, Foote L, Falcioni R, Sonnenberg A, Stringer C, Crouse C, et al. Analysis of the tumor-associated antigen TSP-180. Identity with alpha 6-beta 4 in the integrin superfamily. J Biol Chem. 1989;264:15515-21 pubmed
    ..The mouse TSP-180 complex described here strongly resembles the recently described human integrin alpha 6-beta 4 complex...
  3. DiPersio C, van der Neut R, Georges Labouesse E, Kreidberg J, Sonnenberg A, Hynes R. alpha3beta1 and alpha6beta4 integrin receptors for laminin-5 are not essential for epidermal morphogenesis and homeostasis during skin development. J Cell Sci. 2000;113 ( Pt 17):3051-62 pubmed
    ..These findings show that while alpha3beta1 and alpha6beta4 are both required for integrity of the dermo-epidermal junction, neither one is essential for epidermal morphogenesis during skin development. ..
  4. Sutherland A, Calarco P, Damsky C. Developmental regulation of integrin expression at the time of implantation in the mouse embryo. Development. 1993;119:1175-86 pubmed
    ..abstract truncated at 400 words) ..
  5. Borradori L, Sonnenberg A. Structure and function of hemidesmosomes: more than simple adhesion complexes. J Invest Dermatol. 1999;112:411-8 pubmed
  6. Georges Labouesse E, Mark M, Messaddeq N, Gansmuller A. Essential role of alpha 6 integrins in cortical and retinal lamination. Curr Biol. 1998;8:983-6 pubmed
    ..We previously described mice lacking integrin alpha 6; these mice died at birth with severe skin blistering [7]...
  7. Zuccotti M, Giorgi Rossi P, Fiorillo E, Garagna S, Forabosco A, Redi C. Timing of gene expression and oolemma localization of mouse alpha6 and beta1 integrin subunits during oogenesis. Dev Biol. 1998;200:27-34 pubmed
    ..These data, although not conclusive, support the hypothesis of an involvement of alpha6 and beta1 integrins in sperm-egg fusion. ..
  8. Cooper H, Tamura R, Quaranta V. The major laminin receptor of mouse embryonic stem cells is a novel isoform of the alpha 6 beta 1 integrin. J Cell Biol. 1991;115:843-50 pubmed
    ..The switch from alpha 6 B to alpha 6 A, if confirmed in early embryos, could then be of striking potential relevance to the developmental role of laminin. ..
  9. He Z, Brakebusch C, Fassler R, Kreidberg J, Primakoff P, Myles D. None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion. Dev Biol. 2003;254:226-37 pubmed

More Information


  1. Ziyyat A, Rubinstein E, Monier Gavelle F, Barraud V, Kulski O, Prenant M, et al. CD9 controls the formation of clusters that contain tetraspanins and the integrin alpha 6 beta 1, which are involved in human and mouse gamete fusion. J Cell Sci. 2006;119:416-24 pubmed
    ..By contrast, the addition of an anti-CD9 mAb to zona free eggs had no effect. The integrin alpha 6 beta1, CD151 and CD9 tetraspanins were evenly distributed on human zona-intact oocytes...
  2. Almeida E, Huovila A, Sutherland A, Stephens L, Calarco P, Shaw L, et al. Mouse egg integrin alpha 6 beta 1 functions as a sperm receptor. Cell. 1995;81:1095-104 pubmed
    ..Our results indicate a novel role for the integrin alpha 6 beta 1 as a cell-cell adhesion receptor that mediates sperm-egg binding.
  3. Miller B, Georges Labouesse E, Primakoff P, Myles D. Normal fertilization occurs with eggs lacking the integrin alpha6beta1 and is CD9-dependent. J Cell Biol. 2000;149:1289-96 pubmed
  4. Dowling J, Yu Q, Fuchs E. Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J Cell Biol. 1996;134:559-72 pubmed
  5. Sonnenberg A, Modderman P, Hogervorst F. Laminin receptor on platelets is the integrin VLA-6. Nature. 1988;336:487-9 pubmed
    ..Platelet adhesion to laminin is supported by Mn2+, Co2+ and Mg2+, but not by Ca2+, Zn2+ and Cu2+. This cation preference is distinct from that characteristic for other platelet-adhesive glycoproteins. ..
  6. Tarone G, Russo M, Hirsch E, Odorisio T, Altruda F, Silengo L, et al. Expression of beta 1 integrin complexes on the surface of unfertilized mouse oocyte. Development. 1993;117:1369-75 pubmed
    ..These data demonstrate for the first time the expression of three beta 1 integrin complexes in unfertilized mouse oocytes. Such proteins may have a role in sperm-egg interaction or during very early steps of embryogenesis. ..
