Isl1

Summary

Gene Symbol: Isl1
Description: ISL1 transcription factor, LIM/homeodomain
Alias: Islet 1, Lim-homeodomain protein Islet1, insulin gene enhancer protein ISL-1, insulin related protein, islet-1
Species: mouse

Top Publications

  1. ncbi Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
    S Srinivas
    Department of Genetics and Development, Columbia University, New York, USA
    BMC Dev Biol 1:4. 2001
  2. ncbi Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
    J Ericson
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 90:169-80. 1997
  3. ncbi The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development
    Katja S Grossmann
    Neuroscience Department, Department of Cancer Research, Department of Cardiovascular Research, Max Delbrück Centrum for Molecular Medicine, Robert Rossle Strasse 10, Berlin, Germany
    Proc Natl Acad Sci U S A 106:16704-9. 2009
  4. ncbi Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages
    Karl Ludwig Laugwitz
    Institute of Molecular Medicine, University of California, San Diego, School of Medicine, La Jolla, California 92093, USA
    Nature 433:647-53. 2005
  5. ncbi Wnt signalling required for expansion of neural crest and CNS progenitors
    M Ikeya
    Centre for Molecular and Developmental Biology, Faculty of Science, Kyoto University, Japan
    Nature 389:966-70. 1997
  6. ncbi Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance
    Martine Manuel
    Genes and Development Group, Centres for Integrative Physiology and Neuroscience Research, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, UK
    BMC Dev Biol 8:59. 2008
  7. ncbi Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord
    Yuko Muroyama
    Kondoh Differentiation Signaling Project, Exploratory Research for Advanced Technology ERATO, Japan Science and Technology Corporation JST, Kinki Invention Center, Sakyo ku, Kyoto 606 8305, Japan
    Genes Dev 16:548-53. 2002
  8. ncbi Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis
    Lizhu Lin
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 104:9313-8. 2007
  9. ncbi SOX9 is required for maintenance of the pancreatic progenitor cell pool
    Philip A Seymour
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697 2300, USA
    Proc Natl Acad Sci U S A 104:1865-70. 2007
  10. ncbi BARHL2 differentially regulates the development of retinal amacrine and ganglion neurons
    Qian Ding
    University of Rochester Eye Institute, University of Rochester, Rochester, New York 14642, USA
    J Neurosci 29:3992-4003. 2009

Research Grants

  1. Longitudinal axon guidance by long range cues in the embryonic brain
    GRANT STEPHEN MASTICK; Fiscal Year: 2011
  2. Functional Analysis of Inhibitory Spinal Cord Interneurons
    Martyn Goulding; Fiscal Year: 2007
  3. SELECTIVE AGGREGATION AND SORTING OF SALIVARY PROTEINS
    Douglas Darling; Fiscal Year: 2007
  4. Specification of Dorsal Lbx1-Derived Interneurons
    Martyn Goulding; Fiscal Year: 2007
  5. Control of Hox gene expression and neuronal identity
    Jeh Ping Liu; Fiscal Year: 2007
  6. Identifying Periodontal Antigens By Protein Microarray
    Douglas Darling; Fiscal Year: 2006
  7. Study of a genetic network involved in ear development
    Rick Friedman; Fiscal Year: 2005
  8. Transcriptional Regulation of Pancreas Development and Function
    CATHERINE LEE MAY; Fiscal Year: 2010
  9. Genetic Analysis of Age Related Hearing Impairment
    Rick A Friedman; Fiscal Year: 2010
  10. Transcriptional Regulation of Pancreas Development and Function
    CATHERINE LEE MAY; Fiscal Year: 2010

Detail Information

Publications138 found, 100 shown here

  1. ncbi Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
    S Srinivas
    Department of Genetics and Development, Columbia University, New York, USA
    BMC Dev Biol 1:4. 2001
    ....
  2. ncbi Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
    J Ericson
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 90:169-80. 1997
    ..2. Pax6 establishes distinct ventral progenitor cell populations and controls the identity of motor neurons and ventral interneurons, mediating graded Shh signaling in the ventral spinal cord and hindbrain...
  3. ncbi The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development
    Katja S Grossmann
    Neuroscience Department, Department of Cancer Research, Department of Cardiovascular Research, Max Delbrück Centrum for Molecular Medicine, Robert Rossle Strasse 10, Berlin, Germany
    Proc Natl Acad Sci U S A 106:16704-9. 2009
    ..Together, our genetic and biochemical analyses demonstrate that Shp2 is an essential component in the transduction of Nrg1/ErbB signals...
  4. ncbi Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages
    Karl Ludwig Laugwitz
    Institute of Molecular Medicine, University of California, San Diego, School of Medicine, La Jolla, California 92093, USA
    Nature 433:647-53. 2005
    ..Herein, we report the identification of isl1+ cardiac progenitors in postnatal rat, mouse and human myocardium...
  5. ncbi Wnt signalling required for expansion of neural crest and CNS progenitors
    M Ikeya
    Centre for Molecular and Developmental Biology, Faculty of Science, Kyoto University, Japan
    Nature 389:966-70. 1997
    ..Given the widespread expression of different Wnt genes in discrete areas of the mammalian neural tube, this may represent a general model for the action of Wnt signalling in the developing CNS...
  6. ncbi Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance
    Martine Manuel
    Genes and Development Group, Centres for Integrative Physiology and Neuroscience Research, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, UK
    BMC Dev Biol 8:59. 2008
    ..Here, we examined the consequences of over-expression for the eye and its axonal connections...
