Gene Symbol: importin 13
Description: importin 13
Alias: Imp13, Kap13, Ranbp13, importin-13
Kahle J, Baake M, Doenecke D, Albig W. Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13. Mol Cell Biol. 2005;25:5339-54 pubmed
..by an importin beta-mediated pathway, the NF-YB/NF-YC heterodimer is translocated into the nucleus in an importin 13-dependent manner...
Yamaguchi Y, Tanaka S, Yasuda K, Matsui Y, Tam P. Stage-specific Importin13 activity influences meiosis of germ cells in the mouse. Dev Biol. 2006;297:350-60 pubmed
..Our findings strongly implicate a stage-specific role of IPO13 in nuclear-cytoplasmic translocation of cargoes that accompanies meiotic differentiation of the mouse germ cells. ..
Lin W, Ye W, Cai L, Meng X, Ke G, Huang C, et al
. The roles of multiple importins for nuclear import of murine aristaless-related homeobox protein. J Biol Chem. 2009;284:20428-39 pubmed publisher
..nuclear import assay, we show that import of Arx via NLS2 can be mediated by importin beta1, importin 9, or importin 13, with binding being strongest to importin beta1. All binding is sensitive to RanGTP...
You P, Peng Z, Wang Y, Tao T. Expression and subcellular distribution of imp13 are regulated in brain development. In Vitro Cell Dev Biol Anim. 2013;49:346-53 pubmed publisher
b>Imp13, a member of importin-? superfamily, is found to be one of two bidirectional transport receptors in many nuclear transport activities in mammals...
Cui C, Kunisada M, Esibizione D, Grivennikov S, Piao Y, Nedospasov S, et al
. Lymphotoxin-beta regulates periderm differentiation during embryonic skin development. Hum Mol Genet. 2007;16:2583-90 pubmed
..Overall, LTbeta shows a primary early function in periderm differentiation, with later transient effects on epidermal and hair follicle differentiation. ..
Fatima S, Wagstaff K, Lieu K, Davies R, Tanaka S, Yamaguchi Y, et al
. Interactome of the inhibitory isoform of the nuclear transporter Importin 13. Biochim Biophys Acta Mol Cell Res. 2017;1864:546-561 pubmed publisher
b>Importin 13 (Imp13) is a bidirectional nuclear transporter of proteins involved in a range of important cellular processes, with an N-terminally truncated inhibitory isoform (tImp13) specifically expressed in testis...