Inha

Summary

Gene Symbol: Inha
Description: inhibin alpha
Alias: AW555078, inhibin alpha chain
Species: mouse

Top Publications

  1. ncbi Characterization of mouse inhibin alpha gene and its promoter
    J G Su
    Department of Gynecology Obstetrics, Stanford University Medical Center, CA 94305 5317
    Biochem Biophys Res Commun 186:293-300. 1992
  2. ncbi Gonadal tumorigenesis in transgenic mice bearing the mouse inhibin alpha-subunit promoter/simian virus T-antigen fusion gene: characterization of ovarian tumors and establishment of gonadotropin-responsive granulosa cell lines
    K Kananen
    Department of Physiology, University of Turku, Finland
    Mol Endocrinol 9:616-27. 1995
  3. ncbi Photoperiod-dependent regulation of inhibin in Siberian hamsters: I. Ovarian inhibin production and secretion
    H A Kenny
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Endocrinol 174:71-83. 2002
  4. ncbi Activin regulates estrogen receptor gene expression in the mouse ovary
    Jingjing L Kipp
    Department of Biochemistry, Molecular Biology and Cell Biology, and Center for Reproductive Science, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 282:36755-65. 2007
  5. ncbi Expression of activins and TGF beta 1 and beta 2 RNAs in early postimplantation mouse embryos and uterine decidua
    K Manova
    Department of Cell Biology and Anatomy, Cornell University Medical College, New York, NY 10021
    Mech Dev 36:141-52. 1992
  6. ncbi Identification and mapping of six microdissected genomic DNA probes to the proximal region of mouse chromosome 1
    S M Vidal
    Department of Biochemistry, McGill University, Montreal, Canada
    Genomics 14:32-7. 1992
  7. ncbi Genetic engineering to study testicular tumorigenesis
    Wei Yan
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    APMIS 111:174-81; discussion 182-3. 2003
  8. ncbi The mouse inhibin alpha-subunit promoter directs SV40 T-antigen to Leydig cells in transgenic mice
    K Kananen
    Department of Physiology, University of Turku, Finland
    Mol Cell Endocrinol 119:135-46. 1996
  9. ncbi Gonadotropins are essential modifier factors for gonadal tumor development in inhibin-deficient mice
    T R Kumar
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 137:4210-6. 1996
  10. ncbi Stimulation of activin receptor II signaling pathways inhibits differentiation of multiple gastric epithelial lineages
    Q Li
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Endocrinol 12:181-92. 1998

Scientific Experts

  • Rebecca L Jones
  • Andrew N Shelling
  • Stephanie A Pangas
  • Mai A Sarraj
  • T R Kumar
  • K Kananen
  • David R C Natale
  • Aline Mamin
  • Martin M Matzuk
  • Ankur K Nagaraja
  • Qinglei Li
  • Brendan D Looyenga
  • Michelle Myers
  • Kate L Loveland
  • M M Matzuk
  • Kathleen H Burns
  • Catherine Itman
  • Teresa K Woodruff
  • Kelly E Mayo
  • Yogeshwar Makanji
  • Jie Zhu
  • Li Han
  • Gary D Hammer
  • Julio E Agno
  • Saneal Rajanahally
  • Roopa L Nalam
  • Claudia Andreu-Vieyra
  • Marjut Pihlajoki
  • Shao Yang Ji
  • Canjie Wu
  • Liguo Yang
  • Monica Antenos
  • S C Cipriano
  • Kailai Cai
  • Xiaolan Zhou
  • Brooke S Middlebrook
  • Paula Licona-Limón
  • Ruth M Escalona
  • David B Wilson
  • Markku Heikinheimo
  • Yujin Kim
  • Jeffrey G Reid
  • Anne E O'Connor
  • Daniel S Perrien
  • Jingjing L Kipp
  • B N Cho
  • M L McMullen
  • Amanda H Vesper
  • Jennifer Weck
  • Xuemei Wu
  • Dirk Schmidt
  • Oye Sun Seok
  • Nafis A Rahman
  • T K Woodruff
  • Lei Chen
  • Samuel C Ogbonna
  • Brian M Gummow
  • Wei Yan
  • Alex J Fulcher
  • D Malo
  • Jacinta Martin
  • Hoey Goh
  • Queenie Lee
  • James C G Doery
  • Sarah C Moody
  • Mark P Hedger
  • Sarah Eyre
  • Amanda Bielanowicz
  • H A Kenny
  • Jacqueline F Schmitt
  • Neena B Schwartz
  • Winifred P S Wong
  • Rama Mishra
  • Chris Holmquist
  • Laura Sullivan
  • Hasan Riaz
  • Michael D Brooks
  • Antti Kyrönlahti
  • Jianguo Chen
  • Michael Shoykhet
  • Nadera Mansouri-Attia
  • Xi xia Li
  • Jun Zhang
  • Liya Bai
  • Theresa Hiller
  • Erica L Schoeller
  • Fei Gao
  • Chun Sheng Han
  • Jian Xiu Hao
  • Lei Li

Detail Information

Publications95

  1. ncbi Characterization of mouse inhibin alpha gene and its promoter
    J G Su
    Department of Gynecology Obstetrics, Stanford University Medical Center, CA 94305 5317
    Biochem Biophys Res Commun 186:293-300. 1992
    ..The mouse inhibin alpha genomic clone should be useful for analysis of hormonal control of inhibin alpha transcription and the generation of mice with targeted deletion of this gene...
