Il7r

Summary

Gene Symbol: Il7r
Description: interleukin 7 receptor
Alias: CD127, IL-7Ralpha, IL-7 receptor alpha chain, IL-7 receptor subunit alpha, IL-7R subunit alpha, IL-7R-alpha, IL-7RA, interleukin 7 receptor alpha chain, interleukin-7 receptor subunit alpha
Species: mouse

Top Publications

  1. doi Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
    Kazuyo Moro
    Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Nature 463:540-4. 2010
  2. doi Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1
    Olaf Gross
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    Immunity 36:388-400. 2012
  3. pmc Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
    J J Peschon
    Immunex Research and Development Corporation, Seattle, Washington 98101
    J Exp Med 180:1955-60. 1994
  4. ncbi An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells
    Gerard Eberl
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 5:64-73. 2004
  5. pmc Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes
    Cedric Vonarbourg
    IMMH, Institute of Medical Microbiology and Hygiene, University of Freiburg, 79104 Freiburg, Germany
    Immunity 33:736-51. 2010
  6. pmc Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development
    Sanjiv A Luther
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    J Exp Med 197:1191-8. 2003
  7. ncbi Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine
    Hiromasa Hamada
    Department of Microbiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Immunol 168:57-64. 2002
  8. ncbi Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo
    K S Schluns
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Nat Immunol 1:426-32. 2000
  9. pmc Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis
    K Honda
    Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Syogoin Kawaharacho 53, Sakyo ku, Kyoto 606 8507, Japan
    J Exp Med 193:621-30. 2001
  10. ncbi TCR and IL-7 receptor signals can operate independently or synergize to promote lymphopenia-induced expansion of naive T cells
    Benedict Seddon
    Division of Molecular Immunology, National Institute for Medical Research, London, United Kingdom
    J Immunol 169:3752-9. 2002

Research Grants

  1. Regulation of Lymphocyte Development by HLH Proteins
    BARBARA LYNNE KEE; Fiscal Year: 2010
  2. ROLES OF MOUSE GLI GENES IN HEDGEHOG SIGNALING
    Alexandra Joyner; Fiscal Year: 2006
  3. PATHOGENESIS AND PREVENTION OF AUTOIMMUNE DIABETES
    Richard Flavell; Fiscal Year: 2007
  4. NALT-BASED ADJUVANTS FOR MUCOSAL IMMUNITY IN AGING
    Kohtaro Fujihashi; Fiscal Year: 2007
  5. ROLES OF MOUSE GLI GENES IN HEDGEHOG SIGNALING
    Alexandra Joyner; Fiscal Year: 2007
  6. Roles of Nod2 in the Pathogenesis of Crohn's Disease
    Richard Flavell; Fiscal Year: 2007
  7. Mechanisms of CTLA-4 Function
    Joonsoo Kang; Fiscal Year: 2007
  8. Regulation of T cell development by SOX13
    Joonsoo Kang; Fiscal Year: 2007
  9. Regulation of T cell development by SOX13
    Joonsoo Kang; Fiscal Year: 2009
  10. Homeostatic Regulation of T Lymphocytes
    Booki Min; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications110 found, 100 shown here

  1. doi Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
    Kazuyo Moro
    Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Nature 463:540-4. 2010
    ..These cells do not express lineage (Lin) markers but do express c-Kit, Sca-1 (also known as Ly6a), IL7R and IL33R...
  2. doi Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1
    Olaf Gross
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    Immunity 36:388-400. 2012
    ..Because inflammasomes contribute to the pathology of numerous chronic inflammatory diseases such as gout and diabetes, IL-1α antagonists may be beneficial in the treatment of these disorders...
  3. pmc Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
    J J Peschon
    Immunex Research and Development Corporation, Seattle, Washington 98101
    J Exp Med 180:1955-60. 1994
    ..Significantly, these studies indicate that the phase of thymocyte expansion occurring before the onset of T cell receptor gene rearrangement is critically dependent upon, and mediated by the high affinity receptor for IL-7...
  4. ncbi An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells
    Gerard Eberl
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 5:64-73. 2004
    ..This early LTi cell-mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues...
  5. pmc Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes
    Cedric Vonarbourg
    IMMH, Institute of Medical Microbiology and Hygiene, University of Freiburg, 79104 Freiburg, Germany
    Immunity 33:736-51. 2010
    ..Our data also define a previously unappreciated role of RORγt⁻ NKR-LTi cells for the onset or maintenance of inflammatory bowel diseases...
  6. pmc Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development
    Sanjiv A Luther
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    J Exp Med 197:1191-8. 2003
    ..These findings indicate that CXCL13 and CCR7 ligands promote accumulation of CD4+ CD3- IL-7R alpha hi cells, delivering IL-7R alpha-dependent LT alpha 1 beta 2 signals critical for LN development...
  7. ncbi Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine
    Hiromasa Hamada
    Department of Microbiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Immunol 168:57-64. 2002
    ..These findings indicate that ILF, PP, and CP constitute three distinct organized gut-associated lymphoid tissues that reside in the lamina propria of the mouse small intestine...
  8. ncbi Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo
    K S Schluns
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Nat Immunol 1:426-32. 2000
    ..Homeostatic proliferation of memory cells was also partially dependent on IL-7. These results point to IL-7 as a pivotal cytokine in T cell homeostasis...
  9. pmc Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis
    K Honda
    Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Syogoin Kawaharacho 53, Sakyo ku, Kyoto 606 8507, Japan
    J Exp Med 193:621-30. 2001
    ..Thus, promotion of PP development relies on mutual interaction between mesenchymal and lymphoid cells...