  7. Thorsteinsdottir S, Roelen B, Freund E, Gaspar A, Sonnenberg A, Mummery C. Expression patterns of laminin receptor splice variants alpha 6A beta 1 and alpha 6B beta 1 suggest different roles in mouse development. Dev Dyn. 1995;204:240-58 pubmed
  8. Georges Labouesse E, Messaddeq N, Yehia G, Cadalbert L, Dierich A, Le Meur M. Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice. Nat Genet. 1996;13:370-3 pubmed
    ..They are composed of non-covalently associated alpha and beta chains. Integrin alpha 6 can associate with either beta 1 or beta 4 (refs 2,3)...
  9. Hierck B, Thorsteinsdottir S, Niessen C, Freund E, Iperen L, Feyen A, et al. Variants of the alpha 6 beta 1 laminin receptor in early murine development: distribution, molecular cloning and chromosomal localization of the mouse integrin alpha 6 subunit. Cell Adhes Commun. 1993;1:33-53 pubmed
    ..Molecular cloning of cDNA for the murine integrin alpha 6 subunit from a mammary gland lambda gt11 library showed, as in man, an open reading frame encoding two ..
  10. Larrieu Lahargue F, Welm A, Thomas K, Li D. Netrin-4 activates endothelial integrin {alpha}6{beta}1. Circ Res. 2011;109:770-4 pubmed publisher
    ..The ?6?1 integrin is a netrin-4 receptor in lymphatic endothelium and consequently represents a potential target to inhibit netrin-4-induced metastatic dissemination. ..
  11. Collo G, Domanico S, Klier G, Quaranta V. Gradient of integrin alpha 6A distribution in the myocardium during early heart development. Cell Adhes Commun. 1995;3:101-13 pubmed
    ..We investigated expression of the integrin alpha 6 beta 1, a receptor for the ECM component, laminin in the early mouse embryo...
  12. Fröjdman K, Pelliniemi L. Alpha 6 subunit of integrins in the development and sex differentiation of the mouse ovary. Dev Dyn. 1995;202:397-404 pubmed
    ..The distribution of alpha 6 integrin in ovarian cells shows potentially important sex-specific and developmental differences in epithelial organization when compared with respective changes found earlier by us in the male gonad. ..
  13. Baudoin C, Goumans M, Mummery C, Sonnenberg A. Knockout and knockin of the beta1 exon D define distinct roles for integrin splice variants in heart function and embryonic development. Genes Dev. 1998;12:1202-16 pubmed
    ..We propose that beta1D is less efficient than beta1A in mediating the signaling that regulates cell motility and responses of the cells to mechanical stress. ..
  14. Tennenbaum T, Belanger A, Glick A, Tamura R, Quaranta V, Yuspa S. A splice variant of alpha 6 integrin is associated with malignant conversion in mouse skin tumorigenesis. Proc Natl Acad Sci U S A. 1995;92:7041-5 pubmed
    The epithelial-specific integrin alpha 6 beta 4 is suprabasally expressed in benign skin tumors (papillomas) and is diffusely expressed in carcinomas associated with an increase in the proliferating compartment...
  15. Fenichel P, Durand Clément M. Role of integrins during fertilization in mammals. Hum Reprod. 1998;13 Suppl 4:31-46 pubmed
    ..Experimental data suggest that they may act in a similar way during fertilization and may participate to initiation and/or propagation of the calcium signal via stimulation of phospholipase C gamma and inositol trisphosphate production. ..
  16. Montavon T, Thevenet L, Duboule D. Impact of copy number variations (CNVs) on long-range gene regulation at the HoxD locus. Proc Natl Acad Sci U S A. 2012;109:20204-11 pubmed publisher
    ..These results illustrate the detrimental consequences of interrupting highly conserved regulatory landscapes and reveal a mechanism where genomic duplications lead to partial loss of function of nearby located genes. ..
  17. Durbeej M, Henry M, Ferletta M, Campbell K, Ekblom P. Distribution of dystroglycan in normal adult mouse tissues. J Histochem Cytochem. 1998;46:449-57 pubmed
    ..We suggest that dystroglycan is involved in linking basement membranes to epithelial and muscle cells. Dystroglycan may be important for the maintenance of tissue integrity. ..