  2. ncbi Gonadal tumorigenesis in transgenic mice bearing the mouse inhibin alpha-subunit promoter/simian virus T-antigen fusion gene: characterization of ovarian tumors and establishment of gonadotropin-responsive granulosa cell lines
    K Kananen
    Department of Physiology, University of Turku, Finland
    Mol Endocrinol 9:616-27. 1995
    ....
  3. ncbi Photoperiod-dependent regulation of inhibin in Siberian hamsters: I. Ovarian inhibin production and secretion
    H A Kenny
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Endocrinol 174:71-83. 2002
    ..In addition, dimeric inhibin, as well as inhibin alpha-, beta(A)-, and beta(B)-subunit protein levels were higher in the LD than in the SD hamster ovaries...
  4. ncbi Activin regulates estrogen receptor gene expression in the mouse ovary
    Jingjing L Kipp
    Department of Biochemistry, Molecular Biology and Cell Biology, and Center for Reproductive Science, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 282:36755-65. 2007
    ..Therefore, this study reveals an important role for activin in inducing the expression of ERs in the mouse ovary and suggests important interplay between activin and estrogen signaling...
  5. ncbi Expression of activins and TGF beta 1 and beta 2 RNAs in early postimplantation mouse embryos and uterine decidua
    K Manova
    Department of Cell Biology and Anatomy, Cornell University Medical College, New York, NY 10021
    Mech Dev 36:141-52. 1992
    ..TGF beta 1 is expressed in the secondary decidual zone and in developing endothelial cells in the decidua and embryo. TGF beta 2 is expressed in the mesometrial decidua at 6 1/2 days and in the midline of the cranial neural plate...
  6. ncbi Identification and mapping of six microdissected genomic DNA probes to the proximal region of mouse chromosome 1
    S M Vidal
    Department of Biochemistry, McGill University, Montreal, Canada
    Genomics 14:32-7. 1992
    ..1 cM-Col3a1-8.8 cM-Len-2-2.6 cM-lambda Mm1C-163-1.6 cM-Fn-1-1.6 cM-Tp-1-0.8 cM-lambda Mm1C-165/Vil-0.4 cM-Inha-2.8 cM-lambda Mm1C-153-2.4 cM-lambda Mm1C-156-1.2 cM-Pax-3-5.6 cM-Akp-3-0.8 cM-Acrg-2.0 cM-Sag-0.5 cM-Col6a3-1...
  7. ncbi Genetic engineering to study testicular tumorigenesis
    Wei Yan
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    APMIS 111:174-81; discussion 182-3. 2003
    ..Genetic engineering in mouse models provides a powerful tool to study the mechanisms of testicular tumorigenesis and define the important genetic modifiers in vivo...
  8. ncbi The mouse inhibin alpha-subunit promoter directs SV40 T-antigen to Leydig cells in transgenic mice
    K Kananen
    Department of Physiology, University of Turku, Finland
    Mol Cell Endocrinol 119:135-46. 1996
    ..This gonadal tumor model is valuable for further studies on endocrine functions of Leydig cells and their tumorigenesis in vivo and in vitro...
  9. ncbi Gonadotropins are essential modifier factors for gonadal tumor development in inhibin-deficient mice
    T R Kumar
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 137:4210-6. 1996
    ..These results demonstrate that gonadotropins are essential modifier factors for tumor development in inhibin-deficient mice...
  10. ncbi Stimulation of activin receptor II signaling pathways inhibits differentiation of multiple gastric epithelial lineages
    Q Li
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Endocrinol 12:181-92. 1998
    ..Mice homozygous for a null allele of the alpha-inhibin gene (inha[m1/m1]) develop gonadal sex cord stromal tumors that secrete large amounts of activins A and B...
  11. ncbi Transgenic models to study gonadotropin function: the role of follicle-stimulating hormone in gonadal growth and tumorigenesis
    T R Kumar
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 13:851-65. 1999
    ..However, these results suggest FSH is an important trophic modifier factor for gonadal tumorigenesis in inhibin-deficient mice...
  12. ncbi Regulable expression of inhibin A in wild-type and inhibin alpha null mice
    T M Pierson
    Department of Molecular and Cellular Biology, Baylor College of Medicine Houston, Texas 77030, USA
    Mol Endocrinol 14:1075-85. 2000
    ..In addition, these studies are the first example of an inducible system being used to prevent a lethal knockout phenotype in an animal model...
