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Genomes and Genes
| Itga3SummaryGene Symbol: Itga3 Description: integrin alpha 3 Alias: AA407068, CD49C, GAPB3, CD49 antigen-like family member C, VLA-3 alpha 3, VLA-3 receptor, alpha 3 subunit, VLA-3 subunit alpha, alpha3-integrin, galactoprotein B3, integrin alpha-3 Species: mouse Top Publications
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Publications
Involvement of integrins alpha(3)beta(1) and alpha(5)beta(1) and glycoprotein IIb in megakaryocyte-induced osteoblast proliferationJustin M Lemieux
Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut, USA
J Cell Biochem 109:927-32. 2010..Taken together, these results suggest that although their physiologic and clinical implications are very different, these two models of hematopoietic-mesenchymal cell activation are mechanistically analogous in several ways...
Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesionH Gardner
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142, USA
Dev Biol 175:301-13. 1996..Further in vitro analysis of cell spreading and migration suggests that alpha 1 beta 1 is not required for binding to collagen I and implicates a third receptor, possibly integrin alpha 3 beta 1, in collagen I binding.- (Alpha)3(beta)1 integrin regulates epithelial cytoskeletal organizationZ Wang
Department of Medicine, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Cell Sci 112:2925-35. 1999..These results present direct evidence for integrin:cadherin cross-regulation in which cadherin function is dependent on the presence of an integrin... - Morphofunctional studies of the glomerular wall in mice lacking entactin-1Simon Philippe Lebel
Department of Pathology and Cell Biology, Universite de Montreal, CP 6128 Succ Centre Ville, Montreal, Quebec, Canada H3C 3J7
J Histochem Cytochem 51:1467-78. 2003..Entactin-1 appears to be an essential component in basement membranes because its absence appears to modify the molecular organization leading to alterations in functional properties... - Alpha 3 beta 1 integrin promotes keratinocyte cell survival through activation of a MEK/ERK signaling pathwayAsha Manohar
Center for Cell Biology and Cancer Research, Albany Medical College, MC 165, 47 New Scotland Avenue, Albany, New York, NY 12208, USA
J Cell Sci 117:4043-54. 2004..We propose a model to address the potential importance of alpha 3 beta 1-mediated survival for migrating keratinocytes at the leading edge of a cutaneous wound... - Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neuronsYoshinobu Sugitani
Department of Cell Biology, JFCR Cancer Institute, Tokyo 170 8455, Japan
Genes Dev 16:1760-5. 2002..These data indicate that Brn-1 and Brn-2 share roles in the production and positioning of neocortical neuron development... - Identification of a TLR-independent pathway for Borrelia burgdorferi-induced expression of matrix metalloproteinases and inflammatory mediators through binding to integrin alpha 3 beta 1Aruna K Behera
Tufts New England Medical Center, Tufts University School of Medicine, Tupper Research Institute, Division of Geographic Medicine and Infectious Diseases, Boston, MA 02111
J Immunol 177:657-64. 2006..burgdorferi to integrin alpha(3)beta(1) results in the release of inflammatory mediators and is proposed as a TLR-independent pathway for activation of the innate immune response by the organism... - Inhibition of distal lung morphogenesis in Nkx2.1(-/-) embryosB Yuan
Department of Pediatrics, Women s and Children s Hospital, USC School of Medicine, Los Angeles, California 90033, USA
Dev Dyn 217:180-90. 2000..1 independent, while distal lung morphogenesis appears to be strictly dependent on the wild-type activity of Nkx2.1... - alpha3beta1 Integrin is required for normal development of the epidermal basement membraneC M DiPersio
Center for Cancer Research, and Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
J Cell Biol 137:729-42. 1997..Our findings support a novel role for alpha3beta1 in establishment and/or maintenance of basement membrane integrity, while alpha6beta4 is required for stable adhesion of the epidermis to the basement membrane through hemidesmosomes... - Disabled-1-regulated adhesion of migrating neurons to radial glial fiber contributes to neuronal positioning during early corticogenesisKamon Sanada
Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Neuron 42:197-211. 2004..Importantly, phosphorylation at those sites regulates alpha3 integrin levels, which is critical for the timely detachment of migrating neurons from radial glia... - Expression of beta 1 integrin complexes on the surface of unfertilized mouse oocyteG Tarone
Dipartimento di Genetica, Biologia e Chimica Medica, Universita di Torino, Italy
Development 117:1369-75. 1993..These data demonstrate for the first time the expression of three beta 1 integrin complexes in unfertilized mouse oocytes. Such proteins may have a role in sperm-egg interaction or during very early steps of embryogenesis... - Netrin-1-alpha3beta1 integrin interactions regulate the migration of interneurons through the cortical marginal zoneAmelia Stanco
University of North Carolina Neuroscience Center and Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Proc Natl Acad Sci U S A 106:7595-600. 2009.... - Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesisJ A Kreidberg
Division of Nephrology, Children s Hospital, Boston, MA 02115, USA
Development 122:3537-47. 1996A mutation was targeted to the murine alpha3 integrin gene. Homozygous mutant mice survived to birth, but died during the neonatal period. The mutation caused abnormal kidney and lung development... 
Regulation of neural migration by the CREB/CREM transcription factors and altered Dab1 levels in CREB/CREM mutantsCarmen Díaz-Ruiz
Institute for Research in Biomedicine Barcelona IRB, Department of Cell Biology and CIBERNED ISCIII, University of Barcelona, Barcelona Science Park, Lab A1 S1, Josep Samitier 1 5, Barcelona 08028, Spain
Mol Cell Neurosci 39:519-28. 2008....- Laminin alpha5 is required for dental epithelium growth and polarity and the development of tooth bud and shapeSatoshi Fukumoto
Craniofacial Developmental Biology and Regeneration Branch and Oral and Pharyngeal Cancer Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 281:5008-16. 2006.... - Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidneyDavid Grote
McGill Cancer Centre and Biochemistry Department, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
Development 133:53-61. 2006..Together, these results define Gata3 as a key regulator of nephric duct morphogenesis and guidance in the pro/mesonephric kidney... - Cardiomyocyte contractile status is associated with differences in fibronectin and integrin interactionsXin Wu
Dept of Systems Biology and Translational Medicine, Texas A and M Health Science Center College of Medicine, College Station, TX 77843 1114, USA
Am J Physiol Heart Circ Physiol 298:H2071-81. 2010..Thus, our results demonstrate that integrin binding to FN is modulated by the contractile state of cardiac myocytes... - Alpha3beta1 integrin regulates MMP-9 mRNA stability in immortalized keratinocytes: a novel mechanism of integrin-mediated MMP gene expressionVandana Iyer
Center for Cell Biology and Cancer Research, Albany Medical College, MC 165, 47 New Scotland Avenue, Albany, New York 12208, USA
J Cell Sci 118:1185-95. 2005..They also suggest a role for alpha3beta1 in maintaining high levels of MMP-9 mRNA expression in response to oncogenic activation of MEK/ERK signaling pathways... - alpha3beta1 integrin modulates neuronal migration and placement during early stages of cerebral cortical developmentRalf S Schmid
UNC Neuroscience Center and the Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Development 131:6023-31. 2004We show that alpha3 integrin mutation disrupts distinct aspects of neuronal migration and placement in the cerebral cortex. The preplate develops normally in alpha3 integrin mutant mice... - Immunolocalization of extracellular matrix components and integrins during mouse liver developmentNobuyoshi Shiojiri
Department of Biology, Faculty of Science, Shizuoka University, Oya 836, Shizuoka 422 8529, Japan
Hepatology 40:346-55. 2004..Supplementary material for this article can be found on the HEPATOLOGY website (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html)... - Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesisYingjie Liu
Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Development 136:843-53. 2009..Together, these results demonstrate how signals from integrins and growth factor receptors can be integrated to regulate the expression of an important family of signaling molecules so as to regulate morphogenetic events... - Integrin alpha3beta1 directs the stabilization of a polarized lamellipodium in epithelial cells through activation of Rac1David P Choma