  10. ncbi TCR and IL-7 receptor signals can operate independently or synergize to promote lymphopenia-induced expansion of naive T cells
    Benedict Seddon
    Division of Molecular Immunology, National Institute for Medical Research, London, United Kingdom
    J Immunol 169:3752-9. 2002
    ..Finally, we show that only lck and not fyn can mediate the TCR-driven proliferation, while neither lck nor fyn is required for IL-7R-induced proliferation...
  11. pmc Interleukin 7 receptor-deficient mice lack gammadelta T cells
    K Maki
    Department of Disease Related Gene Regulation Research Sandoz Faculty of Medicine, The Univerisity of Tokyo, Japan
    Proc Natl Acad Sci U S A 93:7172-7. 1996
    ..On the contrary, it is suggested that NK-cell development requires cytokine(s) other than IL-7...
  12. ncbi Failure of B-cell differentiation in mice lacking the transcription factor EBF
    H Lin
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco 94143, USA
    Nature 376:263-7. 1995
    ....
  13. ncbi IL-7 receptor alpha+ CD3(-) cells in the embryonic intestine induces the organizing center of Peyer's patches
    H Yoshida
    Department of Molecular Genetics, Faculty of Medicine, Institute of Genetics, Faculty of Medicine, Kyoto University, Syogoin Kawaharacho 53, Sakyoku, Kyoto 606 850, Japan
    Int Immunol 11:643-55. 1999
    ..Intestinal IL-7Ralpha+ cells are lymphoid in morphology but CD3(-) and functional in both nu/nu and Rag2-/- mice. These results implicate IL-7Ralpha+ CD3(-) cells as the direct inducer of the organizing center of PP...
  14. pmc LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen
    Mark F Vondenhoff
    Department of Molecular Cell Biology and Immunology, VU Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    J Immunol 182:5439-45. 2009
    ..Furthermore, the same signals may regulate lymphangiogenesis to the lymph node through induction of VEGF-C...
  15. ncbi Essential role of IL-7 receptor alpha in the formation of Peyer's patch anlage
    S Adachi
    Molecular Genetics, Faculty of Medicine, Kyoto University, Japan
    Int Immunol 10:1-6. 1998
    ..These results indicate that IL-7Ralpha is an essential signal for an early step of PP anlage formation, without which the subsequent processes cannot be initiated...
  16. doi Increased CD127 expression on activated FOXP3+CD4+ regulatory T cells
    Federico Simonetta
    INSERM, U1012, Le Kremlin Bicetre, France
    Eur J Immunol 40:2528-38. 2010
    ..In addition, Treg are also characterized by low CD127 (IL-7R alpha) expression when compared to conventional T cells and their biology in the periphery is considered ..
  17. ncbi Mucosal T cells expressing high levels of IL-7 receptor are potential targets for treatment of chronic colitis
    Motomi Yamazaki
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Immunol 171:1556-63. 2003
    ....
  18. pmc IL-7 receptor signals inhibit expression of transcription factors TCF-1, LEF-1, and RORgammat: impact on thymocyte development
    Qing Yu
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bldg 10, Rm 4B36, Bethesda, MD 20892, USA
    J Exp Med 200:797-803. 2004
    ..We conclude that IL-7R signals down-regulate transcription factors required for the ISP to DP transition and so must be terminated by the ISP stage of thymocyte development...
  19. doi Discontinued postnatal thymocyte development in sphingosine 1-phosphate-lyase-deficient mice
    Claudia Weber
    Institute for Immunology, Hannover Medical School, Hanover 30625, Germany
    J Immunol 183:4292-301. 2009
    ..Our findings indicate that potentially therapeutic immunosuppression by SGPL1 inhibition should benefit from monitoring ceramides to prevent their increase to apoptosis- inducing levels...
  20. ncbi The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression
    U von Freeden-Jeffry
    Department of Immunobiology, DNAX Research Institute, Palo Alto, California 94304, USA
    Immunity 7:147-54. 1997
    ..These data specify a T cell lineage developmental transition point, prior to T cell antigen receptor rearrangement, where IL-7 signal transduction is linked to an anti-apoptosis mechanism and the cell cycle...
  21. pmc Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor
    Yann M Kerdiles
    Molecular Biology Section, Division of Biological Sciences, Department of Cellular and Molecular Medicine, University of California, San Diego, California 92093 0377, USA
    Nat Immunol 10:176-84. 2009
    ..severe defect in interleukin 7 receptor alpha-chain (IL-7Ralpha) expression associated with its ability to bind an Il7r enhancer. Finally, growth factor withdrawal induced a Foxo1-dependent increase in Sell, Klf2 and Il7r expression...
  22. pmc Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R alpha mutant mice
    Lisa C Osborne
    Department of Microbiology and Immunology, University of British Columbia Vancouver, British Columbia, Canada V6T 1Z3
    J Exp Med 204:619-31. 2007
    Loss of interleukin (IL)-7 or the IL-7 receptor alpha (IL-7Ralpha, CD127) results in severe immunodeficiencies in mice and humans...
  23. ncbi IL-7 receptor and VDJ recombination: trophic versus mechanistic actions
    S Candeias
    SAIC, Frederick Cancer Research and Development Center, National Cancer Institute, Maryland 21702, USA
    Immunity 6:501-8. 1997
  24. pmc Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells
    Y W He
    Department of Microbiology and Immunology, University of Miami School of Medicine, Florida 33101, USA
    J Exp Med 184:289-93. 1996
    ..Thus, IL-7R alpha function is required for the development of gamma delta + T cells but not natural killer cells...
