Itga3

Summary

Gene Symbol: Itga3
Description: integrin alpha 3
Alias: AA407068, CD49C, GAPB3, CD49 antigen-like family member C, VLA-3 alpha 3, VLA-3 receptor, alpha 3 subunit, VLA-3 subunit alpha, alpha3-integrin, galactoprotein B3, integrin alpha-3
Species: mouse

Top Publications

  1. ncbi Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis
    J A Kreidberg
    Division of Nephrology, Children s Hospital, Boston, MA 02115, USA
    Development 122:3537-47. 1996
  2. ncbi Epithelial development and differentiation in the mammary gland is not dependent on alpha 3 or alpha 6 integrin subunits
    T C Klinowska
    School of Biological Sciences, University of Manchester, 3 239 Stopford Building, Oxford Road, Manchester, M13 9PT, United Kingdom
    Dev Biol 233:449-67. 2001
  3. pmc Kidney failure in mice lacking the tetraspanin CD151
    Norman Sachs
    Division of Cell Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands
    J Cell Biol 175:33-9. 2006
  4. pmc alpha3beta1 Integrin is required for normal development of the epidermal basement membrane
    C M DiPersio
    Center for Cancer Research, and Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Cell Biol 137:729-42. 1997
  5. ncbi Developmental regulation of integrin expression at the time of implantation in the mouse embryo
    A E Sutherland
    Department of Stomatology, University of California San Francisco 94143
    Development 119:1175-86. 1993
  6. pmc Galectin-3 promotes lamellipodia formation in epithelial cells by interacting with complex N-glycans on alpha3beta1 integrin
    Chandrassegar Saravanan
    Department of Ophthalmologyand The New England Eye Center, Tufts University School of Medicine, Sackler School of Graduate Biomedical Sciences, Boston, MA 02111, USA
    J Cell Sci 122:3684-93. 2009
  7. pmc Integrin α3 is required for late postnatal stability of dendrite arbors, dendritic spines and synapses, and mouse behavior
    Meghan E Kerrisk
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 33:6742-52. 2013
  8. pmc NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin
    Jun ichi Fukushi
    The Burnham Institute, La Jolla, California 92037, USA
    Mol Biol Cell 15:3580-90. 2004
  9. ncbi The C-terminus of the gamma 2 chain but not of the beta 3 chain of laminin-332 is indirectly but indispensably necessary for integrin-mediated cell reactions
    Alexei Navdaev
    Institute for Physiological Chemistry, Muenster University Hospital, 48149 Muenster, Germany
    Exp Cell Res 314:489-97. 2008
  10. pmc Involvement of integrins alpha(3)beta(1) and alpha(5)beta(1) and glycoprotein IIb in megakaryocyte-induced osteoblast proliferation
    Justin M Lemieux
    Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut, USA
    J Cell Biochem 109:927-32. 2010

Scientific Experts

  • C DiPersio
  • Hiromi Hosako
  • Stefan Plantman
  • Nagako Yoshiba
  • J A Kreidberg
  • N Shiojiri
  • Dawn Davies
  • MARY STEPP
  • A Sue Menko
  • Fang Xu Jiang
  • Walid Barbour
  • C Wylie
  • Jun ichi Fukushi
  • E S Anton
  • Karine Raymond
  • Norman Sachs
  • Vandana Iyer
  • Arnoud Sonnenberg
  • Maaike Kreft
  • Charles Szekeres
  • John M Lamar
  • David P Choma
  • Coert Margadant
  • Ralf S Schmid
  • Louise E Reynolds
  • Amelia Stanco
  • Jeffrey H Miner
  • Meghan E Kerrisk
  • Young Min Hyun
  • Nayia Nicolaou
  • Ai Hasebe
  • Kevin Pumiglia
  • Justin M Lemieux
  • Rita Graça da Silva
  • Xin Wu
  • Kara Mitchell
  • Stephen D Robinson
  • Chandrassegar Saravanan
  • Ian R Hart
  • Kairbaan M Hodivala-Dilke
  • Yingjie Liu
  • Jing Yu
  • R van der Neut
  • Carmen Díaz-Ruiz
  • Alexei Navdaev
  • A Sonnenberg
  • Vincenzo Milano
  • Kevin M Pumiglia
  • Tanja Matilainen
  • John Lamar
  • Richard Belvindrah
  • Cedric Blanpain
  • Yanyang Zhao
  • Satoshi Fukumoto
  • Aruna K Behera
  • David Grote
  • Stephanie Shelton
  • E Georges-Labouesse
  • Z Wang
  • Asha Manohar
  • Kamon Sanada
  • Stefano C Previtali
  • Chi Shing Chan
  • Zhi Yong He
  • Simon Philippe Lebel
  • Anne Laure Bolcato-Bellemin
  • Takumi Kato
  • C Baudoin
  • Virginia Sadl
  • Yoshinobu Sugitani
  • Charles A Greer
  • Anthony J Koleske
  • Roel Goldschmeding
  • M Sixt
  • Minsoo Kim
  • Tomoaki Niimi
  • R Zent
  • D M Owens
  • Nine V A M Knoers
  • Deborah J Fowell
  • Christina M Baker
  • Sietske H Kevelam
  • Kaneyoshi Takahashi
  • Hiroki Tashima
  • Kirsten Y Renkema
  • Elena Lomakina
  • Bert van der Zwaag
  • Michael G Overstreet
  • Shun ichi Kuroda
  • Richard E Waugh

Detail Information

Publications78

  1. ncbi Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis
    J A Kreidberg
    Division of Nephrology, Children s Hospital, Boston, MA 02115, USA
    Development 122:3537-47. 1996
    A mutation was targeted to the murine alpha3 integrin gene. Homozygous mutant mice survived to birth, but died during the neonatal period. The mutation caused abnormal kidney and lung development...