  18. Nikolopoulos S, Blaikie P, Yoshioka T, Guo W, Giancotti F. Integrin beta4 signaling promotes tumor angiogenesis. Cancer Cell. 2004;6:471-83 pubmed
    ..These results provide genetic evidence that alpha6beta4 signaling promotes the onset of the invasive phase of pathological angiogenesis and hence identify a novel target for antiangiogenic therapy. ..
  19. Schep R, Necsulea A, Rodríguez Carballo E, Guerreiro I, Andrey G, Nguyen Huynh T, et al. Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape. Proc Natl Acad Sci U S A. 2016;113:E7720-E7729 pubmed
    ..We propose that Hoxd gene regulation in embryonic MBs evolved by hijacking a preexisting regulatory landscape that was already at work before the emergence of mammals in structures such as the limbs or the intestinal tract. ..
  20. Anderson R, Fassler R, Georges Labouesse E, Hynes R, Bader B, Kreidberg J, et al. Mouse primordial germ cells lacking beta1 integrins enter the germline but fail to migrate normally to the gonads. Development. 1999;126:1655-64 pubmed
    ..These results demonstrate a role for beta1-containing integrins in the development of the germline, although an equivalent role for * integrin subunit(s) has yet to be established. ..
  21. Seano G, Chiaverina G, Gagliardi P, di Blasio L, Puliafito A, Bouvard C, et al. Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis. Nat Cell Biol. 2014;16:931-41, 1-8 pubmed publisher
  22. Buck C, Edelman J, Buck C, Kennedy G, Baldwin H. Expression patterns of adhesion receptors in the developing mouse lung: functional implications. Cell Adhes Commun. 1996;4:69-87 pubmed
    ..The expression of thrombomodulin only at sites of airway branching suggests that the thrombin/thrombomodulin system could play a pivotal, regulatory role in branching morphogenesis. ..
  23. Miyata K, Takebe J. Anodized-hydrothermally treated titanium with a nanotopographic surface structure regulates integrin-?6?4 and laminin-5 gene expression in adherent murine gingival epithelial cells. J Prosthodont Res. 2013;57:99-108 pubmed publisher
    ..p.Ti implant material and subsequently express the integrin-?6?4 adhesion molecule and the laminin-5 extracellular matrix molecule. This cell behavior may play a key role in maintaining the peri-implant oral mucosal tissue barrier. ..
  24. Ayres Martins S, Lannes Vieira J, Farias de Oliveira D, Brito J, Villa Verde D, Savino W. Phagocytic cells of the thymic reticulum interact with thymocytes via extracellular matrix ligands and receptors. Cell Immunol. 2004;229:21-30 pubmed
    ..Conjointly, our data reveal that the ECM-dependence for thymocyte adhesion onto the thymic microenvironment is not restricted to the epithelial cells, being also seen when they encounter non-epithelial phagocytic cells. ..
  25. Driskell I, Oda H, Blanco S, Nascimento E, Humphreys P, Frye M. The histone methyltransferase Setd8 acts in concert with c-Myc and is required to maintain skin. EMBO J. 2012;31:616-29 pubmed publisher
    ..Both overexpression of p63 and deletion of p53 rescue Setd8-induced apoptosis. Thus, Setd8 is a crucial inhibitor of apoptosis in skin and its activity is essential for epidermal stem cell survival, proliferation and differentiation. ..
  26. Lee R, Seo M, Pulin A, Gregory C, Ylostalo J, Prockop D. The CD34-like protein PODXL and alpha6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice. Blood. 2009;113:816-26 pubmed publisher
    ..that were selectively expressed in the early progenitors: podocalyxin-like protein (PODXL), alpha6-integrin (CD49f), alpha4-integrin (CD49d), c-Met, CXCR4, and CX3CR1...
  27. Lallier T, Whittaker C, DeSimone D. Integrin alpha 6 expression is required for early nervous system development in Xenopus laevis. Development. 1996;122:2539-54 pubmed
    The integrin alpha 6 subunit pairs with both the beta 1 and beta 4 subunits to form a subfamily of laminin receptors. Here we report the cDNA cloning and primary sequence for the Xenopus homologue of the mammalian integrin alpha 6 subunit...
  28. Rodius S, Indra G, Thibault C, Pfister V, Georges Labouesse E. Loss of alpha6 integrins in keratinocytes leads to an increase in TGFbeta and AP1 signaling and in expression of differentiation genes. J Cell Physiol. 2007;212:439-49 pubmed
    ..These results are in favor of a role for integrin alpha6beta4 in the maintenance of basal keratinocyte properties and epidermal homeostasis. ..