  13. pmc Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice
    M M Matzuk
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030
    Proc Natl Acad Sci U S A 91:8817-21. 1994
    ..However, these gonadectomized, inhibin-deficient mice eventually develop adrenal cortical sex steroidogenic tumors with nearly 100% penetrance, demonstrating that inhibin is also a tumor suppressor for the adrenal gland...
  14. ncbi Overexpression of activin-beta A subunit mRNA is associated with decreased activin type II receptor mRNA levels in the testes of alpha-inhibin deficient mice
    V L Trudeau
    Neurosciences Unit, University of Ottawa, Loeb Medical Research Institute, ON, Canada
    Biochem Biophys Res Commun 203:105-12. 1994
    ..These results demonstrate that increased expression of activin is accompanied by a tissue specific reduction in the expression of its own receptor mRNA in vivo...
  15. ncbi Functional analysis of activins during mammalian development
    M M Matzuk
    Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030
    Nature 374:354-6. 1995
    ..In contrast to observations in lower vertebrates, zygotic expression of activins is not essential for mesoderm formation in mice...
  16. ncbi Inhibin and p27 interact to regulate gonadal tumorigenesis
    S C Cipriano
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Endocrinol 15:985-96. 2001
    ..we analyzed the regulation of cell cycle proteins in gonadal tumors derived from inhibin alpha knockout mice (Inha(-/-))...
  17. ncbi Hypermethylation of the inhibin alpha-subunit gene in prostate carcinoma
    Jacqueline F Schmitt
    Monash Institute of Reproduction and Development, Monash University, Clayton, Victoria 3168, Australia
    Mol Endocrinol 16:213-20. 2002
    ..These data provide the first demonstration that promoter hypermethylation and LOH are associated with the inhibin alpha-subunit gene and gene locus in prostate cancer...
  18. ncbi Convergence of Wnt signaling and steroidogenic factor-1 (SF-1) on transcription of the rat inhibin alpha gene
    Brian M Gummow
    Department of Molecular and Integrative Physiology, Division of Endocrinology and Metabolism, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 278:26572-9. 2003
    ..These data support the recent observation that beta-catenin can participate in nuclear receptor-mediated transcriptional activation and extend the findings to the monomer binding class of orphan nuclear receptors...
  19. ncbi Sexually dimorphic roles of steroid hormone receptor signaling in gonadal tumorigenesis
    Kathleen H Burns
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 17:2039-52. 2003
    ....
  20. ncbi Regulation of FSHbeta and GnRH receptor gene expression in activin receptor II knockout male mice
    T Rajendra Kumar
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Endocrinol 212:19-27. 2003
    ..Our studies confirm the importance of using in vivo genetic models for studying regulation of the hypothalamic-pituitary-gonadal axis...
  21. ncbi Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice
    M M Matzuk
    Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030
    Nature 360:313-9. 1992
    ..Inhibin is thus a critical negative regulator of gonadal stromal cell proliferation and the first secreted protein identified to have tumour-suppressor activity...
  22. ncbi Developmental changes in inhibin-alpha gene expression in the mouse testis
    Oye Sun Seok
    Department of Life Science, The Catholic University of Korea, Bucheon 421 743, Korea
    Mol Cells 17:67-72. 2004
    ..Taken together, our data reveal that activation of inhibin-alpha gene during testis development correlated with the histological maturation of the testis and the acquisition of fertility in male mice...
  23. ncbi Effects of granulosa cell-specific deletion of Rb in Inha-alpha null female mice
    Claudia Andreu-Vieyra
    Baylor College of Medicine, Department of Pathology, One Baylor Plaza, Smith Building S217, Houston, Texas 77030, USA
    Endocrinology 148:3837-49. 2007
    ..We have previously shown that female mice lacking inhibins (Inha(-/-)) develop granulosa cell tumors and that concurrent loss of p27 accelerates tumor development...
  24. ncbi SMAD3 regulates gonadal tumorigenesis
    Qinglei Li
    Department of Pathology, One Baylor Plaza, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 21:2472-86. 2007
    ..Moreover, the activin-induced cachexia syndrome is potentially mediated through both SMAD2 and SMAD3 or only through SMAD2 in the liver and stomach. These studies identify sexually dimorphic functions of SMAD3 in gonadal tumorigenesis...
  25. ncbi Genetic removal of Smad3 from inhibin-null mice attenuates tumor progression by uncoupling extracellular mitogenic signals from the cell cycle machinery
    Brendan D Looyenga
    Cellular and Molecular Biology Graduate Program, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Mol Endocrinol 21:2440-57. 2007
    ..Unopposed activin signaling in inhibin-null (Inha-/-) mice causes the formation of granulosa cell tumors in the gonads and adrenal cortex, which depend upon FSH for ..
  26. ncbi Prevention of cachexia-like syndrome development and reduction of tumor progression in inhibin-deficient mice following administration of a chimeric activin receptor type II-murine Fc protein
    Qinglei Li
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Hum Reprod 13:675-83. 2007
    ..The current findings have potential implications in the design of new drugs or strategies for the treatment of ovarian and testicular tumors and other conditions where ligands signal through ActRII...