  2. ncbi Epithelial development and differentiation in the mammary gland is not dependent on alpha 3 or alpha 6 integrin subunits
    T C Klinowska
    School of Biological Sciences, University of Manchester, 3 239 Stopford Building, Oxford Road, Manchester, M13 9PT, United Kingdom
    Dev Biol 233:449-67. 2001
    ..This work demonstrates that mammary tissue genetically lacking major laminin-binding integrin receptors is still able to develop and function...
  3. pmc Kidney failure in mice lacking the tetraspanin CD151
    Norman Sachs
    Division of Cell Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands
    J Cell Biol 175:33-9. 2006
    ..Our results support the hypothesis that CD151 plays a key role in strengthening alpha3beta1-mediated adhesion in podocytes...
  4. pmc alpha3beta1 Integrin is required for normal development of the epidermal basement membrane
    C M DiPersio
    Center for Cancer Research, and Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Cell Biol 137:729-42. 1997
    ..Our findings support a novel role for alpha3beta1 in establishment and/or maintenance of basement membrane integrity, while alpha6beta4 is required for stable adhesion of the epidermis to the basement membrane through hemidesmosomes...
  5. ncbi Developmental regulation of integrin expression at the time of implantation in the mouse embryo
    A E Sutherland
    Department of Stomatology, University of California San Francisco 94143
    Development 119:1175-86. 1993
    ..abstract truncated at 400 words)..
  6. pmc Galectin-3 promotes lamellipodia formation in epithelial cells by interacting with complex N-glycans on alpha3beta1 integrin
    Chandrassegar Saravanan
    Department of Ophthalmologyand The New England Eye Center, Tufts University School of Medicine, Sackler School of Graduate Biomedical Sciences, Boston, MA 02111, USA
    J Cell Sci 122:3684-93. 2009
    ..Preincubation of cells with anti-alpha3 integrin function-blocking antibody significantly inhibited the induction of lamellipodia by Gal-3...
  7. pmc Integrin α3 is required for late postnatal stability of dendrite arbors, dendritic spines and synapses, and mouse behavior
    Meghan E Kerrisk
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 33:6742-52. 2013
    ..In addition, these results provide a biochemical and structural explanation for the defects in long-term potentiation, learning, and memory reported previously in mice lacking integrin α3...
  8. pmc NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin
    Jun ichi Fukushi
    The Burnham Institute, La Jolla, California 92037, USA
    Mol Biol Cell 15:3580-90. 2004
    ....
  9. ncbi The C-terminus of the gamma 2 chain but not of the beta 3 chain of laminin-332 is indirectly but indispensably necessary for integrin-mediated cell reactions
    Alexei Navdaev
    Institute for Physiological Chemistry, Muenster University Hospital, 48149 Muenster, Germany
    Exp Cell Res 314:489-97. 2008
    ....
  10. pmc Involvement of integrins alpha(3)beta(1) and alpha(5)beta(1) and glycoprotein IIb in megakaryocyte-induced osteoblast proliferation
    Justin M Lemieux
    Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut, USA
    J Cell Biochem 109:927-32. 2010
    ..Taken together, these results suggest that although their physiologic and clinical implications are very different, these two models of hematopoietic-mesenchymal cell activation are mechanistically analogous in several ways...
  11. ncbi Differential expression of alpha 3 and alpha 6 integrins in the developing mouse inner ear
    Dawn Davies
    Department of Physiology, University of Bristol, School of Medical Sciences, Bristol BS8 1TD, United Kingdom
    J Comp Neurol 445:122-32. 2002
    ....