  25. pmc Distinct regions of the interleukin-7 receptor regulate different Bcl2 family members
    Qiong Jiang
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702 1201, USA
    Mol Cell Biol 24:6501-13. 2004
    ..Thus the IL-7 receptor controls at least two distinct pathways, in addition to Stat5, that are required for cell survival...
  26. pmc Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function
    Li Fen Lee
    Rinat, Pfizer Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 109:12674-9. 2012
    ..The durable efficacy and the multipronged tolerogenic mechanisms of IL-7Rα antibody therapy suggest a unique disease-modifying approach to T1D...
  27. doi CD45 regulates migration, proliferation, and progression of double negative 1 thymocytes
    Jacqueline C Y Lai
    Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    J Immunol 185:2059-70. 2010
    ..CD45(-/-) CD117(-) DN1 cells were also deficient in TCRbeta expression. Thus, CD45 deficiency affects the development and progression of DN1 thymocytes...
  28. ncbi Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival
    Jung Hyun Park
    Experimental Immunology Branch, National Cancer Institute, Building 10 Room 4B36, Bethesda, Maryland 20892, USA
    Immunity 21:289-302. 2004
    ..Consequently, IL7R expression is reduced on T cells that have received cytokine-mediated survival signals so they do not compete with ..
  29. ncbi Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice
    K Akashi
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Cell 89:1033-41. 1997
    ..We propose cell survival signals to be the principal function of IL-7R engagement in thymic and T cell development...
  30. pmc IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development
    Kieng B Vang
    Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 181:3285-90. 2008
    ....
  31. ncbi Critical role of FLT3 ligand in IL-7 receptor independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors
    Ewa Sitnicka
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden
    Blood 110:2955-64. 2007
    ....
  32. ncbi Functional natural killer T cells in experimental mouse strains, including NK1.1- strains
    I Serizawa
    Division of Laboratory Animal Science, Nippon Veterinary and Animal Science University, Tokyo, Japan
    Exp Anim 49:171-80. 2000
    ..This is the first report to show the functional significance of NKT cells in cytokine secretion in various mouse strains in response to a ligand for the T cell receptor of NKT cells...
  33. ncbi STAT5 activation underlies IL7 receptor-dependent B cell development
    Christine A Goetz
    Department of Laboratory Medicine and Pathology, Center for Immunology, Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 172:4770-8. 2004
    Signals initiated by the IL7R are required for B cell development. However, the roles that distinct IL7R-induced signaling pathways play in this process remains unclear...
  34. pmc The V-J recombination of T cell receptor-gamma genes is blocked in interleukin-7 receptor-deficient mice
    K Maki
    Department of Disease Related Gene Regulation Research Sandoz, Faculty of Medicine, University of Tokyo, Japan
    J Exp Med 184:2423-7. 1996
    ..These data demonstrated that the V-J recombination of the TCR gamma genes is specifically blocked in the IL-7R-deficient mice and suggested the presence of highly specific regulation for TCR gamma gene rearrangement...
  35. pmc Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP
    Renata Mazzucchelli
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute NCI, National Institutes of Health NIH, Frederick, MD, USA
    Blood 112:3283-92. 2008
    ....
  36. pmc Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1
    Anmol Chandele
    Department of Immunobiology, Yale Medical School, New Haven, CT 06511, USA
    J Immunol 180:5309-19. 2008
    ....
  37. pmc Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility
    S K Durum
    Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, Maryland 21702, USA
    J Exp Med 188:2233-41. 1998
    ..This data supports the model that IL-7R promotes TCR-gamma gene rearrangement by regulating accessibility of the locus via demethylation and histone acetylation of the locus...
  38. doi FLT3 ligand and not TSLP is the key regulator of IL-7-independent B-1 and B-2 B lymphopoiesis
    Christina T Jensen
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden
    Blood 112:2297-304. 2008
    ..Thus, the same IL-7- and FLT3 ligand-mediated signal-ing regulates alternative pathways of fetal and adult B-1 and B-2 lymphopoiesis...
  39. doi Separation of splenic red and white pulp occurs before birth in a LTalphabeta-independent manner
    Mark F R Vondenhoff
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Leukoc Biol 84:152-61. 2008
    ..The postnatal development of the splenic white pulp, involving the influx of T cells, depends on LTalpha1beta2 expressed by B cells...
  40. pmc A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells
    Allison L Bayer
    Department of Microbiology and Immunology, Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    J Immunol 181:225-34. 2008
    ..Collectively, these data indicate that IL-7R signaling contributes to Treg cell development and peripheral homeostasis...
  41. pmc Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells
    Shin ichiro Sawa
    Laboratory of Developmental Immunology, Graduate School of Frontier Bioscience and Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    J Exp Med 203:1459-70. 2006
    ....
  42. pmc Regulation of T cell-dendritic cell interactions by IL-7 governs T-cell activation and homeostasis
    Manoj Saini
    Medical Research Council Centre for Immune Regulation, Division of Immunity and Infection, Birmingham University, Birmingham, United Kingdom
    Blood 113:5793-800. 2009
    ..Thus, we demonstrate a novel role for IL-7 in regulating T cell-dendritic cell interactions that is essential for both T-cell homeostasis and activation in vivo...
  43. pmc Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis
    Ewa Sitnicka
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University Hospital, BMC 10, Klinikgatan 26, 221 84 Lund, Sweden
    J Exp Med 198:1495-506. 2003
    ..Thus, signaling through the cytokine tyrosine kinase receptor flt3 and IL-7Ralpha are indispensable for fetal and adult B cell development...
