Inpp5d

Summary

Gene Symbol: Inpp5d
Description: inositol polyphosphate-5-phosphatase D
Alias: SHIP, SHIP-1, SHIP1, SIP-145, p150Ship, s-SHIP, phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, SH2 domain-containing inositol 5'-phosphatase 1, SH2 domain-containing inositol phosphatase 1, SH2-containing inositol phosphatase SHIP, Src homology 2 domain-containing inositol-5-phosphatase, inositol polyphosphate-5-phosphatase, 145 kDa
Species: mouse
Products:     Inpp5d

Top Publications

  1. Liu L, Damen J, Ware M, Krystal G. Interleukin-3 induces the association of the inositol 5-phosphatase SHIP with SHP2. J Biol Chem. 1997;272:10998-1001 pubmed
    ..Based on its predicated amino acid sequence and its enzymatic activity, we have called this protein SHIP, for Src homology 2-containing inositol phosphatase...
  2. Helgason C, Antonchuk J, Bodner C, Humphries R. Homeostasis and regeneration of the hematopoietic stem cell pool are altered in SHIP-deficient mice. Blood. 2003;102:3541-7 pubmed
    SH2-containing inositol 5-phosphatase (SHIP) is an important negative regulator of cytokine and immune receptor signaling. SHIP-deficient mice have a number of hematopoietic perturbations, including enhanced cytokine responsiveness...
  3. Nakamura K, Kouro T, Kincade P, Malykhin A, Maeda K, Coggeshall K. Src homology 2-containing 5-inositol phosphatase (SHIP) suppresses an early stage of lymphoid cell development through elevated interleukin-6 production by myeloid cells in bone marrow. J Exp Med. 2004;199:243-54 pubmed
    The Src homology (SH)2-containing inositol 5-phosphatase (SHIP) negatively regulates a variety of immune responses through inhibitory immune receptors...
  4. Moody J, Xu L, Helgason C, Jirik F. Anemia, thrombocytopenia, leukocytosis, extramedullary hematopoiesis, and impaired progenitor function in Pten+/-SHIP-/- mice: a novel model of myelodysplasia. Blood. 2004;103:4503-10 pubmed
    The myeloproliferative disorder of mice lacking the Src homology 2 (SH2)-containing 5' phosphoinositol phosphatase, SHIP, underscores the need for closely regulating phosphatidylinositol 3-kinase (PI3K) pathway activity, and hence levels ..
  5. Haddon D, Antignano F, Hughes M, Blanchet M, Zbytnuik L, Krystal G, et al. SHIP1 is a repressor of mast cell hyperplasia, cytokine production, and allergic inflammation in vivo. J Immunol. 2009;183:228-36 pubmed publisher
    b>SHIP1 inhibits immune receptor signaling through hydrolysis of the PI3K product phosphatidylinositol 3,4,5-trisphosphate, forming phosphatidylinositol 3,4-bisphosphate...
  6. Cremer T, Ravneberg D, Clay C, Piper Hunter M, Marsh C, Elton T, et al. MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response. PLoS ONE. 2009;4:e8508 pubmed publisher
    ..Previous work from our laboratory identified the PI3K/Akt pathway and SHIP as critical modulators of host resistance to Francisella...
  7. Rauh M, Ho V, Pereira C, Sham A, Sly L, Lam V, et al. SHIP represses the generation of alternatively activated macrophages. Immunity. 2005;23:361-74 pubmed
    We recently reported that SHIP restrains LPS-induced classical (M1) activation of in vitro differentiated, bone marrow-derived macrophages (BMMPhis) and that SHIP upregulation is essential for endotoxin tolerance...
  8. Ganesan L, Joshi T, Fang H, Kutala V, Roda J, Trotta R, et al. FcgammaR-induced production of superoxide and inflammatory cytokines is differentially regulated by SHIP through its influence on PI3K and/or Ras/Erk pathways. Blood. 2006;108:718-25 pubmed
    ..Molecular mechanisms regulating these phagocytosis-associated events are not known. SHIP is an inositol phosphatase that downregulates PI3K-mediated activation events...
  9. Maxwell M, Yuan Y, Anderson K, Hibbs M, Salem H, Jackson S. SHIP1 and Lyn Kinase Negatively Regulate Integrin alpha IIb beta 3 signaling in platelets. J Biol Chem. 2004;279:32196-204 pubmed
    ..We demonstrate here a major role for the Src homology 2 domain-containing inositol 5-phosphatase (SHIP1) and Src family kinase, Lyn, in this process...