  12. pmc Knockout and knockin of the beta1 exon D define distinct roles for integrin splice variants in heart function and embryonic development
    C Baudoin
    Division of Cell Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Genes Dev 12:1202-16. 1998
    ..We propose that beta1D is less efficient than beta1A in mediating the signaling that regulates cell motility and responses of the cells to mechanical stress...
  13. ncbi Characterization of the promoter for the mouse alpha 3 integrin gene
    Takumi Kato
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Eur J Biochem 269:4524-32. 2002
    ....
  14. ncbi Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney
    David Grote
    McGill Cancer Centre and Biochemistry Department, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
    Development 133:53-61. 2006
    ..Together, these results define Gata3 as a key regulator of nephric duct morphogenesis and guidance in the pro/mesonephric kidney...
  15. ncbi (Alpha)3(beta)1 integrin regulates epithelial cytoskeletal organization
    Z Wang
    Department of Medicine, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Cell Sci 112:2925-35. 1999
    ..These results present direct evidence for integrin:cadherin cross-regulation in which cadherin function is dependent on the presence of an integrin...
  16. ncbi Identification of a TLR-independent pathway for Borrelia burgdorferi-induced expression of matrix metalloproteinases and inflammatory mediators through binding to integrin alpha 3 beta 1
    Aruna K Behera
    Tufts New England Medical Center, Tufts University School of Medicine, Tupper Research Institute, Division of Geographic Medicine and Infectious Diseases, Boston, MA 02111
    J Immunol 177:657-64. 2006
    ..burgdorferi to integrin alpha(3)beta(1) results in the release of inflammatory mediators and is proposed as a TLR-independent pathway for activation of the innate immune response by the organism...
  17. ncbi Alpha 3 beta 1 integrin promotes keratinocyte cell survival through activation of a MEK/ERK signaling pathway
    Asha Manohar
    Center for Cell Biology and Cancer Research, Albany Medical College, MC 165, 47 New Scotland Avenue, Albany, New York, NY 12208, USA
    J Cell Sci 117:4043-54. 2004
    ..We propose a model to address the potential importance of alpha 3 beta 1-mediated survival for migrating keratinocytes at the leading edge of a cutaneous wound...
  18. doi Integrin alpha3beta1 inhibits directional migration and wound re-epithelialization in the skin
    Coert Margadant
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Cell Sci 122:278-88. 2009
    ..We suggest that integrin alpha3beta1 delays keratinocyte migration during wound re-epithelialization, by binding to the laminin-332 that is newly deposited on the wound bed...
  19. ncbi Morphofunctional studies of the glomerular wall in mice lacking entactin-1
    Simon Philippe Lebel
    Department of Pathology and Cell Biology, Universite de Montreal, CP 6128 Succ Centre Ville, Montreal, Quebec, Canada H3C 3J7
    J Histochem Cytochem 51:1467-78. 2003
    ..Entactin-1 appears to be an essential component in basement membranes because its absence appears to modify the molecular organization leading to alterations in functional properties...
  20. pmc Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons
    Yoshinobu Sugitani
    Department of Cell Biology, JFCR Cancer Institute, Tokyo 170 8455, Japan
    Genes Dev 16:1760-5. 2002
    ..These data indicate that Brn-1 and Brn-2 share roles in the production and positioning of neocortical neuron development...
  21. ncbi Disabled-1-regulated adhesion of migrating neurons to radial glial fiber contributes to neuronal positioning during early corticogenesis
    Kamon Sanada
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Neuron 42:197-211. 2004
    ..Importantly, phosphorylation at those sites regulates alpha3 integrin levels, which is critical for the timely detachment of migrating neurons from radial glia...
  22. pmc Netrin-1-alpha3beta1 integrin interactions regulate the migration of interneurons through the cortical marginal zone
    Amelia Stanco
    University of North Carolina Neuroscience Center and Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 106:7595-600. 2009
    ....
  23. ncbi Reelin, integrin and DAB1 interactions during embryonic cerebral cortical development
    Ralf S Schmid
    UNC Neuroscience Center and the Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Cereb Cortex 15:1632-6. 2005
    ..Thus, alpha3beta1 integrin-reelin interactions may contribute to appropriate neuronal placement in the developing cerebral cortex...
  24. ncbi Inhibition of distal lung morphogenesis in Nkx2.1(-/-) embryos
    B Yuan
    Department of Pediatrics, Women s and Children s Hospital, USC School of Medicine, Los Angeles, California 90033, USA
    Dev Dyn 217:180-90. 2000
    ..1 independent, while distal lung morphogenesis appears to be strictly dependent on the wild-type activity of Nkx2.1...
