Gene Symbol: Itga11
Description: integrin alpha 11
Alias: 4732459H24Rik, integrin alpha-11, integrin a11
Species: mouse
Products:     Itga11

Top Publications

  1. Popova S, Rodriguez Sanchez B, Lidén A, Betsholtz C, Van Den Bos T, Gullberg D. The mesenchymal alpha11beta1 integrin attenuates PDGF-BB-stimulated chemotaxis of embryonic fibroblasts on collagens. Dev Biol. 2004;270:427-42 pubmed
  2. Zhang W, Kapyla J, Puranen J, Knight C, Tiger C, Pentikainen O, et al. alpha 11beta 1 integrin recognizes the GFOGER sequence in interstitial collagens. J Biol Chem. 2003;278:7270-7 pubmed
    ..Future studies will reveal whether alpha(2)beta(1) and alpha(11)beta(1) integrins also show overlapping biological functions. ..
  3. Helary C, Rodriguez Sanchez B, Rodrigues Sanchez B, Vigier S, Giraud Guill M. Dense fibrillar collagen matrices to analyse extracellular matrix receptor function. Pathol Biol (Paris). 2012;60:7-14 pubmed publisher
    ..The present study demonstrates the validity of in vivo-like dense fibrillar collagen matrices to evaluate cell receptor functions more significantly than with 2D cell cultures or loose hydrogels. ..
  4. Blumbach K, Niehoff A, Belgardt B, Ehlen H, Schmitz M, Hallinger R, et al. Dwarfism in mice lacking collagen-binding integrins ?2?1 and ?11?1 is caused by severely diminished IGF-1 levels. J Biol Chem. 2012;287:6431-40 pubmed publisher
    ..Thus, coupling hormone secretion to extracellular matrix signaling via integrins represents a novel concept in the control of endocrine homeostasis...
  5. Pazin D, Gamer L, Cox K, Rosen V. Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow. Dev Dyn. 2012;241:1816-26 pubmed publisher
    ..Our microarray analyses provides a new resource for further investigation of the pathways involved in the morphogenesis of specific synovial joints. ..
  6. Barczyk M, Lu N, Popova S, Bolstad A, Gullberg D. ?11?1 integrin-mediated MMP-13-dependent collagen lattice contraction by fibroblasts: evidence for integrin-coordinated collagen proteolysis. J Cell Physiol. 2013;228:1108-19 pubmed publisher
  7. Schulz J, Zeltz C, Sørensen I, Barczyk M, Carracedo S, Hallinger R, et al. Reduced granulation tissue and wound strength in the absence of α11β1 integrin. J Invest Dermatol. 2015;135:1435-1444 pubmed publisher
    ..Moreover, we suggest that the reduced stability of the scar is a consequence of poor collagen remodeling in α11(-/-) wounds associated with defective transforming growth factor-β-dependent JNK signaling. ..
  8. Li Z, Jia J, Gou J, Tong A, Liu X, Zhao X, et al. Mmu-miR-126a-3p plays a role in murine embryo implantation by regulating Itga11. Reprod Biomed Online. 2015;31:384-93 pubmed publisher
    ..Bioinformatic analysis predicted and luciferase activity assay confirmed that Itga11, a member of the integrin family, was a target gene of miR-126a-3p...
  9. Civitarese R, Talior Volodarsky I, Desjardins J, Kabir G, Switzer J, Mitchell M, et al. The ?11 integrin mediates fibroblast-extracellular matrix-cardiomyocyte interactions in health and disease. Am J Physiol Heart Circ Physiol. 2016;311:H96-H106 pubmed publisher
    ..Furthermore, ?11 integrin deletion impairs cardiac function and alters cardiomyocyte morphology. These findings shed further light on the poorly understood interaction between the fibroblast-cardiomyocyte and the ECM. ..

More Information


  1. Leomil Coelho L, Mota B, Sales P, Marques J, de Oliveira J, Bonjardim C, et al. Integrin alpha 11 is a novel type I interferon stimulated gene. Cytokine. 2006;33:352-61 pubmed
    ..The aim of this work was to investigate whether integrin alpha 11 (ITGA-11), a novel collagen-binding integrin, is responsive to type I IFN treatment...
  2. Popova S, Barczyk M, Tiger C, Beertsen W, Zigrino P, Aszodi A, et al. Alpha11 beta1 integrin-dependent regulation of periodontal ligament function in the erupting mouse incisor. Mol Cell Biol. 2007;27:4306-16 pubmed
    ..Our data show a unique role for alpha11beta1 integrin during tooth eruption. ..
  3. Caswell C, Barczyk M, Keene D, Lukomska E, Gullberg D, Lukomski S. Identification of the first prokaryotic collagen sequence motif that mediates binding to human collagen receptors, integrins alpha2beta1 and alpha11beta1. J Biol Chem. 2008;283:36168-75 pubmed publisher
    ..This work is a stepping stone toward defining the utilization of collagen receptors by microbial collagen-like proteins that are expressed by pathogenic bacteria. ..
  4. Svendsen Ø, Barczyk M, Popova S, Liden A, Gullberg D, Wiig H. The alpha11beta1 integrin has a mechanistic role in control of interstitial fluid pressure and edema formation in inflammation. Arterioscler Thromb Vasc Biol. 2009;29:1864-70 pubmed publisher
    ..Our data suggest that alpha11beta1 integrins on dermal fibroblasts mediate collagen lattice remodeling and have a mechanistic role in controlling Pif in inflammation and thereby fluid extravasation and edema formation in vivo. ..
  5. Gouttenoire J, Bougault C, Aubert Foucher E, Perrier E, Ronzière M, Sandell L, et al. BMP-2 and TGF-beta1 differentially control expression of type II procollagen and alpha 10 and alpha 11 integrins in mouse chondrocytes. Eur J Cell Biol. 2010;89:307-14 pubmed publisher
    ..This result strongly suggests that signaling pathways other than Smad proteins are involved in the effect of BMP-2 on type II procollagen expression. ..
  6. Navab R, Strumpf D, To C, Pasko E, Kim K, Park C, et al. Integrin α11β1 regulates cancer stromal stiffness and promotes tumorigenicity and metastasis in non-small cell lung cancer. Oncogene. 2016;35:1899-908 pubmed publisher
  7. Reigstad I, Smeland H, Skogstrand T, Sortland K, Schmid M, Reed R, et al. Stromal Integrin ?11?1 Affects RM11 Prostate and 4T1 Breast Xenograft Tumors Differently. PLoS ONE. 2016;11:e0151663 pubmed publisher
    ..Deficiency of stromal integrin ?11?1 showed different effects on tumor growth and collagen fibril diameter depending on tumor type, but no effect on tumor PIF or development of lung metastasis. ..