  27. pmc Luteinizing hormone promotes gonadal tumorigenesis in inhibin-deficient mice
    Ankur K Nagaraja
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell Endocrinol 294:19-28. 2008
    ..Mice homozygous for a targeted deletion of the inhibin alpha subunit gene (Inha(-/-)) develop sex cord-stromal tumors in a gonadotropin-dependent manner...
  28. pmc Action mechanism of inhibin α-subunit on the development of Sertoli cells and first wave of spermatogenesis in mice
    Kailai Cai
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Education Ministry of China, Huazhong Agricultural University, Wuhan, People s Republic of China
    PLoS ONE 6:e25585. 2011
    ..we partially silenced both the transcription and translation of the gene for the α-subunit of inhibin, Inha, using recombinant pshRNA vectors developed with RNAi-Ready pSIREN-RetroQ-ZsGreen Vector (Clontech Laboratories, ..
  29. pmc Developmentally regulated SMAD2 and SMAD3 utilization directs activin signaling outcomes
    Catherine Itman
    Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia
    Dev Dyn 238:1688-700. 2009
    ..In transgenic mice with altered activin bioactivity that display fertility phenotypes, Gja1 and Serpina5 are significantly altered. Thus, differential SMAD utilization in response to activin features during Sertoli cell maturation...
  30. pmc Inhibin-A antagonizes TGFbeta2 signaling by down-regulating cell surface expression of the TGFbeta coreceptor betaglycan
    Brendan D Looyenga
    Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Mol Endocrinol 24:608-20. 2010
    ..Inhibin-null (Inha-/-) mice develop both gonadal and adrenocortical tumors, the latter of which depend upon gonadectomy for initiation...
  31. ncbi Transgenic models to study the roles of inhibins and activins in reproduction, oncogenesis, and development
    M M Matzuk
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Recent Prog Horm Res 51:123-54; discussion 155-7. 1996
    ....
  32. ncbi Cyclin D2 and p27 are tissue-specific regulators of tumorigenesis in inhibin alpha knockout mice
    Kathleen H Burns
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 17:2053-69. 2003
    ....
  33. ncbi Follistatin is a modulator of gonadal tumor progression and the activin-induced wasting syndrome in inhibin-deficient mice
    S C Cipriano
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 141:2319-27. 2000
    ..Thus, follistatin can act as a modulator of tumor growth and the activin-induced cancer cachexia-like syndrome in inhibin-deficient mice...
  34. ncbi Gonadal pathologies in transgenic mice expressing the rat inhibin alpha-subunit
    M L McMullen
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
    Endocrinology 142:5005-14. 2001
    ..The antagonist studies are consistent with a direct ovarian effect of the alpha-subunit transgene product mediated by changes in the inhibin-to-activin ratio in these mice...
  35. ncbi Reproductive deficiencies in transgenic mice expressing the rat inhibin alpha-subunit gene
    B N Cho
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
    Endocrinology 142:4994-5004. 2001
    ....
  36. doi Murine Inhibin α-Subunit Haploinsufficiency Causes Transient Abnormalities in Prepubertal Testis Development Followed by Adult Testicular Decline
    Catherine Itman
    Priority Research Centres for Reproductive Science C I, A B, J M, S E and Chemical Biology C I, School of Environmental and Life Sciences, Faculty of Science and Information Technology, University of Newcastle, Callaghan, New South Wales 2308, Australia Departments of Anatomy and Developmental Biology H G, Q L, K L L and Biochemistry and Molecular Biology S C M, K L L and Monash Micro Imaging A J F, Monash University, Clayton, Victoria 3800, Australia and Faculty of Medicine, Nursing, and Health Sciences J C G D, Department of Medicine, Monash Medical Centre, and Monash Institute of Medical Research Prince Henry s Institute of Medical Research M P H, Clayton, Victoria 3168, Australia
    Endocrinology 156:2254-68. 2015
    ..Inhibins are potent activin inhibitors; mice lacking the inhibin-α gene (Inha-/- mice) cannot make inhibin and consequently have highly elevated activin and FSH serum concentrations and ..
  37. ncbi Role of prophet of Pit1 (PROP1) in gonadotrope differentiation and puberty
    Amanda H Vesper
    Department of Human Genetics, University of Michigan, Ann Arbor, 48109 0618, USA
    Endocrinology 147:1654-63. 2006
    ..We hypothesize that variation in PROP1 expression could affect the growth spurt and the onset of puberty in humans...
  38. ncbi Molecular characterization of a deletion encompassing the splotch mutation on mouse chromosome 1
    D J Epstein
    Department of Biology, McGill University, Montreal, Quebec, Canada
    Genomics 10:89-93. 1991
    ..Among nine markers tested in the heterozygote Spr/+mouse, we have identified four genes, Vil, Des, Inha, and Akp-3, which map within the Spr deletion...
