Gene Symbol: Immp2l
Description: IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
Alias: AI853880, IMP2, Tg(HLA-A/H2-D)2Enge, mitochondrial inner membrane protease subunit 2, AAD mice, IMP2-like protein
Species: mouse
Products:     Immp2l

Top Publications

  1. Petek E, Windpassinger C, Vincent J, Cheung J, Boright A, Scherer S, et al. Disruption of a novel gene (IMMP2L) by a breakpoint in 7q31 associated with Tourette syndrome. Am J Hum Genet. 2001;68:848-58 pubmed
    ..The DNA sequence of this fragment revealed two different breaks in 7q31 within a region of approximately 500 kb. IMMP2L, a novel gene coding for the apparent human homologue of the yeast mitochondrial inner membrane peptidase subunit ..
  2. Lu B, Poirier C, Gaspar T, Gratzke C, Harrison W, Busija D, et al. A mutation in the inner mitochondrial membrane peptidase 2-like gene (Immp2l) affects mitochondrial function and impairs fertility in mice. Biol Reprod. 2008;78:601-10 pubmed
    ..a mouse mutant, Immp2lTg(Tyr)979Ove, with a mutation in the inner mitochondrial membrane peptidase 2-like (Immp2l) gene...
  3. Eyles J, Puaux A, Wang X, Toh B, Prakash C, Hong M, et al. Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma. J Clin Invest. 2010;120:2030-9 pubmed publisher
  4. Colella T, Bullock T, Russell L, Mullins D, Overwijk W, Luckey C, et al. Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy. J Exp Med. 2000;191:1221-32 pubmed
    ..The relevance of this model to an understanding of the human immune response to tyrosinase is discussed. ..
  5. Burri L, Strahm Y, Hawkins C, Gentle I, Puryer M, Verhagen A, et al. Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane. Mol Biol Cell. 2005;16:2926-33 pubmed
    ..on sequence conservation and functional complementation, and the novel sequence motif RX(5)P in Imp1 and NX(5)S in Imp2 distinguish the two catalytic subunits...
  6. Newberg M, Smith D, Haertel S, Vining D, Lacy E, Engelhard V. Importance of MHC class 1 alpha2 and alpha3 domains in the recognition of self and non-self MHC molecules. J Immunol. 1996;156:2473-80 pubmed
    ..Surprisingly, the response to non-self human class I MHC determinants was not augmented in AAD mice, indicating that the T cells selected are narrowly focused on AAD-related structures...
  7. George S, Jiao Y, Bishop C, Lu B. Mitochondrial peptidase IMMP2L mutation causes early onset of age-associated disorders and impairs adult stem cell self-renewal. Aging Cell. 2011;10:584-94 pubmed publisher
    ..We recently generated a mouse mutant with mutated inner mitochondrial membrane peptidase 2-like (Immp2l) gene, which impairs the signal peptide sequence processing of mitochondrial proteins cytochrome c1 and glycerol ..
  8. George S, Jiao Y, Bishop C, Lu B. Oxidative stress is involved in age-dependent spermatogenic damage of Immp2l mutant mice. Free Radic Biol Med. 2012;52:2223-33 pubmed publisher
    ..We recently generated a mouse in which the inner mitochondrial membrane peptidase 2-like (Immp2l) gene is mutated...
  9. Lengagne R, Graff Dubois S, Garcette M, Renia L, Kato M, Guillet J, et al. Distinct role for CD8 T cells toward cutaneous tumors and visceral metastases. J Immunol. 2008;180:130-7 pubmed
    ..They also reveal a different role for CD8+ T cells toward early stage of cutaneous tumors and late visceral metastatic stage of the disease. ..

