Itch

Summary

Gene Symbol: Itch
Description: itchy, E3 ubiquitin protein ligase
Alias: 6720481N21Rik, 8030492O04Rik, A130065M08, AIP4, C230047C07Rik, E3 ubiquitin-protein ligase Itchy
Species: mouse

Top Publications

  1. ncbi Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins
    Vigo Heissmeyer
    Center for Blood Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Nat Immunol 5:255-65. 2004
  2. ncbi Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation
    Chun Yang
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92130, USA
    Mol Cell 21:135-41. 2006
  3. pmc The ubiquitin-protein ligase Itch regulates p73 stability
    Mario Rossi
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    EMBO J 24:836-48. 2005
  4. ncbi The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover
    Lufen Chang
    Division of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope, City of Hope National Medical Center, 1500 E Duarte Road, KCRB 3009, Duarte, CA 91010, USA
    Cell 124:601-13. 2006
  5. pmc Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation
    K Venuprasad
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Clin Invest 116:1117-26. 2006
  6. pmc Cbl-b and itch: key regulators of peripheral T-cell tolerance
    K Venuprasad
    Department of Immunology and Microbiology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 70:3009-12. 2010
  7. ncbi Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation
    Deyu Fang
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Nat Immunol 3:281-7. 2002
  8. pmc The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1
    K Venuprasad
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    Nat Immunol 9:245-53. 2008
  9. ncbi Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase
    L Qiu
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 275:35734-7. 2000
  10. ncbi The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice
    W L Perry
    Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    Nat Genet 18:143-6. 1998

Research Grants

Scientific Experts

  • LYDIA ELEANOR MATESIC
  • Holger Hoff
  • K Venuprasad
  • Yun Cai Liu
  • Noula Shembade
  • Edward W Harhaj
  • Deyu Fang
  • Chun Yang
  • Michael Karin
  • Chozhavendan Rathinam
  • Derek W Abbott
  • Gerry Melino
  • Lufen Chang
  • Mario Rossi
  • Hengwei Zhang
  • Justine T Tigno-Aranjuez
  • Chris Elly
  • Julia Mössinger
  • Wei Wei
  • Neesar Ahmed
  • Elena Scotti
  • Haining Huang
  • Joshua A Jadwin
  • Nicole S Harhaj
  • Mingfang Tao
  • Fuping You
  • Christine Demange
  • Young Ho Ahn
  • Rodolphe G Lopez
  • Thomas Enzler
  • Valentino Parravicini
  • Myung Shin Jeon
  • Nan Fang
  • Tung Liang Lee
  • Patricia Chastagner
  • Deborah A Klos Dehring
  • T M Hansen
  • Miao Zhang
  • Andrew Oberst
  • Zhonghua Lu
  • Ewen Gallagher
  • Paula M Oliver
  • Shin Maeda
  • Toshiharu Sakurai
  • Beixue Gao
  • Richard Longnecker
  • Alison Z Shaw
  • Masato Ikeda
  • Yongli Bai
  • Min Gao
  • Vigo Heissmeyer
  • Tiffany A Mathews
  • Akiko Ikeda
  • Kieran F Harvey
  • Andreas Traweger
  • Zhiyu Wang
  • Xing Li
  • Brendan F Boyce
  • Chengwu Wu
  • Lianping Xing
  • Xiaodong Bai
  • Eberhard Krause
  • Volker Haucke
  • S Fang
  • Jiyong Wang
  • Meng Li
  • Michael Krauss
  • Christian Freund
  • Fabian Gerth
  • Marnix Wieffer
  • Fen Nie
  • Lin Li
  • Lisa Polin
  • Noam Zelcer
  • Yan Hu
  • Richard Flavell
  • Pieter J de Jong
  • Yuko Yoshinaga
  • Rima Boyadjian
  • W L Perry
  • Loren G Fong
  • Ramin Massoumi
  • Rajeshree Pujari
  • Minghui Zeng
  • Indrajit Sinha
  • Richard A Flavell
  • Peter Tontonoz
  • Wei Zen Wei
  • Yiping Tu
  • Cynthia Hong

