Gene Symbol: Inpp4b
Description: inositol polyphosphate-4-phosphatase, type II
Alias: E130107I17Rik, type II inositol 3,4-bisphosphate 4-phosphatase, D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase, inositol polyphosphate 4-phosphatase type II beta isoform, phosphatidylinositol-3,4-bisphosphate 4-phosphatase, phosphoinositide 4-phosphatase
Species: mouse
Products:     Inpp4b

Top Publications

  1. Balakrishnan A, Chaillet J. Role of the inositol polyphosphate-4-phosphatase type II Inpp4b in the generation of ovarian teratomas. Dev Biol. 2013;373:118-29 pubmed publisher
    ..The insertion of Tgkd 3' of the Inpp4b gene is associated with decreased expression of Inpp4b and changes in intracellular PI3 Kinase/AKT signaling in ..
  2. Ferron M, Boudiffa M, Arsenault M, Rached M, Pata M, Giroux S, et al. Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans. Cell Metab. 2011;14:466-77 pubmed publisher
    ..identified a regulator of osteoclastogenesis, the murine homolog of inositol polyphosphate 4-phosphatase type II? (Inpp4b?). Expression of Inpp4b? is detected from early osteoclast differentiation to activation stage...
  3. Lemcke S, Müller S, Möller S, Schillert A, Ziegler A, Cepok Kauffeld S, et al. Nerve conduction velocity is regulated by the inositol polyphosphate-4-phosphatase II gene. Am J Pathol. 2014;184:2420-9 pubmed publisher
    ..silico haplotype analyses, and comparative genomics we identified inositol polyphosphate-4-phosphatase, type II (Inpp4b) as the quantitative trait gene for EAE31...
  4. Malek M, Kielkowska A, Chessa T, Anderson K, Barneda D, Pir P, et al. PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K. Mol Cell. 2017;68:566-580.e10 pubmed publisher
    ..PTEN is a major PI(3,4)P2 phosphatase in Mcf10a cytosol, and loss of PTEN and INPP4B, a known PI(3,4)P2 4-phosphatase, leads to synergistic accumulation of PI(3,4)P2, which ..
  5. Maekawa M, Terasaka S, Mochizuki Y, Kawai K, Ikeda Y, Araki N, et al. Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis. Proc Natl Acad Sci U S A. 2014;111:E978-87 pubmed publisher
    ..b>INPP4B, which dephosphorylates PI(3,4)P2 to PI(3)P, was also found to be essential for macropinocytosis...
  6. Hsu I, Yeh C, Slavin S, Miyamoto H, Netto G, Tsai Y, et al. Estrogen receptor alpha prevents bladder cancer via INPP4B inhibited akt pathway in vitro and in vivo. Oncotarget. 2014;5:7917-35 pubmed
    ..Mechanism studies suggest that ERα could control the expression of INPP4B to reduce AKT activity and consequently reduce BCa cell growth...
  7. Li Chew C, Lunardi A, Gulluni F, Ruan D, Chen M, Salmena L, et al. In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes. Cancer Discov. 2015;5:740-51 pubmed publisher
    The phosphatases PTEN and INPP4B have been proposed to act as tumor suppressors by antagonizing PI3K-AKT signaling and are frequently dysregulated in human cancer...
  8. Kofuji S, Kimura H, Nakanishi H, Nanjo H, Takasuga S, Liu H, et al. INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor. Cancer Discov. 2015;5:730-9 pubmed publisher
    Inositol polyphosphate 4-phosphatase B (INPP4B) has been identified as a tumor suppressor mutated in human breast, ovary, and prostate cancers. The molecular mechanism underlying INPP4B's tumor-suppressive role is currently unknown...
  9. Ji L, Kim N, Huh S, Rhee H. Depletion of Inositol Polyphosphate 4-Phosphatase II Suppresses Callosal Axon Formation in the Developing Mice. Mol Cells. 2016;39:501-7 pubmed publisher
    ..Here, we provide the first report on the role of inositol polyphosphate 4-phosphatase II (INPP4B), a PI(3,4)P2 metabolizing 4-phosphatase in the regulation of callosal axon formation...

More Information


  1. Barnache S, Le Scolan E, Kosmider O, Denis N, Moreau Gachelin F. Phosphatidylinositol 4-phosphatase type II is an erythropoietin-responsive gene. Oncogene. 2006;25:1420-3 pubmed
    ..This study provides first insight for a physiological role of PI-4-phosphatase II in the proerythroblast by controlling Epo responsiveness through a negative regulation of the PI3K/Akt pathway. ..
  2. Ferron M, Vacher J. Characterization of the murine Inpp4b gene and identification of a novel isoform. Gene. 2006;376:152-61 pubmed
    ..inositol phosphatases in cell physiology, we have isolated the mouse Inositol polyphosphate 4-phosphatase type II (Inpp4b) cDNA...