  44. ncbi Impaired survival and proliferation in IL-7 receptor-deficient peripheral T cells
    E Maraskovsky
    Department of Cellular Immunology, Immunex Corporation, Seattle, WA 98101, USA
    J Immunol 157:5315-23. 1996
    ..We propose that an absence of IL-7R signaling not only affects T cell development in the thymus, but also results in the accumulation of functionally inactive T cells in the periphery...
  45. ncbi Regulation of thymus size by competition for stromal niches among early T cell progenitors
    Susan E Prockop
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 173:1604-11. 2004
    ..Together with asymmetric use of marrow-derived progenitors to reconstitute the intrathymic pool, these processes facilitate continuous generation of new T cells while maintaining a relatively stable organ size...
  46. ncbi Transient IL-7/IL-7R signaling provides a mechanism for feedback inhibition of immunoglobulin heavy chain gene rearrangements
    Dipanjan Chowdhury
    Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Immunity 18:229-41. 2003
    ..Thus, transient signals mediate V(H) gene activation and inactivation during development...
  47. pmc The earliest step in B lineage differentiation from common lymphoid progenitors is critically dependent upon interleukin 7
    Juli P Miller
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Exp Med 196:705-11. 2002
    ..These findings challenge previous notions regarding the point in B cell development affected by the loss of IL-7R signaling and suggest that IL-7 plays a key and requisite role during the earliest phases of B cell development...
  48. ncbi Selective thymus settling regulated by cytokine and chemokine receptors
    Benjamin A Schwarz
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 178:2008-17. 2007
    ..We conclude that fms-like tyrosine kinase receptor-3 signaling is required for the generation of T lineage-competent progenitors, which selectively express molecules, including CCR9, that allow them to settle within the thymus...
  49. ncbi Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor
    A E Corcoran
    Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    Nature 391:904-7. 1998
    ..This mechanism augments the recombinational diversity of the primary antibody repertoire...
  50. ncbi A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127
    Christian A J Vosshenrich
    Unité des Cytokines et Développement Lymphoide, Institut National de la Santé et de la Recherche Médicale U668, Institut Pasteur, Paris F 75724, France
    Nat Immunol 7:1217-24. 2006
    ..Here we identify the transcription factor GATA-3 and CD127 (IL-7R alpha) as molecular markers of a pathway of mouse NK cell development that originates in the thymus...
  51. pmc Stat5a/b are essential for normal lymphoid development and differentiation
    Zhengju Yao
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:1000-5. 2006
    ..Thus, deficiency of Stat5 results in severe combined immunodeficiency, similar in many respects to deficiency of IL-7R, gammac, and Jak3...
  52. pmc The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development
    J P Di Santo
    Institut National de la Santé et de la Recherche Médicale INSERM U429, Hopital Necker Enfants Malades, F 75743 Paris, France
    J Exp Med 189:563-74. 1999
    ..Thus, a series of overlapping signals derived from cytokine and T cell receptors guide the process of alpha/beta thymocyte development...
  53. ncbi Thymic stromal-derived lymphopoietin distinguishes fetal from adult B cell development
    Christian A J Vosshenrich
    Unité des Cytokines et Développement Lymphoide, INSERM Equipe, 101 Institut Pasteur, 75724 Paris, France
    Nat Immunol 4:773-9. 2003
    ..The residual B cells found in IL-7R alpha-deficient mice required fetal liver kinase 2 (Flk-2) for their development. Thus, IL-7R alpha- and Flk-2-mediated signals account for the generation of almost all mouse B lymphocytes...
  54. ncbi PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors
    Rodney P DeKoter
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, The University of Chicago, 5841 S Maryland Ave, MC1028, Chicago, IL 60637, USA
    Immunity 16:297-309. 2002
    ..1 in early B cell development, it is not required. These results demonstrate that PU.1 functions to regulate early B cell development in part by controlling the expression of the IL-7Ralpha gene...
  55. ncbi Interleukin-7 induces the association of phosphatidylinositol 3-kinase with the alpha chain of the interleukin-7 receptor
    A R Venkitaraman
    Medical Research Council, Laboratory of Molecular Biology, Cambridge, GB
    Eur J Immunol 24:2168-74. 1994
    ..PtdIns 3-kinase may, therefore, play a unique and important role in the biological response to IL-7...
  56. ncbi Spontaneous and homeostatic proliferation of CD4 T cells are regulated by different mechanisms
    Booki Min
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:6039-44. 2005
    ..Our results reveal the complexity and heterogeneity of lymphopenia-driven T cell proliferation and suggest that they may have fundamentally distinct roles in the maintenance of CD4 T cell homeostasis...
  57. ncbi Cell-fate decisions in early T cell development: regulation by cytokine receptors and the pre-TCR
    M C Haks
    Division of Immunology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Plesmanlaan 121, Amsterdam, CX, 1066, The Netherlands
    Semin Immunol 11:23-37. 1999
    ....
  58. pmc In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells
    Qing Yu
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 197:475-87. 2003
    ..Thus, cytokine receptors provide both survival and trophic/differentiative signals with varying degrees of redundancy that are required for differentiation of signaled DP thymocytes into functionally mature CD8(+) T cells...
  59. ncbi Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells
    Satoshi Fukuyama
    Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    Immunity 17:31-40. 2002
    ....
  60. ncbi Multiple gamma c-dependent cytokines regulate T-cell development
    T R Malek
    Dept of Microbiology and Immunology, University of Miami School of Medicine, FL 33136, USA
    Immunol Today 20:71-6. 1999
    ..Here, Thomas Malek and colleagues discuss the contribution of individual gamma c-dependent cytokines in both conventional and intraepithelial T-cell development...