More Information

Publications72

  1. Huber M, Helgason C, Scheid M, Duronio V, Humphries R, Krystal G. Targeted disruption of SHIP leads to Steel factor-induced degranulation of mast cells. EMBO J. 1998;17:7311-9 pubmed
    To investigate the role of the src homology 2 (SH2)-containing inositol 5' phosphatase (SHIP) in growth factor-mediated signalling, we compared Steel factor (SF)-induced events in bone marrow-derived mast cells (BMMCs) from SHIP-/- and ..
  2. Tarasenko T, Kole H, Chi A, Mentink Kane M, Wynn T, Bolland S. T cell-specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses. Proc Natl Acad Sci U S A. 2007;104:11382-7 pubmed
    The 5'-phosphoinositol phosphatase SHIP negatively regulates signaling pathways triggered by antigen, cytokine and Fc receptors in both lymphocytes and myeloid cells...
  3. Helgason C, Kalberer C, Damen J, Chappel S, Pineault N, Krystal G, et al. A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of b lymphocytes in ship -/- mice. J Exp Med. 2000;191:781-94 pubmed
    In this report, we demonstrate that the Src homology 2 domain-containing inositol-5-phosphatase (SHIP) plays a critical role in regulating both B cell development and responsiveness to antigen stimulation...
  4. Kalesnikoff J, Baur N, Leitges M, Hughes M, Damen J, Huber M, et al. SHIP negatively regulates IgE + antigen-induced IL-6 production in mast cells by inhibiting NF-kappa B activity. J Immunol. 2002;168:4737-46 pubmed
    ..proinflammatory cytokine production is substantially higher in Src homology-2-containing inositol 5'-phosphatase (SHIP)(-/-) than in SHIP(+/+) bone marrow-derived mast cells (BMMCs)...
  5. Nakamura K, Malykhin A, Coggeshall K. The Src homology 2 domain-containing inositol 5-phosphatase negatively regulates Fcgamma receptor-mediated phagocytosis through immunoreceptor tyrosine-based activation motif-bearing phagocytic receptors. Blood. 2002;100:3374-82 pubmed
    Molecular mechanisms by which the Src homology 2 domain-containing inositol 5-phosphatase (SHIP) negatively regulates phagocytosis in macrophages are unclear...
  6. Costinean S, Sandhu S, Pedersen I, Tili E, Trotta R, Perrotti D, et al. Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B cells of Emicro-MiR-155 transgenic mice. Blood. 2009;114:1374-82 pubmed publisher
    ..We determine that Src homology 2 domain-containing inositol-5-phosphatase (SHIP) and CCAAT enhancer-binding protein beta (C/EBPbeta), 2 important regulators of the interleukin-6 signaling pathway,..
  7. Brauweiler A, Tamir I, Dal Porto J, Benschop R, Helgason C, Humphries R, et al. Differential regulation of B cell development, activation, and death by the src homology 2 domain-containing 5' inositol phosphatase (SHIP). J Exp Med. 2000;191:1545-54 pubmed
    Although the Src homology 2 domain-containing 5' inositol phosphatase (SHIP) is a well-known mediator of inhibitory signals after B cell antigen receptor (BCR) coaggregation with the low affinity Fc receptor, it is not known whether SHIP ..
  8. Antignano F, Ibaraki M, Kim C, Ruschmann J, Zhang A, Helgason C, et al. SHIP is required for dendritic cell maturation. J Immunol. 2010;184:2805-13 pubmed publisher
    Although several groups have investigated the role of SHIP in macrophage (M) development and function, SHIP's contribution to the generation, maturation, and innate immune activation of dendritic cells (DCs) is poorly understood...
  9. Roongapinun S, Oh S, Wu F, Panthong A, Zheng T, Zhu Z. Role of SHIP-1 in the adaptive immune responses to aeroallergen in the airway. PLoS ONE. 2010;5:e14174 pubmed publisher
    ..We previously reported that SHIP-1, a negative regulator of the PI3K pathway, is essential in maintaining lung immunohomeostasis, potentially ..