  39. ncbi Cd28 and Ctla-4, two related members of the Ig supergene family, are tightly linked on proximal mouse chromosome 1
    T A Howard
    Department of Medicine, Duke University Medical Center, Durham, NC 27705
    Immunogenetics 33:74-6. 1991
  40. pmc Genetic evidence that SMAD2 is not required for gonadal tumor development in inhibin-deficient mice
    Saneal Rajanahally
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
    Reprod Biol Endocrinol 8:69. 2010
    ....
  41. ncbi Activin disrupts epithelial branching morphogenesis in developing glandular organs of the mouse
    O Ritvos
    Department of Bacteriology and Immunology, University of Helsinki, Finland
    Mech Dev 50:229-45. 1995
    ..Our results are suggestive of a potential role for the activin-follistatin system as an intrinsic regulator of epithelial branching morphogenesis during mammalian organogenesis...
  42. ncbi Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins
    A Feijen
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht
    Development 120:3621-37. 1994
    ..Taken together, the present data suggest that follistatin, but not one of the known activin forms (A,B,AB) is involved in early postimplantation development.(ABSTRACT TRUNCATED AT 400 WORDS)..
  43. ncbi Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development
    R N Freiman
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720 3204, USA
    Science 293:2084-7. 2001
    ....
  44. pmc Defective gonadotropin-dependent ovarian folliculogenesis and granulosa cell gene expression in inhibin-deficient mice
    Ankur K Nagaraja
    Department of Pathology and Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Endocrinology 151:4994-5006. 2010
    Inhibin-α knockout (Inha-/-) female mice develop sex cord-stromal ovarian cancer with complete penetrance and previous studies demonstrate that the pituitary gonadotropins (FSH and LH) are influential modifiers of granulosa cell tumor ..
  45. pmc GDF9 modulates the reproductive and tumor phenotype of female inha-null mice
    Michelle Myers
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Biol Reprod 88:86. 2013
    ..In the absence of inhibin in prepubertal mice (Inha(-/-)), there are marked alterations in preantral follicle growth, but no evidence of ovarian tumors characteristic ..
  46. ncbi Role of androgens in testicular tumor development in inhibin-deficient mice
    W Shou
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 138:5000-5. 1997
    ..These results suggest that androgens are not required for testicular tumor development in inhibin-deficient mice, but may play a regulatory role in testicular tumor progression...
  47. pmc Inhibin at 90: from discovery to clinical application, a historical review
    Yogeshwar Makanji
    Department of Obstetrics and Gynecology Y M, J Z, C H, W P S W, T K W, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60610 Center for Molecular Innovation and Drug Discovery R M, C H, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208 and Department of Molecular Biosciences N B S, K E M, T K W, Center for Reproductive Science, Northwestern University, Evanston, Illinois 60208
    Endocr Rev 35:747-94. 2014
    ....
  48. pmc Characterization of the mechanism of inhibin α-subunit gene in mouse anterior pituitary cells by RNA interference
    Li Han
    State Key Laboratory of Agricultural Microbiology, Laboratory of Animal Infectious Diseases, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China
    PLoS ONE 8:e74596. 2013
    ..In this study, Inhibin α-subunit [Inha] gene was knocked down successfully in mice primary anterior pituitary cells at both transcriptional and ..
  49. pmc Regulation of the ovarian reserve by members of the transforming growth factor beta family
    Stephanie A Pangas
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Reprod Dev 79:666-79. 2012
    ....
  50. pmc Expression of inhibin-alpha is regulated synergistically by Wilms' tumor gene 1 (Wt1) and steroidogenic factor-1 (Sf1) in sertoli cells
    Shao Yang Ji
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 8:e53140. 2013
    ....
  51. pmc Conditional mutagenesis of Gata6 in SF1-positive cells causes gonadal-like differentiation in the adrenal cortex of mice
    Marjut Pihlajoki
    Department of Pediatrics, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Endocrinology 154:1754-67. 2013
    ..Our findings offer genetic proof that GATA6 regulates the differentiation of steroidogenic progenitors into adrenocortical cells...
  52. doi Mutations in inhibin and activin genes associated with human disease
    Andrew N Shelling
    Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Mol Cell Endocrinol 359:113-20. 2012
    ....
  53. pmc Inhibin α-subunit N terminus interacts with activin type IB receptor to disrupt activin signaling
    Jie Zhu
    Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 287:8060-70. 2012
    ....
  54. doi Activin promotes differentiation of cultured mouse trophoblast stem cells towards a labyrinth cell fate
    David R C Natale
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, The University of Calgary, Calgary, AB, Canada T2N 4N1
    Dev Biol 335:120-31. 2009
    ..These results suggest that Activin rather than TGF-beta (or Nodal) acts directly on TS cells influencing both TS cell maintenance and cell fate, depending on whether the cells are also exposed to FGF4...
  55. ncbi Complex expression patterns support potential roles for maternally derived activins in the establishment of pregnancy in mouse
    Rebecca L Jones
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Reproduction 132:799-810. 2006
    ..These data are consistent with a role for maternally derived activins in the support of the pre-implantation embryo, and during gastrulation and embryogenesis...