  61. ncbi Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice
    E Maraskovsky
    Department of Cellular Immunology, Immunex Research and Development Corporation, Seattle, Washington 98101, USA
    Cell 89:1011-9. 1997
    ..These results provide evidence that blocking apoptosis is the essential function of IL-7R during differentiation and activation of T lymphocytes and that pre-TCR signaling blocks a pathway to apoptosis that is insensitive to Bcl-2...
  62. ncbi A transgenic T cell receptor restores thymocyte differentiation in interleukin-7 receptor alpha chain-deficient mice
    T Crompton
    Imperial Cancer Research Fund, London, GB
    Eur J Immunol 27:100-4. 1997
    ..In contrast, once cells have progressed beyond the DN stage of development the IL-7R alpha chain becomes no longer essential for RAG expression...
  63. ncbi Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor
    S K Ye
    Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan
    Immunity 11:213-23. 1999
    ..Therefore, this study reveals a potential role of Stat5 in T cell development and also implies that IL-7R may control the accessibility of the TCRgamma locus through Stat5-induced germline transcription...
  64. ncbi TCR-gamma genes are rearranged but not transcribed in IL-7R alpha-deficient mice
    N B Perumal
    The University of Pittsburgh Cancer Institute and Department of Pathology, University of Pittsburgh School of Medicine, PA 15213, USA
    J Immunol 158:5744-50. 1997
    ....
  65. ncbi Control of T cell development in vivo by subdomains within the IL-7 receptor alpha-chain cytoplasmic tail
    B O Porter
    Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33101, USA
    J Immunol 166:262-9. 2001
    ..Thus, separate cytoplasmic domains of the IL-7R alpha chain differentially control distinct functions during T cell development, whereas normal IL-7R-dependent thymic development requires the integrated activity of all these domains...
  66. ncbi Regulation of experimental autoimmune encephalomyelitis in the C57BL/6J mouse by NK1.1+, DX5+, alpha beta+ T cells
    R B Fritz
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 166:4209-15. 2001
    ..Only recipients of the former recovered normally from clinical disease. These results indicate that recovery from acute EAE is an active process that requires NK1.1(+), DX5(+) alpha beta(+) TCR spleen cells and IFN-gamma...
  67. ncbi Bax deficiency partially corrects interleukin-7 receptor alpha deficiency
    Annette R Khaled
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute Frederick, MD 21702, USA
    Immunity 17:561-73. 2002
    ..The BH3 only proteins, Bad and Bim, were also part of the death pathway repressed by IL-7. Thus, in young mice, Bax emerges as an essential protein in the death pathway induced by IL-7 deficiency...
  68. pmc The interleukin 7 receptor is required for T cell receptor gamma locus accessibility to the V(D)J recombinase
    M S Schlissel
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
    J Exp Med 191:1045-50. 2000
    ..We found a reduction in chromatin accessibility for Rag-mediated cleavage in IL-7R-/- thymocytes compared with wild-type. Thus, IL-7 controls recombination at the TCR-gamma locus by regulating locus accessibility...
  69. ncbi Defective T-cell receptor gamma gene rearrangement in interleukin-7 receptor knockout mice
    S Candeias
    SAIC, NCI FCRDC, Frederick, MD 21702 1201, USA
    Immunol Lett 57:9-14. 1997
    ..These findings indicate that one or both of the two known ligands of IL-7R, IL-7 and thymic stromal lymphopoietin (TSLP) serves as an extrinsic signal to specifically rearrange the TCR gamma locus...
  70. pmc Prevention of graft-versus-host disease by anti IL-7Ralpha antibody
    Brile Chung
    Division of Stem Cell Transplantation, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Blood 110:2803-10. 2007
    ..Blockade of IL-7R by anti-IL-7Ralpha antibody resulted in elimination of alloreactive T cells, prevention of GVHD, and improvement of donor T-cell reconstitution...
  71. ncbi Mesenchymal cells are required for functional development of thymic epithelial cells
    Manami Itoi
    Department of Immunology and Microbiology, Meiji University of Oriental Medicine, Hiyoshi cho, Nantan, Kyoto 629 0392, Japan
    Int Immunol 19:953-64. 2007
    ..In addition, our data suggest that mesenchymal cells are required to create the thymic microenvironment and to maintain epithelial architecture and function...
  72. pmc Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8(+) T cells
    Megan J Palmer
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Immunol Cell Biol 89:581-94. 2011
    ..Our findings indicate that IL-7R-mediated signaling not only maintains the size but also impacts the diversity of the naïve T-cell repertoire...
  73. doi Upregulated IL-7 receptor α expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis
    Tamako Shinohara
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Immunol 186:2623-32. 2011
    ..Therefore, therapeutic approaches targeting the IL-7/IL-7R signaling pathway in colitogenic CD4(+) T cells may be feasible for the treatment of inflammatory bowel diseases...
  74. pmc IL-7 receptor expression provides the potential for long-term survival of both CD62Lhigh central memory T cells and Th1 effector cells during Leishmania major infection
    Sara L Colpitts
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 182:5702-11. 2009
    ..whether the prosurvival cytokine IL-7 contributes to maintaining these T cells, we examined expression of the IL7R on CD4(+) T cells activated during L. major infection...
  75. doi Accessibility control of TCR Vγ region by STAT5
    Shizue Tani-Ichi
    Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Int Immunol 22:693-703. 2010
    ..Thus, this study implies a potential role of STAT5 in accessibility control of Vgamma region, especially at Vgamma5 and HsA...