  7. ncbi Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord
    Yuko Muroyama
    Kondoh Differentiation Signaling Project, Exploratory Research for Advanced Technology ERATO, Japan Science and Technology Corporation JST, Kinki Invention Center, Sakyo ku, Kyoto 606 8305, Japan
    Genes Dev 16:548-53. 2002
    ..Thus, Wnt signaling plays a critical role in the specification of cell types for dorsal interneurons...
  8. ncbi Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis
    Lizhu Lin
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 104:9313-8. 2007
    Recent studies have demonstrated that the LIM homeodomain transcription factor Islet1 (Isl1) marks pluripotent cardiovascular progenitor cells and is required for proliferation, survival, and migration of recently defined second heart ..
  9. ncbi SOX9 is required for maintenance of the pancreatic progenitor cell pool
    Philip A Seymour
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697 2300, USA
    Proc Natl Acad Sci U S A 104:1865-70. 2007
    ..These findings will be of major significance for the development of in vitro protocols for cell replacement therapies...
  10. ncbi BARHL2 differentially regulates the development of retinal amacrine and ganglion neurons
    Qian Ding
    University of Rochester Eye Institute, University of Rochester, Rochester, New York 14642, USA
    J Neurosci 29:3992-4003. 2009
    ..Thus, BARHL2 appears to have numerous roles in retinal development, including regulating neuronal subtype specification, differentiation, and survival...
  11. ncbi Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells
    Yunfu Sun
    Skaggs School of Pharmacy, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Dev Biol 304:286-96. 2007
    Islet1 (Isl1) is a LIM homedomain protein that plays a pivotal role in cardiac progenitors of the second heart field...
  12. ncbi Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart
    Chen Leng Cai
    Institute of Molecular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Dev Cell 5:877-89. 2003
    Hearts of mice lacking Isl1, a LIM homeodomain transcription factor, are completely missing the outflow tract, right ventricle, and much of the atria...
  13. ncbi Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses
    D Wolpowitz
    Columbia University, College of Physicians and Surgeons, Program in Neurobiology and Behavior, New York, New York 10032, USA
    Neuron 25:79-91. 2000
    ....
  14. ncbi All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3
    C Brian Bai
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Dev Cell 6:103-15. 2004
    ..Therefore, in the spinal cord all Hh signaling is Gli dependent. Furthermore, a combination of Gli2 and Gli3 is required to regulate motor neuron development and spatial patterning of ventral spinal cord progenitors...
  15. ncbi MuSK controls where motor axons grow and form synapses
    Natalie Kim
    Molecular Neurobiology Program, The Helen L and Martin S Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University Medical School, New York, NY 10016, USA
    Nat Neurosci 11:19-27. 2008
    ....
  16. ncbi Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve
    Quenten Schwarz
    Department of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
    Genes Dev 18:2822-34. 2004
    ..These observations demonstrate, for the first time, that VEGF contributes to neuronal patterning in vivo, and that different compartments of one cell can be co-ordinately patterned by structurally distinct ligands for a shared receptor...
  17. ncbi Specification of motor axon trajectory by ephrin-B:EphB signaling: symmetrical control of axonal patterning in the developing limb
    Victor Luria
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Neuron 60:1039-53. 2008
    ..The involvement of ephrin:Eph signaling in guiding both sets of motor axons raises the possibility that other signaling systems function primarily to refine or modulate a core Eph signaling program...
  18. ncbi Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection
    Q Richard Lu
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cell 109:75-86. 2002
    ..Neither Olig gene is required for astrocytes. These findings, together with fate mapping analysis of Olig-expressing cells, indicate that oligodendrocytes are derived from Olig-specified progenitors that give rise also to neurons...
  19. ncbi Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits
    Christopher P Myers
    Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Neuron 46:37-49. 2005
    ..These findings suggest that the cholinergic neurotransmitter pathway is involved in configuring the CPG during a transient period of development...
  20. ncbi Expression patterns of developmental control genes in normal and Engrailed-1 mutant mouse spinal cord reveal early diversity in developing interneurons
    M P Matise
    New York University Medical School, Skirball Institute of Biomolecular Medicine, Developmental Genetics Program, New York, New York 10016, USA
    J Neurosci 17:7805-16. 1997
    ..Rather, it is suggested that En-1 may function to distinguish a subset of interneurons during the later maturation of the spinal cord...
  21. ncbi The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation
    Junfeng Wang
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Dev Biol 266:178-89. 2004
    ..This role of Pax4 appears to be accomplished via its genetic interaction with another homeobox gene, Nkx2.2...
  22. ncbi Motor neurons with axial muscle projections specified by Wnt4/5 signaling
    Dritan Agalliu
    Howard Hughes Medical Institute, Kavli Institute for Brain Science, Departments of Neuroscience and Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
    Neuron 61:708-20. 2009
    ..Thus, two dorsoventral signaling pathways, mediated by Shh and Wnt4/5, are required to establish an early binary divergence in motor neuron columnar identity...
  23. ncbi Emergence of the sensory nervous system as defined by Foxs1 expression
    Andreas Montelius
    Laboratory of Molecular Neurobiology, Karolinska Institute, MBB, Scheeles väg 1 Stockholm, Sweden
    Differentiation 75:404-17. 2007
    ..These data define a sequential emergence of neuronal precursors of the sensory nervous system with different molecular characteristics, starting during migration and continuing well after DRG condensation...