  56. ncbi Inhibin A is an endocrine stimulator of bone mass and strength
    Daniel S Perrien
    Department of Physiology and Biophysics, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, 4301 West Markham, Slot 505, Little Rock, Arkansas 72205, USA
    Endocrinology 148:1654-65. 2007
    ..demonstration that inhibins acutely regulate bone cell differentiation in vitro led us to test whether inhibin A (InhA) regulates bone mass in vivo...
  57. ncbi Implication of inhibin and related proteins in fetal development
    G Jenkin
    Department of Physiology, Monash University, Clayton, Vic, Australia
    Reprod Fertil Dev 7:323-31. 1995
    ....
  58. ncbi Mapping of genes for inhibin subunits alpha, beta A, and beta B on human and mouse chromosomes and studies of jsd mice
    D E Barton
    Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510
    Genomics 5:91-9. 1989
    ..The possibility that the mutation in jsd involves the INH alpha or INH beta B gene was investigated by Southern blotting of DNA from jsd/jsd mice, and no major deletions or rearrangements were detected...
  59. pmc Mouse let-7 miRNA populations exhibit RNA editing that is constrained in the 5'-seed/ cleavage/anchor regions and stabilize predicted mmu-let-7a:mRNA duplexes
    Jeffrey G Reid
    Department of Chemistry, University of Houston, Houston, Texas 77204, USA
    Genome Res 18:1571-81. 2008
    ..U-to-G results in a significant increase in stability of down-regulated let-7a targets in inhibin-deficient mice (Inha-/-). An excess of U-insertions (14.8%) over U-deletions (1...
  60. ncbi Genetic mapping of the Gs-alpha subunit gene (GNAS1) to the distal long arm of chromosome 20 using a polymorphism detected by denaturing gradient gel electrophoresis
    P V Gejman
    Clinical Neurogenetics Branch, NIMH, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 9:782-3. 1991
  61. pmc Activins and inhibins: novel regulators of thymocyte development
    Paula Licona-Limón
    Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Circuito Escolar s n, Mexico, DF 04510, Mexico
    Biochem Biophys Res Commun 381:229-35. 2009
    ....
  62. doi Reducing betaglycan expression by RNA interference (RNAi) attenuates inhibin bioactivity in LbetaT2 gonadotropes
    Ruth M Escalona
    Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
    Mol Cell Endocrinol 307:149-56. 2009
    ..045, respectively) in cells co-transfected with betaglycan siRNAs. These results demonstrated that endocrine effects of inhibin as a negative feedback controller of FSH production in gonadotropes are dependent on betaglycan expression...
  63. pmc Loss of inhibin alpha uncouples oocyte-granulosa cell dynamics and disrupts postnatal folliculogenesis
    Michelle Myers
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dev Biol 334:458-67. 2009
    Targeted disruption of the inhibin alpha gene (Inha(-)(/)(-)) in mice results in an ovarian phenotype of granulosa cell tumors that renders the animals infertile. Little is known about the reproductive defects prior to tumor development...
  64. pmc Absence of inhibin alpha and retinoblastoma protein leads to early sertoli cell dysfunction
    Roopa L Nalam
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 5:e11797. 2010
    ..We hypothesized that RB is an important mediator of Sertoli cell tumorigenesis in inhibin alpha knockout (Inha KO) mice...
  65. doi Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival
    Xiaolan Zhou
    Departments of Metabolic Disorders and Protein Science, Amgen Research, Thousand Oaks, CA 91320, USA
    Cell 142:531-43. 2010
    ..Thus ActRIIB antagonism is a promising new approach for treating cancer cachexia, whose inhibition per se prolongs survival...
  66. pmc Role of PCSK5 expression in mouse ovarian follicle development: identification of the inhibin α- and β-subunits as candidate substrates
    Monica Antenos
    Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    PLoS ONE 6:e17348. 2011
    ..Our data support the role of proconvertase PCSK5 in the processing of ovarian inhibin subunits during folliculogenesis and suggest that this enzyme may be an important regulator of inhibin and activin bioavailability...
  67. ncbi Genetic mapping and assignment of a long-range repeat cluster to band D of chromosome 1 in Mus musculus and M. spretus
    W Traut
    Medizinische Universitat zu Lubeck, Institut fur Biologie, FRG
    Cytogenet Cell Genet 60:128-30. 1992
    ..3 +/- 2.1 cM distal to the Inha locus and the same distance proximal to the Bcl-2 locus...
  68. ncbi Switching of NR5A proteins associated with the inhibin alpha-subunit gene promoter after activation of the gene in granulosa cells
    Jennifer Weck
    Department of Biochemistry, Molecular Biology, and Cell Biology, and Center for Reproductive Science, 2205 Tech Drive, Northwestern University, Evanston, Illinois 60208, USA
    Mol Endocrinol 20:1090-103. 2006
    ....