  76. doi Activation of the mouse TCRgamma enhancers by STAT5
    Shizue Tani-Ichi
    Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, 53 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Int Immunol 21:1079-88. 2009
    ..Therefore, this study implies that the Egamma elements might be activated in two successive steps, first by Runx and c-Myb and next by STAT5...
  77. ncbi An interspecific linkage map of mouse chromosome 15 positioned with respect to the centromere
    C I Brannan
    Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702
    Genomics 13:1075-81. 1992
    ....
  78. ncbi STAT5 is required for thymopoiesis in a development stage-specific manner
    Joonsoo Kang
    Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 173:2307-14. 2004
    ....
  79. ncbi Distinct roles of the interleukin-7 receptor alpha chain in fetal and adult thymocyte development revealed by analysis of interleukin-7 receptor alpha-deficient mice
    T Crompton
    Department of Biology, Imperial College of Science, Technology and Medicine, London, GB
    Eur J Immunol 28:1859-66. 1998
    ..These data suggest that the IL-7Ralpha chain is a key regulator of both survival and proliferation during thymocyte development but that it is not essential for the production of T cells during fetal thymopoiesis...
  80. ncbi Pre-pro-B cell growth-stimulating factor (PPBSF) upregulates IL-7Ralpha chain expression and enables pro-B cells to respond to monomeric IL-7
    Chiju Wei
    Department of Pathology, School of Medicine, University of Connecticut Health Center, Farmington, CT 06030 3105, USA
    J Interferon Cytokine Res 22:823-32. 2002
    ....
  81. ncbi Mammalian Polycomb complexes are required for Peyer's patch development by regulating lymphoid cell proliferation
    Toru Sato
    Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba, Japan
    Gene 379:166-74. 2006
    ..We suggest that PcG complexes may act to mediate certain inductive signals maybe through IL-7Ralpha to allow sufficient proliferation of lymphoid inducer cells during PP organogenesis...
  82. pmc Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25
    Klaus Gossens
    The Biomedical Research Centre, University of British Columbia, Vancouver, Canada
    J Exp Med 206:761-78. 2009
    ..Our findings suggest a model whereby thymic TCP importation is controlled by both early thymic niche occupancy and the peripheral lymphocyte pool via S1P...
  83. ncbi IL-7 exacerbates chronic colitis with expansion of memory IL-7Rhigh CD4+ mucosal T cells in mice
    Eriko Okada
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Am J Physiol Gastrointest Liver Physiol 288:G745-54. 2005
    ..Therefore, therapeutic approaches targeting the IL-7R pathway may be feasible in the treatment of human inflammatory bowel disease...
  84. ncbi Impaired B-1 and B-2 B cell development and atypical splenic B cell structures in IL-7 receptor-deficient mice
    Lena Erlandsson
    Laboratory of Lymphocyte Signaling and Development, The Babraham Institute, Cambridge, UK
    Eur J Immunol 34:3595-603. 2004
    ..The impairment of marginal zone and B-1 B cells in IL-7 receptor- but not IL-7-deficient mice suggests non-redundant functions for the IL-7 receptor ligands, IL-7 and thymic stromal lymphopoietin...
  85. ncbi GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cells
    Hai Hui Xue
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10, Room 7N252, Bethesda, Maryland 20892 1674, USA
    Nat Immunol 5:1036-44. 2004
    ....
  86. pmc Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development
    Malay Mandal
    Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA
    Nat Immunol 10:1110-7. 2009
    ..Our data show how pre-BCR signaling poises pre-B cells to undergo differentiation after escape from IL-7R signaling...
  87. ncbi Bone marrow CD8 cells down-modulate membrane IL-7Ralpha expression and exhibit increased STAT-5 and p38 MAPK phosphorylation in the organ environment
    Giuliana Cassese
    Institute of Genetics and Biophysics Adriano Buzzati Traverso, Consiglio Nazionale delle Ricerche, Naples, Italy
    Blood 110:1960-9. 2007
    ..within the organ; in vitro response to interleukin-7 (IL-7), IL-15, IL-21; ex vivo expression of membrane CD127 (IL-7Ralpha), intracellular Bcl-2, phospho-STAT-5 (signal transducer and activator of transcription 5), phospho-..
  88. ncbi Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting
    M Matsumoto
    Division of Informative Cytology, University of Tokushima, Japan
    J Med Invest 46:141-50. 1999
    ....
  89. pmc Defective development of gamma/delta T cells in interleukin 7 receptor-deficient mice is due to impaired expression of T cell receptor gamma genes
    J Kang
    Department of Molecular and Cell Biology and The Cancer Research Laboratory, Division of Immunology, University of California at Berkeley, Berkeley, California 94720, USA
    J Exp Med 190:973-82. 1999
    ..The results indicate that the absence of gamma/delta T cells in IL-7Ralpha(-/-) mice is due to insufficient TCR-gamma gene expression...
  90. ncbi Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice
    A M Beebe
    DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304, USA
    Immunity 6:551-7. 1997
    ..The presence of all six loci was not necessary to confer resistance and no single locus was required. Rather, a variety of combinations of these loci may be capable of interacting to confer resistance...
  91. ncbi The mouse and human excitatory amino acid transporter gene (EAAT1) maps to mouse chromosome 15 and a region of syntenic homology on human chromosome 5
    M A Kirschner
    Vollum Institute for Advanced Biomedical Research, Portland, Oregon
    Genomics 22:631-3. 1994
    ..The Eaat1 locus appears not to be linked to the epilepsy mutant stg locus, which is also on chromosome 15. The EAAT1 locus is located in a region of 5p deletions that have been associated with mental retardation and microcephaly...
