Gene Symbol: Inpp4a
Description: inositol polyphosphate-4-phosphatase, type I
Alias: 107kDa, 9630012D15, D130048C09Rik, R74740, type I inositol 3,4-bisphosphate 4-phosphatase
Species: mouse
Products:     Inpp4a

Top Publications

  1. Ivetac I, Gurung R, Hakim S, Horan K, Sheffield D, Binge L, et al. Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1. EMBO Rep. 2009;10:487-93 pubmed publisher
    ..This study provides the first evidence, to our knowledge, that 4-ptase-1 controls the activation of Akt and thereby cell proliferation, survival and tumorigenesis. ..
  2. Nystuen A, Legare M, Shultz L, Frankel W. A null mutation in inositol polyphosphate 4-phosphatase type I causes selective neuronal loss in weeble mutant mice. Neuron. 2001;32:203-12 pubmed
    ..mapping was used to localize the mutation to the gene encoding inositol polyphosphate 4-phosphatase type I (Inpp4a), where a single nucleotide deletion results in a likely null allele...
  3. Ivetac I, Munday A, Kisseleva M, Zhang X, Luff S, Tiganis T, et al. The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane. Mol Biol Cell. 2005;16:2218-33 pubmed
    ..The 4-phosphatase therefore both generates and terminates phosphoinositide 3-kinase signals at distinct subcellular locations. ..
  4. Shin H, Hayashi M, Christoforidis S, Lacas Gervais S, Hoepfner S, Wenk M, et al. An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway. J Cell Biol. 2005;170:607-18 pubmed
    ..Our data provide the first evidence for a dual role of a Rab GTPase in regulating both generation and turnover of PIs via PI kinases and phosphatases to coordinate signaling functions with organelle homeostasis. ..
  5. Sachs A, David S, Haider N, Nystuen A. Patterned neuroprotection in the Inpp4a(wbl) mutant mouse cerebellum correlates with the expression of Eaat4. PLoS ONE. 2009;4:e8270 pubmed publisher
    The weeble mutant mouse has a frame shift mutation in inositol polyphosphate 4-phosphatase type I (Inpp4a)...
  6. Sasaki J, Kofuji S, Itoh R, Momiyama T, Takayama K, Murakami H, et al. The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death. Nature. 2010;465:497-501 pubmed publisher
    ..Here we show that inositol polyphosphate phosphatase 4A (INPP4A), a PtdIns(3,4)P(2) phosphatase, is a suppressor of glutamate excitotoxicity in the central nervous system...
  7. Aich J, Mabalirajan U, Ahmad T, Khanna K, Rehman R, Agrawal A, et al. Resveratrol attenuates experimental allergic asthma in mice by restoring inositol polyphosphate 4 phosphatase (INPP4A). Int Immunopharmacol. 2012;14:438-43 pubmed publisher
    ..3,4) bis-phosphate {PtdIns(3,4)P2} which is the major substrate for inositol polyphosphate 4 phosphatase (INPP4A). PtdIns(3,4)P2 in turn activates PI3K pathway and contributes to oxidative stress...
  8. Vyas P, Norris F, Joseph R, Majerus P, Orkin S. Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1. Proc Natl Acad Sci U S A. 2000;97:13696-701 pubmed
    ..Overexpression of 4-Ptase I also markedly reduces growth of NIH 3T3 fibroblasts. Taken together, these data indicate that 4-Ptase I is a regulator of cell proliferation. ..
  9. Lalonde R, Strazielle C. Behavioral effects of neonatal lesions on the cerebellar system. Int J Dev Neurosci. 2015;43:58-65 pubmed publisher
    ..during the neonatal period, including Grid2(Lc), Rora(sg), Dab1(scm), Girk2(Wv), Lmx1a(dr-sst), Myo5a(dn), Inpp4a(wbl), and Cacna1a(rol) mice as well as shaker and dystonic rats...

More Information


  1. Morioka S, Nigorikawa K, Sasaki J, Hazeki K, Kasuu Y, Sasaki T, et al. Myeloid cell-specific inositol polyphosphate-4-phosphatase type I knockout mice impair bacteria clearance in a murine peritonitis model. Innate Immun. 2016;22:444-51 pubmed publisher
    ..The present study focused on the role of inositol polyphosphate-4-phosphatase type I (Inpp4a), which dephosphorylates PtdIns(3,4)P2 to PtdIns(3)P, in bacterial infections...
  2. Segawa T, Hazeki K, Nigorikawa K, Nukuda A, Tanizawa T, Miyamoto K, et al. Inhibitory receptor Fc?RIIb mediates the effects of IgG on a phagosome acidification and a sequential dephosphorylation system comprising SHIPs and Inpp4a. Innate Immun. 2017;23:401-409 pubmed publisher
    ..The lack of a PI 4-phosphatase Inpp4a also impaired the accelerated PIs clearance...