  10. Liu Q, Oliveira Dos Santos A, Mariathasan S, Bouchard D, Jones J, Sarao R, et al. The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling. J Exp Med. 1998;188:1333-42 pubmed
    b>Ship is an Src homology 2 domain containing inositol polyphosphate 5-phosphatase which has been implicated as an important signaling molecule in hematopoietic cells...
  11. Huber M, Helgason C, Damen J, Liu L, Humphries R, Krystal G. The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation. Proc Natl Acad Sci U S A. 1998;95:11330-5 pubmed
    To clarify the role that the src homology 2-containing inositol phosphatase (SHIP) plays in mast cell degranulation, the gene for SHIP was disrupted by homologous recombination in embryonic stem cells...
  12. Giuriato S, Pesesse X, Bodin S, Sasaki T, Viala C, Marion E, et al. SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels. Biochem J. 2003;376:199-207 pubmed
    Src homology domain 2-containing inositol 5-phosphatases 1 and 2 (SHIP1 and SHIP2) are capable of dephosphorylating the second messenger PtdIns(3,4,5) P3 (phosphatidylinositol 3,4,5-trisphosphate) and interacting with several signalling ..
  13. Paraiso K, Ghansah T, Costello A, Engelman R, Kerr W. Induced SHIP deficiency expands myeloid regulatory cells and abrogates graft-versus-host disease. J Immunol. 2007;178:2893-900 pubmed
    ..showed that engraftment of MHC-mismatched BM is enhanced and GVHD abrogated in recipients homozygous for a germline SHIP mutation...
  14. Nishio M, Watanabe K, Sasaki J, Taya C, Takasuga S, Iizuka R, et al. Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol. 2007;9:36-44 pubmed
    ..Here, we show that Src homology 2 (SH2) domain-containing inositol-5-phosphatase 1 (SHIP1), a PtdIns(3,4,5)P(3) phosphatase, is a key regulator of neutrophil migration...
  15. Kuroda E, Ho V, Ruschmann J, Antignano F, Hamilton M, Rauh M, et al. SHIP represses the generation of IL-3-induced M2 macrophages by inhibiting IL-4 production from basophils. J Immunol. 2009;183:3652-60 pubmed publisher
    ..and, to a lesser extent, GM-CSF skew murine Mphi progenitors toward an M2 phenotype, especially in the absence of SHIP. Specifically, the addition of these cytokines, with or without M-CSF, to adherence- or lineage-depleted (Lin(-)) ..
  16. Collazo M, Wood D, Paraiso K, Lund E, Engelman R, Le C, et al. SHIP limits immunoregulatory capacity in the T-cell compartment. Blood. 2009;113:2934-44 pubmed publisher
    ..We previously showed that either germline or induced SH2 domain-containing inositol 5-phosphatase (SHIP) deficiency in the host abrogates GVHD...
  17. Helgason C, Damen J, Rosten P, Grewal R, Sorensen P, Chappel S, et al. Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span. Genes Dev. 1998;12:1610-20 pubmed
    b>SHIP is a 145-kD SH2-containing inositol-5-phosphatase widely expressed in hemopoietic cells. It was first identified as a tyrosine phosphoprotein associated with Shc in response to numerous cytokines...
  18. Ono M, Okada H, Bolland S, Yanagi S, Kurosaki T, Ravetch J. Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling. Cell. 1997;90:293-301 pubmed
    ..the modulation of immune receptor activation by inhibitory coreceptors: an inositol polyphosphate 5'-phosphatase, SHIP, and a tyrosine phosphatase, SHP-1...
  19. Chacko G, Tridandapani S, Damen J, Liu L, Krystal G, Coggeshall K. Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP. J Immunol. 1996;157:2234-8 pubmed
    ..We have identified this protein as the novel inositol polyphosphate 5-phosphatase (SHIP)...
  20. Kavanaugh W, Pot D, Chin S, Deuter Reinhard M, Jefferson A, Norris F, et al. Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2. Curr Biol. 1996;6:438-45 pubmed
    ..Furthermore, SIP-110, SIP-130 and SIP-145 prefer 3-phosphorylated substrates, suggesting a link to the phosphatidylinositol 3-kinase signaling pathway. ..
  21. Crowley J, Stadanlick J, Cambier J, Cancro M. FcgammaRIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation. Blood. 2009;113:1464-73 pubmed publisher
    ..FcgammaRIIB coligation, and optimal action relies on the Src-homology-2 (SH2)-containing inositol 5 phosphase-1 (SHIP1)...