  92. pmc IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF
    Kazu Kikuchi
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Med 201:1197-203. 2005
    ..Thus, IL-7 receptor signaling is a participant in the formation of the transcription factor network during B lymphopoiesis by up-regulating EBF, allowing stage transition from the pre-pro-B to further maturational stages...
  93. pmc Ebf1-mediated down-regulation of Id2 and Id3 is essential for specification of the B cell lineage
    Melissa A Thal
    Department of Microbiology, The University of Alabama Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 106:552-7. 2009
    ..Collectively, these studies suggest a model where Ebf1 induction specifies the B cell fate by dramatically increasing activity of E47 at the posttranslational level...
  94. ncbi Intradermal administration of thymic stromal lymphopoietin induces a T cell- and eosinophil-dependent systemic Th2 inflammatory response
    Heidi K Jessup
    Inflammation Research, Amgen, Seattle, WA 98119, USA
    J Immunol 181:4311-9. 2008
    ..TSLP-induced responses were significantly, but not completely reduced in IL-4- and IL-13-deficient mice. These results shed light on the pathways and cell types involved in TSLP-induced inflammation...
  95. ncbi Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells
    DENNIS J HARTIGAN-O'CONNOR
    Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Immunol Methods 319:41-52. 2007
    ..T-regs, but consistent and specific discrimination of functional T-regs was only made possible by focus on CD127, the alpha chain of the IL-7 receptor...
  96. pmc Direct interaction between Kit and the interleukin-7 receptor
    Thomas Jahn
    Division of Research Immunology and Bone Marrow Transplantation, Childrens Hospital Los Angeles, CA, USA
    Blood 110:1840-7. 2007
    ..Such indirect activation of the Jak-Stat pathway induced by the interaction between an RTK and type I cytokine receptor could be the underlying mechanism for a context-specific signaling repertoire of a pleiotropic RTK-like Kit...
  97. ncbi Severely impaired clonal deletion of CD4+ T cells in low-dose irradiated mice: role of T cell antigen receptor and IL-7 receptor signals
    Elena Shklovskaya
    Centenary Institute of Cancer Medicine and Cell Biology, Faculty of Medicine, University of Sydney, Newtown, New South Wales 2042, Australia
    J Immunol 177:8320-30. 2006
    ..Failure of clonal deletion in irradiated hosts represents a novel mechanism limiting TCR diversity in a lymphopenic environment and may contribute to subsequent autoimmunity...
  98. ncbi Proteomics analysis of interleukin (IL)-7-induced signaling effectors shows selective changes in IL-7Ralpha449F knock-in T cell progenitors
    Kia A Duthie
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada
    Mol Cell Proteomics 6:1700-10. 2007
    ....
  99. ncbi Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells
    Alison H Banham
    LRF Lymphoma Antigens Group, Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Trends Immunol 27:541-4. 2006
    ..Two recent studies have demonstrated that downregulation of the interleukin-7 receptor (CD127) distinguishes Treg cells from activated T cells, facilitating both Treg-cell purification and their functional ..
  100. pmc Cutting edge: IL-7-independent regulation of IL-7 receptor alpha expression and memory CD8 T cell development
    Kimberly D Klonowski
    Department of Immunology, Center for Integrative Immunology and Vaccine Research, University of Connecticut Health Center, 2634 Farmington Avenue, Farmington, CT 06030, USA
    J Immunol 177:4247-51. 2006
    ..Thus, IL-7Ralpha regulation occurs independently of IL-7 in responding CD8 T cells, indicating that CD8 memory T cell precursors are not selected by IL-7/IL-7Ralpha interactions...
  101. pmc Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes
    Mark C Coles
    Division of Molecular Immunology and Immune Cell Biology and Confocal Microscopy and Image Analysis Laboratory, National Institute for Medical Research, Mill Hill, London, United Kingdom
    Proc Natl Acad Sci U S A 103:13457-62. 2006
    ..anlage persists for a week after birth but disperses subsequently, a process reversible by neonatal transfer of WT IL7r(+) TCR(+) T or natural killer (NK) cells, suggesting a role for IL7/IL7r interactions...

Research Grants62

  1. Regulation of Lymphocyte Development by HLH Proteins
    BARBARA LYNNE KEE; Fiscal Year: 2010
    ..Our studies will provide insight into how to how to manipulate this program to avoid disease and how therapeutic interventions will impact on NK cell development. ..
  2. ROLES OF MOUSE GLI GENES IN HEDGEHOG SIGNALING
    Alexandra Joyner; Fiscal Year: 2006
    ..4. To determine whether some cells receiving Shh signaling move away from the source of Shh and thus receive a shorter exposure to Shh than other cells using a Cre/loxP fate mapping approach with Gli1- CreEr mice. ..
  3. PATHOGENESIS AND PREVENTION OF AUTOIMMUNE DIABETES
    Richard Flavell; Fiscal Year: 2007
    ..We will determine whether TGF-beta is instrumental in this process and we will elucidate the mechanism whereby this occurs. ..
  4. NALT-BASED ADJUVANTS FOR MUCOSAL IMMUNITY IN AGING
    Kohtaro Fujihashi; Fiscal Year: 2007
    ....
  5. ROLES OF MOUSE GLI GENES IN HEDGEHOG SIGNALING
    Alexandra Joyner; Fiscal Year: 2007
    ....
  6. Roles of Nod2 in the Pathogenesis of Crohn's Disease
    Richard Flavell; Fiscal Year: 2007
    ..Furthermore, by using mice in which Rip2, the kinase downstream of Nod2, is deficient, we will try to reveal if the IBD pathology caused by Nod2 mutation is dependent on Rip2. ..
