Gene Symbol: Iqsec2
Description: IQ motif and Sec7 domain 2
Alias: Brag1, IQ motif and SEC7 domain-containing protein 2
Species: mouse
Products:     Iqsec2

Top Publications

  1. Tsuchiya K, Greally J, Yi Y, Noel K, Truong J, Disteche C. Comparative sequence and x-inactivation analyses of a domain of escape in human xp11.2 and the conserved segment in mouse. Genome Res. 2004;14:1275-84 pubmed
    ..Our findings indicate that genomic context, as well as gene-specific regulatory elements, interact to determine expression of a gene from the inactive X-chromosome. ..
  2. Filippova G, Cheng M, Moore J, Truong J, Hu Y, Nguyen D, et al. Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development. Dev Cell. 2005;8:31-42 pubmed
    ..Furthermore, the evolution of X chromosome domains appears to be associated with repositioning of chromatin boundary elements. ..
  3. Casanova J. Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors. Traffic. 2007;8:1476-85 pubmed
    ..Here we review recent progress in our understanding of the structure, localization and biology of the different classes of Arf GEFs. ..
  4. Sakagami H, Sanda M, Fukaya M, Miyazaki T, Sukegawa J, Yanagisawa T, et al. IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6 that interacts with PSD-95 at postsynaptic density of excitatory synapses. Neurosci Res. 2008;60:199-212 pubmed publisher
    ..Here, we characterized IQ-ArfGEF/BRAG1, a guanine nucleotide exchange factor (GEF) for Arf6, in the mouse brain...
  5. Sanda M, Kamata A, Katsumata O, Fukunaga K, Watanabe M, Kondo H, et al. The postsynaptic density protein, IQ-ArfGEF/BRAG1, can interact with IRSp53 through its proline-rich sequence. Brain Res. 2009;1251:7-15 pubmed publisher
    IQ-ArfGEF/BRAG1, a guanine nucleotide exchange factor for Arf1 and Arf6, is localized at the postsynaptic density (PSD) and interacts with PSD-95...
  6. Scholz R, Berberich S, Rathgeber L, Kolleker A, Köhr G, Kornau H. AMPA receptor signaling through BRAG2 and Arf6 critical for long-term synaptic depression. Neuron. 2010;66:768-80 pubmed publisher
    ..We conclude that BRAG2-mediated Arf6 activation triggered by AMPA receptors is the convergent step of different forms of LTD, thus providing an essential mechanism for the control of vesicle formation by endocytic cargo. ..
  7. Elagabani M, Briševac D, Kintscher M, Pohle J, Köhr G, Schmitz D, et al. Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation. J Biol Chem. 2016;291:9105-18 pubmed publisher
    ..6 (Arf6) by consecutively recruiting two related brefeldin A-resistant Arf guanine nucleotide exchange factors, BRAG1 and BRAG2, in a GluN2 subunit-dependent manner...
  8. Hinze S, Jackson M, Lie S, Jolly L, Field M, Barry S, et al. Incorrect dosage of IQSEC2, a known intellectual disability and epilepsy gene, disrupts dendritic spine morphogenesis. Transl Psychiatry. 2017;7:e1110 pubmed publisher
    ..The intelligence quotient (IQ) motif and SEC7 domain containing protein 2 gene (IQSEC2) is located on the X-chromosome and harbors mutations that contribute to non-syndromic ID with and without early-..