  25. pmc Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels
    Young Min Hyun
    Department of Microbiology and Immunology, David H Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY 14642, USA
    J Exp Med 209:1349-62. 2012
    ..These findings suggest that uropod elongation is a final step in the leukocyte extravasation cascade, which may be important for precise regulation of leukocyte recruitment into inflamed tissues...
  26. pmc Gain of glycosylation in integrin α3 causes lung disease and nephrotic syndrome
    Nayia Nicolaou
    Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Invest 122:4375-87. 2012
    ..Here, we report on a patient homozygous for a novel missense mutation in the human ITGA3 gene, causing fatal interstitial lung disease and congenital nephrotic syndrome...
  27. ncbi Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion
    H Gardner
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142, USA
    Dev Biol 175:301-13. 1996
    ..Further in vitro analysis of cell spreading and migration suggests that alpha 1 beta 1 is not required for binding to collagen I and implicates a third receptor, possibly integrin alpha 3 beta 1, in collagen I binding.
  28. pmc Loss of integrin α3 prevents skin tumor formation by promoting epidermal turnover and depletion of slow-cycling cells
    Norman Sachs
    Division of Cell Biology, The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 109:21468-73. 2012
    ..Using epidermis-specific Itga3 KO mice subjected to the 7,12-dimethylbenzanthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate two-stage skin ..
  29. ncbi Expression of beta 1 integrin complexes on the surface of unfertilized mouse oocyte
    G Tarone
    Dipartimento di Genetica, Biologia e Chimica Medica, Universita di Torino, Italy
    Development 117:1369-75. 1993
    ..These data demonstrate for the first time the expression of three beta 1 integrin complexes in unfertilized mouse oocytes. Such proteins may have a role in sperm-egg interaction or during very early steps of embryogenesis...
  30. ncbi Localized distribution of alpha 9 integrin in the cornea and changes in expression during corneal epithelial cell differentiation
    M A Stepp
    Department of Anatomy, George Washington University Medical School, Washington, DC 20037
    J Histochem Cytochem 43:353-62. 1995
    ..abstract truncated at 400 words)..
  31. doi The C-terminal region of NELL1 mediates osteoblastic cell adhesion through integrin α3β1
    Ai Hasebe
    Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464 8601, Japan
    FEBS Lett 586:2500-6. 2012
    ..Further, focal adhesion kinase activation is involved in NELL1 signaling...
  32. ncbi Beta1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex
    Richard Belvindrah
    Department of Cell Biology, Institute for Childhood and Neglected Disease, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 27:13854-65. 2007
    ..We conclude that beta1 integrins in radial glia are required for the proper development of the cerebral cortex, whereas beta1 integrins in migrating neurons are not essential for glial-guided migration and reelin signaling...
  33. ncbi Integrin alpha3beta1-dependent activation of FAK/Src regulates Rac1-mediated keratinocyte polarization on laminin-5
    David P Choma
    Center for Cell Biology and Cancer Research, Albany Medical College, Albany, New York 12208 3479, USA
    J Invest Dermatol 127:31-40. 2007
    ..These findings reveal a novel pathway in migratory keratinocytes wherein alpha3beta1-laminin-5 interactions regulate src kinase signaling through FAK, promoting Rac1 activation and polarized lamellipodium extension...
  34. ncbi Laminin alpha5 is required for dental epithelium growth and polarity and the development of tooth bud and shape
    Satoshi Fukumoto
    Craniofacial Developmental Biology and Regeneration Branch and Oral and Pharyngeal Cancer Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:5008-16. 2006
    ....
  35. ncbi Alpha3beta1 integrin regulates MMP-9 mRNA stability in immortalized keratinocytes: a novel mechanism of integrin-mediated MMP gene expression
    Vandana Iyer
    Center for Cell Biology and Cancer Research, Albany Medical College, MC 165, 47 New Scotland Avenue, Albany, New York 12208, USA
    J Cell Sci 118:1185-95. 2005
    ..They also suggest a role for alpha3beta1 in maintaining high levels of MMP-9 mRNA expression in response to oncogenic activation of MEK/ERK signaling pathways...
  36. ncbi Association of TIMP-2 with extracellular matrix exposed to mechanical stress and its co-distribution with periostin during mouse mandible development
    Nagako Yoshiba
    Division of Cariology, Operative Dentistry and Endodontics, Department of Oral Health Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Cell Tissue Res 330:133-45. 2007
    ..We suggest that TIMP-2 and periostin are co-distributed on ECM exposed to mechanical forces and coordinately function as ECM modulators...