More Information


  1. Soler R, Fullhase C, Lu B, Bishop C, Andersson K. Bladder dysfunction in a new mutant mouse model with increased superoxide--lack of nitric oxide?. J Urol. 2010;183:780-5 pubmed publisher
    ..Mice with mutation in the Immp2l gene have high superoxide ion levels and a consequent decrease in the bioavailable amount of nitric oxide...
  2. Han C, Zhao Q, Lu B. The role of nitric oxide signaling in food intake; insights from the inner mitochondrial membrane peptidase 2 mutant mice. Redox Biol. 2013;1:498-507 pubmed publisher
    ..We previously reported that Immp2l mutation in mice causes excessive mitochondrial superoxide generation, which causes infertility and early signs of ..
  3. Tewalt E, Cohen J, Rouhani S, Guidi C, Qiao H, Fahl S, et al. Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells. Blood. 2012;120:4772-82 pubmed publisher
    ..Because LECs express numerous peripheral tissue antigens, lack of costimulation coupled to rapid high-level up-regulation of inhibitory receptors may be generally important in systemic peripheral tolerance. ..
  4. Nichols L, Chen Y, Colella T, Bennett C, Clausen B, Engelhard V. Deletional self-tolerance to a melanocyte/melanoma antigen derived from tyrosinase is mediated by a radio-resistant cell in peripheral and mesenteric lymph nodes. J Immunol. 2007;179:993-1003 pubmed
    ..This suggests that direct presentation of tyrosinase by radio-resistant lymph node resident cells is entirely responsible for tolerance to this endogenous melanocyte differentiation Ag. ..
  5. Liu C, Li X, Lu B. The Immp2l mutation causes age-dependent degeneration of cerebellar granule neurons prevented by antioxidant treatment. Aging Cell. 2016;15:167-76 pubmed publisher
    ..We recently showed that mice with a mutation in the Inner Mitochondrial Membrane Peptidase 2-like (Immp2l) gene had elevated levels of mitochondrial superoxide, impaired fertility and age-associated phenotypes, including ..
  6. Madsen C, Petersen C, Lavrsen K, Harndahl M, Buus S, Clausen H, et al. Cancer associated aberrant protein O-glycosylation can modify antigen processing and immune response. PLoS ONE. 2012;7:e50139 pubmed publisher
    ..GalNAc glycosylation of MUC1 antigen therefore facilitates uptake, MHC class II presentation, and antibody response but might block the antigen presentation to CD8+ T cells. ..
  7. Toh B, Wang X, Keeble J, Sim W, Khoo K, Wong W, et al. Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor. PLoS Biol. 2011;9:e1001162 pubmed publisher
    ..These findings explain how cancer cells acquire a motile phenotype so early and provide a mechanistic explanation for the long recognized link between inflammation and cancer progression. ..
  8. Brinkman C, Rouhani S, Srinivasan N, Engelhard V. Peripheral tissue homing receptors enable T cell entry into lymph nodes and affect the anatomical distribution of memory cells. J Immunol. 2013;191:2412-25 pubmed publisher
    ..These novel cells share properties of both central and effector memory cells and reside in LN based on previously undescribed mechanisms of entry. ..
  9. Hong M, Puaux A, Huang C, Loumagne L, Tow C, MacKay C, et al. Chemotherapy induces intratumoral expression of chemokines in cutaneous melanoma, favoring T-cell infiltration and tumor control. Cancer Res. 2011;71:6997-7009 pubmed publisher
    ..Therefore, identifying chemotherapeutic drugs able to induce the expression of T-cell-attracting chemokines in cancer cells may represent a novel strategy to improve the efficacy of cancer immunotherapy. ..
  10. Rosendahl Huber S, Luimstra J, van Beek J, Hoppes R, Jacobi R, Hendriks M, et al. Chemical Modification of Influenza CD8+ T-Cell Epitopes Enhances Their Immunogenicity Regardless of Immunodominance. PLoS ONE. 2016;11:e0156462 pubmed publisher
    ..Thus, enhancing binding affinity of peptides provides a valuable tool to improve the immunogenicity and range of preventive T cell-targeted peptide vaccines. ..
  11. Gregg R, Nichols L, Chen Y, Lu B, Engelhard V. Mechanisms of spatial and temporal development of autoimmune vitiligo in tyrosinase-specific TCR transgenic mice. J Immunol. 2010;184:1909-17 pubmed publisher
    ..Genetic ablation of CXCR3 or IFN-gamma also resulted in scarce CD8 T cell infiltration into the skin. Our results identify unexpected complexity in vitiligo development and point toward possible therapeutic interventions. ..
  12. Qian J, Dong Y, Pang Y, Ibrahim R, Berzofsky J, Schiller J, et al. Combined prophylactic and therapeutic cancer vaccine: enhancing CTL responses to HPV16 E2 using a chimeric VLP in HLA-A2 mice. Int J Cancer. 2006;118:3022-9 pubmed
  13. Fujii Y, Kishi Y, Gotoh Y. IMP2 regulates differentiation potentials of mouse neocortical neural precursor cells. Genes Cells. 2013;18:79-89 pubmed publisher
    ..In this study, we found that HMGA2 promotes the expression of insulin-like growth factor 2 mRNA-binding protein 2 (IMP2, Igf2bp2) in neocortical NPCs...
  14. Ma Y, Mehta S, Lu B, Li P. Deficiency in the inner mitochondrial membrane peptidase 2-like (Immp21) gene increases ischemic brain damage and impairs mitochondrial function. Neurobiol Dis. 2011;44:270-6 pubmed publisher
    Mitochondrial dysfunction plays an important role in mediating ischemic brain damage. Immp2l is an inner mitochondrial membrane peptidase that processes mitochondrial protein cytochrome c1 (Cyc1)...
  15. Cohen J, Tewalt E, Rouhani S, Buonomo E, Bruce A, Xu X, et al. Tolerogenic properties of lymphatic endothelial cells are controlled by the lymph node microenvironment. PLoS ONE. 2014;9:e87740 pubmed publisher
    ..This work uncovers a critical role for the lymph node microenvironment in endowing lymphatic endothelial cells with potent tolerogenic properties. ..
  16. Bharadwaj M, Zhou Y, Molina A, Criswell T, Lu B. Examination of bioenergetic function in the inner mitochondrial membrane peptidase 2-like (Immp2l) mutant mice. Redox Biol. 2014;2:1008-15 pubmed publisher
    Inner mitochondrial membrane peptidase 2-like (IMMP2L) protein is a mitochondrial inner membrane peptidase that cleaves the signal peptide sequences of cytochrome c1 (CYC1) and mitochondrial glycerol phosphate dehydrogenase (GPD2)...