  69. ncbi Strong induction of activin expression after injury suggests an important role of activin in wound repair
    G Hübner
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Dev Biol 173:490-8. 1996
    ..Our data provide evidence for a novel function of activin and indicate that--besides TGF beta s themselves--other members of this superfamily might also play an important role in tissue repair...
  70. ncbi [Family of inhibins and activins: from endocrine to paracrine action]
    P Pigny
    Laboratoire d Endocrinologie, Clinique Marc Linquette, CHRU de Lille
    Ann Endocrinol (Paris) 57:385-94. 1996
    ..Inhibins and activins seem to be involved in the regulation of spermatogenesis in males and in follicular maturation in females. Potential involvements of inhibins and activins in the pathophysiology of reproduction are discussed...
  71. ncbi Changes in the immunoreactivity for inhibin in mouse retina during development of photoreceptor cells
    S Y Ying
    Department of Cell and Neurobiology, University of Southern California Medical School, Los Angeles 90033, USA
    Dev Neurosci 19:184-8. 1997
    ..These findings suggest that inhibin may play a role in the development of the eye cup and the retina...
  72. ncbi Identification of an inhibin receptor in gonadal tumors from inhibin alpha-subunit knockout mice
    L B Draper
    Department of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 273:398-403. 1998
    ..Four proteins were eluted from the column that bind iodinated inhibin but not iodinated activin. These data suggest that inhibin-specific membrane-associated proteins (receptors) exist...
  73. ncbi Molecular cloning of DNA for inhibin alpha-subunit from equine ovary
    K Yamanouchi
    Department of Veterinary Physiology, Veterinary Medical Science, University of Tokyo, Japan
    J Vet Med Sci 57:905-9. 1995
    ..Northern blot analysis revealed that a single major band at 1.5 kb was present in the RNA samples both from equine follicles and testes...
  74. ncbi Expression and function of activin beta A during mouse cardiac cushion tissue formation
    C S Moore
    Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Dev Dyn 212:548-62. 1998
    ....
  75. ncbi Transgenic mouse models for gonadal tumorigenesis
    N A Rahman
    Department of Physiology, University of Turku, Kiinamyllynkatu, Finland
    Mol Cell Endocrinol 145:167-74. 1998
    ..Besides studies of formation, regulation and therapy of the tumors in vivo, immortalized cell lines derived from them provide models for studies of gonadal somatic cell functions in vitro...
  76. ncbi Activins are expressed in preimplantation mouse embryos and in ES and EC cells and are regulated on their differentiation
    R M Albano
    Laboratory of Developmental Biology, National Institute for Medical Research, Mill Hill, London, UK
    Development 117:711-23. 1993
    ..F9 EC cells express only activin beta B, together with low levels of the inhibin alpha chain. When ES and EC cells are induced to differentiate, levels of activin fall dramatically...
  77. ncbi High-resolution linkage map in the vicinity of the host resistance locus Bcg
    D Malo
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Genomics 16:655-63. 1993
    ..have developed eight new highly polymorphic markers (simple sequence repeats) corresponding to cloned genes (Vil, Inha, Des), microdissected chromosome 1 anonymous probes (lambda Mm1C136, lambda Mm1C163, lambda Mm1C165), or novel DNA ..
  78. ncbi Inhibin: a candidate gene for premature ovarian failure
    A N Shelling
    Research Centre in Reproductive Medicine, Department of Obstetrics and Gynaecology, National Women s Hospital, Auckland, New Zealand
    Hum Reprod 15:2644-9. 2000
    ..7%) (Fisher's exact test, P < 0.035). Further analysis of the inhibin gene in POF patients and matched controls will determine its role in the aetiology of POF...
  79. ncbi Gonadotropin-dependent and gonadotropin-independent development of inhibin subunit messenger ribonucleic acid levels in the mouse ovary
    P J O'Shaughnessy
    Department of Veterinary Physiology, University of Glasgow Veterinary School, United Kingdom
    Endocrinology 136:2060-5. 1995
    ..The inhibin alpha-subunit, in contrast, is expressed at a high level during development independent of gonadotropin stimulation...
  80. ncbi Comparative mapping of the gene coding for inhibin-alpha (INHA) to chromosome 2 in sheep and cattle
    R M Brunner
    Forschungsbereich Molekularbiologie, Institut fur die Biologie landwirtschaftlicher Nutztiere, Dummerstorf, Germany
    Mamm Genome 6:309. 1995
  81. ncbi Mapping of the gene encoding for inhibin-beta A (INHBA) to chromosome 4q26 in sheep
    R M Brunner
    Forschungsbereich Molekularbiologie, Institut fur die Biologie landwirtschaftlicher Nutztiere, Dummerstorf, Germany
    Mamm Genome 6:308-9. 1995
  82. ncbi Activin inhibits but inhibin activates mouse placental lactogen-II secretion
    M Yamaguchi
    Department of Obstetrics and Gynecology, Osaka University Medical School, Japan
    J Endocrinol 146:469-74. 1995
    ..These findings suggest that activin and inhibin regulate mPL-II secretion and suggest the presence of an autocrine or paracrine regulation of mPL-II secretion in mouse placenta by activin and inhibin after mid-pregnancy in vivo...