  37. ncbi Analysis of Netrin 1 receptors during inner ear development
    Tanja Matilainen
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Finland, and Department of Medicine, The Children s Hospital, Boston, MA, USA
    Int J Dev Biol 51:409-13. 2007
    ..Neo1), Unc5c as well as integrin b1 (Itgb1) are expressed in periotic mesenchyme, while Dcc, Unc5b, Unc5c, Itga3, Itga6 and Itgb1 are expressed in different parts of the otic epithelium...
  38. doi Regulation of neural migration by the CREB/CREM transcription factors and altered Dab1 levels in CREB/CREM mutants
    Carmen Díaz-Ruiz
    Institute for Research in Biomedicine Barcelona IRB, Department of Cell Biology and CIBERNED ISCIII, University of Barcelona, Barcelona Science Park, Lab A1 S1, Josep Samitier 1 5, Barcelona 08028, Spain
    Mol Cell Neurosci 39:519-28. 2008
    ....
  39. pmc Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis
    Yingjie Liu
    Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Development 136:843-53. 2009
    ..Together, these results demonstrate how signals from integrins and growth factor receptors can be integrated to regulate the expression of an important family of signaling molecules so as to regulate morphogenetic events...
  40. doi Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitro
    Stefan Plantman
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Mol Cell Neurosci 39:50-62. 2008
    ....
  41. pmc alpha3beta1 integrin-controlled Smad7 regulates reepithelialization during wound healing in mice
    Louise E Reynolds
    Centre for Tumour Biology, Institute of Cancer Research and Cancer Research UK Clinical Centre, Barts and The London, Queen Mary s School of Medicine and Dentistry, John Vane Science Centre, London, United Kingdom
    J Clin Invest 118:965-74. 2008
    ..We have shown here that retarded reepithelialization in Itga3(-/-) mouse skin wounds is due predominantly to repressed TGF-beta1-mediated responses...
  42. pmc An immortalization-dependent switch in integrin function up-regulates MMP-9 to enhance tumor cell invasion
    John M Lamar
    Center for Cell Biology and Cancer Research, Albany Medical College, Albany, New York 12208 3479, USA
    Cancer Res 68:7371-9. 2008
    ..Our results show that loss of p53 function leads to changes in integrin-mediated gene regulation that occur during SCC progression and play a critical role in tumor cell invasion...
  43. pmc Alpha3beta1 integrin in epidermis promotes wound angiogenesis and keratinocyte-to-endothelial-cell crosstalk through the induction of MRP3
    Kara Mitchell
    Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208, USA
    J Cell Sci 122:1778-87. 2009
    ..Such a mechanism represents a novel paradigm for integrin-mediated regulation of wound angiogenesis that extends beyond traditional roles for integrins in cell adhesion and migration...
  44. pmc Cardiomyocyte contractile status is associated with differences in fibronectin and integrin interactions
    Xin Wu
    Dept of Systems Biology and Translational Medicine, Texas A and M Health Science Center College of Medicine, College Station, TX 77843 1114, USA
    Am J Physiol Heart Circ Physiol 298:H2071-81. 2010
    ..Thus, our results demonstrate that integrin binding to FN is modulated by the contractile state of cardiac myocytes...
  45. pmc Endothelial alpha3beta1-integrin represses pathological angiogenesis and sustains endothelial-VEGF
    Rita Graça da Silva
    Adhesion and Angiogenesis Laboratory, Barts Institute of Cancer, Queen Mary University of London, London, UK
    Am J Pathol 177:1534-48. 2010
    ..These data, therefore, identify directly that endothelial alpha3beta1 negatively regulates pathological angiogenesis and implicate an unexpected role for low levels of endothelial-VEGF as an activator of neovascularization...
  46. pmc Integrin alpha3beta1 potentiates TGFbeta-mediated induction of MMP-9 in immortalized keratinocytes
    John M Lamar
    Center for Cell Biology and Cancer Research, Albany Medical College, Albany, New York 12208 3479, USA
    J Invest Dermatol 128:575-86. 2008
    ..These findings provide early evidence of a role for alpha3beta1 in augmenting TGFbeta-mediated induction of MMP-9 in immortalized or transformed keratinocytes during skin carcinogenesis...
  47. ncbi Deletion of core fucosylation on alpha3beta1 integrin down-regulates its functions
    Yanyang Zhao
    Department of Biochemistry, Osaka University Graduate School of Medicine, B1, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 281:38343-50. 2006
    ..The reintroduction of Fut8 potentially restored laminin 5-induced migration and intracellular signaling. Collectively, these results suggested that core fucosylation is essential for the functions of alpha3beta1 integrin...
  48. ncbi alpha3beta1 integrin modulates neuronal migration and placement during early stages of cerebral cortical development
    Ralf S Schmid
    UNC Neuroscience Center and the Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Development 131:6023-31. 2004
    We show that alpha3 integrin mutation disrupts distinct aspects of neuronal migration and placement in the cerebral cortex. The preplate develops normally in alpha3 integrin mutant mice...