Center for Cell Biology and Cancer Research, Albany Medical College, MC 165, 47 New Scotland Avenue, Albany, NY 12208, USA
J Cell Sci 117:3947-59. 2004.... - NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrinJun ichi Fukushi
The Burnham Institute, La Jolla, California 92037, USA
Mol Biol Cell 15:3580-90. 2004.... - Endothelial alpha3beta1-integrin represses pathological angiogenesis and sustains endothelial-VEGFRita Graça da Silva
Adhesion and Angiogenesis Laboratory, Barts Institute of Cancer, Queen Mary University of London, London, UK
Am J Pathol 177:1534-48. 2010..These data, therefore, identify directly that endothelial alpha3beta1 negatively regulates pathological angiogenesis and implicate an unexpected role for low levels of endothelial-VEGF as an activator of neovascularization... - Alpha3beta1 integrin in epidermis promotes wound angiogenesis and keratinocyte-to-endothelial-cell crosstalk through the induction of MRP3Kara Mitchell
Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208, USA
J Cell Sci 122:1778-87. 2009..Such a mechanism represents a novel paradigm for integrin-mediated regulation of wound angiogenesis that extends beyond traditional roles for integrins in cell adhesion and migration... - Integrin alpha3beta1-dependent activation of FAK/Src regulates Rac1-mediated keratinocyte polarization on laminin-5David P Choma
Center for Cell Biology and Cancer Research, Albany Medical College, Albany, New York 12208 3479, USA
J Invest Dermatol 127:31-40. 2007..These findings reveal a novel pathway in migratory keratinocytes wherein alpha3beta1-laminin-5 interactions regulate src kinase signaling through FAK, promoting Rac1 activation and polarized lamellipodium extension... - Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitroStefan Plantman
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
Mol Cell Neurosci 39:50-62. 2008.... - alpha3beta1 integrin-controlled Smad7 regulates reepithelialization during wound healing in miceLouise E Reynolds
Centre for Tumour Biology, Institute of Cancer Research and Cancer Research UK Clinical Centre, Barts and The London, Queen Mary s School of Medicine and Dentistry, John Vane Science Centre, London, United Kingdom
J Clin Invest 118:965-74. 2008..We have shown here that retarded reepithelialization in Itga3(-/-) mouse skin wounds is due predominantly to repressed TGF-beta1-mediated responses... - Beta1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortexRichard Belvindrah
Department of Cell Biology, Institute for Childhood and Neglected Disease, The Scripps Research Institute, La Jolla, California 92037, USA
J Neurosci 27:13854-65. 2007..We conclude that beta1 integrins in radial glia are required for the proper development of the cerebral cortex, whereas beta1 integrins in migrating neurons are not essential for glial-guided migration and reelin signaling... - The C-terminus of the gamma 2 chain but not of the beta 3 chain of laminin-332 is indirectly but indispensably necessary for integrin-mediated cell reactionsAlexei Navdaev
Institute for Physiological Chemistry, Muenster University Hospital, 48149 Muenster, Germany
Exp Cell Res 314:489-97. 2008.... - An immortalization-dependent switch in integrin function up-regulates MMP-9 to enhance tumor cell invasionJohn M Lamar
Center for Cell Biology and Cancer Research, Albany Medical College, Albany, New York 12208 3479, USA
Cancer Res 68:7371-9. 2008..Our results show that loss of p53 function leads to changes in integrin-mediated gene regulation that occur during SCC progression and play a critical role in tumor cell invasion... - Integrin alpha3beta1 potentiates TGFbeta-mediated induction of MMP-9 in immortalized keratinocytesJohn M Lamar
Center for Cell Biology and Cancer Research, Albany Medical College, Albany, New York 12208 3479, USA
J Invest Dermatol 128:575-86. 2008..These findings provide early evidence of a role for alpha3beta1 in augmenting TGFbeta-mediated induction of MMP-9 in immortalized or transformed keratinocytes during skin carcinogenesis... - Analysis of Netrin 1 receptors during inner ear developmentTanja Matilainen
Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Finland, and Department of Medicine, The Children s Hospital, Boston, MA, USA
Int J Dev Biol 51:409-13. 2007..Neo1), Unc5c as well as integrin b1 (Itgb1) are expressed in periotic mesenchyme, while Dcc, Unc5b, Unc5c, Itga3, Itga6 and Itgb1 are expressed in different parts of the otic epithelium... - Association of TIMP-2 with extracellular matrix exposed to mechanical stress and its co-distribution with periostin during mouse mandible developmentNagako Yoshiba
Division of Cariology, Operative Dentistry and Endodontics, Department of Oral Health Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Cell Tissue Res 330:133-45. 2007..We suggest that TIMP-2 and periostin are co-distributed on ECM exposed to mechanical forces and coordinately function as ECM modulators... - Deletion of core fucosylation on alpha3beta1 integrin down-regulates its functionsYanyang Zhao
Department of Biochemistry, Osaka University Graduate School of Medicine, B1, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
J Biol Chem 281:38343-50. 2006..The reintroduction of Fut8 potentially restored laminin 5-induced migration and intracellular signaling. Collectively, these results suggested that core fucosylation is essential for the functions of alpha3beta1 integrin... - Integrin alpha3beta1 inhibits directional migration and wound re-epithelialization in the skinCoert Margadant
Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
J Cell Sci 122:278-88. 2009..We suggest that integrin alpha3beta1 delays keratinocyte migration during wound re-epithelialization, by binding to the laminin-332 that is newly deposited on the wound bed... - Kidney failure in mice lacking the tetraspanin CD151Norman Sachs
Division of Cell Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands
J Cell Biol 175:33-9. 2006..Our results support the hypothesis that CD151 plays a key role in strengthening alpha3beta1-mediated adhesion in podocytes... - Laminin alpha5 chain is required for intestinal smooth muscle developmentAnne Laure Bolcato-Bellemin
INSERM U381, Ontogenese et Pathologie du Systeme Digestif, Avenue Moliere, Strasbourg, France
Dev Biol 260:376-90. 2003.... - Reelin binds alpha3beta1 integrin and inhibits neuronal migrationL Dulabon
Department of Biology and Neuroscience, Pennsylvania State University, University Park 16802, USA
Neuron 27:33-44. 2000..Thus, Reelin may arrest neuronal migration and promote normal cortical lamination by binding alpha3beta1 integrin and modulating integrin-mediated cellular adhesion... - alpha3beta1 and alpha6beta4 integrin receptors for laminin-5 are not essential for epidermal morphogenesis and homeostasis during skin developmentC M DiPersio
Howard Hughes Medical Institute, Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Cell Sci 113:3051-62. 2000..These findings show that while alpha3beta1 and alpha6beta4 are both required for integrity of the dermo-epidermal junction, neither one is essential for epidermal morphogenesis during skin development... - Partial rescue of epithelial phenotype in integrin beta4 null mice by a keratin-5 promoter driven human integrin beta4 transgeneR van der Neut
Division of Cell Biology, Netherlands Cancer Institute, Plesmanlaan 121, The Netherlands
J Cell Sci 112:3911-22. 1999.... - Cell type-specific integrin variants with alternative alpha chain cytoplasmic domainsR N Tamura
Scripps Research Institute, La Jolla, CA 92037
Proc Natl Acad Sci U S A 88:10183-7. 1991..Alternative cytoplasmic domains may provide a means for varying the cellular responses to the ligands of alpha 6 and alpha 3 integrins according to the cell type... - Role of integrins during fertilization in mammalsP Fenichel
Groupe de Recherche sur l Interaction Gamétique, CJF INSERM 95 04, Faculte de Medecine, Nice, France
Hum Reprod 13:31-46. 1998..Experimental data suggest that they may act in a similar way during fertilization and may participate to initiation and/or propagation of the calcium signal via stimulation of phospholipase C gamma and inositol trisphosphate production... - Mouse primordial germ cells lacking beta1 integrins enter the germline but fail to migrate normally to the gonadsR Anderson
Department of Cell Biology and Neuroanatomy and Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