  22. Wang J, Howson J, Ghansah T, Desponts C, Ninos J, May S, et al. Influence of SHIP on the NK repertoire and allogeneic bone marrow transplantation. Science. 2002;295:2094-7 pubmed
    ..We find that SH2-containing inositol phosphatase (SHIP) influences the repertoire of NK receptors...
  23. Lakhanpal G, Vecchiarelli Federico L, Li Y, Cui J, Bailey M, Spaner D, et al. The inositol phosphatase SHIP-1 is negatively regulated by Fli-1 and its loss accelerates leukemogenesis. Blood. 2010;116:428-36 pubmed publisher
    ..Down-regulation of the Src homology 2 (SH2) domain-containing inositol-5-phosphatase-1 (SHIP-1) is associated with erythropoietin-stimulated erythroleukemic cells and correlates with increased proliferation ..
  24. Liu C, Miller H, Hui K, Grooman B, Bolland S, Upadhyaya A, et al. A balance of Bruton's tyrosine kinase and SHIP activation regulates B cell receptor cluster formation by controlling actin remodeling. J Immunol. 2011;187:230-9 pubmed publisher
    ..In this study, we show that both the stimulatory Bruton's tyrosine kinase (Btk) and the inhibitory SHIP-1 are required for efficient BCR self-aggregation...
  25. Brauweiler A, Merrell K, Gauld S, Cambier J. Cutting Edge: Acute and chronic exposure of immature B cells to antigen leads to impaired homing and SHIP1-dependent reduction in stromal cell-derived factor-1 responsiveness. J Immunol. 2007;178:3353-7 pubmed
    ..BCR signal-mediated hyporesponsiveness to SDF-1 is associated with phosphorylation of the 5-inositol phosphatase SHIP1 and requires SHIP1 expression...
  26. Maeda K, Baba Y, Nagai Y, Miyazaki K, Malykhin A, Nakamura K, et al. IL-6 blocks a discrete early step in lymphopoiesis. Blood. 2005;106:879-85 pubmed
    Animals lacking Src homology 2 domain-containing inositol 5-phosphatase (SHIP) display a reduction in lymphopoiesis and a corresponding enhancement of myelopoiesis...
  27. Lioubin M, Algate P, Tsai S, Carlberg K, Aebersold A, Rohrschneider L. p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity. Genes Dev. 1996;10:1084-95 pubmed
    ..Ectopic expression of p150 in fibroblasts does not inhibit growth. This novel protein, p150(ship) (SH2-containing inositol phosphatase), identifies a component of a new growth factor-receptor signaling pathway in ..
  28. Leung W, Tarasenko T, Biesova Z, Kole H, Walsh E, Bolland S. Aberrant antibody affinity selection in SHIP-deficient B cells. Eur J Immunol. 2013;43:371-81 pubmed publisher
    ..Here, we have used mice with B-cell-specific deletion of the 5'-inositol phosphatase SHIP as a model to study affinity selection in cells that are hyperresponsive to Ag and cytokine receptor stimulation...
  29. Damen J, Liu L, Rosten P, Humphries R, Jefferson A, Majerus P, et al. The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. Proc Natl Acad Sci U S A. 1996;93:1689-93 pubmed
    ..This novel signal transduction intermediate may serve to modulate both Ras and inositol signaling pathways. Based on its properties, we suggest the 145-kDa protein be called SHIP for SH2-containing inositol phosphatase.
  30. Lucas D, Rohrschneider L. A novel spliced form of SH2-containing inositol phosphatase is expressed during myeloid development. Blood. 1999;93:1922-33 pubmed
    SH2-containing Inositol Phosphatase (SHIP) is a 145 kD protein expressed in hematopoietic cells. SHIP is phosphorylated on tyrosine after receptor binding by several cytokines and has a negative role in hematopoiesis...
  31. Rohrschneider L, Fuller J, Wolf I, Liu Y, Lucas D. Structure, function, and biology of SHIP proteins. Genes Dev. 2000;14:505-20 pubmed
  32. Takeshita S, Namba N, Zhao J, Jiang Y, Genant H, Silva M, et al. SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts. Nat Med. 2002;8:943-9 pubmed
    The hematopoietic-restricted protein Src homology 2-containing inositol-5-phosphatase (SHIP) blunts phosphatidylinositol-3-kinase-initiated signaling by dephosphorylating its major substrate, phosphatidylinositol-3,4,5-trisphosphate...