  49. ncbi Loss of alpha3beta1 integrin function results in an altered differentiation program in the mouse submandibular gland
    A S Menko
    Department of Anatomy, Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Dev Dyn 220:337-49. 2001
    ..laminin, by characterizing embryonic day 18 (E18) SMGs isolated from mice carrying a targeted mutation in the alpha3 integrin gene...
  50. ncbi Reelin binds alpha3beta1 integrin and inhibits neuronal migration
    L Dulabon
    Department of Biology and Neuroscience, Pennsylvania State University, University Park 16802, USA
    Neuron 27:33-44. 2000
    ..Thus, Reelin may arrest neuronal migration and promote normal cortical lamination by binding alpha3beta1 integrin and modulating integrin-mediated cellular adhesion...
  51. ncbi alpha3beta1 and alpha6beta4 integrin receptors for laminin-5 are not essential for epidermal morphogenesis and homeostasis during skin development
    C M DiPersio
    Howard Hughes Medical Institute, Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Cell Sci 113:3051-62. 2000
    ..These findings show that while alpha3beta1 and alpha6beta4 are both required for integrity of the dermo-epidermal junction, neither one is essential for epidermal morphogenesis during skin development...
  52. ncbi Partial rescue of epithelial phenotype in integrin beta4 null mice by a keratin-5 promoter driven human integrin beta4 transgene
    R van der Neut
    Division of Cell Biology, Netherlands Cancer Institute, Plesmanlaan 121, The Netherlands
    J Cell Sci 112:3911-22. 1999
    ....
  53. ncbi Role of integrins during fertilization in mammals
    P Fenichel
    Groupe de Recherche sur l Interaction Gamétique, CJF INSERM 95 04, Faculte de Medecine, Nice, France
    Hum Reprod 13:31-46. 1998
    ..Experimental data suggest that they may act in a similar way during fertilization and may participate to initiation and/or propagation of the calcium signal via stimulation of phospholipase C gamma and inositol trisphosphate production...
  54. ncbi Mouse primordial germ cells lacking beta1 integrins enter the germline but fail to migrate normally to the gonads
    R Anderson
    Department of Cell Biology and Neuroanatomy and Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    Development 126:1655-64. 1999
    ..These results demonstrate a role for beta1-containing integrins in the development of the germline, although an equivalent role for * integrin subunit(s) has yet to be established...
  55. ncbi Distinct functions of alpha3 and alpha(v) integrin receptors in neuronal migration and laminar organization of the cerebral cortex
    E S Anton
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510 8001, USA
    Neuron 22:277-89. 1999
    ..Furthermore, the targeted mutation of the alpha3 integrin gene results in abnormal layering of the cerebral cortex...
  56. ncbi Role of integrins in mouse eyelid development: studies in normal embryos and embryos in which there is a failure of eyelid fusion
    J M Carroll
    Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Mech Dev 78:37-45. 1998
    ..We speculate that selective and coordinated expression of the alpha5beta1 integrin and fibronectin in eyelid tip cells is required for eyelid fusion and may be under the control of growth factors that include TGF-alpha...
  57. pmc Cre-loxP-mediated inactivation of the alpha6A integrin splice variant in vivo: evidence for a specific functional role of alpha6A in lymphocyte migration but not in heart development
    C Gimond
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Cell Biol 143:253-66. 1998
    ..Nevertheless, the expression of alpha6A might be necessary for optimal lymphocyte migration on laminin in certain pathological conditions...
  58. ncbi Localization of extracellular matrix molecules, integrins and their regulators, TGF betas, is correlated with axon pathfinding in the spinal cord of normal and Danforth's short tail mice
    K Ohyama
    Department of Anatomy, School of Medicine, Keio University, Tokyo, Japan
    Brain Res Dev Brain Res 103:143-54. 1997
    ..These results suggest that the restricted localization of ECMs, integrins, and TGF betas at the floor plate is involved in the pathfinding of commissural and longitudinal axons...
  59. ncbi Differential expression of integrin alpha subunits supports distinct roles during lung branching morphogenesis
    J E Wu
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Dev Dyn 206:169-81. 1996
    ....
  60. ncbi cDNA cloning of mouse VLA-3 alpha subunit
    K Takeuchi
    Division of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan
    J Cell Biochem 57:371-7. 1995
    ..A higher level of its message was detected in thymus than in kidney, stomach, spleen, liver, brain, or lung by Northern blotting analysis...
  61. pmc Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis
    M Sixt
    Interdisciplinary Center for Clinical Research IZKF, Nikolaus Fiebiger Center, University of Erlangen Nuremberg, Glückstr 6, 91054 Erlangen, Germany
    J Cell Biol 153:933-46. 2001
    ....