Development 126:1655-64. 1999..These results demonstrate a role for beta1-containing integrins in the development of the germline, although an equivalent role for * integrin subunit(s) has yet to be established... - Distinct functions of alpha3 and alpha(v) integrin receptors in neuronal migration and laminar organization of the cerebral cortexE S Anton
Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510 8001, USA
Neuron 22:277-89. 1999..Furthermore, the targeted mutation of the alpha3 integrin gene results in abnormal layering of the cerebral cortex... - Role of integrins in mouse eyelid development: studies in normal embryos and embryos in which there is a failure of eyelid fusionJ M Carroll
Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Mech Dev 78:37-45. 1998..We speculate that selective and coordinated expression of the alpha5beta1 integrin and fibronectin in eyelid tip cells is required for eyelid fusion and may be under the control of growth factors that include TGF-alpha... - Cre-loxP-mediated inactivation of the alpha6A integrin splice variant in vivo: evidence for a specific functional role of alpha6A in lymphocyte migration but not in heart developmentC Gimond
Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
J Cell Biol 143:253-66. 1998..Nevertheless, the expression of alpha6A might be necessary for optimal lymphocyte migration on laminin in certain pathological conditions... - Localization of extracellular matrix molecules, integrins and their regulators, TGF betas, is correlated with axon pathfinding in the spinal cord of normal and Danforth's short tail miceK Ohyama
Department of Anatomy, School of Medicine, Keio University, Tokyo, Japan
Brain Res Dev Brain Res 103:143-54. 1997..These results suggest that the restricted localization of ECMs, integrins, and TGF betas at the floor plate is involved in the pathfinding of commissural and longitudinal axons... - Differential expression of integrin alpha subunits supports distinct roles during lung branching morphogenesisJ E Wu
Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Dev Dyn 206:169-81. 1996.... - cDNA cloning of mouse VLA-3 alpha subunitK Takeuchi
Division of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan
J Cell Biochem 57:371-7. 1995..A higher level of its message was detected in thymus than in kidney, stomach, spleen, liver, brain, or lung by Northern blotting analysis... - Loss of alpha3beta1 integrin function results in an altered differentiation program in the mouse submandibular glandA S Menko
Department of Anatomy, Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Dev Dyn 220:337-49. 2001..laminin, by characterizing embryonic day 18 (E18) SMGs isolated from mice carrying a targeted mutation in the alpha3 integrin gene... - Changes in integrin expression during chondrogenesis in vitro: an immunomorphological studyM Shakibaei
Institute of Anatomy, Free University of Berlin, Germany
J Histochem Cytochem 43:1061-9. 1995..Therefore, a strict correlation between the collagen type synthesized by the cells and the appropriate receptor presented by the cells is suggested... - Integrin requirement for hippocampal synaptic plasticity and spatial memoryChi Shing Chan
Department of Molecular and Cellular Biology, Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 23:7107-16. 2003..Mice with genetically reduced expression of alpha3 integrin fail to maintain long-term potentiation (LTP) generated in hippocampal CA1 neurons... - Expression of laminin receptors in schwann cell differentiation: evidence for distinct rolesStefano C Previtali
Neuropathology Unit, Department of Neuroscience and DIBIT, San Raffaele Scientific Institute, 20132 Milan, Italy
J Neurosci 23:5520-30. 2003..These data suggest that the action of laminin is mediated by beta1 integrins during axonal sorting and by dystroglycan, alpha6beta1, and alpha6beta4 integrins during myelination... - None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusionZhi Yong He
Section of Molecular and Cellular Biology, University of California Davis, Davis, CA 95616, USA
Dev Biol 254:226-37. 2003..Some of these integrins are also reported to be receptors for ADAMs, which are expressed on sperm. Using alpha3 integrin null eggs, we found that the alpha3beta1 integrin was not essential for sperm-egg binding and fusion... - Characterization of the promoter for the mouse alpha 3 integrin geneTakumi Kato
Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