  24. ncbi PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates
    Xiaowei Lu
    Department of Biological Sciences, Howard Hughes Medical Institute, Stanford, California 94305, USA
    Nature 430:93-8. 2004
    ..These results identify PTK7 as a novel regulator of PCP in vertebrates...
  25. ncbi Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas
    Aiping Du
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 58:2059-69. 2009
    ....
  26. ncbi VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm
    Lynda Erskine
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, UK
    Neuron 70:951-65. 2011
    ..These findings have identified a permissive midline signal for axons at the chiasm midline and provide in vivo evidence that VEGF-A is an essential axon guidance cue...
  27. ncbi Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain
    John Jacob
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 136:2477-85. 2009
    ..Thus, Insm1 regulates the synthesis of distinct monoaminergic neurotransmitters by acting combinatorially with, or independently of, Ascl1 in specific monoaminergic populations...
  28. ncbi Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas
    M Sander
    Hormone Research Institute, University of California San Francisco, San Francisco, CA 94143 0534, USA
    Development 127:5533-40. 2000
    ..Together, these experiments reveal two independently controlled pathways for beta-cell differentiation, and place Nkx6.1 downstream of Nkx2.2 in the major pathway of beta-cell differentiation...
  29. ncbi Npn-1 contributes to axon-axon interactions that differentially control sensory and motor innervation of the limb
    Rosa Eva Huettl
    Institute of Developmental Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Biol 9:e1001020. 2011
    ..Thus, motor and sensory axons are mutually dependent on each other for the generation of their trajectories and interact in part through Npn-1-mediated fasciculation before and within the plexus region of the limbs...
  30. ncbi Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development
    Nan Gao
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Genes Dev 22:3435-48. 2008
    ..Thus, the regulation of Pdx1 expression by Foxa1 and Foxa2 is a key early event controlling the expansion and differentiation of the pancreatic primordia...
  31. ncbi Semaphorin 3A-Neuropilin-1 signaling regulates peripheral axon fasciculation and pathfinding but not developmental cell death patterns
    Corinna Haupt
    Institute of Developmental Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstadter Landstrasse 1, D 85764 Munich Neuherberg, Germany
    Eur J Neurosci 31:1164-72. 2010
    ..Thus, Sema3A-Npn-1 signaling plays an important role in the guidance and fasciculation of motor and sensory axons but does not contribute to the developmental elimination of these neurons...
  32. ncbi LIM homeodomain transcription factor Isl-1 enhances follicle stimulating hormone-beta and luteinizing hormone-beta gene expression and mediates the activation of leptin on gonadotropin synthesis
    Yingjie Wu
    State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, People s Republic of China
    Endocrinology 151:4787-800. 2010
    ..In conclusion, the results demonstrate that the LIM-homeodomain transcription factor Isl-1 functions to increase FSHβ/LHβ gene transcription, and mediates the effects of leptin on gonadotropin synthesis...
  33. ncbi Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development
    S Leah Etheridge
    Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA
    PLoS Genet 4:e1000259. 2008
    ..Finally, we establish several developmental processes in which the three Dvls are functionally redundant...
  34. ncbi Active suppression of interneuron programs within developing motor neurons revealed by analysis of homeodomain factor HB9
    J Thaler
    Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Neuron 23:675-87. 1999
    ..Thus, MNs actively suppress interneuron genetic programs to establish their identity...
  35. ncbi Multiple requirements for Hes 1 during early eye formation
    Hae Young Lee
    Department of Pediatrics, Northwestern University Medical School at Children s Memorial Institute for Education and Research, Chicago, IL 60614, USA
    Dev Biol 284:464-78. 2005
    ..Together, these studies demonstrate that Hes1, like Pax6, simultaneously regulates multiple developmental processes during optic development...
  36. ncbi Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme
    Josefina Edsbagge
    Department of Medical Biochemistry, Box 440, Goteborg University, S 405 30 Goteborg, Sweden
    Development 132:1085-92. 2005
    ..Thus, we propose a new model where blood vessel-derived sphingosine-1-phosphate stimulates growth and budding of the dorsal pancreatic endoderm by induction of mesenchymal cell proliferation...
  37. ncbi Hoxc10 and Hoxd10 regulate mouse columnar, divisional and motor pool identity of lumbar motoneurons
    Yuanyuan Wu
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Development 135:171-82. 2008
    ..Together, these results show that Hoxc10 and Hoxd10 play key roles in establishing lumbar motoneuron columnar, divisional and motor pool identity...
  38. ncbi Control of hindbrain motor neuron differentiation by the homeobox gene Phox2b
    A Pattyn
    Laboratoire de Genetique et Physiologie du Developpement, Developmental Biology Institute of Marseille, CNRS INSERM Univ Méditerranée AP de Marseille, Luminy Case 907, France
    Development 127:1349-58. 2000
    ..Thus, the loss of function of Phox2b in hindbrain motor neurons exemplifies a novel control point in the generation of CNS neurons...
  39. ncbi Islet-1 controls the differentiation of retinal bipolar and cholinergic amacrine cells
    Yasser Elshatory
    Department of Ophthalmology, University of Rochester, Rochester, New York 14642, USA
    J Neurosci 27:12707-20. 2007
    ..pools is governed by coordinately acting LIM-homeodomain proteins including the Islet-class factor Islet-1 (Isl1)...
  40. ncbi Notch 1 inhibits photoreceptor production in the developing mammalian retina
    Ashutosh P Jadhav
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Development 133:913-23. 2006
    ..These cone enriched mutant mice should prove to be a valuable resource for the study of this relatively rare mammalian photoreceptor cell type...