  62. ncbi Changes in integrin expression during chondrogenesis in vitro: an immunomorphological study
    M Shakibaei
    Institute of Anatomy, Free University of Berlin, Germany
    J Histochem Cytochem 43:1061-9. 1995
    ..Therefore, a strict correlation between the collagen type synthesized by the cells and the appropriate receptor presented by the cells is suggested...
  63. ncbi Laminin alpha5 chain is required for intestinal smooth muscle development
    Anne Laure Bolcato-Bellemin
    INSERM U381, Ontogenese et Pathologie du Systeme Digestif, Avenue Moliere, Strasbourg, France
    Dev Biol 260:376-90. 2003
    ....
  64. ncbi Integrin requirement for hippocampal synaptic plasticity and spatial memory
    Chi Shing Chan
    Department of Molecular and Cellular Biology, Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 23:7107-16. 2003
    ..Mice with genetically reduced expression of alpha3 integrin fail to maintain long-term potentiation (LTP) generated in hippocampal CA1 neurons...
  65. ncbi Integrin alpha3beta1 directs the stabilization of a polarized lamellipodium in epithelial cells through activation of Rac1
    David P Choma
    Center for Cell Biology and Cancer Research, Albany Medical College, MC 165, 47 New Scotland Avenue, Albany, NY 12208, USA
    J Cell Sci 117:3947-59. 2004
    ....
  66. ncbi Expression of laminin receptors in schwann cell differentiation: evidence for distinct roles
    Stefano C Previtali
    Neuropathology Unit, Department of Neuroscience and DIBIT, San Raffaele Scientific Institute, 20132 Milan, Italy
    J Neurosci 23:5520-30. 2003
    ..These data suggest that the action of laminin is mediated by beta1 integrins during axonal sorting and by dystroglycan, alpha6beta1, and alpha6beta4 integrins during myelination...
  67. ncbi Immunolocalization of extracellular matrix components and integrins during mouse liver development
    Nobuyoshi Shiojiri
    Department of Biology, Faculty of Science, Shizuoka University, Oya 836, Shizuoka 422 8529, Japan
    Hepatology 40:346-55. 2004
    ..Supplementary material for this article can be found on the HEPATOLOGY website (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html)...
  68. ncbi None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion
    Zhi Yong He
    Section of Molecular and Cellular Biology, University of California Davis, Davis, CA 95616, USA
    Dev Biol 254:226-37. 2003
    ..Some of these integrins are also reported to be receptors for ADAMs, which are expressed on sperm. Using alpha3 integrin null eggs, we found that the alpha3beta1 integrin was not essential for sperm-egg binding and fusion...
  69. ncbi The mouse Kreisler (Krml1/MafB) segmentation gene is required for differentiation of glomerular visceral epithelial cells
    Virginia Sadl
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
    Dev Biol 249:16-29. 2002
    ..However, these observations alone are unlikely to account for the aberrant podocyte foot process formation. Thus, Kreisler must regulate other unknown genes required for podocyte function and with possible roles in kidney disease...
  70. ncbi Involvement of laminin binding integrins and laminin-5 in branching morphogenesis of the ureteric bud during kidney development
    R Zent
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0693, USA
    Dev Biol 238:289-302. 2001
    ..These data may help to partially explain the renal phenotype seen in integrin alpha3 and alpha3/alpha6 subunit-deficient animals...
  71. ncbi Functional comparison of the alpha3A and alpha3B cytoplasmic domain variants of the chicken alpha3 integrin subunit
    C M DiPersio
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Exp Cell Res 268:45-60. 2001
    ..Our findings suggest that the alpha3B cytoplasmic domain harbors a retention signal that is regulated in an intact integrin and can alter cell surface expression and distribution of alpha3beta1...
  72. pmc Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains
    R N Tamura
    Scripps Research Institute, La Jolla, CA 92037
    Proc Natl Acad Sci U S A 88:10183-7. 1991
    ..Alternative cytoplasmic domains may provide a means for varying the cellular responses to the ligands of alpha 6 and alpha 3 integrins according to the cell type...
  73. ncbi Differential expression of laminin chain-specific mRNA transcripts during mouse preimplantation embryo development
    C Shim
    Department of Molecular Biology, Seoul National University, South Korea
    Mol Reprod Dev 44:44-55. 1996
    ..These changes in laminin mRNAs were parallel with its receptors such as integrin alpha 3 and alpha 6...
  74. pmc Canonical notch signaling functions as a commitment switch in the epidermal lineage
    Cedric Blanpain
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Genes Dev 20:3022-35. 2006
    ....
