Gene Symbol: Ipw
Description: imprinted gene in the Prader-Willi syndrome region
Wevrick R, Francke U. An imprinted mouse transcript homologous to the human imprinted in Prader-Willi syndrome (IPW) gene. Hum Mol Genet. 1997;6:325-32 pubmed
..b>IPW, a paternally expressed gene cloned from this region, is not expressed in individuals with PWS, and is thus a ..
Yang T, Adamson T, Resnick J, Leff S, Wevrick R, Francke U, et al
. A mouse model for Prader-Willi syndrome imprinting-centre mutations. Nat Genet. 1998;19:25-31 pubmed
..Snrpn and the putative PWS-IC lack expression of the imprinted genes Zfp127 (mouse homologue of ZNF127), Ndn and Ipw, and manifest several phenotypes common to PWS infants...
Gerard M, Hernandez L, Wevrick R, Stewart C. Disruption of the mouse necdin gene results in early post-natal lethality. Nat Genet. 1999;23:199-202 pubmed
..Imprinted genes mapped to this region include SNRPN (refs 3,4), ZNF127 (ref. 5), IPW (ref. 6) and NDN (which encodes the DNA-binding protein necdin; refs 7,8,9,10)...
Beechey C. Appendix: imprinted genes and regions in mouse and human. Results Probl Cell Differ. 1999;25:303-23 pubmed
Lee S, Walker C, Wevrick R. Prader-Willi syndrome transcripts are expressed in phenotypically significant regions of the developing mouse brain. Gene Expr Patterns. 2003;3:599-609 pubmed
..Snrpn, Ipw and Ndn are widely expressed at high levels throughout the mouse brain, whereas Magel2, Mkrn3 and the snoRNA MBII-..
Dhar M, Hauser L, Nicholls R, Johnson D. Physical mapping of the pink-eyed dilution complex in mouse chromosome 7 shows that Atp10c is the only transcript between Gabrb3 and Ube3a. DNA Seq. 2004;15:306-9 pubmed
..Data show that Atp10c, a novel type IV ATPase a putative phospholipid transporter, is the only coding unit in this region of the chromosome. ..
Skryabin B, Gubar L, Seeger B, Pfeiffer J, Handel S, Robeck T, et al
. Deletion of the MBII-85 snoRNA gene cluster in mice results in postnatal growth retardation. PLoS Genet. 2007;3:e235 pubmed publisher
..This is the first example in a multicellular organism of genetic deletion of a C/D box snoRNA gene resulting in a pronounced phenotype. ..
Seibt J, Armant O, Le Digarcher A, Castro D, Ramesh V, Journot L, et al
. Expression at the imprinted dlk1-gtl2 locus is regulated by proneural genes in the developing telencephalon. PLoS ONE. 2012;7:e48675 pubmed publisher
..This raises the possibility that the transcripts of this selective locus participate in the biological effects of proneural genes in the developing telencephalon. ..