Gene Symbol: Inhbe
Description: inhibin beta-E
Alias: inhibin beta E chain, activin beta-E chain
Species: mouse
Products:     Inhbe

Top Publications

  1. Lau A, Nishimori K, Matzuk M. Structural analysis of the mouse activin beta C gene. Biochim Biophys Acta. 1996;1307:145-8 pubmed
    ..1 kb. The liver-specific expression of activin beta C suggests an important role of dimeric activin beta C in normal liver function. These studies allow us to address the function of activin beta C in mammalian development. ..
  2. Fang J, Yin W, Smiley E, Wang S, Bonadio J. Molecular cloning of the mouse activin beta E subunit gene. Biochem Biophys Res Commun. 1996;228:669-74 pubmed
    ..Therefore, activin beta A and beta B are most related to one another, while activin beta C, beta D, and beta E may represent a subset of related sequences. ..
  3. Lau A, Kumar T, Nishimori K, Bonadio J, Matzuk M. Activin betaC and betaE genes are not essential for mouse liver growth, differentiation, and regeneration. Mol Cell Biol. 2000;20:6127-37 pubmed
    ..Our results suggest that activin betaC and betaE are not essential for either embryonic development or liver function. ..
  4. Hashimoto O, Ushiro Y, Sekiyama K, Yamaguchi O, Yoshioka K, Mutoh K, et al. Impaired growth of pancreatic exocrine cells in transgenic mice expressing human activin betaE subunit. Biochem Biophys Res Commun. 2006;341:416-24 pubmed
    ..Our findings suggest a role for activin E in regulating the proliferation of pancreatic exocrine cells. ..
  5. Sekiyama K, Hashimoto O, Ushiro Y, Adachi C, Kikusui T, Tanemura K, et al. Abnormalities in aggression and anxiety in transgenic mice overexpressing activin E. Biochem Biophys Res Commun. 2009;385:319-23 pubmed publisher
    ..This suggests that synthesis of corticotrophin-releasing hormone induced by stress was decreased in TgActbetaE mice. Taking these results together, activin E may act as a regulator of the hypothalamic-pituitary-adrenal axis. ..
  6. Lee S, Lee Y, Zimmers T, Soleimani A, Matzuk M, Tsuchida K, et al. Regulation of muscle mass by follistatin and activins. Mol Endocrinol. 2010;24:1998-2008 pubmed publisher
  7. Lu R, Matsuyama S, Nishihara M, Takahashi M. Developmental expression of activin/inhibin beta A, beta B, and alpha subunits, and activin receptor-IIB genes in preimplantation mouse embryos. Biol Reprod. 1993;49:1163-9 pubmed
    ..These results suggest that activin is physiologically involved in the process of early development of mouse embryos. ..
  8. Schmitt J, Hötten G, Jenkins N, Gilbert D, Copeland N, Pohl J, et al. Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene. Genomics. 1996;32:358-66 pubmed
    ..Ribonuclease protection analyses reveal that mouse Inhbc is predominantly expressed in adult liver. Embryonic expression is detected beginning from Day 14.5 of gestation. ..
  9. Fang J, Wang S, Smiley E, Bonadio J. Genes coding for mouse activin beta C and beta E are closely linked and exhibit a liver-specific expression pattern in adult tissues. Biochem Biophys Res Commun. 1997;231:655-61 pubmed
    ..To our knowledge, this report is the first to demonstrate close chromosomal linkage between members of the TGF-beta superfamily as well as a liver-restricted expression pattern for a TGF-beta-like gene. ..

More Information


  1. Wada W, Medina J, Kuwano H, Kojima I. Comparison of the function of the beta(C) and beta(E) subunits of activin in AML12 hepatocytes. Endocr J. 2005;52:169-75 pubmed
    ..These results indicate that the beta(C) and beta(E) subunits form homo- and heterodimers, and that the functions of the two subunits are quite different. ..
  2. Suragani R, Cadena S, Cawley S, Sako D, Mitchell D, Li R, et al. Transforming growth factor-? superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis. Nat Med. 2014;20:408-14 pubmed publisher
    ..These findings implicate transforming growth factor-? (TGF-?) superfamily signaling in erythroid maturation and identify ACE-536 as a new potential treatment for anemia, including that caused by ineffective erythropoiesis. ..