  75. ncbi Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse
    A De Arcangelis
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, CU de Strasbourg, France
    Development 126:3957-68. 1999
    ..The presence of novel phenotypes in double mutant embryos demonstrates the synergism between alpha3 and alpha6 integrins and their essential roles in multiple processes during embryogenesis...
  76. pmc A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney
    Jing Yu
    Department of Molecular and Cellular Biology and Harvard Stem Cell Institute, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 136:161-71. 2009
    ..These findings demonstrate that Wnt7b is a key regulator of the tissue architecture that establishes a functional physiologically active mammalian kidney...
  77. ncbi Influence of beta1 integrins on epidermal squamous cell carcinoma formation in a transgenic mouse model: alpha3beta1, but not alpha2beta1, suppresses malignant conversion
    D M Owens
    Imperial Cancer Research Fund, Keratinocyte Laboratory, London WC2A 3PX, United Kingdom
    Cancer Res 61:5248-54. 2001
    ..Our results demonstrate that the alpha3beta1 integrin can suppress malignant conversion, and that the mechanism may involve CD81...
  78. ncbi Expression patterns of beta1-related alpha integrin subunits in murine lens during embryonic development and wound healing
    Walid Barbour
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Curr Eye Res 29:1-10. 2004
    ..To study the expression patterns of b1-related alpha integrin subunits in murine lens epithelial cells, comparing embryonic fiber differentiation with injury-induced epithelial mesenchymal transition (EMT)...

Research Grants35

  1. CONTROL OF MATRIX PROTEOLYSIS BY INTEGRIN A3B1 IN SKIN
    C DiPersio; Fiscal Year: 2005
    ....
  2. Regulation of MMP-9 mRNA stability and tumor growth by alpha3 beta1 integrin
    C Michael DiPersio; Fiscal Year: 2010
    ..The proposed studies will identify novel molecular pathways that are turned on in cancer cells to promote malignant tumor growth and metastasis. These pathways may be exploitable as therapeutic targets. ..
  3. Regulation of MMP-9 mRNA stability and tumor growth by alpha3 beta1 integrin
    C DiPersio; Fiscal Year: 2009
    ..The proposed studies will identify novel molecular pathways that are turned on in cancer cells to promote malignant tumor growth and metastasis. These pathways may be exploitable as therapeutic targets. ..
  4. MOLECULAR ASPECTS OF CORNEAL EPITHELIAL MIGRATION
    Mary Ann Stepp; Fiscal Year: 2007
    ..Significant progress has been made in understanding how the cornea heals but improved treatment options need to be developed for patients with pathological healing due to trauma. ..
  5. MOLECULAR ASPECTS OF CORNEAL EPITHELIAL MIGRATION
    Mary Ann Stepp; Fiscal Year: 2010
    ..Significant progress has been made in understanding how the cornea heals but improved treatment options need to be developed for patients with pathological healing due to trauma. ..
  6. Characterization of Corneal Epithelial Stem Cells
    Mary Ann Stepp; Fiscal Year: 2005
    ..Discovering specific molecular markers for the limbal stem cells will aid in the development of treatments for stem cell deficiency diseases of the ocular surface in humans. ..
  7. MOLECULAR ASPECTS OF CORNEAL EPITHELIAL MIGRATION
    Mary Ann Stepp; Fiscal Year: 2006
    ..By examining the mechanism of delayed corneal wound healing in genetically engineered mice, basic concepts regulating healing will be revealed and better treatments for those suffering from poor healing can be developed. ..
  8. MOLECULAR ASPECTS OF CORNEAL EPITHELIAL MIGRATION
    MARY STEPP; Fiscal Year: 1993
    ..These experiments will help accomplish our goal of obtaining a better understanding, at the molecular level, of the role of integrins in the normal cornea and in epithelial cell migration during wound healing...
  9. MOLECULAR ASPECTS OF CORNEAL EPITHELIAL MIGRATION
    MARY STEPP; Fiscal Year: 1992
    ..The proposed studies of integrin expression in corneal epithelium will provide insight into the basic cell biology of migration and the role of integrin:cell matrix interactions in the healing of corneal wounds...
  10. MOLECULAR ASPECTS OF CORNEAL EPITHELIAL MIGRATION
    Mary Ann Stepp; Fiscal Year: 2001
    ..The proposed studies of integrin expression in the corneal epithelium will provide insight into the basic cell biology of migration and the role of integrin:matrix interactions in the healing of corneal wounds. ..
  11. MOLECULAR ASPECTS OF CORNEAL EPITHELIAL MIGRATION
    Mary Ann Stepp; Fiscal Year: 2009
    ..Significant progress has been made in understanding how the cornea heals but improved treatment options need to be developed for patients with pathological healing due to trauma. ..