  41. ncbi Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway
    Jessica Svärd
    Department of Biosciences at Novum, Karolinska Institutet, SE 141 57 Huddinge, Sweden
    Dev Cell 10:187-97. 2006
    ..Our data demonstrate that, in striking contrast to Drosophila, in mammals, Sufu has a central role, and its loss of function leads to potent ligand-independent activation of the Hh pathway...
  42. ncbi The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice
    Andreas Petri
    Department of Molecular Genetics, Novo Nordisk A S, DK 2880 Bagsvaerd, Denmark
    J Mol Endocrinol 37:301-16. 2006
    ..These data suggest that Irx1 and Irx2 serve an evolutionary conserved role in the regulation of alpha-cell-specific gene expression...
  43. ncbi Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina
    Liang Feng
    Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA
    Development 133:4815-25. 2006
    ..Our results reveal that a bHLH transcription factor cascade is involved in regulating retinal cell differentiation and imply that Bhlhb5 functions downstream of retinogenic factors to specify bipolar and amacrine subtypes...
  44. ncbi Dynamic regulation of the expression of neurotrophin receptors by Runx3
    Souichiro Nakamura
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8577, Japan
    Development 135:1703-11. 2008
    ..Moreover, we show that the number of TrkA-positive DRG neurons is reduced in Runx3(-/-) mice, as compared with the wild type. These results suggest that Runx3 positively regulates the expression of TrkC and TrkA in DRG neurons...
  45. ncbi Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis
    Alexandra Klaus
    Max Delbrueck Center of Molecular Medicine, Robert Roessle Strasse 10, 13125 Berlin, Germany
    Proc Natl Acad Sci U S A 104:18531-6. 2007
    ..Although myocardial progenitor markers such as Nkx2-5 and Isl1 and the differentiation marker MLC2a were detected in the small, remaining cardiac field in these mutants, the ..
  46. ncbi Neuronal defects in the hindbrain of Hoxa1, Hoxb1 and Hoxb2 mutants reflect regulatory interactions among these Hox genes
    Anthony Gavalas
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 130:5663-79. 2003
    ..Therefore, we have delineated the functional requirements in hindbrain neuronal patterning that follow the establishment of the genetic regulatory hierarchy between Hoxa1, Hoxb1 and Hoxb2...
  47. ncbi Pax6 influences the time and site of origin of glial precursors in the ventral neural tube
    T Sun
    Department of Biology, University College London, Gower Street, London, WC1E 6BT
    Mol Cell Neurosci 12:228-39. 1998
    ..OLs developed normally in explants of Isl1(-/-) spinal cords, which lack MNs, arguing against feedback control and suggesting that the neuron-glia switch is ..
  48. ncbi Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system
    M P Matise
    Developmental Genetics Program and Howard Hughes Medical Institute, and Department of Cell Biology and Physiology and Neuroscience, NYU Medical Center, New York, NY 10016, USA
    Development 125:2759-70. 1998
    ....
  49. ncbi Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord
    Michael K Gross
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 34:535-49. 2002
    ..Lbx1, therefore, plays a critical role in the development of sensory pathways in the spinal cord that relay pain and touch...
  50. ncbi Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation
    X Yang
    Molecular Neurobiology Program, Skirball Institute, New York University Medical School, New York, NY 10011, USA
    Neuron 30:399-410. 2001
    ..Our results demonstrate that AChR expression is patterned in the absence of innervation, raising the possibility that similarly prepatterned muscle-derived cues restrict axon growth and initiate synapse formation...
  51. ncbi The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord
    Thomas Muller
    Department of Medical Genetics, Max Delbruck Center for Molecular Medicine, 13122 Berlin, Germany
    Neuron 34:551-62. 2002
    ..We conclude that Lbx1 distinguishes two major neuronal classes in the dorsal spinal cord and is an important determinant of their distinct differentiation programs...
  52. ncbi The winged-helix transcription factor Foxd3 suppresses interneuron differentiation and promotes neural crest cell fate
    M Dottori
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Development 128:4127-38. 2001
    ..Together these results suggest Foxd3 can function independently of Slug and RhoB to promote the development of neural crest cells from neural tube progenitors...
  53. ncbi Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain gene
    J T Eggenschwiler
    Molecular Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Dev Biol 227:648-60. 2000
    ..The data indicate that opb(+) could act as either a novel component of a dorsalizing pathway or a novel intracellular negative regulator of the Shh signal transduction pathway...
  54. ncbi Proprioceptor pathway development is dependent on Math1
    N A Bermingham
    Howard Hughes Medical Institute, One Baylor Plaza, Houston, TX 77030, USA
    Neuron 30:411-22. 2001
    ..We also identify three downstream genes of Math1 (Lh2A, Lh2B, and Barhl1) and establish that Math1 governs the development of multiple components of the proprioceptive pathway...
  55. ncbi Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects
    M Ishibashi
    Institute for Immunology, Kyoto University Faculty of Medicine, Japan
    Genes Dev 9:3136-48. 1995
    ..These results suggest that HES-1 normally controls the proper timing of neurogenesis and regulates neural tube morphogenesis...
  56. ncbi Nestin is expressed in mesenchymal and not epithelial cells of the developing mouse pancreas
    Lars Selander
    Department of Molecular Biology, Umeå Center for Molecular Medicine, Umea University, SE 901 87 Umea, Sweden
    Mech Dev 113:189-92. 2002
    ..The data presented demonstrate that nestin is expressed in mesenchymal and not epithelial cells of the developing mouse pancreas...