Detail Information

Publications51

  1. ncbi Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins
    Vigo Heissmeyer
    Center for Blood Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Nat Immunol 5:255-65. 2004
    ..Calcineurin increased mRNA and protein of the E3 ubiquitin ligases Itch, Cbl-b and GRAIL and induced expression of Tsg101, the ubiquitin-binding component of the ESCRT-1 endosomal sorting ..
  2. ncbi Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation
    Chun Yang
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92130, USA
    Mol Cell 21:135-41. 2006
    ..mechanism involves regulation of the E3 Ub ligase, for example, the JNK-dependent phosphorylation and activation of Itch E3 ligase, which controls the turnover of Jun proteins and T cell differentiation...
  3. pmc The ubiquitin-protein ligase Itch regulates p73 stability
    Mario Rossi
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    EMBO J 24:836-48. 2005
    ..However, unlike p53, p73 binds to, but is not degraded by, MDM2. Here we describe the binding of p73 to Itch, a Hect ubiquitin-protein ligase...
  4. ncbi The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover
    Lufen Chang
    Division of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope, City of Hope National Medical Center, 1500 E Duarte Road, KCRB 3009, Duarte, CA 91010, USA
    Cell 124:601-13. 2006
    ..direct c-FLIP phosphorylation but depends on JNK-mediated phosphorylation and activation of the E3 ubiquitin ligase Itch, which specifically ubiquitinates c-FLIP and induces its proteasomal degradation...
  5. pmc Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation
    K Venuprasad
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Clin Invest 116:1117-26. 2006
    ..containing a mitogen and extracellular kinase kinase 1 (MEKK1) mutant or lacking JNK1 or the E3 ubiquitin ligase Itch cannot be tolerized...
  6. pmc Cbl-b and itch: key regulators of peripheral T-cell tolerance
    K Venuprasad
    Department of Immunology and Microbiology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 70:3009-12. 2010
    E3 ligases Cbl-b and Itch have emerged as dominant "tolerogenic" regulators of T cells because their deficiency results in severe autoimmune diseases...
  7. ncbi Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation
    Deyu Fang
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Nat Immunol 3:281-7. 2002
    b>Itch is an E3 ubiquitin ligase that is disrupted in nonagouti-lethal or itchy mice. Itch deficiency leads to severe immune and inflammatory disorders and constant itching of the skin...
  8. pmc The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1
    K Venuprasad
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    Nat Immunol 9:245-53. 2008
    ..However, the molecular mechanisms leading to Foxp3 induction remain unclear. Here we show that Itch-/- T cells were resistant to TGF-beta treatment and had less Foxp3 expression...
  9. ncbi Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase
    L Qiu
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 275:35734-7. 2000
    Genetic studies identified Itch, which is a homologous to the E6-associated protein carboxyl terminus (Hect) domain-containing E3 ubiquitin-protein ligase that is disrupted in non-agouti lethal mice or Itchy mice...
  10. ncbi The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice
    W L Perry
    Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    Nat Genet 18:143-6. 1998
    ..affects two loci: agouti and another, as yet unidentified locus designated itchy (the provisional gene symbol is Itch), that is responsible for the immunological phenotype of a18H mice...
  11. ncbi Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch
    Min Gao
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Science 306:271-5. 2004
    ..protein kinase cascade after T cell stimulation accelerated degradation of c-Jun and JunB through phosphorylation-dependent activation of the E3 ligase Itch. This pathway modulates cytokine production by effector T cells.
  12. pmc Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation
    Toshiharu Sakurai
    Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California at San Diego, 9500 Gilman Drive MC 0723, La Jolla, CA 92093 0723, USA
    Proc Natl Acad Sci U S A 103:10544-51. 2006
    ....
  13. pmc The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch
    Andrew Oberst
    Biochemistry Laboratory, Istituto Dermopatico dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, University of Rome Tor Vergata, 00133 Rome, Italy
    Proc Natl Acad Sci U S A 104:11280-5. 2007