  33. Tu Z, Ninos J, Ma Z, Wang J, Lemos M, Desponts C, et al. Embryonic and hematopoietic stem cells express a novel SH2-containing inositol 5'-phosphatase isoform that partners with the Grb2 adapter protein. Blood. 2001;98:2028-38 pubmed
    SH2-containing inositol 5'-phosphatase (SHIP) modulates the activation of immune cells after recruitment to the membrane by Shc and the cytoplasmic tails of receptors...
  34. Ghansah T, Paraiso K, Highfill S, Desponts C, May S, McIntosh J, et al. Expansion of myeloid suppressor cells in SHIP-deficient mice represses allogeneic T cell responses. J Immunol. 2004;173:7324-30 pubmed
    Previously we demonstrated that SHIP(-/-) mice accept allogeneic bone marrow transplants (BMT) without significant acute graft-vs-host disease (GvHD)...
  35. Kim C, Hangoc G, Cooper S, Helgason C, Yew S, Humphries R, et al. Altered responsiveness to chemokines due to targeted disruption of SHIP. J Clin Invest. 1999;104:1751-9 pubmed
    b>SHIP has been implicated in negative signaling in a number of hematopoietic cell types and is postulated to downregulate phosphatidylinositol-3-kinase- (PI-3K-) initiated events in diverse receptor signaling pathways...
  36. Fang H, Pengal R, Cao X, Ganesan L, Wewers M, Marsh C, et al. Lipopolysaccharide-induced macrophage inflammatory response is regulated by SHIP. J Immunol. 2004;173:360-6 pubmed
    ..b>SHIP is an inositol phosphatase that can reverse the activation events initiated by PI3K, including the activation of ..
  37. Gabhann J, Higgs R, Brennan K, Thomas W, Damen J, Ben Larbi N, et al. Absence of SHIP-1 results in constitutive phosphorylation of tank-binding kinase 1 and enhanced TLR3-dependent IFN-beta production. J Immunol. 2010;184:2314-20 pubmed publisher
    ..We have identified the inositol 5' phosphatase SHIP-1 as a negative regulator of TLR3-induced type I IFN production...
  38. Vedham V, Phee H, Coggeshall K. Vav activation and function as a rac guanine nucleotide exchange factor in macrophage colony-stimulating factor-induced macrophage chemotaxis. Mol Cell Biol. 2005;25:4211-20 pubmed
    ..by hydrolysis of its products, a function performed by the 145-kDa SH2 domain-containing inositol phosphatase (SHIP)...
  39. O Neill S, Getahun A, Gauld S, Merrell K, Tamir I, Smith M, et al. Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy. Immunity. 2011;35:746-56 pubmed publisher
    ..In studies reported here, Src homology-2 (SH2)-containing inositol 5-phosphatase SHIP-1 and its adaptor Dok-1 were found to be constitutively phosphorylated in anergic B cells, and activation of this ..
  40. Maeda K, Mehta H, Drevets D, Coggeshall K. IL-6 increases B-cell IgG production in a feed-forward proinflammatory mechanism to skew hematopoiesis and elevate myeloid production. Blood. 2010;115:4699-706 pubmed publisher
    Src homology 2 domain-containing inositol 5-phosphatase (SHIP(-/-)) animals display an age-related increase in interleukin-6 (IL-6), a decrease in B lymphopoiesis, and an elevation in myelopoiesis...
  41. Rajaram M, Butchar J, Parsa K, Cremer T, Amer A, Schlesinger L, et al. Akt and SHIP modulate Francisella escape from the phagosome and induction of the Fas-mediated death pathway. PLoS ONE. 2009;4:e7919 pubmed publisher
    ..Our studies also demonstrate that constitutive activation of Akt, or deletion of SHIP, promotes phago-lysosomal fusion and limits bacterial burden in the host cytosol, and the subsequent induction of ..
  42. Karlsson M, Guinamard R, Bolland S, Sankala M, Steinman R, Ravetch J. Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone. J Exp Med. 2003;198:333-40 pubmed
    ..Disruption of the negative signaling inositol phosphatase, SH2-containing inositol-5-phosphatase 1 (SHIP), results in the loss of marginal zone B cells (MZBs) with reorganization of marginal zone macrophages (MZMOs) to ..