  57. ncbi Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
    C Brian Bai
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 129:4753-61. 2002
    ..Our studies demonstrate that, in mammals, Gli1 is not required for Shh signaling and that Gli2 mediates inappropriate activation of the pathway due to loss of the negative regulator Ptc...
  58. ncbi ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons
    S Arber
    Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Cell 101:485-98. 2000
    ..ER81 therefore controls a late step in the establishment of functional sensory-motor circuitry in the developing spinal cord...
  59. ncbi Family of Ebf/Olf-1-related genes potentially involved in neuronal differentiation and regional specification in the central nervous system
    S Garel
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, Paris, France
    Dev Dyn 210:191-205. 1997
    ..These data suggest that Ebf genes may be involved in the control of neuronal differentiation in the CNS and in enforcing regional diversity in populations of post-mitotic forebrain neurons...
  60. ncbi Differential expression of LIM-homeodomain genes in the embryonic murine brain
    K Matsumoto
    Department of Structural Cellular Biology, Nara Institute of Science and Technology NAIST, Japan
    Neurosci Lett 211:147-50. 1996
    ..These mRNAs showed mutually exclusive expression patterns suggesting that these factors may be involved in region-specific differentiation in the developing brain...
  61. ncbi Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo
    S L Dunwoodie
    Department of Mammalian Development, National Institute for Medical Research, Mill Hill, London, UK
    Development 124:3065-76. 1997
    ..We hypothesise that Dll1 is involved in the release of cells from the precursor population and that Dll3 is required later to divert neurons along a specific differentiation pathway...
  62. ncbi Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1
    M Studer
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, Mill Hill, London, UK
    Nature 384:630-4. 1996
    ..These results demonstrate that, as a part of its role in maintaining rhombomere identity, Hoxb-1 is involved in controlling migratory properties of motor neurons in the hindbrain...
  63. ncbi Restricted patterns of Hoxd10 and Hoxd11 set segmental differences in motoneuron subtype complement in the lumbosacral spinal cord
    Mala Misra
    Department of Neurobiology and Center for Neuroscience, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261, USA
    Dev Biol 330:54-72. 2009
    ..We hypothesize that one of the roles played by Hoxd11 is to modulate Hoxd10 and local retinoic acid levels and thus, perhaps define the caudal boundaries of the LMC and its subtype complement...
  64. ncbi The on/off of Pax6 controls the tempo of neuronal differentiation in the developing spinal cord
    Sophie Bel-Vialar
    Centre de Biologie du Developpement, CNRS UMR5547 Bât 4R3, Universite Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 09, France
    Dev Biol 305:659-73. 2007
    ..We present a model in which the level of Pax6 activity first conditions the moment when a given progenitor will leave the cell cycle and second, the moment when a selected neuronal precursor will irreversibly differentiate...
  65. ncbi The protocadherin gene Celsr3 is required for interneuron migration in the mouse forebrain
    Guoxin Ying
    Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    Mol Cell Biol 29:3045-61. 2009
    ..These results demonstrate that the protocadherin Celsr3 gene is essential for both tangential and radial interneuron migrations in a class-specific manner...
  66. ncbi Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity
    Mi Ryoung Song
    Bioimaging Research Center and Cell Dynamics Research Center, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea
    Development 136:2923-32. 2009
    ..Here we examined how the dosage of LIM homeodomain proteins Isl1 and Isl2 and LIM-only protein Lmo4 influences the assembly and function of complexes involved in the generation of ..
  67. ncbi A role for Gsh1 in the developing striatum and olfactory bulb of Gsh2 mutant mice
    H Toresson
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, Solvegatan 17, BMC A11, S 221 84 Lund, Sweden
    Development 128:4769-80. 2001
    ....
  68. ncbi Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis
    A Bhushan
    INSERM 457, Hospital Robert Debre, 75019 Paris, France
    Development 128:5109-17. 2001
    ..These results indicate that Fgf10 signalling is required for the normal development of the pancreas and should prove useful in devising methods to expand pancreatic progenitor cells...
  69. ncbi Gli2 and Gli3 play distinct roles in the dorsoventral patterning of the mouse hindbrain
    Melanie Lebel
    Program in Developmental Biology, The Hospital for Sick Children, Room 13 314, Toronto Medical Discovery Tower, Ontario, Canada
    Dev Biol 302:345-55. 2007
    ..Taken together, these observations indicate that Gli2 and Gli3 perform rhombomere-specific function during DV patterning of the hindbrain...
  70. ncbi Tbx3 is required for outflow tract development
    Karim Mesbah
    Developmental Biology Institute of Marseilles Luminy, France
    Circ Res 103:743-50. 2008
    ....
  71. ncbi Dynamics of embryonic pancreas development using real-time imaging
    Sapna Puri
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Dev Biol 306:82-93. 2007
    ..Thus, pancreas growth in vitro can be documented by live imaging, allowing visualization of the developing pancreas in real-time...
  72. ncbi The chirality of gut rotation derives from left-right asymmetric changes in the architecture of the dorsal mesentery
    Nicole M Davis
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 15:134-45. 2008
    ..These properties are instructed by a set of transcription factors: Pitx2 and Isl1 specifically expressed on the left side, and Tbx18 expressed on the right, regulated downstream of the secreted ..