  7. Mechanisms of CTLA-4 Function
    Joonsoo Kang; Fiscal Year: 2007
    ..Understanding these processes is critical for designing novel therapeutic approaches for vaccine development, autoimmune disease, and in transplant and tumor immunology. ..
  8. Regulation of T cell development by SOX13
    Joonsoo Kang; Fiscal Year: 2007
    ..Collectively, the genetic program controlling T cell lineage commitment and maturation will be determined, allowing a better understanding of leukemogenesis. ..
  9. Regulation of T cell development by SOX13
    Joonsoo Kang; Fiscal Year: 2009
    ..Collectively, the genetic program controlling T cell lineage commitment and maturation will be determined, allowing a better understanding of leukemogenesis. ..
  10. Homeostatic Regulation of T Lymphocytes
    Booki Min; Fiscal Year: 2009
    ..The current proposal aims to investigate underlying cellular mechanism, and the results will aid our understanding of the immune mechanism and facilitate therapeutic strategies to treat disorders caused by the dysregulation. ..
  11. The role of Bcl-Rambo in thymic involution
    Richard Flavell; Fiscal Year: 2009
    ....
  12. ITK: an emerging target for treatment of T cell-mediated autoimmune disease
    Leslie J Berg; Fiscal Year: 2011
    ..A better understanding of this mechanism may provide opportunities to prevent the onset of autoimmune processes in susceptible individuals and to treat and cure patients with these diseases. ..
  13. Understanding Hemotopoietic Neoplasias using Humanized Mice
    MARKUS GABRIEL MANZ; Fiscal Year: 2010
    ..This model will serve as a platform for preclinical testing of medicines against cancer with a better likelihood of how well these medicines will work in people. ..
  14. Homeostatic Regulation of T Lymphocytes
    Booki Min; Fiscal Year: 2011
    ..The current proposal aims to investigate underlying cellular mechanism, and the results will aid our understanding of the immune mechanism and facilitate therapeutic strategies to treat disorders caused by the dysregulation. ..
  15. ADENOVIRUS FLT3 LIGAND INDUCES NALT DCs FOR SALIVARY GLAND S-lgA Ab RESPONSES
    Kohtaro Fujihashi; Fiscal Year: 2009
    ..4) Determination of the precise mechanism for cross-talk between Ad-FL-induced salivary DCs, B-1 B cells and yS T cells for salivary S-lgA Ab responses. ..
  16. Mechanisms of Lymphocyte Gene Regulation by E2A and Notch1
    BARBARA LYNNE KEE; Fiscal Year: 2010
    ..abstract_text> ..
  17. Critical roles of GA binding protein in HSC maintenance and ageing
    Hai Hui Xue; Fiscal Year: 2010
    ....
  18. Homeostatic Regulation of T Lymphocytes
    Booki Min; Fiscal Year: 2010
    ..The current proposal aims to investigate underlying cellular mechanism, and the results will aid our understanding of the immune mechanism and facilitate therapeutic strategies to treat disorders caused by the dysregulation. ..
  19. NALT-BASED ADJUVANTS FOR MUCOSAL IMMUNITY IN AGING
    Kohtaro Fujihashi; Fiscal Year: 2009
    ....
  20. ADENOVIRUS FLT3 LIGAND INDUCES NALT DCs FOR SALIVARY GLAND S-lgA Ab RESPONSES
    Kohtaro Fujihashi; Fiscal Year: 2009
    ..4) Determination of the precise mechanism for cross-talk between Ad-FL-induced salivary DCs, B-1 B cells and yS T cells for salivary S-lgA Ab responses. ..
  21. The Role of IL-2 in Autoimmune Diabetes
    Richard Flavell; Fiscal Year: 2007
    ..We will utilize our IL-2 knock-in mice to test these two mutually nonexclusive hypotheses. ..
  22. Ab5 Toxins Nasal Adjuvant Target the Olfactory Bulbs/CNS
    Kohtaro Fujihashi; Fiscal Year: 2004
    ..These proposed studies will provide essential new information to determine potential side effects of CT-B derivatives as nasal adjuvants, and point to ways where these toxic effects can be avoided. ..
  23. Determination of Mechanism of T cell Lineage Committment
    Joonsoo Kang; Fiscal Year: 2006
    ..The long-term objective of this application is to identify genes that determine T cell lineage fate. ..
  24. Dys/Regulation of the Immune System in Autoimmunity
    Richard Flavell; Fiscal Year: 2006
    ..The program is coordinated by frequent meetings of the program faculty and research workers bringing together these diverse approaches to address a common goal. ..
  25. Vaccine responsiveness to Borrelia burgdorferi OspA
    Richard Flavell; Fiscal Year: 2006
    ..abstract_text> ..
  26. A ROLE FOR INNATE IMMUNITY IN SALIVARY IgA RESPONSES
    Kohtaro Fujihashi; Fiscal Year: 2006
    ....
  27. Immunoregulatory Mechanisms in Autoimmune Diabetes
    Richard Flavell; Fiscal Year: 2005
    ..We will use regulated expression of TGF beta in the islets and a new T cell transgene which renders T cells resistant to inhibition to TGF beta to ask how TGF beta blocks IDDM and what happens in conditions when it cannot act. ..
  28. The function of membrane vesiculation in CTLA-4-mediate*
    Joonsoo Kang; Fiscal Year: 2005
    ..To date there has been limited advancement on the ability to increase CTLA-4 function. The proposed model of CTLA-4 function would provide a novel means to increase CTLA-4-mediated inhibition in vivo. ..