  43. Desponts C, Hazen A, Paraiso K, Kerr W. SHIP deficiency enhances HSC proliferation and survival but compromises homing and repopulation. Blood. 2006;107:4338-45 pubmed
    The SH2 domain-containing inositol 5'-phosphatase-1 (SHIP) has the potential to modulate multiple signaling pathways downstream of receptors that impact hematopoietic stem cell (HSC) biology...
  44. Liu Q, Sasaki T, Kozieradzki I, Wakeham A, Itie A, Dumont D, et al. SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival. Genes Dev. 1999;13:786-91 pubmed
    b>SHIP is an inositol 5' phosphatase that hydrolyzes the PI3'K product PI(3,4,5)P3...
  45. Tsantikos E, Maxwell M, Kountouri N, Harder K, Tarlinton D, Hibbs M. Genetic interdependence of Lyn and negative regulators of B cell receptor signaling in autoimmune disease development. J Immunol. 2012;189:1726-36 pubmed publisher
    ..we generated mice harboring double heterozygous loss-of-function mutations in Lyn and SHP-1 or Lyn and SHIP-1...
  46. Velazquez L, Gish G, van der Geer P, Taylor L, Shulman J, Pawson T. The shc adaptor protein forms interdependent phosphotyrosine-mediated protein complexes in mast cells stimulated with interleukin 3. Blood. 2000;96:132-8 pubmed
    ..with the Tyr-phosphorylated beta subunit of the IL-3 receptor and with the SH2-containing 5' inositol phosphatase (SHIP), and it recognized specific NXXpY phosphopeptides from these binding partners...
  47. Huber M, Kalesnikoff J, Reth M, Krystal G. The role of SHIP in mast cell degranulation and IgE-induced mast cell survival. Immunol Lett. 2002;82:17-21 pubmed
    ..The src homology 2-containing inositol-polyphosphate 5'-phosphatase, SHIP, has been shown to be a key 'gatekeeper' of mast cell degranulation...
  48. Keck S, Freudenberg M, Huber M. Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a Lyn/PI3K module and promoted by SHIP1. J Immunol. 2010;184:5809-18 pubmed publisher
    ..In this line, SHIP1(-/-) BMM Phis, exerting enhanced PI3K-pathway activation, produced fewer cytokines than did WT BMM Phis...
  49. Miletic A, Anzelon Mills A, Mills D, Omori S, Pedersen I, Shin D, et al. Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases. J Exp Med. 2010;207:2407-20 pubmed publisher
    ..phosphatases phosphatase and tensin homologue (PTEN) and Src homology 2 domain-containing inositol phosphatase (SHIP) negatively regulate phosphatidylinositol-3-kinase (PI3K)-mediated growth, survival, and proliferation of ..
  50. Brooks R, Iyer S, Akada H, Neelam S, Russo C, Chisholm J, et al. Coordinate expansion of murine hematopoietic and mesenchymal stem cell compartments by SHIPi. Stem Cells. 2015;33:848-58 pubmed publisher
    ..Previous genetic studies suggested a pivotal role for SH2 domain-containing inositol-5-phosphatase 1 (SHIP1) in limiting the size of the hematopoietic stem cell (HSC) compartment...
  51. Lind E, Millar D, Dissanayake D, Savage J, Grimshaw N, Kerr W, et al. miR-155 Upregulation in Dendritic Cells Is Sufficient To Break Tolerance In Vivo by Negatively Regulating SHIP1. J Immunol. 2015;195:4632-40 pubmed publisher
    ..Further analysis showed that miR-155 influenced the level of the phosphatase SHIP1 in DCs and that the lack of SHIP1 in DCs was sufficient to break T cell tolerance in vivo, again in the absence of ..
  52. Zhang J, Walk S, Ravichandran K, Garrison J. Regulation of the Src homology 2 domain-containing inositol 5'-phosphatase (SHIP1) by the cyclic AMP-dependent protein kinase. J Biol Chem. 2009;284:20070-8 pubmed publisher
    ..The SH2 domain-containing inositol 5' phosphatase, SHIP1, regulates hematopoietic cell function by opposing the action of phos pha tidyl ino si tol 3-kinase and reducing ..
  53. Huang L, Zhang Y, Xu C, Gu X, Niu L, Wang J, et al. Rictor positively regulates B cell receptor signaling by modulating actin reorganization via ezrin. PLoS Biol. 2017;15:e2001750 pubmed publisher
    ..Overall, our study provides a new pathway linking cell metablism to BCR activation, in which Rictor regulates BCR signaling via actin reorganization. ..