  73. ncbi Early forebrain wiring: genetic dissection using conditional Celsr3 mutant mice
    Libing Zhou
    Developmental Neurobiology, Universite Catholique de Louvain, 1200 Bruxelles, Belgique
    Science 320:946-9. 2008
    ..These observations provide in vivo evidence that Celsr3-mediated interactions between axons and guidepost cells govern axonal tract formation in mammals...
  74. ncbi Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation
    Nicolas Jonckheere
    Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA 92697 2300, USA
    Dev Biol 318:224-35. 2008
    ..Together, our data suggest a previously unappreciated role for mesenchymal Wnt signaling in regulating pancreatic organ growth and cell differentiation...
  75. ncbi Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells
    Quenten Schwarz
    Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, UK
    Development 135:1605-13. 2008
    ..We conclude that neuropilins play multiple roles in the sensory nervous system by directing cranial neural crest cells, positioning sensory neurons and organising their axonal projections...
  76. ncbi Premature differentiation and aberrant movement of pituitary cells lacking both Hes1 and Prop1
    Ashley D Himes
    University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Dev Biol 325:151-61. 2009
    ..Our data reveal important overlapping functions of Hes1 and Prop1 in cell differentiation and movement that are critical for pituitary organogenesis...
  77. ncbi A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling
    Kei Hori
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Genes Dev 22:166-78. 2008
    ....
  78. ncbi CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis
    G Kolle
    Centre for Molecular and Cellular Biology, The University of Queensland, Brisbane, Australia
    Mech Dev 90:181-93. 2000
    ..Our results suggest a role for CRIM1/Crim1 in CNS development possibly via growth factor binding...
  79. ncbi Pax6 regulates the identity of embryonic diencephalic neurons
    G S Mastick
    Department of Biology, University of Nevada, Reno, Nevada 89557, USA
    Mol Cell Neurosci 17:190-207. 2001
    ..Pax6 up-regulation occurred only several hours postdifferentiation. The loss of Pax6 altered progenitor specification, and the Lhx1 neuronal marker was lost, indicating a role for Pax6 in the specification of forebrain neuron identity...
  80. ncbi OL-Protocadherin is essential for growth of striatal axons and thalamocortical projections
    Masato Uemura
    RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Nat Neurosci 10:1151-9. 2007
    ..The inability of the striatum to extend axons is also observed in vitro. These results show that OL-pc is essential for both elongation of striatal axons and patterning of the putative guidance cues for thalamocortical projections...
  81. ncbi Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract
    Yi Hui Chen
    Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center and Hospital, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Dev Biol 308:421-37. 2007
    ....
  82. ncbi Abnormal positioning of diencephalic cell types in neocortical tissue in the dorsal telencephalon of mice lacking functional Gli3
    Vassiliki Fotaki
    Genes and Development Group, Biomedical Sciences, The University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 26:9282-92. 2006
    ..We propose that Gli3 is indispensable for formation of an intact telencephalic-diencephalic boundary and for preventing the abnormal positioning of diencephalic cells in the dorsal telencephalon...
  83. ncbi Noggin regulates Bmp4 activity during pituitary induction
    Shannon W Davis
    Department of Human Genetics, University of Michigan Medical School, 4909 Buhl Building, 1241 E Catherine St, Ann Arbor, MI 48109 0618, USA
    Dev Biol 305:145-60. 2007
    ..This work demonstrates the importance of attenuating the activity of Bmp signaling during pituitary induction in order to maintain the proper balance of signaling factors necessary for pituitary organogenesis...
  84. ncbi Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid
    N Suzuki
    Howard Hughes Medical Institute, Vanderbilt University Medical School, Nashville, TN 37232 2175, USA
    Development 122:3587-95. 1996
    ..Metabolical labelling and immunofluorescence studies also reveal abnormal processing and deposition of procollagen by homozygous mutant fibroblasts in culture...
  85. ncbi GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regeneration
    Hideki Enomoto
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 44:623-36. 2004
    ..Thus RET-independent GFRalpha1 is dispensable for organogenesis and nerve regeneration in vivo, indicating that trans-signaling and GFRalpha-dependent NCAM signaling play a minor role physiologically...
  86. ncbi Distinct origins and genetic programs of head muscle satellite cells
    Itamar Harel
    Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
    Dev Cell 16:822-32. 2009
    ..Lineage tracing experiments with Isl1Cre mice demonstrated the robust contribution of Isl1(+) cells to distinct jaw muscle-derived satellite cells...
  87. ncbi Control of roof plate formation by Lmx1a in the developing spinal cord
    Victor V Chizhikov
    Department of Human Genetics, University of Chicago, 920 East 58th Street, CLSC 319, Chicago, IL 60637, USA
    Development 131:2693-705. 2004
    ..We conclude that Lmx1a controls multiple aspects of dorsal midline patterning and is a major mediator of early Bmp signaling in the developing spinal cord...
  88. ncbi Ectopic expression of Gcm1 induces congenital spinal cord abnormalities
    Brahim Nait-Oumesmar
    Department of Molecular, Cellular and Developmental Biology and Department of Radiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Development 129:3957-64. 2002
    ..The multiple spinal cords remain but are enclosed in a single spinal column as in the human diastematomyelia. The animals live a normal life time, are fertile and do not exhibit any obvious weakness or motor disabilities...
  89. ncbi Spatiotemporal features of early neuronogenesis differ in wild-type and albino mouse retina
    Rivka A Rachel
    Center for Neurobiology and Behavior, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Neurosci 22:4249-63. 2002
    ..These results point to spatiotemporal defects in neuronal production in the albino retina, which could perturb expression of genes that specify cell fate, number, and/or projection phenotype...