Eur J Biochem 269:4524-32. 2002.... - The mouse Kreisler (Krml1/MafB) segmentation gene is required for differentiation of glomerular visceral epithelial cellsVirginia Sadl
Samuel Lunenfeld Research Institute, Mt Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
Dev Biol 249:16-29. 2002..However, these observations alone are unlikely to account for the aberrant podocyte foot process formation. Thus, Kreisler must regulate other unknown genes required for podocyte function and with possible roles in kidney disease... - Differential expression of alpha 3 and alpha 6 integrins in the developing mouse inner earDawn Davies
Department of Physiology, University of Bristol, School of Medical Sciences, Bristol BS8 1TD, United Kingdom
J Comp Neurol 445:122-32. 2002.... - Involvement of laminin binding integrins and laminin-5 in branching morphogenesis of the ureteric bud during kidney developmentR Zent
Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0693, USA
Dev Biol 238:289-302. 2001..These data may help to partially explain the renal phenotype seen in integrin alpha3 and alpha3/alpha6 subunit-deficient animals... - Epithelial development and differentiation in the mammary gland is not dependent on alpha 3 or alpha 6 integrin subunitsT C Klinowska
School of Biological Sciences, University of Manchester, 3 239 Stopford Building, Oxford Road, Manchester, M13 9PT, United Kingdom
Dev Biol 233:449-67. 2001..This work demonstrates that mammary tissue genetically lacking major laminin-binding integrin receptors is still able to develop and function... - Functional comparison of the alpha3A and alpha3B cytoplasmic domain variants of the chicken alpha3 integrin subunitC M DiPersio
Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Exp Cell Res 268:45-60. 2001..Our findings suggest that the alpha3B cytoplasmic domain harbors a retention signal that is regulated in an intact integrin and can alter cell surface expression and distribution of alpha3beta1... - Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitisM Sixt
Interdisciplinary Center for Clinical Research IZKF, Nikolaus Fiebiger Center, University of Erlangen Nuremberg, Glückstr 6, 91054 Erlangen, Germany
J Cell Biol 153:933-46. 2001.... - Differential expression of laminin chain-specific mRNA transcripts during mouse preimplantation embryo developmentC Shim
Department of Molecular Biology, Seoul National University, South Korea
Mol Reprod Dev 44:44-55. 1996..These changes in laminin mRNAs were parallel with its receptors such as integrin alpha 3 and alpha 6... - Influence of beta1 integrins on epidermal squamous cell carcinoma formation in a transgenic mouse model: alpha3beta1, but not alpha2beta1, suppresses malignant conversionD M Owens
Imperial Cancer Research Fund, Keratinocyte Laboratory, London WC2A 3PX, United Kingdom
Cancer Res 61:5248-54. 2001..Our results demonstrate that the alpha3beta1 integrin can suppress malignant conversion, and that the mechanism may involve CD81... - A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidneyJing Yu
Department of Molecular and Cellular Biology and Harvard Stem Cell Institute, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Development 136:161-71. 2009..These findings demonstrate that Wnt7b is a key regulator of the tissue architecture that establishes a functional physiologically active mammalian kidney... - Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouseA De Arcangelis
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, CU de Strasbourg, France
Development 126:3957-68. 1999..The presence of novel phenotypes in double mutant embryos demonstrates the synergism between alpha3 and alpha6 integrins and their essential roles in multiple processes during embryogenesis... - Canonical notch signaling functions as a commitment switch in the epidermal lineageCedric Blanpain
Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
Genes Dev 20:3022-35. 2006.... - Expression patterns of beta1-related alpha integrin subunits in murine lens during embryonic development and wound healingWalid Barbour
Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
Curr Eye Res 29:1-10. 2004..To study the expression patterns of b1-related alpha integrin subunits in murine lens epithelial cells, comparing embryonic fiber differentiation with injury-induced epithelial mesenchymal transition (EMT)...