  29. Kuster J, Guarnieri M, Ault J, Flaherty L, Swiatek P. IAP insertion in the murine LamB3 gene results in junctional epidermolysis bullosa. Mamm Genome. 1997;8:673-81 pubmed
    ..These findings suggest a role for laminin-5 in hemidesmosome formation and indicate that the LamB3(IAP) mutant is a useful mouse model for HJEB. ..
  30. Ramovs V, Te Molder L, Sonnenberg A. The opposing roles of laminin-binding integrins in cancer. Matrix Biol. 2017;57-58:213-243 pubmed publisher
    ..In this review we discuss the dual role of the laminin-binding integrins ?3?1 and ?6?4 in tumor development and progression, and examine the factors and mechanisms involved in these opposing effects. ..
  31. Crish J, Conti M, Sakai T, Adelstein R, Egelhoff T. Keratin 5-Cre-driven excision of nonmuscle myosin IIA in early embryo trophectoderm leads to placenta defects and embryonic lethality. Dev Biol. 2013;382:136-48 pubmed publisher
    ..5 in the forming epidermis, may be widely useful as drivers for activation of cre/lox based gene excision in early embryo extraembronic trophoblast tissues as well. ..
  32. Lopez Escobar B, De Felipe B, Sánchez Alcázar J, Sasaki T, Copp A, Ybot Gonzalez P. Laminin and integrin expression in the ventral ectodermal ridge of the mouse embryo: implications for regulation of BMP signalling. Dev Dyn. 2012;241:1808-15 pubmed publisher
    ..Laminin532 could interact with α6-containing integrin to direct differentiation of the specialised VER cells from surface ectoderm. ..
  33. Nodari A, Previtali S, Dati G, Occhi S, Court F, Colombelli C, et al. Alpha6beta4 integrin and dystroglycan cooperate to stabilize the myelin sheath. J Neurosci. 2008;28:6714-9 pubmed publisher
    ..These data indicate that, similar to its role in skin, alpha6beta4 integrin confers stability to myelin in peripheral nerves. ..
  34. Pirity M, Wang W, Wolf L, Tamm E, Schreiber Agus N, Cvekl A. Rybp, a polycomb complex-associated protein, is required for mouse eye development. BMC Dev Biol. 2007;7:39 pubmed
    ..We propose that the multiple functions for Rybp in regulating mouse retinal and lens development are mediated by genetic, epigenetic and physical interactions between these genes and proteins. ..
  35. Salmivirta K, Gullberg D, Hirsch E, Altruda F, Ekblom P. Integrin subunit expression associated with epithelial-mesenchymal interactions during murine tooth development. Dev Dyn. 1996;205:104-13 pubmed
    ..During early tooth development, integrins possessing the alpha 6 subunit might also be involved in cell-cell interactions independently of laminins. ..
  36. Chung J, Yoon S, Lipscomb E, Mercurio A. The Met receptor and alpha 6 beta 4 integrin can function independently to promote carcinoma invasion. J Biol Chem. 2004;279:32287-93 pubmed
    ..These data argue that the invasive function of Met can be independent of alpha(6)beta(4) and that alpha(6)beta(4) has a generic influence on the invasion of carcinoma cells that is not specific to Met. ..
  37. Ruzzi L, Gagnoux Palacios L, Pinola M, Belli S, Meneguzzi G, D Alessio M, et al. A homozygous mutation in the integrin alpha6 gene in junctional epidermolysis bullosa with pyloric atresia. J Clin Invest. 1997;99:2826-31 pubmed
  38. Bajanca F, Luz M, Raymond K, Martins G, Sonnenberg A, Tajbakhsh S, et al. Integrin alpha6beta1-laminin interactions regulate early myotome formation in the mouse embryo. Development. 2006;133:1635-44 pubmed
    ..Engagement of laminin by alpha6beta1 also plays a role in maintaining the undifferentiated state of cells in the dermomyotome prior to their entry into the myotome. ..
  39. Ezhkova E, Pasolli H, Parker J, Stokes N, Su I, Hannon G, et al. Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell. 2009;136:1122-35 pubmed publisher
    ..They maintain their proliferative potential and globally repressing undesirable differentiation programs while selectively establishing a specific terminal differentiation program in a stepwise fashion. ..