  90. ncbi Conversion of biliary system to pancreatic tissue in Hes1-deficient mice
    Ryo Sumazaki
    Department of Child Health, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
    Nat Genet 36:83-7. 2004
    ..Thus, biliary epithelium has the potential for pancreatic differentiation and Hes1 determines biliary organogenesis by preventing the pancreatic differentiation program, probably by directly repressing transcription of Neurog3...
  91. ncbi Tlx controls proliferation and patterning of lateral telencephalic progenitor domains
    Jan M Stenman
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Neurosci 23:10568-76. 2003
    ..Our results show that, although Gsh2 and Tlx have additive effects on striatal development, they differentially regulate the establishment of ventral pallial identity...
  92. ncbi Mutations in dynein link motor neuron degeneration to defects in retrograde transport
    Majid Hafezparast
    Department of Neurodegenerative Disease, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Science 300:808-12. 2003
    ..These mutations exclusively perturb neuron-specific functions of dynein...
  93. ncbi Hox3 genes coordinate mechanisms of genetic suppression and activation in the generation of branchial and somatic motoneurons
    Gary O Gaufo
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Development 130:5191-201. 2003
    ....
  94. ncbi The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain
    Yangu Zhao
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:9005-10. 2003
    ..These results provide genetic evidence supporting an important role for Lhx8 in development of cholinergic neurons in the forebrain...
  95. ncbi Dlx transcription factors regulate differentiation of dopaminergic neurons of the ventral thalamus
    Gracie L Andrews
    Biology and Biochemistry Departments, Cell and Molecular Biology Graduate Program, University of Nevada, Reno 89557, USA
    Mol Cell Neurosci 23:107-20. 2003
    ..and in the differentiating neurons (PAX6, along with a combination of LIM-type homeodomain factors, including ISL1, Lhx1/Lim1, and Lhx5/Lim2)...
  96. ncbi EphB receptor tyrosine kinases control morphological development of the ventral midbrain
    Amy L Altick
    Biochemistry Graduate Program, Department of Biology, University of Nevada, Mail Stop 200, Reno, NV 89557, USA
    Mech Dev 122:501-12. 2005
    ..Our data suggests a role for EphB signaling in morphological organization of specific regions of the developing neural tube...
  97. ncbi Synchronization of neurogenesis and motor neuron specification by direct coupling of bHLH and homeodomain transcription factors
    Soo Kyung Lee
    Gene Expression Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 38:731-45. 2003
    ..bHLH proteins Ngn2 and NeuroM controlling neurogenesis functionally converge with LIM-homeodomain (LIM-HD) factors Isl1 and Lhx3 involved in motor neuron subtype specification...
  98. ncbi Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2
    E Andersson
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A11, Sweden
    Development 133:507-16. 2006
    ....
  99. ncbi The LIM homeodomain transcription factors Lhx6 and Lhx7 are key regulators of mammalian dentition
    Myrto Denaxa
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Dev Biol 333:324-36. 2009
    ..Our experiments demonstrate that the redundant activities of the LIM homeodomain proteins Lhx6 and Lhx7 are critical for craniofacial development and patterning of mammalian dentition...
  100. ncbi Persistent expression of Hlxb9 in the pancreatic epithelium impairs pancreatic development
    H Li
    Umeå Center for Molecular Medicine, Umea University, Umea, SE 901 87, Sweden
    Dev Biol 240:247-53. 2001
    ..Thus, a total loss of Hlxb9 expression results in a block of the initiation of the dorsal pancreatic program, while a temporally extended expression of Hlxb9 results in a complete impairment of pancreatic development...
  101. ncbi Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes
    Leping Cheng
    Dana Farber Cancer Institute, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Nat Neurosci 8:1510-5. 2005
    ..These genetic studies suggest that Lbx1 expression defines a basal GABAergic differentiation state, and Tlx3 acts to antagonize Lbx1 to promote glutamatergic differentiation...

Research Grants68

  1. Longitudinal axon guidance by long range cues in the embryonic brain
    GRANT STEPHEN MASTICK; Fiscal Year: 2011
    ....
  2. Functional Analysis of Inhibitory Spinal Cord Interneurons
    Martyn Goulding; Fiscal Year: 2007
    ..More importantly, they will lay the groundwork for strategies to treat spinal cord injury and degeneration disorders that affect normal voluntary movements. ..
  3. SELECTIVE AGGREGATION AND SORTING OF SALIVARY PROTEINS
    Douglas Darling; Fiscal Year: 2007
    ..This will lead to a better understanding of the formation of saliva and provide the basis for efficient delivery of therapeutic proteins from salivary glands. ..
  4. Specification of Dorsal Lbx1-Derived Interneurons
    Martyn Goulding; Fiscal Year: 2007
    ..These studies will provide important insights into the development and organization of neural circuits in the dorsal horn that sense and relay pain. ..
  5. Control of Hox gene expression and neuronal identity
    Jeh Ping Liu; Fiscal Year: 2007
    ....
  6. Identifying Periodontal Antigens By Protein Microarray
    Douglas Darling; Fiscal Year: 2006
    ..The R21 Exploratory Grant is an appropriate mechanism since proteomics have not been used for periodontal disease, and bacterial genomic expression libraries and antigen microarrays need to be developed. ..