    ..Here, we describe a previously unrecognized functional interaction between N4BP1 and Itch, a Nedd4 structurally related E3, which contains four WW domains, conferring substrate-binding activity...
  14. pmc The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida, USA
    Nat Immunol 12:834-43. 2011
    ..with proinflammatory cytokines, the deubiquitinase A20 inducibly interacts with the regulatory molecules TAX1BP1, Itch and RNF11 to form the A20 ubiquitin-editing complex...
  15. pmc Ubiquitin E3 ligase Itch negatively regulates osteoclast formation by promoting deubiquitination of tumor necrosis factor (TNF) receptor-associated factor 6
    Hengwei Zhang
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 288:22359-68. 2013
    b>Itch is a ubiquitin E3 ligase that regulates protein stability. Itch(-/-) mice develop an autoimmune disease phenotype characterized by itchy skin and multiorgan inflammation...
  16. pmc Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    Science 327:1135-9. 2010
    ..These findings suggest mechanism of A20 action in the inhibition of inflammatory signaling pathways...
  17. pmc Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch
    Julia Mössinger
    Institute of Chemistry and Biochemistry, Freie Universitat Berlin, Takustraße 6, 14195 Berlin, Germany
    EMBO Rep 13:1087-94. 2012
    ..Here we identify the E3 ubiquitin ligase Itch as binding partner and regulator of PI4KIIα function...
  18. pmc A discrete ubiquitin-mediated network regulates the strength of NOD2 signaling
    Justine T Tigno-Aranjuez
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Mol Cell Biol 33:146-58. 2013
    ..and subsequent NOD2 signaling, this positive regulation is countered by another E3 ubiquitin ligase, ITCH, through direct ubiquitination of cIAP1. This ITCH-mediated ubiquitination leads to cIAP1's lysosomal degradation...
  19. pmc The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein
    Wei Wei
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Mol Cell Biol 32:3903-12. 2012
    ..Here, we identify the HECT-containing Nedd4-like ubiquitin E3 ligase ITCH as a new Dvl-binding protein...
  20. doi PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4
    Fuping You
    The Education Ministry Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing, China
    Nat Immunol 10:1300-8. 2009
    ..PCBP2 recruited the HECT domain-containing E3 ligase AIP4 to polyubiquitinate and degrade MAVS...
  21. doi MEKK1 binds HECT E3 ligase Itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression
    Thomas Enzler
    Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 183:3831-8. 2009
    MEKK1-dependent signaling regulates HECT E3 ligase Itch, resulting in elevated catalytic activity. After TCR costimulation, MEKK1 predominantly induces JNK1 activation, whereas the related kinase MEKK2 regulates ERK5 activation...
  22. pmc Late domain-independent rescue of a release-deficient Moloney murine leukemia virus by the ubiquitin ligase itch
    Joshua A Jadwin
    Laboratory of Molecular Microbiology, NIAID, NIH, 4 Center Dr, Bethesda, MD 20892, USA
    J Virol 84:704-15. 2010
    ..However, low-level expression of the ubiquitin ligase Itch potently rescued the release and infectivity of MoMLV lacking PPPY function...
  23. doi C/EBPalpha and beta couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation
    Rodolphe G Lopez
    EMBL Mouse Biology Unit, Monterotondo, 00016 Italy
    Nat Cell Biol 11:1181-90. 2009
    ..C/EBPs, therefore, couple basal keratinocyte cell cycle exit to commitment to differentiation through E2F repression and DNA binding, respectively, and may act to restrict the epidermal stem cell compartment...
  24. pmc MKK4/SEK1 is negatively regulated through a feedback loop involving the E3 ubiquitin ligase itch
    Young Ho Ahn
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 284:29399-404. 2009
    ..MKK4 ubiquitination required JNK kinase activity. The JNK substrate Itch (a HECT domain-containing Nedd4-like ubiquitin protein ligase) bound to MKK4, ubiquitinated lysines 140 and 143, ..
  25. doi CTLA-4 (CD152) inhibits T cell function by activating the ubiquitin ligase Itch
    Holger Hoff
    Deutsches Rheuma ForschungsZentrum Berlin, 10117 Berlin, Germany
    Mol Immunol 47:1875-81. 2010
    ..Here we demonstrate similarities of CTLA-4 and Itch deficient mice and that CTLA-4 deficient T cells show a massive reduction in the overall ubiquitination of proteins...
  26. doi A model of partnership co-opted by the homeodomain protein TGIF and the Itch/AIP4 ubiquitin ligase for effective execution of TNF-alpha cytotoxicity
    Christine Demange
    INSERM U, Paris, France
    Mol Cell 36:1073-85. 2009
