Gene Symbol: Ipo7
Description: importin 7
Alias: A330055O14Rik, C330016G14, Imp7, Ranbp7, importin-7, RAN binding protein 7
Smitherman M, Lee K, Swanger J, Kapur R, Clurman B. Characterization and targeted disruption of murine Nup50, a p27(Kip1)-interacting component of the nuclear pore complex. Mol Cell Biol. 2000;20:5631-42 pubmed
..We conclude that Nup50 is a nucleoporin with essential functions during mouse development. ..
Mühlhäusser P, Müller E, Otto A, Kutay U. Multiple pathways contribute to nuclear import of core histones. EMBO Rep. 2001;2:690-6 pubmed
..Our results suggest that multiple pathways of import exist to provide efficient nuclear uptake of these abundant, essential proteins. ..
Cichutek A, Brueckmann T, Seipel B, Hauser H, Schlaubitz S, Prawitt D, et al
. Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1). Cytogenet Cell Genet. 2001;93:277-83 pubmed
..established, proving the conserved order of the genes and markers in both species: "cen-WEE1-D11S2043-ZNF143-RANBP7-CEGF1- ST5-D11S932-LMO1-D11S572-TUB-tel", with inverted order of the murine genes with respect to the ..
Kahle J, Baake M, Doenecke D, Albig W. Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13. Mol Cell Biol. 2005;25:5339-54 pubmed
..Importin 13 competes with NF-YA for binding to the NF-YB/NF-YC dimer. Our data suggest that a distinct binding platform derived from the HFM of both subunits, NF-YB/NF-YC, mediates those interactions. ..
Saijou E, Itoh T, Kim K, Iemura S, Natsume T, Miyajima A. Nucleocytoplasmic shuttling of the zinc finger protein EZI Is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms. J Biol Chem. 2007;282:32327-37 pubmed
Yang I, Wade C, Kang H, Alper S, Rutledge H, Lackford B, et al
. Identification of novel genes that mediate innate immunity using inbred mice. Genetics. 2009;183:1535-44 pubmed publisher
..genes that have not previously been implicated in innate immunity, namely, 1110058L19Rik, 4933415F23Rik, Fbxo9, and Ipo7. These genes could represent potential sepsis biomarkers or therapeutic targets that should be further investigated ..
Lee A, Kim S, Lee S, Jiang H, Kim S, Hong S, et al
. Knockdown of Importin 7 Inhibits Lung Tumorigenesis in K-rasLA1 Lung Cancer Mice. Anticancer Res. 2017;37:2381-2386 pubmed
Loebel D, O Rourke M, Steiner K, Banyer J, Tam P. Isolation of differentially expressed genes from wild-type and Twist mutant mouse limb buds. Genesis. 2002;33:103-13 pubmed