Research Grants
- CONTROL OF MATRIX PROTEOLYSIS BY INTEGRIN A3B1 IN SKINC DiPersio; Fiscal Year: 2005....
- Regulation of MMP-9 mRNA stability and tumor growth by alpha3 beta1 integrinC Michael DiPersio; Fiscal Year: 2010..The proposed studies will identify novel molecular pathways that are turned on in cancer cells to promote malignant tumor growth and metastasis. These pathways may be exploitable as therapeutic targets. ..
- Regulation of MMP-9 mRNA stability and tumor growth by alpha3 beta1 integrinC DiPersio; Fiscal Year: 2009..The proposed studies will identify novel molecular pathways that are turned on in cancer cells to promote malignant tumor growth and metastasis. These pathways may be exploitable as therapeutic targets. ..
- MOLECULAR ASPECTS OF CORNEAL EPITHELIAL MIGRATIONMary Ann Stepp; Fiscal Year: 2007..Significant progress has been made in understanding how the cornea heals but improved treatment options need to be developed for patients with pathological healing due to trauma. ..
- MOLECULAR ASPECTS OF CORNEAL EPITHELIAL MIGRATIONMary Ann Stepp; Fiscal Year: 2010..Significant progress has been made in understanding how the cornea heals but improved treatment options need to be developed for patients with pathological healing due to trauma. ..
- Characterization of Corneal Epithelial Stem CellsMary Ann Stepp; Fiscal Year: 2005..Discovering specific molecular markers for the limbal stem cells will aid in the development of treatments for stem cell deficiency diseases of the ocular surface in humans. ..
- MOLECULAR ASPECTS OF CORNEAL EPITHELIAL MIGRATIONMary Ann Stepp; Fiscal Year: 2006..By examining the mechanism of delayed corneal wound healing in genetically engineered mice, basic concepts regulating healing will be revealed and better treatments for those suffering from poor healing can be developed. ..
- MOLECULAR ASPECTS OF CORNEAL EPITHELIAL MIGRATIONMARY STEPP; Fiscal Year: 1993..These experiments will help accomplish our goal of obtaining a better understanding, at the molecular level, of the role of integrins in the normal cornea and in epithelial cell migration during wound healing...
- MOLECULAR ASPECTS OF CORNEAL EPITHELIAL MIGRATIONMARY STEPP; Fiscal Year: 1992..The proposed studies of integrin expression in corneal epithelium will provide insight into the basic cell biology of migration and the role of integrin:cell matrix interactions in the healing of corneal wounds...
- MOLECULAR ASPECTS OF CORNEAL EPITHELIAL MIGRATIONMary Ann Stepp; Fiscal Year: 2001..The proposed studies of integrin expression in the corneal epithelium will provide insight into the basic cell biology of migration and the role of integrin:matrix interactions in the healing of corneal wounds. ..
- MOLECULAR ASPECTS OF CORNEAL EPITHELIAL MIGRATIONMary Ann Stepp; Fiscal Year: 2009..Significant progress has been made in understanding how the cornea heals but improved treatment options need to be developed for patients with pathological healing due to trauma. ..