    ..role of TGIF does not appear to rely on transcriptional modulation but instead is executed in conjunction with Itch/AIP4, an E3 ubiquitin ligase operating in TNF-alpha-induced apoptosis through its ability to target the caspase ..
  27. pmc K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling
    Haining Huang
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Immunity 33:60-70. 2010
    ..E3 ubiquitin ligases such as Cbl-b and Itch have been implicated in T cell activation and tolerance induction...
  28. pmc Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists
    Elena Scotti
    Howard Hughes Medical Institute, UCLA School of Medicine, Box 951662, Los Angeles, CA 90095 1662, USA
    Mol Cell Biol 31:1885-93. 2011
    ..These results demonstrate that the LXR-Idol pathway is an important contributor to feedback inhibition of the LDLR by sterols and a biological determinant of cellular LDL uptake...
  29. doi The E3 ligase Itch is a negative regulator of the homeostasis and function of hematopoietic stem cells
    Chozhavendan Rathinam
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Immunol 12:399-407. 2011
    ..Here we showed that the E3 ubiquitin ligase Itch negatively regulated the development and function of HSCs...
  30. pmc The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation
    Neesar Ahmed
    Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Nat Immunol 12:1176-83. 2011
    ..Here we demonstrate that E3 ligase Itch and deubiquitinase Cyld formed a complex via interaction through 'WW-PPXY' motifs...
  31. pmc ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways
    Mingfang Tao
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Curr Biol 19:1255-63. 2009
    ....
  32. pmc A C-terminal sequence in the guanine nucleotide exchange factor Sec7 mediates Golgi association and interaction with the Rsp5 ubiquitin ligase
    Deborah A Klos Dehring
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 283:34188-96. 2008
    ..These observations identify a new functional region within the Sec7/BIG family of Arf GEFs that is required for trans-Golgi network localization...
  33. doi Itch regulates p45/NF-E2 in vivo by Lys63-linked ubiquitination
    Tung Liang Lee
    Graduate Institute of Life Sciences, National Defense Medical Center, Neihu, Taipei 114, Taiwan, ROC
    Biochem Biophys Res Commun 375:326-30. 2008
    ..We describe the first in vivo evidence for the interaction between p45/NF-E2 and the E3 ubiquitin ligase Itch, and the subsequent ubiquitination of p45/NF-E2 by Itch...
  34. pmc The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum
    S Fang
    Regulation of Protein Function Laboratory, Center for Cancer Research, National Cancer Institute, Building 10, Room 1B34, 9000 Rockville Pike, Bethesda, MD 20892 1152, USA
    Proc Natl Acad Sci U S A 98:14422-7. 2001
    ..gp78 has thus been found to be an example of a mammalian cellular E3 intrinsic to the ER, suggesting a potential link between ubiquitylation, ERAD, and metastasis...
  35. ncbi N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein
    Kieran F Harvey
    Hanson Center for Cancer Research, Institute of Medical and Veterinary Science, Frome Road, Adelaide, South Australia 5000, Australia
    J Biol Chem 277:9307-17. 2002
    ..Based on previous observations in yeast, we propose that N4WBP5 may act as an adaptor for Nedd4-like proteins and their putative targets to control ubiquitin-dependent protein sorting and trafficking...
  36. ncbi The tight junction-specific protein occludin is a functional target of the E3 ubiquitin-protein ligase itch
    Andreas Traweger
    Institute of Molecular Biology, Austrian Academy of Sciences, 5020 Salzburg, Austria
    J Biol Chem 277:10201-8. 2002
    ..two-hybrid screening we have identified a novel interaction between occludin and the E3 ubiquitin-protein ligase Itch, a member of the HECT domain-containing ubiquitin-protein ligases...
  37. ncbi Regulation of immune responses by E3 ubiquitin-protein ligases
    Nan Fang
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, Calif, USA
    Curr Dir Autoimmun 5:161-75. 2002
  38. pmc Itchy, a Nedd4 ubiquitin ligase, downregulates latent membrane protein 2A activity in B-cell signaling
    Akiko Ikeda
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Virol 77:5529-34. 2003
    ..Itchy, a mouse homologue of human AIP4, is a Nedd4 family E3 and is also the most abundant Nedd4 family E3 found in LMP2A affinity precipitates from B ..
  39. ncbi Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylation
    Yongli Bai
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Mol Cell 15:825-31. 2004
    ..Here we show that loss of Itch E3 ligase in mouse embryonic fibroblasts (MEFs) results in reduced susceptibility of TGF-beta-induced cell growth ..
  40. ncbi Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression
    Tiffany A Mathews
    Department of Chemistry, The Pennsylvania State University, 104 Chemistry Building, University Park, PA 16802 6300, USA
    J Neurosci Methods 140:169-81. 2004
    ..Furthermore, use of zero net flux microdialysis appears warranted in investigations of serotonergic synaptic function where modest changes in extracellular 5-HT are thought to occur in response to altered uptake...
  41. ncbi Phosphorylation of either Ser16 or Thr30 does not disrupt the structure of the Itch E3 ubiquitin ligase third WW domain
    Alison Z Shaw
    ICREA and the Biomedical Research Institute of Barcelona, Barcelona Science Park, Barcelona, Spain
    Proteins 60:558-60. 2005
  42. ncbi The tyrosine kinase c-Abl protects c-Jun from ubiquitination-mediated degradation in T cells
    Beixue Gao
    Department of Otolaryngology Head and Neck Surgery, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212, USA
    J Biol Chem 281:29711-8. 2006
    ..We have previously demonstrated that c-Jun is a substrate of Itch, a HECT-type E3 ubiquitin ligase. c-Jun is also a substrate of the tyrosine kinase c-Abl...
  43. ncbi Itch genetically interacts with Notch1 in a mouse autoimmune disease model
    Lydia E Matesic
    Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    Hum Mol Genet 15:3485-97. 2006
    ..Phylogenetic and in vitro analyses suggest that Itch is a negative regulator of Notch signaling...
  44. pmc Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation
    Paula M Oliver
    Howard Hughes Medical Institute, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Immunity 25:929-40. 2006
    ..This phenotype resembled that of Itchy mutant mice, suggesting that Ndfip1 might affect the function of Itch, an E3 ubiquitin ligase...
  45. pmc Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction
    Zhonghua Lu
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 177:1077-89. 2007
    ..These results identify a synapse-associated E3 ubiquitin ligase as an important regulator of MuSK signaling...
  46. ncbi Itch inhibition regulates chemosensitivity in vitro
    T M Hansen
    Medical Research Council, Toxicology Unit, Hodgkin Building, P O Box 138, Leicester University, Lancaster Road, Leicester LE1 9HN, UK
    Biochem Biophys Res Commun 361:33-6. 2007
    b>Itch is a member of the HECT family of ubiquitin E3 ligases, and regulates the stability of several proteins involved in response to genotoxic stress...
  47. ncbi Ubiquitinylation of Ig beta dictates the endocytic fate of the B cell antigen receptor
    Miao Zhang
    Section of Rheumatology, Department of Medicine, University of Chicago, IL 60637, USA
    J Immunol 179:4435-43. 2007
    ..demonstrate that the Ig beta component of the BCR is diubiquitinylated and that this is dependent on the E3 ligase Itch. Itch-/- B lymphocytes manifest both a defect in ligand-induced BCR internalization and endocytic trafficking to ..
  48. doi The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    Nat Immunol 9:254-62. 2008
    ..Here we demonstrate that the regulatory molecule TAX1BP1 recruited the E3 ligase Itch to A20 via two 'PPXY' motifs...
  49. pmc Itch-/- alphabeta and gammadelta T cells independently contribute to autoimmunity in Itchy mice
    Valentino Parravicini
    Division of Molecular Immunology, Medical Research Council, National Institute for Medical Research, London, UK
    Blood 111:4273-7282. 2008
    ..Itchy mice lack the E3 ligase, Itch, and show dysregulation of T lymphocytes and the induction of a lethal autoimmune inflammatory condition...
  50. pmc AIP4/Itch regulates Notch receptor degradation in the absence of ligand
    Patricia Chastagner
    Unite de Signalisation Moleculaire et Activation Cellulaire, URA 2582, CNRS, Institut Pasteur, Paris, France
    PLoS ONE 3:e2735. 2008
    ..The mammalian ortholog of Su(dx), Itch/AIP4, has been shown to have multiple substrates, including Notch, but the precise events regulated by Itch/AIP4 in the ..
  51. pmc Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus
    C M Hustad
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research and Development Center, Maryland 21702, USA
    Genetics 140:255-65. 1995
    ..Cloning the breakpoints of this putative inversion should allow us to identify the gene that confers this interesting immunological disorder...

Research Grants1

  1. Intracellular Sorting of Connexin 43 by the Ubiquitin Ligase Wwp1
    LYDIA ELEANOR MATESIC; Fiscal Year: 2010
    ..This application defines how a novel player, Wwp1, controls the amount of Connexin43, and as such might serve as a diagnostic to identify those hypertrophic cardiomyopathy patients most likely to suffer sudden cardiac death. ..