  40. Egawa G, Osawa M, Uemura A, Miyachi Y, Nishikawa S. Transient expression of ephrin b2 in perinatal skin is required for maintenance of keratinocyte homeostasis. J Invest Dermatol. 2009;129:2386-95 pubmed publisher
  41. Chapman H, Li X, Alexander J, Brumwell A, Lorizio W, Tan K, et al. Integrin ?6?4 identifies an adult distal lung epithelial population with regenerative potential in mice. J Clin Invest. 2011;121:2855-62 pubmed publisher
  42. Ohnishi K, Shimizu T, Karasuyama H, Melchers F. The identification of a nonclassical cadherin expressed during B cell development and its interaction with surrogate light chain. J Biol Chem. 2000;275:31134-44 pubmed
    ..We call this B lineage-, intestine-, liver- and leukocyte-expressed gene BILL-cadherin. The possible functions of BILL-cadherin in B cell development are discussed. ..
  43. Hendley A, Provost E, Bailey J, WANG Y, Cleveland M, Blake D, et al. p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas. Dev Biol. 2015;399:41-53 pubmed publisher
    ..Taken together, our data demonstrate an essential role for p120 catenin in pancreas development. ..
  44. Bouvard C, Segaoula Z, De Arcangelis A, Galy Fauroux I, Mauge L, Fischer A, et al. Tie2-dependent deletion of α6 integrin subunit in mice reduces tumor growth and angiogenesis. Int J Oncol. 2014;45:2058-64 pubmed publisher
    ..These findings demonstrate that α6 integrin subunit plays a major role in tumor angiogenesis and TEM infiltration. Targeting α6 could be used as a strategy to reduce tumor growth. ..
  45. Kadmon G, Imhof B, Altevogt P, Schachner M. Adhesive hierarchy involving the cell adhesion molecules L1, CD24, and alpha 6 integrin in murine neuroblastoma N2A cells. Biochem Biophys Res Commun. 1995;214:94-101 pubmed
    ..These results indicate that neural cells might employ a strategy of adhesion cascade in establishing stable contacts. ..
  46. Koyama N, Hayashi T, Gresik E, Kashimata M. Role of alpha 6 integrin subunit in branching morphogenesis of fetal mouse submandibular gland: investigation by mesenchyme-free epithelial culture system. J Med Invest. 2009;56 Suppl:247-9 pubmed
  47. Chan C, Weeber E, Kurup S, Sweatt J, Davis R. Integrin requirement for hippocampal synaptic plasticity and spatial memory. J Neurosci. 2003;23:7107-16 pubmed
    ..These results demonstrate that several different integrins are involved in physiological plasticity and provide the first evidence of their requirement for behavioral plasticity in vertebrates. ..
  48. Jensen U, Yan X, Triel C, Woo S, Christensen R, Owens D. A distinct population of clonogenic and multipotent murine follicular keratinocytes residing in the upper isthmus. J Cell Sci. 2008;121:609-17 pubmed publisher
    ..These cells are non-quiescent and possess a unique transcript profile compared with bulge stem cells and may represent a distinct reservoir of epidermal stem or progenitor cells...
  49. Wadehra M, Iyer R, Goodglick L, Braun J. The tetraspan protein epithelial membrane protein-2 interacts with beta1 integrins and regulates adhesion. J Biol Chem. 2002;277:41094-100 pubmed
    ..This study demonstrates for the first time the interaction of a GAS3/PMP22 family member with an integrin protein and suggests that such interactions and their functional consequences are a physiologic role of GAS3/PMP22 proteins. ..
  50. Shim C, Kwon H, Kim K. Differential expression of laminin chain-specific mRNA transcripts during mouse preimplantation embryo development. Mol Reprod Dev. 1996;44:44-55 pubmed
    ..The uterine environment enclosing the preimplantation embryos appears, therefore, to play an important role in the regulation of laminin gene expression during blastocyst development. ..
  51. Rosahl T, Spillane D, Missler M, Herz J, Selig D, Wolff J, et al. Essential functions of synapsins I and II in synaptic vesicle regulation. Nature. 1995;375:488-93 pubmed
  52. Maalouf S, Theivakumar S, Owens D. Epidermal ?6?4 integrin stimulates the influx of immunosuppressive cells during skin tumor promotion. J Dermatol Sci. 2012;66:108-18 pubmed publisher
    ..We conclude that aberrant expression of ?6?4 integrin in post-mitotic epidermal keratinocytes stimulates a pro-tumorigenic skin microenvironment by augmenting the influx of immunosuppressive granular cells during tumor promotion. ..
  53. Flintoff Dye N, Welser J, Rooney J, Scowen P, Tamowski S, Hatton W, et al. Role for the alpha7beta1 integrin in vascular development and integrity. Dev Dyn. 2005;234:11-21 pubmed