Gene Symbol: Inpp5e
Description: inositol polyphosphate-5-phosphatase E
Alias: 1200002L24Rik, 72kDa, mKIAA0123, 72 kDa inositol polyphosphate 5-phosphatase, inositol polyphosphate-5-phosphatase, 72 kDa, phosphatidylinositol 4,5-bisphosphate 5-phosphatase, phosphatidylinositol polyphosphate 5-phosphatase type IV
Species: mouse
Products:     Inpp5e

Top Publications

  1. Jacoby M, Cox J, Gayral S, Hampshire D, Ayub M, Blockmans M, et al. INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse. Nat Genet. 2009;41:1027-31 pubmed publisher
    ..Here, we report that mice deficient for the lipid 5-phosphatase Inpp5e develop a multiorgan disorder associated with structural defects of the primary cilium...
  2. Fansa E, Kösling S, Zent E, Wittinghofer A, Ismail S. PDE6?-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity. Nat Commun. 2016;7:11366 pubmed publisher
    ..Here we show using the inositol polyphosphate 5'-phosphatase E (INPP5E) and the GTP-binding protein (Rheb) that cargo sorting depends on the affinity towards PDE6? and the specificity ..
  3. Conduit S, Ramaswamy V, Remke M, Watkins D, Wainwright B, Taylor M, et al. A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma. Oncogene. 2017;36:5969-5984 pubmed publisher
    ..b>INPP5E is an inositol polyphosphate 5-phosphatase that hydrolyses PtdIns(4,5)P2 and more potently, the ..
  4. Kong A, Speed C, O Malley C, Layton M, Meehan T, Loveland K, et al. Cloning and characterization of a 72-kDa inositol-polyphosphate 5-phosphatase localized to the Golgi network. J Biol Chem. 2000;275:24052-64 pubmed
    ..We propose that the novel 5-phosphatase hydrolyzes phosphatidylinositol 3,4, 5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby may regulate Golgi-vesicular trafficking. ..
  5. Dyson J, Conduit S, Feeney S, Hakim S, DiTommaso T, Fulcher A, et al. INPP5E regulates phosphoinositide-dependent cilia transition zone function. J Cell Biol. 2017;216:247-263 pubmed publisher
    ..The inositol polyphosphate 5-phosphatase INPP5E localizes to cilia and is mutated in JBTS...
  6. Kawamoto S, Matsumoto Y, Mizuno K, Okubo K, Matsubara K. Expression profiles of active genes in human and mouse livers. Gene. 1996;174:151-8 pubmed
    ..This comparative analysis using expression profiling should find a wide application in comparative biology. ..
  7. Segawa T, Hazeki K, Nigorikawa K, Morioka S, Guo Y, Takasuga S, et al. Inpp5e increases the Rab5 association and phosphatidylinositol 3-phosphate accumulation at the phagosome through an interaction with Rab20. Biochem J. 2014;464:365-75 pubmed publisher
    ..We prepared RAW264.7 macrophages deficient in Inpp5e (shInpp5e) to clarify the role of this lipid phosphatase...
  8. Xu Q, Zhang Y, Wei Q, Huang Y, Hu J, Ling K. Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis. Nat Commun. 2016;7:10777 pubmed publisher
    ..phosphatidylinositol 4-phosphate (PtdIns(4)P) 5-kinase (PIPKIγ) and inositol polyphosphate-5-phosphatase E (INPP5E), a Joubert syndrome protein, localize to the centrosome and coordinate the initiation of ciliogenesis...
  9. Sun M, Mondal K, Patel V, Horner V, Long A, Cutler D, et al. Multiplex Chromosomal Exome Sequencing Accelerates Identification of ENU-Induced Mutations in the Mouse. G3 (Bethesda). 2012;2:143-50 pubmed publisher

More Information


  1. Horan K, Watanabe K, Kong A, Bailey C, Rasko J, Sasaki T, et al. Regulation of FcgammaR-stimulated phagocytosis by the 72-kDa inositol polyphosphate 5-phosphatase: SHIP1, but not the 72-kDa 5-phosphatase, regulates complement receptor 3 mediated phagocytosis by differential recruitment of these 5-phosphatases to t. Blood. 2007;110:4480-91 pubmed
    ..Therefore, 72-5ptase and SHIP1 exhibit specificity in regulating FcgammaR- versus CR3-stimulated phagocytosis by controlling the amplitude and duration of PtdIns(3,4,5)P(3) at the phagocytic cup. ..
  2. Chávez M, Ena S, van Sande J, de Kerchove d Exaerde A, Schurmans S, Schiffmann S. Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output. Dev Cell. 2015;34:338-50 pubmed publisher
    ..Mutations in inositol polyphosphate 5-phosphatase E (INPP5E) have been associated with ciliary dysfunction; however, its role in regulating ciliary phosphoinositides is ..
  3. Garcia Gonzalo F, Phua S, Roberson E, Garcia G, Abedin M, Schurmans S, et al. Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling. Dev Cell. 2015;34:400-409 pubmed publisher
    ..This distribution is created by Inpp5e, a ciliary phosphoinositide 5-phosphatase...
  4. Hakim S, Dyson J, Feeney S, Davies E, Sriratana A, Koenig M, et al. Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling. Hum Mol Genet. 2016;25:2295-2313 pubmed
    Polycystic kidney disease (PKD) is a common cause of renal failure with few effective treatments. INPP5E is an inositol polyphosphate 5-phosphatase that dephosphorylates phosphoinositide 3-kinase (PI3K)-generated PI(3,4,5)P3 ..
  5. Sierra Potchanant E, Cerabona D, Sater Z, He Y, Sun Z, Gehlhausen J, et al. INPP5E Preserves Genomic Stability through Regulation of Mitosis. Mol Cell Biol. 2017;37: pubmed publisher
    ..Previous studies revealed that INPP5E, the inositol polyphosphate-5-phosphatase that is mutated in the developmental disorders Joubert and MORM ..