  7. Study of a genetic network involved in ear development
    Rick Friedman; Fiscal Year: 2005
    ..These and future experiments represent the natural progression from my Mentored Clinical Scientist Development Award (K08). ..
  8. Transcriptional Regulation of Pancreas Development and Function
    CATHERINE LEE MAY; Fiscal Year: 2010
    ..The experiments described in this application will help delineate the mechanisms controlling the growth and development of -cells and bring us closer to generating functional -cells for cell replacement therapy. ..
  9. Genetic Analysis of Age Related Hearing Impairment
    Rick A Friedman; Fiscal Year: 2010
    ..This improved knowledge base can be anticipated to constitute fertile ground for developing new evidence-based preventive and therapeutic approaches to treating ARHI. ..
  10. Transcriptional Regulation of Pancreas Development and Function
    CATHERINE LEE MAY; Fiscal Year: 2010
    ..The experiments described in this application will help delineate the mechanisms controlling the growth and development of -cells and bring us closer to generating functional -cells for cell replacement therapy. ..
  11. Mathematical Model of Parotid Acinar Differentiation
    Grzegorz A Rempala; Fiscal Year: 2010
    ..This research is a necessary foundation for developing new technologies such as gene transfer therapy and biologics for treating or alleviating the oral symptoms of xerostomia. ..
  12. Transcriptional Regulation of Pancreas Development and Function
    CATHERINE MAY; Fiscal Year: 2009
    ..The experiments described in this application will help delineate the mechanisms controlling the growth and development of -cells and bring us closer to generating functional -cells for cell replacement therapy. ..
  13. Mathematical Model of Parotid Acinar Differentiation
    Douglas Darling; Fiscal Year: 2009
    ..This research is a necessary foundation for developing new technologies such as gene transfer therapy and biologics for treating or alleviating the oral symptoms of xerostomia. ..
  14. Longitudinal axon guidance by long range cues in the embryonic brain
    GRANT STEPHEN MASTICK; Fiscal Year: 2010
    ....
  15. Genetic Analysis of Age Related Hearing Impairment
    Rick Friedman; Fiscal Year: 2009
    ..This improved knowledge base can be anticipated to constitute fertile ground for developing new evidence-based preventive and therapeutic approaches to treating ARHI. ..
  16. Notch signaling regulates pituitary gland organogenesis
    Lori Raetzman; Fiscal Year: 2009
    ..They may also reveal genetic causes of congenital pituitary hormone deficiency and pituitary tumorigenesis and offer novel insight into the function of Notch signaling in endocrine cell differentiation. ..
  17. Genetic dissection of skeletal patterning
    Claudia Kappen; Fiscal Year: 2006
    ..The identification of modifier loci that act on skeletal patterning will reveal new molecular mechanisms in skeletal development and has important implications for the evolution of vertebrate body plans. ..
  18. Functional Analysis of Spinal Cord Interneurons
    Martyn Goulding; Fiscal Year: 2005
    ..These studies will provide valuable insights into the development and organization of circuits in the spinal cord that control locomotor behavior, and will lay the groundwork for strategies to treat spinal cord injury and degeneration. ..
  19. PAX 3 REGULATION OF CELL MIGRATION AND TRANSCRIPTION
    Martyn Goulding; Fiscal Year: 1999
    ..Finally a zinc-finger transcription factor, PIP1, has been identified that interacts specifically with Pax-3. Further studies will be undertaken to analyze the interaction between Pax-3 and PIP1. ..
  20. TRANSCRIPTION FACTORS REGULATING PALATOGENESIS
    Douglas Darling; Fiscal Year: 2002
    ..Subsequent work will investigate the molecular mechanism(s) of Zfhep action during craniofacial development. ..
  21. MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHY
    Claudia Kappen; Fiscal Year: 2000
    ..Finally, the regulation of Isl-1 will be investigated using deletion analysis of the Isl-1 promoter. It is hoped that understanding the effects of Isl-1 overexpression will lead to new reagents to study diabetic embryopathy. ..
  22. Genome-wide discovery of beta cell gene control elements
    Claudia Kappen; Fiscal Year: 2004
    ..Together, our studies will show how speck gene expression is achieved in beta cells and provide a framework to integrate gene transcription and beta cell biology. ..
  23. INVESTIGATING THE ROLE OF CDO IN BRAIN DEVELOPMENT
    Ami Okada; Fiscal Year: 2004
    ..These experiments should also contribute to the overall understanding of the signals that are important in the assembly of the nervous system. ..
  24. The Role of Neurogenin 3 in Pancreas Development
    CATHERINE MAY; Fiscal Year: 2004
    ..2) To identify early and late target genes of Ngn3 using microarray technology. ..
  25. PIONEER AXON GUIDANCE IN THE EMBRYONIC FOREBRAIN
    GRANT MASTICK; Fiscal Year: 2004
    ..In addition, the mechanisms of axon growth during development may give insight into how regeneration of the nervous system may be stimulated following trauma or disease. ..
  26. PAX GENE REGULATION IN EMBRYOGENESIS
    Martyn Goulding; Fiscal Year: 1993
    ..The long term goal of this project is to define the role of Pax-3 in neural development and begin to identify the signals that regulate its expression pattern in the vertebrate nervous system...
  27. REGULATION OF INTERNEURON IDENTITY BY ENL AND EVXL
    Martyn Goulding; Fiscal Year: 2000
    ..The longterm aim of these studies is to molecularly define how these two populations of interneurons are generated during embryonic development. ..