  54. Park Min K, Serbina N, Yang W, Ma X, Krystal G, Neel B, et al. FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin. Immunity. 2007;26:67-78 pubmed
  55. Pilon Thomas S, Nelson N, Vohra N, Jerald M, Pendleton L, Szekeres K, et al. Murine pancreatic adenocarcinoma dampens SHIP-1 expression and alters MDSC homeostasis and function. PLoS ONE. 2011;6:e27729 pubmed publisher
    ..In response to cytokine/chemokine receptor activation, src homology 2 domain-containing inositol 5'-phosphatase-1 (SHIP-1) influences phosphatidylinositol-3-kinase (PI3K) signaling events, which regulate immunohomeostasis...
  56. Sly L, Hamilton M, Kuroda E, Ho V, Antignano F, Omeis S, et al. SHIP prevents lipopolysaccharide from triggering an antiviral response in mice. Blood. 2009;113:2945-54 pubmed publisher
    ..We demonstrate herein that SH2-containing inositol-5'-phosphatase (SHIP) protein levels are dramatically increased in murine macrophages via the MyD88-dependent pathway, by up-regulating ..
  57. Gold M, Antignano F, Hughes M, Zaph C, McNagny K. Dendritic-cell expression of Ship1 regulates Th2 immunity to helminth infection in mice. Eur J Immunol. 2016;46:122-30 pubmed publisher
    ..In the current work, mice with a specific deletion of SHIP-1 in DCs (Ship1(ΔDC) ) were infected with the parasite T. muris...
  58. Getahun A, Beavers N, Larson S, Shlomchik M, Cambier J. Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells. J Exp Med. 2016;213:751-69 pubmed publisher
    ..of independent inhibitory signaling pathways involving the tyrosine phosphatase SHP-1 and the inositol phosphatase SHIP-1 are required to maintain anergy...
  59. Gimborn K, Lessmann E, Kuppig S, Krystal G, Huber M. SHIP down-regulates FcepsilonR1-induced degranulation at supraoptimal IgE or antigen levels. J Immunol. 2005;174:507-16 pubmed
    ..We identified SHIP, possibly in association with the FcepsilonR1 beta-chain, as a critical negative regulator acting within the ..
  60. Parihar R, Trotta R, Roda J, Ferketich A, Tridandapani S, Caligiuri M, et al. Src homology 2-containing inositol 5'-phosphatase 1 negatively regulates IFN-gamma production by natural killer cells stimulated with antibody-coated tumor cells and interleukin-12. Cancer Res. 2005;65:9099-107 pubmed
    ..The phosphatase Src homology 2-containing inositol 5'-phosphatase 1 (SHIP1) is known to exert inhibitory effects on Fc receptor (FcR) signaling via its enzymatic activity on ..
  61. Fessler S, Rosenberg N, Baughn L. SH2-containing inositol 5'-phosphatase inhibits transformation of Abelson murine leukemia virus. J Virol. 2011;85:9239-42 pubmed publisher
    ..This pathway is antagonized by SH2-containing inositol 5'-phosphatase (SHIP), raising the possibility that v-Abl modulates PI3K signaling through SHIP...
  62. Li F, Li L, Cheng M, Wang X, Hao J, Liu S, et al. SHIP, a novel factor to ameliorate extracellular matrix accumulation via suppressing PI3K/Akt/CTGF signaling in diabetic kidney disease. Biochem Biophys Res Commun. 2017;482:1477-1483 pubmed publisher
    ..Furthermore, in vivo delivery of rAd-INPP5D vector (SHIP expression vector) via intraperitoneal injection in diabetic mice increased SHIP expression by 3...
  63. Cox D, Dale B, Kashiwada M, Helgason C, Greenberg S. A regulatory role for Src homology 2 domain-containing inositol 5'-phosphatase (SHIP) in phagocytosis mediated by Fc gamma receptors and complement receptor 3 (alpha(M)beta(2); CD11b/CD18). J Exp Med. 2001;193:61-71 pubmed
    The Src homology 2 domain-containing inositol 5'-phosphatase (SHIP) is recruited to immunoreceptor tyrosine-based inhibition motif (ITIM)-containing proteins, thereby suppressing phosphatidylinositol 3-kinase (PI 3-kinase)-dependent ..