  83. ncbi Expression of inhibin subunits and follistatin during postimplantation mouse development: decidual expression of activin and expression of follistatin in primitive streak, somites and hindbrain
    R M Albano
    Laboratory of Developmental Biology, National Institute for Medical Research, London, UK
    Development 120:803-13. 1994
    ..Follistatin is a single-chain polypeptide which inhibits activin function. Expression of the inhibin alpha chain could not be detected in embryonic or extraembryonic tissues at any of the stages studied (5.5 to 8...
  84. ncbi Expression profiling analyses of gonadotropin responses and tumor development in the absence of inhibins
    Kathleen H Burns
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 144:4492-507. 2003
    ..These 10 genes have expression patterns and postulated functions suggesting that they mediate important processes in the physiology and pathology of ovarian and adrenal tissue...
  85. ncbi Adrenocortical tumorigenesis in transgenic mice expressing the inhibin alpha-subunit promoter/simian virus 40 T-antigen transgene: relationship between ectopic expression of luteinizing hormone receptor and transcription factor GATA-4
    Nafis A Rahman
    Department of Physiology, University of Turku, 20520 Turku, Finland
    Mol Endocrinol 18:2553-69. 2004
    ..There is apparently a positive and reciprocal feed-forward amplification link between LHR and GATA-4 expression. This mechanism gradually and in synergy with Tag expression leads to formation of the LH-dependent adrenocortical tumors...
  86. ncbi Structure of two human ovarian inhibins
    A J Mason
    Biochem Biophys Res Commun 135:957-64. 1986
    ....
  87. ncbi Interrelationship of growth differentiation factor 9 and inhibin in early folliculogenesis and ovarian tumorigenesis in mice
    Xuemei Wu
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 18:1509-19. 2004
    ..Our findings on these Inha Gdf9 double-mutant mice are as follows: 1)...
  88. ncbi A high-resolution linkage map of the tight skin 2 (Tsk2) locus: a mouse model for scleroderma (SSc) and other cutaneous fibrotic diseases
    P J Christner
    Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Mamm Genome 7:610-2. 1996
  89. ncbi Origin and identity of adrenocortical tumors in inhibin knockout mice: implications for cellular plasticity in the adrenal cortex
    Brendan D Looyenga
    Cellular and Molecular Biology Graduate Program, Division of Endocrinology, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Mol Endocrinol 20:2848-63. 2006
    Inhibin knockout (Inha-/-) mice develop gonadal sex-cord tumors and--when gonadectomized--adrenocortical tumors...
  90. ncbi Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3
    D J Epstein
    Department of Biology, McGill University, Montreal, Canada
    Cell 67:767-74. 1991
    ..We mapped the paired box gene Pax-3 within the Inha to Akp3 interval, near or at the Sp locus on chromosome 1, and found Pax-3 to be deleted in heterozygous Spr/+ mice...
  91. ncbi The host resistance locus Bcg is tightly linked to a group of cytoskeleton-associated protein genes that include villin and desmin
    D Malo
    Department of Biochemistry, McGill University, Montreal, Canada
    Genomics 10:356-64. 1991
    ..strains to position four new marker genes, transition protein 1 (Tp-1), desmin (Des), the alpha subunit of inhibin (Inha), and retinal S-antigen (Sag), in the vicinity of the host resistance locus, Bcg...
  92. ncbi The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance
    Dirk Schmidt
    Developmental Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Development 131:933-42. 2004
    ..In addition to providing a molecular mechanism for premature ovarian failure in BPES, these results suggest that granulosa cell function is not only crucial for oocyte growth but also to maintain follicular quiescence in vivo...
  93. ncbi Physical delineation of the minimal chromosomal segment encompassing the murine host resistance locus Bcg
    D Malo
    Department of Biochemistry, McGill University, Montreal, Canada
    Genomics 17:667-75. 1993
    ..1 cM)-lambda Mm1C165/Vil/Bcg-(0.2 cM)-lambda Mm1C136-(0.3 cM)-Des-(0.1 cM)-Inha. In an effort to clone genomic sequences overlapping Bcg, we have used pulsed-field gel electrophoresis (PFGE) and ..
  94. pmc The expression and localization of inhibin isotypes in mouse testis during postnatal development
    Yujin Kim
    Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Center, Chonnam National University, Gwangju 500 757, Korea
    J Vet Sci 9:345-9. 2008
    ..We conclude that the expression of inhibin isotypes increases progressively in the testis of mice with increasing postnatal age, suggesting that inhibin is associated with a negative feedback signal for FSH in testicular maturation...
  95. ncbi Haplotype mapping and sequence analysis of the mouse Nramp gene predict susceptibility to infection with intracellular parasites
    D Malo
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    Genomics 23:51-61. 1994
    ....